公开(公告)号：US20230357737A1

公开(公告)日：2023-11-09

申请号：US18201537

申请日：2023-05-24

申请人： UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER

发明人： Jin LIU ,  Zhicheng ZUO ,  Yu-Chieh WANG

IPC分类号： C12N9/22 ,  G16B15/00 ,  G16B5/00 ,  G06F30/20 ,  C12N15/11 ,  G06F17/16

CPC分类号： C12N9/22 ,  G16B15/00 ,  G16B5/00 ,  G06F30/20 ,  C12N15/11 ,  G06F17/16 ,  G06F2111/10

摘要： Certain embodiments are directed to modified or variant Cas9 proteins, and/or methods of using the same.

公开(公告)号：US20240016828A1

公开(公告)日：2024-01-18

申请号：US18454671

申请日：2023-08-23

申请人： University of North Texas Health Science Center

发明人： Yu-Chieh WANG ,  Victor J.T. LIN ,  Ashwini Ashwini ZOLEKAR ,  Kyle A. EMMITTE ,  Nigam M. MISHRA ,  Jin LIU

IPC分类号： A61K31/7105 ,  A61P35/00 ,  C07D309/14 ,  C12N15/113

CPC分类号： A61K31/7105 ,  A61P35/00 ,  C07D309/14 ,  C12N15/1137 ,  A61K45/06

摘要： In one aspect, the present disclosure provides GlcNAc-Asn analogs of the formula:






wherein the variables are as defined herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of using the compounds disclosed herein. Additionally, the present disclosure also provides methods of treating cancer comprising inhibiting NGLY1.