METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR UTILIZING A THERAPEUTIC ULTRASOUND DEVICE TO PERFORM MITRAL VALVE DECALCIFICATION

    公开(公告)号:US20220409169A1

    公开(公告)日:2022-12-29

    申请号:US17770431

    申请日:2020-10-21

    Abstract: Methods, systems, and computer readable media for utilizing a therapeutic ultrasound device to perform mitral valve decalcification are disclosed. One method includes acquiring, via an ultrasound imaging component, imaging data of a mitral valve in real-time, defining a therapeutic region of interest corresponding to the mitral valve, and utilizing, by a system controller engine, imaging data from the ultrasound imaging component to determine an interval period of minimal mitral annular movement. The method further includes defining a sequence of therapeutic targets within the region of interest of the mitral valve, utilizing the imaging data acquired in real-time by the ultrasound imaging component to provide a therapeutic ultrasound transducer array with a location and depth of an intra-annular focal zone within the mitral valve, and emitting a high intensity focused ultrasound (HIFU) pulse wave from the therapeutic ultrasound transducer array to each of the therapeutic targets of the mitral valve during the determined interval period and in accordance with the defined sequence.

    Systems and Methods for Three-Dimensional Spiral Perfusion Imaging
    8.
    发明申请
    Systems and Methods for Three-Dimensional Spiral Perfusion Imaging 有权
    三维螺旋灌注成像系统与方法

    公开(公告)号:US20160148378A1

    公开(公告)日:2016-05-26

    申请号:US14952859

    申请日:2015-11-25

    Abstract: Some aspects of the present disclosure relate to systems and methods for three-dimensional spiral perfusion imaging. In one embodiment, a method for perfusion imaging of a subject includes acquiring perfusion imaging data associated with the heart of a subject. The acquiring includes applying an imaging pulse sequence with a three-dimensional stack-of-spirals trajectory. The method also includes reconstructing perfusion images from the acquired perfusion imaging data. The reconstructing includes parallel imaging and motion-guided compressed sensing. The method also includes determining, from the reconstructed perfusion images, absolute perfusion values based on time-intensity relationships to quantify myocardial blood flow of the heart of the subject, and generating a quantitative volumetric perfusion flow map based on the determined absolute perfusion values.

    Abstract translation: 本公开的一些方面涉及用于三维螺旋灌注成像的系统和方法。 在一个实施例中,用于对象的灌注成像的方法包括获取与受试者的心脏相关联的灌注成像数据。 该采集包括应用具有三维叠加螺旋轨迹的成像脉冲序列。 该方法还包括从获取的灌注成像数据重建灌注图像。 重建包括并行成像和运动引导压缩感测。 该方法还包括根据重建的灌注图像确定基于时间 - 强度关系的绝对灌注值,以量化受试者心脏的心肌血流量,以及基于确定的绝对灌注值产生定量体积灌注流程图。

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