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公开(公告)号：US12157018B2
公开(公告)日：2024-12-03
申请号：US16712680
申请日：2019-12-12
Applicant: University of Washington , KONINKLIJKE PHILIPS N.V., A CORPORPORATION ORGANIZED AND EXISTING UNDER THE LAWS OF KINGDOM OF THE NETHERLANDS
Inventor： Vera Khokhlova , Michael R. Bailey , Navid Farr , Tatiana D. Khokhlova , Wayne Kreider , Adam D. Maxwell , Ari Partanen , Oleg A. Sapozhnikov , George R. Schade , Yak-Nam Wang
Abstract: An example method includes generating an acoustic ultrasound wave that is focused at a focal point. The method further includes sequentially directing the focal point upon distinct portions of an object to form respective shock waves at the distinct portions of the object. The method further includes, via the respective shock waves, causing the distinct portions of the object to boil and form respective vapor cavities. The method further includes causing substantially uniform ablation of a region of the object that comprises the distinct portions. The substantially uniform ablation is caused via interaction of the respective shock waves with the respective vapor cavities. An example ablation system and an example non-transitory computer-readable medium, both related to the example method, are also disclosed.
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2.发明申请公开(公告)号：US20220304588A1
公开(公告)日：2022-09-29
申请号：US17543276
申请日：2021-12-06
Applicant: University of Washington , Koninlkijke Philips N.V., a corporation organized and existing under the laws of Kingdom of the Net
Inventor： Ari Ilkka Mikael Partanen , Wayne Kreider , Vera Khokhlova
IPC: A61B5/055 , A61B5/00 , A61B5/01 , A61B5/02 , A61N7/02 , G01R33/48 , G01R33/50 , G01R33/56 , G01R33/563
Abstract: Disclosed herein are example embodiments of devices, systems, and methods for mechanical fractionation of biological tissue using magnetic resonance imaging (MRI) feedback control. The examples may involve displaying an image representing first MRI data corresponding to biological tissue, and receiving input identifying one or more target regions of the biological tissue to be mechanically fractionated via exposure to first ultrasound waves. The examples may further involve applying the first ultrasound waves and, contemporaneous to or after applying the first ultrasound waves, acquiring second MRI data corresponding to the biological tissue. The examples may also involve determining, based on the second MRI data, one or more second parameters for applying second ultrasound waves to the biological tissue, and applying the second ultrasound waves to the biological tissue according to the one or more second parameters.
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3.发明申请公开(公告)号：US20170254887A1
公开(公告)日：2017-09-07
申请号：US15446923
申请日：2017-03-01
Applicant: University of Washington
Inventor： Oleg A. Sapozhnikov , Wayne Kreider , Adam D. Maxwell , Vera Khokhlova
CPC classification number: G01S7/5205 , A61B8/58 , A61N7/02 , A61N2007/0078 , G01S15/8918 , G01S15/899
Abstract: The present technology relates generally to receiving arrays to measure a characteristic of an acoustic beam and associated systems and methods. The receiving arrays can include elongated elements having at least one dimension, such as a length, that is larger than a width of an emitted acoustic beam and another dimension, such as a width, that is smaller than half of a characteristic wavelength of an ultrasound wave. The elongated elements can be configured to capture waveform measurements of the beam based on a characteristic of the emitted acoustic beam as the acoustic beam crosses a plane of the array, such as a transverse plane. The methods include measuring at least one characteristic of an ultrasound source using an array-based acoustic holography system and defining a measured hologram at the array surface based, at least in part, on the waveform measurements. The measured hologram can be processed to reconstruct a characteristic of the ultrasound source. The ultrasound source can be calibrated and/or re-calibrated based on the characteristic.
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4.发明授权Portable acoustic holography systems for therapeutic ultrasound sources and associated devices and methods 有权用于治疗性超声波的便携式声全息系统及相关装置及方法公开(公告)号：US09588491B2
公开(公告)日：2017-03-07
申请号：US13894333
申请日：2013-05-14
Inventor： Oleg A. Sapozhnikov , Michael R. Bailey , Peter J. Kaczkowski , Vera A. Khokhlova , Wayne Kreider
CPC classification number: G03H3/00 , A61B8/00 , G01N29/0663 , Y10S359/901
Abstract: The present technology relates generally to portable acoustic holography systems for therapeutic ultrasound sources, and associated devices and methods. In some embodiments, a method of characterizing an ultrasound source by acoustic holography includes the use of a transducer geometry characteristic, a transducer operation characteristic, and a holography system measurement characteristic. A control computer can be instructed to determine holography measurement parameters. Based on the holography measurement parameters, the method can include scanning a target surface to obtain a hologram. Waveform measurements at a plurality of points on the target surface can be captured. Finally, the method can include processing the measurements to reconstruct at least one characteristic of the ultrasound source.
Abstract translation: 本技术一般涉及用于治疗性超声源的便携式声全息系统，以及相关的装置和方法。 在一些实施例中，通过声全息技术来表征超声源的方法包括使用换能器几何特征，换能器操作特性和全息系统测量特性。 可以指示控制计算机来确定全息测量参数。 基于全息测量参数，该方法可以包括扫描目标表面以获得全息图。 可以捕获目标表面上的多个点处的波形测量。 最后，该方法可以包括处理测量以重建超声源的至少一个特征。
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5.发明申请公开(公告)号：US20200227018A1
公开(公告)日：2020-07-16
申请号：US16740320
申请日：2020-01-10
Applicant: University of Washington
Inventor： Adam D. Maxwell , Oleg A. Sapozhnikov , Wayne Kreider , Michael R. Bailey
Abstract: A method includes transmitting a focused ultrasound wave into a medium to form (i) an ultrasound intensity well within the medium that exhibits a first range of acoustic pressure and (ii) a surrounding region of the medium that surrounds the ultrasound intensity well and exhibits a second range of acoustic pressure that exceeds the first range of acoustic pressure. The method further includes confining an object within the ultrasound intensity well. Additionally, an acoustic lens is configured to be acoustically coupled to an acoustic transducer. The acoustic lens has a varying longitudinal thickness that increases proportionally with respect to increasing azimuth angle of the acoustic lens. Another acoustic lens is configured to be acoustically coupled to an acoustic transducer. The acoustic lens includes a plurality of segments. Each of the plurality of segments has a varying longitudinal thickness that increases proportionally with respect to increasing azimuth angle of the segment.
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Patent Agency Ranking
公开(公告)号：US20200222728A1
公开(公告)日：2020-07-16
申请号：US16712680
申请日：2019-12-12
Applicant: UNIVERSITY OF WASHINGTON , KONINKLIJKE PHILIPS N.V., A CORPORPORATION ORGANIZED AND EXISTING UNDER THE LAWS OF KINGDOM OF THE
Inventor： Vera Khokhlova , Michael R. Bailey , Navid Farr , Tatiana D. Khokhlova , Wayne Kreider , Adam D. Maxwell , Ari Partanen , Oleg A. Sapozhnikov , George R. Schade , Yak-Nam Wang
IPC: A61N7/02
Abstract: An example method includes generating an acoustic ultrasound wave that is focused at a focal point. The method further includes sequentially directing the focal point upon distinct portions of an object to form respective shock waves at the distinct portions of the object. The method further includes, via the respective shock waves, causing the distinct portions of the object to boil and form respective vapor cavities. The method further includes causing substantially uniform ablation of a region of the object that comprises the distinct portions. The substantially uniform ablation is caused via interaction of the respective shock waves with the respective vapor cavities. An example ablation system and an example non-transitory computer-readable medium, both related to the example method, are also disclosed.
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公开(公告)号：US10535332B2
公开(公告)日：2020-01-14
申请号：US15508841
申请日：2015-08-26
Applicant: University of Washington
Inventor： Adam D. Maxwell , Oleg A. Sapozhnikov , Wayne Kreider , Michael R. Bailey
IPC: H01L41/09 , G10K11/00 , G10K11/30 , G10K15/00 , G10K11/20 , G10K11/24 , H03H9/64 , A61B17/225 , G10K11/34 , A61B17/22
Abstract: A method includes transmitting a focused ultrasound wave into a medium to form (i) an ultrasound intensity well within the medium that exhibits a first range of acoustic pressure and (ii) a surrounding region of the medium that surrounds the ultrasound intensity well and exhibits a second range of acoustic pressure that exceeds the first range of acoustic pressure. The method further includes confining an object within the ultrasound intensity well. Additionally, an acoustic lens is configured to be acoustically coupled to an acoustic transducer. The acoustic lens has a varying longitudinal thickness that increases proportionally with respect to increasing azimuth angle of the acoustic lens. Another acoustic lens is configured to be acoustically coupled to an acoustic that increases proportionally with respect to increasing azimuth angle of the segment.
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公开(公告)号：US20190117243A1
公开(公告)日：2019-04-25
申请号：US16169945
申请日：2018-10-24
Applicant: University of Washington
Inventor： Tatiana Khokhlova , Vera Khoklova , Oleg A. Sapozhnikov , Wayne Kreider , Adam D. Maxwell , Joo Ha Hwang
Abstract: Apparatus and method for improved cavitation-induced drug delivery is disclosed. In one embodiment, a method for delivering a treatment composition to a target tissue using ultrasound includes: directing ultrasound waveforms toward the target tissue of a patient; generating ultrasound shock fronts at the target tissue of a patient; generating a cavitation inside the target tissue of a patient by the ultrasound shock front; and delivering the treatment composition to the patient. Absorption of the treatment composition by the target tissue is increased by the cavitation inside the target tissue. In some embodiments, the treatment composition may be delivered within a time period of +/−1 week from generating the cavitation.
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9.发明申请METHODS AND SYSTEMS FOR NON-INVASIVE TREATMENT OF TISSUE USING HIGH INTENSITY FOCUSED ULTRASOUND THERAPY 有权使用高强度聚焦超声治疗非组织治疗组织的方法和系统公开(公告)号：US20150119763A1
公开(公告)日：2015-04-30
申请号：US14516442
申请日：2014-10-16
Inventor： Michael S. Canney , Michael R. Bailey , Lawrence A. Crum , Vera A. Khokhlova , Tatiana D. Khokhlova , Wayne Kreider , Joo Ha Hwang , Oleg A. Sapozhnikov
IPC: A61N7/02
CPC classification number: A61N7/02 , A61B2017/00084 , A61B2018/00005 , A61B2090/374 , A61B2090/378
Abstract: Methods and systems for non-invasive treatment of tissue using high intensity focused ultrasound (“HIFU”) therapy. A method of non-invasively treating tissue in accordance with an embodiment of the present technology, for example, can include positioning a focal plane of an ultrasound source at a target site in tissue. The ultrasound source can be configured to emit HIFU waves. The method can further include pulsing ultrasound energy from the ultrasound source toward the target site, and generating shock waves in the tissue to induce boiling of the tissue at the target site within milliseconds. The boiling of the tissue at least substantially emulsifies the tissue.
Abstract translation: 使用高强度聚焦超声（“HIFU”）治疗非侵入性治疗组织的方法和系统。 例如，根据本技术的实施例的非侵入性治疗组织的方法可以包括将超声源的焦平面定位在组织中的目标部位。 超声波源可被配置为发射HIFU波。 该方法还可以包括将来自超声源的超声能量脉冲向目标部位，并在组织内产生冲击波，以在毫秒内诱导目标部位的组织沸腾。 组织的沸腾至少基本上乳化组织。
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公开(公告)号：US11857813B2
公开(公告)日：2024-01-02
申请号：US16927860
申请日：2020-07-13
Applicant: University of Washington
Inventor： Yak-Nam Wang , Michael R. Bailey , Tatiana D. Khokhlova , Wayne Kreider , Adam D. Maxwell , George R. Schade , Vera A. Khokhlova
CPC classification number: A61N7/02 , A61N2007/0004 , A61N2007/0091
Abstract: High intensity focused ultrasound systems for treating tissue are disclosed herein. A system of treating tissue in a patient in accordance with an embodiment of the present technology can include, for example, an ultrasound source having a focal region and configured to deliver high intensity focused ultrasound energy to a target site in tissue of the patient. The system can further include a controller operably coupled to the ultrasound source. The controller comprises a pulsing protocol for delivering the high intensity focused ultrasound energy with the ultrasound source to the target site. The controller is configured to cause the ultrasound source to pulse high intensity focused ultrasound waves to lyse cells in a volume of the tissue of the subject while preserving an extracellular matrix in the volume of the tissue exposed to the high intensity focused ultrasound waves.
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