公开(公告)号：US20240180158A1

公开(公告)日：2024-06-06

申请号：US18417805

申请日：2024-01-19

申请人： University of North Carolina at Wilmington ,  THE UNIVERSITY OF TOLEDO

发明人： Christopher John HALKIDES ,  Ronald E. Viola

IPC分类号： A01N43/42 ,  A01N31/04 ,  A01N37/06 ,  A01N37/22 ,  A01N43/16 ,  A01P1/00 ,  A01P3/00 ,  C12N9/99

CPC分类号： A01N43/42 ,  A01N31/04 ,  A01N37/06 ,  A01N37/22 ,  A01N43/16 ,  A01P1/00 ,  A01P3/00 ,  C12N9/99 ,  C12Y102/01031

摘要： In one aspect, compounds and associated pharmaceutical compositions are described herein for the treatment of various fungal infections and/or other diseases. In some embodiments, a method for the inactivation of a microbial enzyme is provided comprising providing a compound having a selective inactivation activity, providing an enzyme target, and inactivating the enzyme target. In some example embodiments, the compound comprises a sulfonyl group.

公开(公告)号：US10449168B2

公开(公告)日：2019-10-22

申请号：US15755447

申请日：2016-08-29

申请人： The University of Toledo

发明人： Ronald E. Viola ,  Bharani Thangavelu ,  Vinay Mutthamsetty ,  Qinzhe Wang ,  Pravin Bhansali

IPC分类号： A61K31/198 ,  C07C229/38 ,  A61P25/28 ,  A61P31/00 ,  C07C227/18

摘要： Phthalate derivatives that are aspartate-P-semialdehyde dehydrogenase (ASADH) inhibitor compounds, aspartate N-acetyltransferase (ANAT) inhibitor compounds, or both, are described, as well as methods of making the same, and methods of using the same.

公开(公告)号：US20180250252A1

公开(公告)日：2018-09-06

申请号：US15755447

申请日：2016-08-29

申请人： The University of Toledo

发明人： Ronald E. Viola ,  Bharani Thangavelu ,  Vinay Mutthamsetty ,  Qinzhe Wang ,  Pravin Bhansali

IPC分类号： A61K31/198 ,  A61P31/00 ,  C07C227/18 ,  A61P25/28

CPC分类号： A61K31/198 ,  A61P25/28 ,  A61P31/00 ,  C07C227/18 ,  C07C229/38 ,  Y02A50/475 ,  Y02A50/481

摘要： Phthalate derivatives that are aspartate-P-semialdehyde dehydrogenase (ASADH) inhibitor compounds, aspartate N-acetyltransferase (ANAT) inhibitor compounds, or both, are described, as well as methods of making the same, and methods of using the same.

公开(公告)号：US20230128972A1

公开(公告)日：2023-04-27

申请号：US17794911

申请日：2021-01-29

申请人： Atomwise Inc. ,  The University of Toledo

发明人： Ronald E. Viola ,  Adrian Stecula

IPC分类号： A61K31/498 ,  A61K31/505 ,  A61K31/433 ,  A61K31/4365 ,  A61K31/4245

摘要： Inhibitors of a critical brain enzyme, N-acetyltransferase (ANAT), and methods of discovering, making and using the same for the treatment of disease are disclosed.

公开(公告)号：US11186541B2

公开(公告)日：2021-11-30

申请号：US16088248

申请日：2017-03-23

申请人： The University of Toledo

发明人： Ronald E. Viola ,  Bharani Thangavelu ,  Vinay Mutthamsetty ,  Qinzhe Wang

IPC分类号： C07C233/51 ,  C07C229/36 ,  C07C269/06 ,  C07C271/22

摘要： Compounds, compositions, and methods for the treatment of Canavan disease are described.

公开(公告)号：US20180340156A1

公开(公告)日：2018-11-29

申请号：US15757837

申请日：2016-09-08

申请人： The University of Toledo

发明人： Ronald E. Viola ,  Qinzhe Wang ,  Mojun Zhao ,  Gwenn Parungao

IPC分类号： C12N9/10 ,  C12N9/02 ,  C07K14/245 ,  C12Q1/48

摘要： Fusion proteins that include N-acetylaspartate synthetase (ANAT) and at least one solubilizing partner, such as glutathione 5-transferase (GST), thioredoxin (TRX), or maltose binding protein (MBP), are described. Also described are methods of making the fusion proteins, methods of solubilizing the fusion proteins, methods of purifying the fusion proteins, and methods of using the fusion proteins.

公开(公告)号：US20200270202A1

公开(公告)日：2020-08-27

申请号：US16088248

申请日：2017-03-23

申请人： The University of Toledo

发明人： Ronald E. Viola ,  Bharani Thangavelu ,  Vinay Mutthamsetty ,  Qinzhe Wang

IPC分类号： C07C233/51 ,  C07C271/22 ,  C07C229/36 ,  C07C269/06

摘要： Compounds, compositions, and methods for the treatment of Canavan disease are described.