公开(公告)号：US12157018B2

公开(公告)日：2024-12-03

申请号：US16712680

申请日：2019-12-12

Applicant: University of Washington ,  KONINKLIJKE PHILIPS N.V., A CORPORPORATION ORGANIZED AND EXISTING UNDER THE LAWS OF KINGDOM OF THE NETHERLANDS

Inventor： Vera Khokhlova ,  Michael R. Bailey ,  Navid Farr ,  Tatiana D. Khokhlova ,  Wayne Kreider ,  Adam D. Maxwell ,  Ari Partanen ,  Oleg A. Sapozhnikov ,  George R. Schade ,  Yak-Nam Wang

IPC: A61N7/02 ,  A61B17/22

Abstract: An example method includes generating an acoustic ultrasound wave that is focused at a focal point. The method further includes sequentially directing the focal point upon distinct portions of an object to form respective shock waves at the distinct portions of the object. The method further includes, via the respective shock waves, causing the distinct portions of the object to boil and form respective vapor cavities. The method further includes causing substantially uniform ablation of a region of the object that comprises the distinct portions. The substantially uniform ablation is caused via interaction of the respective shock waves with the respective vapor cavities. An example ablation system and an example non-transitory computer-readable medium, both related to the example method, are also disclosed.

公开(公告)号：US20200222728A1

公开(公告)日：2020-07-16

申请号：US16712680

申请日：2019-12-12

Applicant: UNIVERSITY OF WASHINGTON ,  KONINKLIJKE PHILIPS N.V., A CORPORPORATION ORGANIZED AND EXISTING UNDER THE LAWS OF KINGDOM OF THE

Inventor： Vera Khokhlova ,  Michael R. Bailey ,  Navid Farr ,  Tatiana D. Khokhlova ,  Wayne Kreider ,  Adam D. Maxwell ,  Ari Partanen ,  Oleg A. Sapozhnikov ,  George R. Schade ,  Yak-Nam Wang

IPC: A61N7/02

Abstract: An example method includes generating an acoustic ultrasound wave that is focused at a focal point. The method further includes sequentially directing the focal point upon distinct portions of an object to form respective shock waves at the distinct portions of the object. The method further includes, via the respective shock waves, causing the distinct portions of the object to boil and form respective vapor cavities. The method further includes causing substantially uniform ablation of a region of the object that comprises the distinct portions. The substantially uniform ablation is caused via interaction of the respective shock waves with the respective vapor cavities. An example ablation system and an example non-transitory computer-readable medium, both related to the example method, are also disclosed.

公开(公告)号：US10702719B2

公开(公告)日：2020-07-07

申请号：US15288372

申请日：2016-10-07

Applicant: University of Washington

Inventor： Tatiana Khokhlova ,  Thomas J. Matula ,  Wayne L. Monsky ,  Yak-Nam Wang

IPC: A61N7/02 ,  A61B17/22

Abstract: Methods for treating an extravascular hematoma in a patient can include liquefying a first portion of the extravascular hematoma by applying a first series of focused acoustic pulses to the extravascular hematoma at a first frequency; and liquefying a second portion of the extravascular hematoma by applying a second series of focused acoustic pulses to the extravascular hematoma at a second frequency. Liquefied remains of the extravascular hematoma can be aspirated from the patient following liquefaction and disruption.

公开(公告)号：US20170100145A1

公开(公告)日：2017-04-13

申请号：US15288372

申请日：2016-10-07

Applicant: University of Washington

Inventor： Tatiana D. Khoklova ,  Thomas J. Matula ,  Wayne L. Monsky ,  Yak-Nam Wang

IPC: A61B17/22 ,  A61N7/02 ,  A61N7/00

CPC classification number: A61N7/02 ,  A61B2017/22008 ,  A61B2017/22079 ,  A61B2217/005

Abstract: Methods for treating an extravascular hematoma in a patient can include liquefying a first portion of the extravascular hematoma by applying a first series of focused acoustic pulses to the extravascular hematoma at a first frequency; and liquefying a second portion of the extravascular hematoma by applying a second series of focused acoustic pulses to the extravascular hematoma at a second frequency. Liquefied remains of the extravascular hematoma can be aspirated from the patient following liquefaction and disruption.

公开(公告)号：US11857813B2

公开(公告)日：2024-01-02

申请号：US16927860

申请日：2020-07-13

Applicant: University of Washington

Inventor： Yak-Nam Wang ,  Michael R. Bailey ,  Tatiana D. Khokhlova ,  Wayne Kreider ,  Adam D. Maxwell ,  George R. Schade ,  Vera A. Khokhlova

IPC: A61N7/00 ,  A61N7/02

CPC classification number: A61N7/02 ,  A61N2007/0004 ,  A61N2007/0091

Abstract: High intensity focused ultrasound systems for treating tissue are disclosed herein. A system of treating tissue in a patient in accordance with an embodiment of the present technology can include, for example, an ultrasound source having a focal region and configured to deliver high intensity focused ultrasound energy to a target site in tissue of the patient. The system can further include a controller operably coupled to the ultrasound source. The controller comprises a pulsing protocol for delivering the high intensity focused ultrasound energy with the ultrasound source to the target site. The controller is configured to cause the ultrasound source to pulse high intensity focused ultrasound waves to lyse cells in a volume of the tissue of the subject while preserving an extracellular matrix in the volume of the tissue exposed to the high intensity focused ultrasound waves.

公开(公告)号：US20210038924A1

公开(公告)日：2021-02-11

申请号：US16927860

申请日：2020-07-13

Applicant: University of Washington

Inventor： Yak-Nam Wang ,  Michael R. Bailey ,  Tatiana D. Khokhlova ,  Wayne Kreider ,  Adam D. Maxwell ,  George R. Schade ,  Vera A. Khokhlova

IPC: A61N7/02

Abstract: High intensity focused ultrasound systems for treating tissue are disclosed herein. A system of treating tissue in a patient in accordance with an embodiment of the present technology can include, for example, an ultrasound source having a focal region and configured to deliver high intensity focused ultrasound energy to a target site in tissue of the patient. The system can further include a controller operably coupled to the ultrasound source. The controller comprises a pulsing protocol for delivering the high intensity focused ultrasound energy with the ultrasound source to the target site. The controller is configured to cause the ultrasound source to pulse high intensity focused ultrasound waves to lyse cells in a volume of the tissue of the subject while preserving an extracellular matrix in the volume of the tissue exposed to the high intensity focused ultrasound waves.

公开(公告)号：US10694974B2

公开(公告)日：2020-06-30

申请号：US15120812

申请日：2015-03-27

Applicant: UNIVERSITY OF WASHINGTON ,  KONINKLIJKE PHILIPS N.V.

Inventor： Ari Partanen ,  Vera Khokhlova ,  Navid Farr ,  Donghoon Lee ,  Wayne Kreider ,  Tatiana Khokhlova ,  Adam Maxwell ,  Yak-Nam Wang ,  George Schade ,  Michael Bailey

IPC: A61B5/055 ,  A61N7/02 ,  A61B5/01 ,  A61B5/00 ,  G01R33/28 ,  G01R33/48 ,  A61B90/00 ,  G01R33/50 ,  G01R33/563 ,  G01R33/56

Abstract: Example embodiments of system and method for magnetic resonance imaging (MRI) techniques for planning, real-time monitoring, control, and post-treatment assessment of high intensity focused ultrasound (HIFU) mechanical fractionation of biological material are disclosed. An adapted form of HIFU, referred to as “boiling histotripsy” (BH), can be used to cause mechanical fractionation of biological material. In contrast to conventional HIFU, which cause pure thermal ablation, BH can generate therapeutic destruction of biological tissue with a degree of control and precision that allows the process to be accurately measured and monitored in real-time as well as the outcome of the treatment can be evaluated using a variety of MRI techniques. Real-time monitoring also allow for real-time control of BH.

公开(公告)号：US20170072228A1

公开(公告)日：2017-03-16

申请号：US15126131

申请日：2015-03-30

Applicant: University of Washington

Inventor： Yak-Nam Wang ,  Michael R. Bailey ,  Tatiana D. Khokhlova ,  Wayne Kreider ,  Adam D. Maxwell ,  George R. Schade ,  Vera A. Khokhlova

IPC: A61N7/02

CPC classification number: A61N7/02 ,  A61N2007/0004 ,  A61N2007/0091

Abstract: Methods and systems for selectively disrupting tissue using high intensity focused ultrasound (“HIFU”) therapy are disclosed herein. A method of treating tissue in accordance with an embodiment of the present technology can include, for example, pulsing HIFU waves from an ultrasound source toward a volume of tissue that includes an extracellular matrix (“ECM”) and generating, from nonlinear propagation of the HIFU waves, shock waves in the tissue to induce boiling in the volume of the tissue. The method can further include lysing cells in the volume of tissue while leaving the ECM at least substantially intact. The emulsification of cells can be to a sufficient degree to decellularize the tissue and form a decellularized scaffold for subsequent tissue growth.

Abstract translation: 本文公开了使用高强度聚焦超声（“HIFU”）治疗选择性地破坏组织的方法和系统。 根据本技术的实施例的治疗组织的方法可以包括例如将来自超声源的HIFU波脉冲到包括细胞外基质（“ECM”）的组织体积，并从 HIFU波，组织中的冲击波诱导组织体积沸腾。 该方法可以进一步包括裂解组织体内的细胞，同时离开ECM至少基本完整。 细胞的乳化可以足够的程度使组织脱细胞并形成用于随后组织生长的脱细胞支架。