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公开(公告)号：US20220062461A1
公开(公告)日：2022-03-03
申请号：US17463245
申请日：2021-08-31
申请人： University of Washington , Seattle Children's Hospital (dba Seattle Children's Research Institute)
发明人： James Chen , Tanner Clark , Thomas Lendvay
摘要： Methods for making disinfecting compositions based on phototherapy, systems for use in disinfecting with a combination of photosensitizers, and the disinfecting compositions themselves, are described. Concentrations of the photosensitizers can be based on the particular light source and the wavebands or fluence rates emitted by the light source for maximum singlet oxygen generation. Concentrations of the photosensitizers can also be based on the quantum yield of the photosensitizers.
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公开(公告)号：US20220054149A1
公开(公告)日：2022-02-24
申请号：US17244610
申请日：2021-04-29
申请人： University of Washington , Seattle Children's Hospital (dba Seattle Children's Research Institute)
发明人： James Chen , Tanner Clark , Thomas Lendvay
摘要： An apparatus for vaccine generation includes a syringe with a cavity that includes a solution with photosensitizers. Microbial particles are added to the solution. A light source is capable of emitting one or more wavebands of light that are effectively absorbed by the one photosensitizers to generate singlet oxygen in the solution and other radical species that rapidly react with and damage lipids, proteins, DNA, and RNA of the microbial particles. This damage produces immunogens that can be applied as a vaccine to viruses and other infectious microbial particles. A plunger that fits within a proximal opening in the syringe is used for forcing the solution including the immunogens through the filter and out of the syringe while the photosensitizers, debris and unwanted microbial particles are trapped within the filter.
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公开(公告)号：US20220168740A1
公开(公告)日：2022-06-02
申请号：US17441186
申请日：2020-03-20
申请人： University of Washington , Seattle Children's Hospital d/b/a Seattle Children's Research Institute
摘要： Systems, kits, and related methods of making fecal transplants are described. In an embodiment, the system comprises a sample collector defining a sample collection chamber shaped to collect a fecal sample from fecal matter; a sample processing module defining a sample port shaped to receive the sample collector and comprising: a channel positioned to receive at a proximal end of the channel the fecal sample from the sample collection chamber when the sample collector is received by the sample port; and a capsule fluidically coupled to a distal end of the channel adapted to receive a portion of the fecal sample passed therethrough; and a sample processing unit comprising: a housing defining an opening shaped to receive the sample processing module; and an actuator disposed in the housing and configured to urge the sample from the sample collection chamber through the channel to the capsule.
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公开(公告)号：US11529153B2
公开(公告)日：2022-12-20
申请号：US17244610
申请日：2021-04-29
发明人： James Chen , Tanner Clark , Thomas Lendvay
IPC分类号： A61B17/20 , A61M5/31 , A61M5/32 , A61K9/00 , A61K39/215 , B01L3/02 , A61K41/00 , A61B10/00 , A61K39/00
摘要： An apparatus for vaccine generation includes a syringe with a cavity that includes a solution with photosensitizers. Microbial particles are added to the solution. A light source is capable of emitting one or more wavebands of light that are effectively absorbed by the one photosensitizers to generate singlet oxygen in the solution and other radical species that rapidly react with and damage lipids, proteins, DNA, and RNA of the microbial particles. This damage produces immunogens that can be applied as a vaccine to viruses and other infectious microbial particles. A plunger that fits within a proximal opening in the syringe is used for forcing the solution including the immunogens through the filter and out of the syringe while the photosensitizers, debris and unwanted microbial particles are trapped within the filter.
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公开(公告)号：US11425905B2
公开(公告)日：2022-08-30
申请号：US17244688
申请日：2021-04-29
发明人： James Chen , Tanner Clark , Thomas Lendvay
IPC分类号： A01N25/34 , A41D31/30 , A61L9/20 , A01N43/84 , A01N43/16 , A01N43/90 , A61L9/18 , E04H15/54 , A62B18/02 , A62B31/00 , E04H15/46
摘要： An antimicrobial preventive netting is disclosed that includes one or more photosensitizers that are capable of generating a cloud of singlet oxygen on each surface and openings through the netting in response to incident light. A depth of the singlet oxygen cloud may be less than 0.7 centimeters from a netting surface. The netting may be supported by screens, enclosures or headgear. The netting can be made by dipping or soaking the netting in a solution of one or more photosensitizers.
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公开(公告)号：US20220061318A1
公开(公告)日：2022-03-03
申请号：US17244688
申请日：2021-04-29
申请人： University of Washington , Seattle Children's Hospital (dba Seattle Children's Research Institute)
发明人： James Chen , Tanner Clark , Thomas Lendvay
IPC分类号： A01N25/34 , A01N43/84 , A01N43/16 , A01N43/90 , A61L9/18 , E04H15/46 , E04H15/54 , A62B18/02 , A62B31/00 , A41D31/30
摘要： An antimicrobial preventive netting is disclosed that includes one or more photosensitizers that are capable of generating a cloud of singlet oxygen on each surface and openings through the netting in response to incident light. A depth of the singlet oxygen cloud may be less than 0.7 centimeters from a netting surface. The netting may be supported by screens, enclosures or headgear. The netting can be made by dipping or soaking the netting in a solution of one or more photosensitizers.
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公开(公告)号：US11612669B2
公开(公告)日：2023-03-28
申请号：US17405900
申请日：2021-08-18
发明人： James Chen , Tanner Clark , Thomas Lendvay
IPC分类号： A61L2/08 , A61L31/12 , A61L31/16 , A41D13/11 , A41D13/00 , A41D13/12 , A61L2/28 , A61L2/18 , A61L101/44
摘要： Photosensitizers are incorporated into articles, such a personal protective equipment. A method of applying continuous and consistent light includes fitting the articles with light sources and optical fibers to apply light to the areas of the articles incorporated with the photosensitizers. Photosensitizers can be applied to articles by various applicators in either a gel or solution. A gel can be particularly effective when used on hydrophobic surfaces. Photodynamic reactor systems can be used to determine the effective doses of photosensitizers and the light dosimetry which can then be applied for use with the articles.
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公开(公告)号：US20220054672A1
公开(公告)日：2022-02-24
申请号：US17405900
申请日：2021-08-18
申请人： University of Washington , Seattle Children's Hospital (dba Seattle Children's Research Institute)
发明人： James Chen , Tanner Clark , Thomas Lendvay
摘要： Photosensitizers are incorporated into articles, such a personal protective equipment. A method of applying continuous and consistent light includes fitting the articles with light sources and optical fibers to apply light to the areas of the articles incorporated with the photosensitizers. Photosensitizers can be applied to articles by various applicators in either a gel or solution. A gel can be particularly effective when used on hydrophobic surfaces. Photodynamic reactor systems can be used to determine the effective doses of photosensitizers and the light dosimetry which can then be applied for use with the articles.
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公开(公告)号：US20220054667A1
公开(公告)日：2022-02-24
申请号：US17389936
申请日：2021-07-30
申请人： University of Washington , Seattle Children's Hospital (dba Seattle Children's Research Institute)
发明人： James Chen , Tanner Clark , Thomas Lendvay
IPC分类号： A61L2/00 , A61L2/08 , A61L2/025 , A61K41/00 , A61K9/70 , A01N25/34 , A01P1/00 , A61N5/06 , A61N7/00
摘要： Antimicrobial films for generating singlet oxygen and their use is described. The antimicrobial films are generally thin films having two surfaces or faces. The first surface of the film is adhesive. Various adhesives, including, electrostatic charges, are possible. The second surface faces in a direction opposite from the first surface. The second surface of the film emits singlet oxygen when activated by light or ultrasound. Various photosensitizers can be incorporated onto the second surface of the films for generating the singlet oxygen. The singlet oxygen and other radical species generated from the antimicrobial films diffuses out from and in proximity to the films to form a layer or cloud of singlet oxygen at a concentration sufficient to inactivate microbial particles, e.g., viruses and other pathogens, that come within the singlet oxygen layer to provide a protective zone against microbial particles.
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公开(公告)号：US10350439B2
公开(公告)日：2019-07-16
申请号：US14777949
申请日：2014-03-28
申请人： University of Washington through its Center for Commercialization , The Trustees of Columbia University in the City of New York
发明人： Adam Maxwell , Ryan Hsi , Thomas Lendvay , Pasquale Casale , Michael Bailey
摘要： Methods for diagnosing a pathologic tissue membrane, as well as a focused ultrasound apparatus and methods of treatment are disclosed to perform ureterocele puncture noninvasively using focused ultrasound-generated cavitation or boiling bubbles to controllably erode a hole through the tissue. An example ultrasound apparatus may include (a) a therapy transducer having a treatment surface, wherein the therapy transducer comprises a plurality of electrically isolated sections, (b) at least one concave acoustic lens defining a therapy aperture in the treatment surface of the therapy transducer, (c) an imaging aperture defined by either the treatment surface of the therapy transducer or by the at least one concave acoustic lens and (d) an ultrasound imaging probe axially aligned with a central axis of the therapy aperture.
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