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    Compositions and methods for cell dedifferentiation and tissue regeneration
    2.
    发明申请
    Compositions and methods for cell dedifferentiation and tissue regeneration 审中-公开
    细胞去分化和组织再生的组合物和方法

    公开(公告)号：US20080227738A1

    公开(公告)日：2008-09-18

    申请号：US11880435

    申请日：2007-07-20

    申请人： Mark T. Keating ,  Shannon J. Odelberg ,  Kenneth D. Poss

    发明人： Mark T. Keating ,  Shannon J. Odelberg ,  Kenneth D. Poss

    IPC分类号： A61K31/70 ,  C12N5/06 ,  C12Q1/02 ,  A61P43/00

    CPC分类号： G01N33/5023 ,  A61K38/1706 ,  A61K38/1709 ,  A61K38/179 ,  A61K38/18 ,  A61K38/1825 ,  A61K38/1875 ,  A61K38/45 ,  A61K38/465 ,  C12N5/0662 ,  C12N2500/80 ,  C12N2501/115 ,  C12N2501/60 ,  C12N2506/1323

    摘要： The present invention provides methods and compositions to dedifferentiate a cell. The ability of the methods and compositions of the present invention to promote the dedifferentiation of differentiated cells, including terminally differentiated cells, can be used to promote regeneration of tissues and organs in vivo. The ability of the methods and compositions of the present invention to promote the dedifferentiation of differentiated cells, including terminally differentiated cells, can further be used to produce populations of stem or progenitor cells which can be used to promote regeneration of tissues and/or organs damaged by injury or disease. Accordingly, the present invention provides novel methods for the treatment of a wide range of injuries and diseases that affect many diverse cell types.

    摘要翻译： 本发明提供了去分化细胞的方法和组合物。 本发明的方法和组合物促进分化细胞（包括终末分化细胞）去分化的能力可用于促进体内组织和器官的再生。 本发明的方法和组合物促进分化细胞（包括终末分化细胞）去分化的能力可进一步用于产生干细胞或祖细胞群，其可用于促进组织和/或器官的再生损伤 受伤或疾病。 因此，本发明提供了用于治疗影响许多不同细胞类型的多种损伤和疾病的新方法。

    METHOD FOR ACTIVATING OCT4 FOR INDUCTION OF PLURIPOTENT STEM CELLS
    7.
    发明申请
    METHOD FOR ACTIVATING OCT4 FOR INDUCTION OF PLURIPOTENT STEM CELLS 有权
    用于激活OCT4以诱导大脑干细胞的方法

    公开(公告)号：US20150267173A1

    公开(公告)日：2015-09-24

    申请号：US14411506

    申请日：2012-06-29

    申请人： Stefan WOLFL

    发明人： Ralf Mrowka ,  Gunter Wolf ,  Stefan Wolfl ,  Xinlai Cheng

    IPC分类号： C12N5/074

    CPC分类号： C12N5/0696 ,  C12N2501/603 ,  C12N2501/605 ,  C12N2501/999 ,  C12N2506/09 ,  C12N2506/11 ,  C12N2506/1315 ,  C12N2506/1323 ,  C12N2506/14 ,  C12N2506/25

    摘要： The invention relates to a method for inducing pluripotent stem cells, wherein a mammalian cell is contacted with a compound characterized by a general formula 1 wherein R1 is (CH2)mE, with E being CCH or CN and m being 0, 1, or 2, and R2 is selected from F, CI, Br, OR3 and R3, with R3 being selected from H, (CHyF2-y)n CHXF3-X, with n=0 or 1. The invention further relates to stem cells obtained by the method of the invention, and culture media comprising the compound of the invention.

    摘要翻译： 本发明涉及一种用于诱导多能干细胞的方法，其中哺乳动物细胞与其中R 1是（CH 2）mE，其中E是CCH或CN并且m是0,1或2的通式1所表征的化合物接触 并且R 2选自F，Cl，Br，OR 3和R 3，其中R 3选自H，（CH 2 F 2 -Y）n CHXF 3-X，n = 0或1.本发明还涉及通过 本发明的方法和包含本发明化合物的培养基。

    METHODS OF INDUCING TISSUE REGENERATION
    8.
    发明申请
    METHODS OF INDUCING TISSUE REGENERATION 审中-公开
    诱导组织再生的方法

    公开(公告)号：US20150037295A1

    公开(公告)日：2015-02-05

    申请号：US14507571

    申请日：2014-10-06

    申请人： The Board of Trustees of the Leland Stanford Junior University

    发明人： Helen M. Blau ,  Kostandin Pajcini ,  Jason Pomerantz

    IPC分类号： C12N5/077 ,  A61K35/34 ,  G01N33/50 ,  A61K31/713

    CPC分类号： C12N5/0658 ,  A61K31/713 ,  A61K35/34 ,  C12N2501/00 ,  C12N2501/40 ,  C12N2501/405 ,  C12N2506/1323 ,  G01N33/502

    摘要： Methods are provided for producing cells within a lineage (lineage restricted cells) from post-mitotic differentiated cells of the same lineage ex vivo and in vivo, and for treating a subject in need of tissue regeneration therapy by employing these lineage-restricted cells. In addition, the production of lineage restricted cells from postmitotic tissues derived from patients with diseases allows for a characterization of pathways that have gone awry in these diseases and for screening of drugs that will ameliorate or correct the defects as a means of novel drug discovery. Also provided are kits for performing these methods.

    摘要翻译： 提供了用于从离体和体内相同谱系的有丝分裂后分化细胞的谱系（谱系受限细胞）内产生细胞的方法，并且通过使用这些谱系限制细胞来治疗需要组织再生治疗的受试者。 此外，从疾病患者衍生的血管内组织的谱系限制性细胞的产生允许表征在这些疾病中失败的途径，并筛选将改善或纠正缺陷作为新药物发现的手段。 还提供了用于执行这些方法的套件。