公开(公告)号：US12133728B2

公开(公告)日：2024-11-05

申请号：US18094206

申请日：2023-01-06

Applicant: University of Washington ,  Fred Hutchinson Cancer Research Center

Inventor： John R. Chevillet ,  Tatiana D. Khokhlova ,  George R. Schade ,  Joo Ha Hwang ,  Muneesh Tewari

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/15 ,  A61B8/08 ,  A61B10/00 ,  A61N7/02 ,  C12Q1/6886

Abstract: The present disclosure is directed to relates to systems and methods for evaluating tissue using high intensity focused ultrasound (HIFU) energy. In one embodiment, for example, a system for treating a patient comprises an ultrasound source configured to deliver HIFU energy to a target tissue mass of the patient and a function generator operably coupled to the ultrasound source for initiating a pulsing protocol for delivering the HIFU energy. The system further comprises a controller configured to perform operations comprising applying HIFU energy to induce cavitation in the target tissue mass and cause a biomarker to be released, comparing a baseline concentration of the biomarker from a first fluid sample to a concentration of the biomarker in a second fluid sample within 2 hours after applying HIFU, and repeating the applying and comparing until the concentration of the biomarker in the fluid sample falls below a threshold value.

公开(公告)号：US20200222728A1

公开(公告)日：2020-07-16

申请号：US16712680

申请日：2019-12-12

Applicant: UNIVERSITY OF WASHINGTON ,  KONINKLIJKE PHILIPS N.V., A CORPORPORATION ORGANIZED AND EXISTING UNDER THE LAWS OF KINGDOM OF THE

Inventor： Vera Khokhlova ,  Michael R. Bailey ,  Navid Farr ,  Tatiana D. Khokhlova ,  Wayne Kreider ,  Adam D. Maxwell ,  Ari Partanen ,  Oleg A. Sapozhnikov ,  George R. Schade ,  Yak-Nam Wang

IPC: A61N7/02

Abstract: An example method includes generating an acoustic ultrasound wave that is focused at a focal point. The method further includes sequentially directing the focal point upon distinct portions of an object to form respective shock waves at the distinct portions of the object. The method further includes, via the respective shock waves, causing the distinct portions of the object to boil and form respective vapor cavities. The method further includes causing substantially uniform ablation of a region of the object that comprises the distinct portions. The substantially uniform ablation is caused via interaction of the respective shock waves with the respective vapor cavities. An example ablation system and an example non-transitory computer-readable medium, both related to the example method, are also disclosed.

公开(公告)号：US12157018B2

公开(公告)日：2024-12-03

申请号：US16712680

申请日：2019-12-12

Applicant: University of Washington ,  KONINKLIJKE PHILIPS N.V., A CORPORPORATION ORGANIZED AND EXISTING UNDER THE LAWS OF KINGDOM OF THE NETHERLANDS

Inventor： Vera Khokhlova ,  Michael R. Bailey ,  Navid Farr ,  Tatiana D. Khokhlova ,  Wayne Kreider ,  Adam D. Maxwell ,  Ari Partanen ,  Oleg A. Sapozhnikov ,  George R. Schade ,  Yak-Nam Wang

IPC: A61N7/02 ,  A61B17/22

Abstract: An example method includes generating an acoustic ultrasound wave that is focused at a focal point. The method further includes sequentially directing the focal point upon distinct portions of an object to form respective shock waves at the distinct portions of the object. The method further includes, via the respective shock waves, causing the distinct portions of the object to boil and form respective vapor cavities. The method further includes causing substantially uniform ablation of a region of the object that comprises the distinct portions. The substantially uniform ablation is caused via interaction of the respective shock waves with the respective vapor cavities. An example ablation system and an example non-transitory computer-readable medium, both related to the example method, are also disclosed.

公开(公告)号：US20240041358A1

公开(公告)日：2024-02-08

申请号：US18094206

申请日：2023-01-06

Applicant: University of Washington ,  Fred Hutchinson Cancer Research Center

Inventor： John R. Chevillet ,  Tatiana D. Khokhlova ,  George R. Schade ,  Joo Ha Hwang ,  Muneesh Tewari

IPC: A61B5/145 ,  A61B8/08 ,  C12Q1/6886 ,  A61B5/15 ,  A61B5/00 ,  A61B10/00 ,  A61N7/02

CPC classification number: A61B5/14546 ,  A61B8/08 ,  A61B8/5223 ,  A61B5/145 ,  C12Q1/6886 ,  A61B5/14507 ,  A61B5/15 ,  A61B5/4836 ,  A61B10/0038 ,  A61B10/007 ,  A61N7/022 ,  A61N7/02 ,  C12Q2600/118 ,  C12Q2600/158 ,  A61B2010/0077

Abstract: The present disclosure is directed to relates to systems and methods for evaluating tissue using high intensity focused ultrasound (HIFU) energy. In one embodiment, for example, a system for treating a patient comprises an ultrasound source configured to deliver HIFU energy to a target tissue mass of the patient and a function generator operably coupled to the ultrasound source for initiating a pulsing protocol for delivering the HIFU energy. The system further comprises a controller configured to perform operations comprising applying HIFU energy to induce cavitation in the target tissue mass and cause a biomarker to be released, comparing a baseline concentration of the biomarker from a first fluid sample to a concentration of the biomarker in a second fluid sample within 2 hours after applying HIFU, and repeating the applying and comparing until the concentration of the biomarker in the fluid sample falls below a threshold value.

公开(公告)号：US20210038135A1

公开(公告)日：2021-02-11

申请号：US16936095

申请日：2020-07-22

Applicant: University of Washington ,  Fred Hutchinson Cancer Research Center

Inventor： John R. Chevillet ,  Tatiana D. Khokhlova ,  George R. Schade ,  Joo Ha Hwang ,  Muneesh Tewari

IPC: A61B5/145 ,  A61B8/08 ,  C12Q1/6886 ,  A61B5/15 ,  A61B5/00 ,  A61B10/00 ,  A61N7/02

Abstract: The present disclosure is directed to relates to systems and methods for evaluating tissue using high intensity focused ultrasound (HIFU) energy. In one embodiment, for example, a system for treating a patient comprises an ultrasound source configured to deliver HIFU energy to a target tissue mass of the patient and a function generator operably coupled to the ultrasound source for initiating a pulsing protocol for delivering the HIFU energy. The system further comprises a controller configured to perform operations comprising applying HIFU energy to induce cavitation in the target tissue mass and cause a biomarker to be released, comparing a baseline concentration of the biomarker from a first fluid sample to a concentration of the biomarker in a second fluid sample within 2 hours after applying HIFU, and repeating the applying and comparing until the concentration of the biomarker in the fluid sample falls below a threshold value.

公开(公告)号：US11857813B2

公开(公告)日：2024-01-02

申请号：US16927860

申请日：2020-07-13

Applicant: University of Washington

Inventor： Yak-Nam Wang ,  Michael R. Bailey ,  Tatiana D. Khokhlova ,  Wayne Kreider ,  Adam D. Maxwell ,  George R. Schade ,  Vera A. Khokhlova

IPC: A61N7/00 ,  A61N7/02

CPC classification number: A61N7/02 ,  A61N2007/0004 ,  A61N2007/0091

Abstract: High intensity focused ultrasound systems for treating tissue are disclosed herein. A system of treating tissue in a patient in accordance with an embodiment of the present technology can include, for example, an ultrasound source having a focal region and configured to deliver high intensity focused ultrasound energy to a target site in tissue of the patient. The system can further include a controller operably coupled to the ultrasound source. The controller comprises a pulsing protocol for delivering the high intensity focused ultrasound energy with the ultrasound source to the target site. The controller is configured to cause the ultrasound source to pulse high intensity focused ultrasound waves to lyse cells in a volume of the tissue of the subject while preserving an extracellular matrix in the volume of the tissue exposed to the high intensity focused ultrasound waves.

公开(公告)号：US20210038924A1

公开(公告)日：2021-02-11

申请号：US16927860

申请日：2020-07-13

Applicant: University of Washington

Inventor： Yak-Nam Wang ,  Michael R. Bailey ,  Tatiana D. Khokhlova ,  Wayne Kreider ,  Adam D. Maxwell ,  George R. Schade ,  Vera A. Khokhlova

IPC: A61N7/02

Abstract: High intensity focused ultrasound systems for treating tissue are disclosed herein. A system of treating tissue in a patient in accordance with an embodiment of the present technology can include, for example, an ultrasound source having a focal region and configured to deliver high intensity focused ultrasound energy to a target site in tissue of the patient. The system can further include a controller operably coupled to the ultrasound source. The controller comprises a pulsing protocol for delivering the high intensity focused ultrasound energy with the ultrasound source to the target site. The controller is configured to cause the ultrasound source to pulse high intensity focused ultrasound waves to lyse cells in a volume of the tissue of the subject while preserving an extracellular matrix in the volume of the tissue exposed to the high intensity focused ultrasound waves.

公开(公告)号：US20170072228A1

公开(公告)日：2017-03-16

申请号：US15126131

申请日：2015-03-30

Applicant: University of Washington

Inventor： Yak-Nam Wang ,  Michael R. Bailey ,  Tatiana D. Khokhlova ,  Wayne Kreider ,  Adam D. Maxwell ,  George R. Schade ,  Vera A. Khokhlova

IPC: A61N7/02

CPC classification number: A61N7/02 ,  A61N2007/0004 ,  A61N2007/0091

Abstract: Methods and systems for selectively disrupting tissue using high intensity focused ultrasound (“HIFU”) therapy are disclosed herein. A method of treating tissue in accordance with an embodiment of the present technology can include, for example, pulsing HIFU waves from an ultrasound source toward a volume of tissue that includes an extracellular matrix (“ECM”) and generating, from nonlinear propagation of the HIFU waves, shock waves in the tissue to induce boiling in the volume of the tissue. The method can further include lysing cells in the volume of tissue while leaving the ECM at least substantially intact. The emulsification of cells can be to a sufficient degree to decellularize the tissue and form a decellularized scaffold for subsequent tissue growth.

Abstract translation: 本文公开了使用高强度聚焦超声（“HIFU”）治疗选择性地破坏组织的方法和系统。 根据本技术的实施例的治疗组织的方法可以包括例如将来自超声源的HIFU波脉冲到包括细胞外基质（“ECM”）的组织体积，并从 HIFU波，组织中的冲击波诱导组织体积沸腾。 该方法可以进一步包括裂解组织体内的细胞，同时离开ECM至少基本完整。 细胞的乳化可以足够的程度使组织脱细胞并形成用于随后组织生长的脱细胞支架。

公开(公告)号：US20240245937A1

公开(公告)日：2024-07-25

申请号：US18438692

申请日：2024-02-12

Applicant: UNIVERSITY OF WASHINGTON

Inventor： Vera Khokhlova ,  Pavel Rosnitskiy ,  Petr V. Yuldashev ,  Tatiana D. Khokhlova ,  Oleg A. Sapozhnikov ,  George R. Schade

IPC: A61N7/02 ,  A61B8/00 ,  A61B8/12 ,  A61B17/00 ,  A61B17/32 ,  A61N7/00

CPC classification number: A61N7/022 ,  A61B8/12 ,  A61B8/445 ,  A61B2017/00274 ,  A61B2017/320069 ,  A61N2007/0039 ,  A61N2007/0052 ,  A61N2007/0078

Abstract: Transrectal ultrasound probe for boiling histotripsy ablation of prostate are presented herein. In one embodiment, a method for a transrectal ultrasound treatment uses high intensity focused ultrasound (HIFU). The method includes: generating a boiling histotripsy (BH) therapy ultrasound by a therapy transducer in a frequency range of 1 MHz to 2.8 MHz and a surface intensity range of 10 W/cm2 to 80 W/cm2. The therapy transducer may be about 50 mm long and about 35 mm wide. The method also includes applying the therapy ultrasound by directing ultrasound pulses having ultrasound shock waves to a target tissue at a focal depth of 2.5 cm to 5.5 cm; generating at least one μm-scale vapor bubble at a target region; growing the at least one vapor bubble to at least one mm-scale bubble; and mechanically disintegrating a surrounding tissue by interactions between mm-scale bubbles and the ultrasound shock waves within a pulse.

公开(公告)号：US11896853B2

公开(公告)日：2024-02-13

申请号：US16871980

申请日：2020-05-11

Applicant: University of Washington

Inventor： Vera Khokhlova ,  Pavel Rosnitskiy ,  Petr V. Yuldashev ,  Tatiana D. Khokhlova ,  Oleg A. Sapozhnikov ,  George R. Schade

IPC: A61N7/02 ,  A61B8/12 ,  A61B8/00 ,  A61B17/32 ,  A61B17/00 ,  A61N7/00

CPC classification number: A61N7/022 ,  A61B8/12 ,  A61B8/445 ,  A61B2017/00274 ,  A61B2017/320069 ,  A61N2007/0039 ,  A61N2007/0052 ,  A61N2007/0078

Abstract: Transrectal ultrasound probe for boiling histotripsy ablation of prostate are presented herein. In one embodiment, a method for a transrectal ultrasound treatment uses high intensity focused ultrasound (HIFU). The method includes: generating a boiling histotripsy (BH) therapy ultrasound by a therapy transducer in a frequency range of 1 MHz to 2.8 MHz and a surface intensity range of 10 W/cm2 to 80 W/cm2. The therapy transducer may be about 50 mm long and about 35 mm wide. The method also includes applying the therapy ultrasound by directing ultrasound pulses having ultrasound shock waves to a target tissue at a focal depth of 2.5 cm to 5.5 cm; generating at least one μm-scale vapor bubble at a target region; growing the at least one vapor bubble to at least one mm-scale bubble; and mechanically disintegrating a surrounding tissue by interactions between mm-scale bubbles and the ultrasound shock waves within a pulse.