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    Compositions and methods for decreasing leukocyte extravasation and vessel fluid leakage
    4.
    发明授权
    Compositions and methods for decreasing leukocyte extravasation and vessel fluid leakage 有权
    减少白细胞外渗和血管液体渗漏的组合物和方法

    公开(公告)号：US09434951B2

    公开(公告)日：2016-09-06

    申请号：US14401629

    申请日：2013-05-21

    申请人： University of Massachusetts

    发明人： Michael P. Czech ,  Rachel Roth Flach

    IPC分类号： A61K48/00 ,  C12N15/113 ,  A61K31/713 ,  A61K45/06 ,  A61K9/00

    CPC分类号： C12N15/1137 ,  A61K9/0019 ,  A61K31/713 ,  A61K45/06 ,  C12N2310/11 ,  C12N2310/12 ,  C12N2310/14 ,  C12N2320/31 ,  C12Y207/11001

    摘要： Provided herein are methods of decreasing leukocyte extravasation from a lymph or blood vessel into a tissue in a mammal, methods of decreasing fluid leakage from a lymph or blood vessel in a mammal in need thereof, methods of decreasing formation of atherosclerotic plaques in a mammal in need thereof, and methods of treating atherosclerosis in a mammal that include administering to the mammal an oligonucleotide that decreases Mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4) mRNA expression in an endothelial cell. Also provided are methods of identifying a candidate agent useful for decreasing leukocyte extravasation or decreasing fluid leakage from a lymph or blood vessel in a mammal, and compositions containing an oligonucleotide that decreases Map4k4 mRNA expression in an endothelial cell and additional therapeutic agents.

    摘要翻译： 本文提供的是减少从淋巴或血管进入哺乳动物组织的白细胞外渗的方法，减少有需要的哺乳动物的淋巴或血管的流体泄漏的方法，减少哺乳动物的动脉粥样硬化斑块的形成的方法 其需要，以及治疗哺乳动物动脉粥样硬化的方法，包括向哺乳动物施用降低内皮细胞中丝裂原活化蛋白激酶激酶激酶激酶4（Map4k4）mRNA表达的寡核苷酸。 还提供了鉴定用于减少白细胞外渗或减少哺乳动物的淋巴或血管的液体渗漏的候选药剂的方法，以及含有降低内皮细胞中的Map4k4mRNA表达的寡核苷酸和其它治疗剂的组合物的方法。

    COMPOSITIONS AND METHODS FOR INDUCING MYOBLAST DIFFERENTIATION AND MYOTUBE FORMATION
    5.
    发明申请
    COMPOSITIONS AND METHODS FOR INDUCING MYOBLAST DIFFERENTIATION AND MYOTUBE FORMATION 有权
    用于诱导MYOBLAST分化和MYOTUBE形成的组合物和方法

    公开(公告)号：US20150133520A1

    公开(公告)日：2015-05-14

    申请号：US14401612

    申请日：2013-05-21

    申请人： University of Massachusetts

    发明人： Michael P. Czech ,  Mengxi Wang

    IPC分类号： C12N5/077 ,  G01N33/50 ,  A61K45/06 ,  A61K31/713 ,  A61K31/7105

    CPC分类号： C12N5/0658 ,  A61K9/0019 ,  A61K9/127 ,  A61K9/51 ,  A61K31/7105 ,  A61K31/7115 ,  A61K31/712 ,  A61K31/7125 ,  A61K31/713 ,  A61K45/06 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/12 ,  C12N2310/14 ,  C12N2501/40 ,  C12N2506/1323 ,  C12Y207/11001 ,  G01N33/5023 ,  G01N33/5061 ,  G01N33/5073 ,  G01N2333/91205 ,  G01N2333/91215 ,  G01N2800/10

    摘要： Provided herein are methods of inducing differentiation of a mammalian myoblast into a mammalian myocyte that include contacting a mammalian myoblast with an oligonucleotide that decreases Mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4) mRNA expression in a mammalian myoblast or myocyte. Also provided are methods of inducing mammalian myoblasts or myocytes to form a myotube that include contacting two or more mammalian myoblasts or two or more mammalian myocytes with an oligonucleotide that decreases Map4k4 mRNA expression in a mammalian myoblast or myocyte. Also provided are methods of identifying a candidate agent useful for inducing muscle formation, and compositions containing an oligonucleotide that decreases Map4k4 mRNA expression in mammalian myoblast or myocyte and one or more additional muscle therapeutic agents and/or muscle-building neutraceuticals.

    摘要翻译： 本文提供诱导哺乳动物成肌细胞分化为哺乳动物肌细胞的方法，其包括使哺乳动物成肌细胞与哺乳动物成肌细胞或肌细胞中降低丝裂原活化蛋白激酶激酶激酶4（Map4k4）mRNA表达的寡核苷酸接触。 还提供了诱导哺乳动物成肌细胞或肌细胞形成肌管的方法，其包括使两种或更多种哺乳动物成肌细胞或两种或更多种哺乳动物肌细胞与哺乳动物成肌细胞或肌细胞中降低Map4k4 mRNA表达的寡核苷酸接触。 还提供了鉴定用于诱导肌肉形成的候选药剂的方法，以及含有降低哺乳动物成肌细胞或肌细胞中的Map4k4mRNA表达的寡核苷酸和一种或多种另外的肌肉治疗剂和/或肌肉建立中性药物的组合物。

    COMPOSITIONS AND METHODS FOR DECREASING LEUKOCYTE EXTRAVASATION AND VESSEL FLUID LEAKAGE
    6.
    发明申请
    COMPOSITIONS AND METHODS FOR DECREASING LEUKOCYTE EXTRAVASATION AND VESSEL FLUID LEAKAGE 有权
    降低低渗透油和流体流体泄漏的组合物和方法

    公开(公告)号：US20150111947A1

    公开(公告)日：2015-04-23

    申请号：US14401629

    申请日：2013-05-21

    申请人： University of Massachusetts

    发明人： Michael P. Czech ,  Rachel Roth Flach

    IPC分类号： C12N15/113 ,  A61K45/06 ,  A61K31/713

    CPC分类号： C12N15/1137 ,  A61K9/0019 ,  A61K31/713 ,  A61K45/06 ,  C12N2310/11 ,  C12N2310/12 ,  C12N2310/14 ,  C12N2320/31 ,  C12Y207/11001

    摘要： Provided herein are methods of decreasing leukocyte extravasation from a lymph or blood vessel into a tissue in a mammal, methods of decreasing fluid leakage from a lymph or blood vessel in a mammal in need thereof, methods of decreasing formation of atherosclerotic plaques in a mammal in need thereof, and methods of treating atherosclerosis in a mammal that include administering to the mammal an oligonucleotide that decreases Mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4) mRNA expression in an endothelial cell. Also provided are methods of identifying a candidate agent useful for decreasing leukocyte extravasation or decreasing fluid leakage from a lymph or blood vessel in a mammal, and compositions containing an oligonucleotide that decreases Map4k4 mRNA expression in an endothelial cell and additional therapeutic agents.

    摘要翻译： 本文提供的是减少从淋巴或血管进入哺乳动物组织的白细胞外渗的方法，减少有需要的哺乳动物的淋巴或血管的流体泄漏的方法，减少哺乳动物的动脉粥样硬化斑块的形成的方法 其需要，以及治疗哺乳动物动脉粥样硬化的方法，包括向哺乳动物施用降低内皮细胞中丝裂原活化蛋白激酶激酶激酶激酶4（Map4k4）mRNA表达的寡核苷酸。 还提供了鉴定用于减少白细胞外渗或减少哺乳动物的淋巴或血管的液体渗漏的候选药剂的方法，以及含有降低内皮细胞中的Map4k4mRNA表达的寡核苷酸和其它治疗剂的组合物的方法。