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1.发明申请Use of antisense oligonucleotides for the treatment of degenerative skin conditions 审中-公开使用反义寡核苷酸治疗退行性皮肤病公开(公告)号：US20060025363A1
公开(公告)日：2006-02-02
申请号：US11064037
申请日：2005-02-22
申请人： Ute Breitenbach , Stephan Gallinat , Ludger Kolbe , Claudia Mundt , Volker Schreiner , Franz Stab , Rainer Wolber , Helga Biergiesser , Heiko Mielke , Thomas Blatt , Kirsten Venzke , Kyra Sanger
发明人： Ute Breitenbach , Stephan Gallinat , Ludger Kolbe , Claudia Mundt , Volker Schreiner , Franz Stab , Rainer Wolber , Helga Biergiesser , Heiko Mielke , Thomas Blatt , Kirsten Venzke , Kyra Sanger
CPC分类号： A61Q19/007 , A61K8/606 , A61K31/7105 , A61K31/712 , A61K31/7125 , A61Q19/00 , A61Q19/08
摘要： A pharmaceutical or cosmetic composition for topical application containing one or more oligonucleotides which are capable of hybridizing with a mRNA or a gene sequence which codes for a connective-tissue decomposing enzyme, or a physiologically compatible salt thereof. The compositions are suitable in particular for the treatment of degenerative skin conditions.
摘要翻译： 一种用于局部应用的药物或化妆品组合物，其含有一种或多种能够与编码结缔组织分解酶的mRNA或基因序列杂交的寡核苷酸或其生理上相容的盐。 该组合物特别适用于治疗退行性皮肤病症。
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2.发明申请OLIGORIBONUCLEOTIDES FOR THE TREATMENT OF DEGENERATIVE SKIN CONDITIONS BY RNA INTERFERENCE 审中-公开通过RNA干扰治疗变性皮肤病的低分子量化公开(公告)号：US20080182808A1
公开(公告)日：2008-07-31
申请号：US11850315
申请日：2007-09-05
申请人： Ute Breitenbach , Stefan Gallinat , Ludger Kolbe , Thomas Blatt , Helga Biergiesser , Rainer Wolber , Franz Stab , Kyra Sanger
发明人： Ute Breitenbach , Stefan Gallinat , Ludger Kolbe , Thomas Blatt , Helga Biergiesser , Rainer Wolber , Franz Stab , Kyra Sanger
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/14 , C12N2310/3125 , C12N2310/314 , C12N2310/315 , C12N2310/3233 , C12N2310/53 , C12Y302/01035 , C12Y304/21071
摘要： The invention relates to oligoribonucleotides, which are capable of inducing breakdown of the mrna enzymes that break down connective tissue, and to pharmaceutical and cosmetic compositions, which are provided for topical application and which contain the oligoribonucleotides. The compositions are particularly suited for treating degenerative skin disorders.
摘要翻译： 本发明涉及能够诱导破坏结缔组织的细胞分解的寡核糖核苷酸，以及提供用于局部应用并含有寡核糖核苷酸的药物和化妆品组合物。 组合物特别适用于治疗退行性皮肤病。
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3.发明申请Oligoribonucleotides for the treatment of degenerative skin conditions by RNA interference 审中-公开用于通过RNA干扰治疗退行性皮肤病症的寡核苷酸公开(公告)号：US20060058256A1
公开(公告)日：2006-03-16
申请号：US11134141
申请日：2005-05-20
申请人： Ute Breitenbach , Stefan Gallinat , Ludger Kolbe , Thomas Blatt , Helga Biergiesser , Rainer Wolber , Franz Stab , Kyra Sanger
发明人： Ute Breitenbach , Stefan Gallinat , Ludger Kolbe , Thomas Blatt , Helga Biergiesser , Rainer Wolber , Franz Stab , Kyra Sanger
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/14 , C12N2310/3125 , C12N2310/314 , C12N2310/315 , C12N2310/3233 , C12N2310/53 , C12Y302/01035 , C12Y304/21071
摘要： The invention relates to oligoribonucleotides, which are capable of inducing breakdown of the mRNA enzymes that break down connective tissue, and to pharmaceutical and cosmetic compositions, which are provided for topical application and which contain the oligoribonucleotides. The compositions are particularly suited for treating degenerative skin disorders.
摘要翻译： 本发明涉及能够诱导破坏结缔组织的mRNA酶分解的寡核糖核苷酸，以及提供用于局部应用并含有寡核糖核苷酸的药物和化妆品组合物。 组合物特别适用于治疗退行性皮肤病。
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4.发明申请Cosmetic and/or dermatological preparation comprising 2,3-dibenzylbutyrolactones 审中-公开包含2,3-二苄基丁内酯的化妆品和/或皮肤病学制剂公开(公告)号：US20060093633A1
公开(公告)日：2006-05-04
申请号：US10515000
申请日：2003-05-22
申请人： Franz Stab , Rainer Wolber , Thomas Blatt , Ludger Kolbe , Claudia Mundt , Stefan Galliant , Kirsten Venzke , Karen Dieck , Ute Breitenbach
发明人： Franz Stab , Rainer Wolber , Thomas Blatt , Ludger Kolbe , Claudia Mundt , Stefan Galliant , Kirsten Venzke , Karen Dieck , Ute Breitenbach
IPC分类号： A61K8/97 , A61K8/73 , A61K36/28 , A61K31/365
CPC分类号： A61Q5/006 , A61K8/4973 , A61K8/602 , A61K8/97 , A61Q5/00 , A61Q5/02 , A61Q5/12 , A61Q19/08 , A61Q19/10
摘要： Cosmetic and/or dermatological preparation containing one or more 2,3-dibenzylbutyrolactone derivatives and/or their glycosides besides optionally additional cosmetic and/or dermatological active ingredients, auxiliary agents, and additives.
摘要翻译： 包含一种或多种2,3-二苄基丁内酯衍生物和/或其糖苷的化妆品和/或皮肤病学制剂，除了任选的另外的化妆品和/或皮肤病学活性成分，辅助剂和添加剂。
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公开(公告)号：US20050026862A1
公开(公告)日：2005-02-03
申请号：US10896786
申请日：2004-07-21
申请人： Thomas Blatt , Franz Stab , Rainer Wolber , Ludger Kolbe , Stefan Gallinat , Ute Breitenbach , Kyra Sanger
发明人： Thomas Blatt , Franz Stab , Rainer Wolber , Ludger Kolbe , Stefan Gallinat , Ute Breitenbach , Kyra Sanger
摘要： The invention is a cosmetic or dermatological preparation comprising at least one reaction product of DNA selected from the group consisting of oxidation products of mononucleosides, oxidation products of nucleobases, photoproducts of mononucleosides, and photoproducts of nucleobases. In one embodiment, the invention includes a cosmetic or dermatological preparation comprising at least one 8-hydroxypurine nucleoside. The invention also includes methods for preventing or treating degenerative or inflammatory skin symptoms, reducing skin wrinkles, preventing skin aging or firming the skin comprising applying the cosmetic or dermatological preparation to the skin, optionally in combination with laser or abrasive treatment.
摘要翻译： 本发明是一种化妆品或皮肤病学制剂，其包含至少一种选自单核苷的氧化产物，核碱基的氧化产物，单核苷的光产物和核碱基的光产物的反应产物。 在一个实施方案中，本发明包括包含至少一种8-羟基嘌呤核苷的化妆品或皮肤病学制剂。 本发明还包括用于预防或治疗退行性或炎症性皮肤症状，减少皮肤皱纹，防止皮肤老化或使皮肤紧致的方法，包括将化妆品或皮肤病学制剂施用于皮肤，任选地与激光或磨蚀剂处理组合。
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6.发明申请Oligoribonucleotides for the treatment of irritative or inflammatory skin symptoms through RNA interference 审中-公开用于通过RNA干扰治疗刺激性或炎症性皮肤症状的寡核苷酸公开(公告)号：US20050261222A1
公开(公告)日：2005-11-24
申请号：US11072031
申请日：2005-03-03
申请人： Rainer Wolber , Ludger Kolbe , Claudia Mundt , Stefan Gallinat , Ute Breitenbach
发明人： Rainer Wolber , Ludger Kolbe , Claudia Mundt , Stefan Gallinat , Ute Breitenbach
IPC分类号： A61K31/713 , C12N15/11 , C12N15/113 , A61K48/00 , C07H21/04
CPC分类号： C12N15/1136 , C12N15/111 , C12N15/1137 , C12N2310/14 , C12N2320/32 , C12Y114/99001
摘要： The invention is a double-stranded oligoribonucleotide or a physiologically compatible salt thereof, which is capable of inducing the degradation of mRNA of one of more structures involved in inflammation or irritation of the skin. The invention is also cosmetic or therapeutic compositions comprising one or more such double-stranded oligoribonucleotide and methods of treatment by use thereof.
摘要翻译： 本发明是双链寡核糖核苷酸或其生理上相容的盐，其能够诱导涉及炎症或刺激皮肤的多种结构之一的mRNA的降解。 本发明也是包含一种或多种这样的双链寡核糖核苷酸的化妆品或治疗组合物及其使用的治疗方法。
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7.发明申请Use Of Licochalcone A Or Of An Extract Of Licochalcone A From Radix Glycyrrhizae Inflatae Against Skin Aging 审中-公开利用查尔酮A或从甘草提取物中提取柠檬酮A提取物对皮肤老化的使用公开(公告)号：US20070196289A1
公开(公告)日：2007-08-23
申请号：US10571530
申请日：2004-08-16
申请人： Thomas Blatt , Ute Breitenbach , Stefan Gallinat , Ludger Kolbe , Christopher Mummert , Franz Staeb , Rainer Wolber
发明人： Thomas Blatt , Ute Breitenbach , Stefan Gallinat , Ludger Kolbe , Christopher Mummert , Franz Staeb , Rainer Wolber
摘要： Use of licochalcone A or of an extract containing licochalcone A from Radix Glycyrrhizae inflatae in cosmetic and dermatological preparations for the treatment and prophylaxis of the symptoms of intrinsic and/or extrinsic skin ageing and the treatment and prophylaxis of the damaging effects of ultraviolet radiation on the skin.
摘要翻译： 在化妆品和皮肤病学制剂中使用利多卡酮A或含有吡罗昔酮A的萃取酮A的提取物，用于治疗和预防内在和/或外在皮肤老化的症状，以及治疗和预防紫外线辐射对 皮肤。
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8.发明申请Cosmetic or dermatological preparations containing one or more ketohexoses 审中-公开含有一种或多种酮己糖的化妆品或皮肤病学制剂公开(公告)号：US20050002880A1
公开(公告)日：2005-01-06
申请号：US10477511
申请日：2002-05-16
申请人： Christopher Mummert , Thomas Blatt , Claudia Mundt , Ludger Kolbe , Alexandra Erlach , Thomas Doring , Rainer Wolber
发明人： Christopher Mummert , Thomas Blatt , Claudia Mundt , Ludger Kolbe , Alexandra Erlach , Thomas Doring , Rainer Wolber
IPC分类号： A61K8/00 , A61K8/04 , A61K8/60 , A61K8/68 , A61K31/70 , A61K31/715 , A61Q19/00 , A61Q19/08 , A61K7/135
CPC分类号： A61Q19/004 , A61K8/60 , A61Q17/04 , A61Q19/007 , A61Q19/08
摘要： Cosmetic or dermatological preparations with a content of one or more ketohexoses.
摘要翻译： 具有一种或多种酮己糖的含量的化妆品或皮肤病学制剂。
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9.发明授权Cosmetic or dermatological preparations containing licochalcone A or an extract of radix glycyrrhizae inflatae, containing licochalcone A 有权化妆品或皮肤病学制剂，其含有哌甲屈酮A或甘草提取物，含有苯甲酮酮A公开(公告)号：US08470349B2
公开(公告)日：2013-06-25
申请号：US10889114
申请日：2004-07-13
申请人： Karen Tom Dieck , Ludger Kolbe , Claudia Mundt , Ursula Wensorra , Rainer Wolber
发明人： Karen Tom Dieck , Ludger Kolbe , Claudia Mundt , Ursula Wensorra , Rainer Wolber
摘要： Cosmetic or dermatological preparations with a content of an aqueous extract of Radix Glycyrrhizae inflatae or licochalcone A, one or more ethoxylated or propoxylated raw materials, optionally one or more polyols.
摘要翻译： 化妆品或皮肤病学制剂，其含量为甘草酸甘草或丙酸查耳酮A的水提取物，一种或多种乙氧基化或丙氧基化原料，任选的一种或多种多元醇。
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10.发明申请Cosmetic or dermatological preparations containing licochalcone A or an extract of radix glycyrrhizae inflatae, containing licochalcone A 有权化妆品或皮肤病学制剂，其含有哌甲屈酮A或甘草提取物，含有苯甲酮酮A公开(公告)号：US20050037042A1
公开(公告)日：2005-02-17
申请号：US10889114
申请日：2004-07-13
申请人： Karen Tom Dieck , Ludger Kolbe , Claudia Mundt , Ursula Wensorra , Rainer Wolber
发明人： Karen Tom Dieck , Ludger Kolbe , Claudia Mundt , Ursula Wensorra , Rainer Wolber
摘要： Cosmetic or dermatological preparations with a content of an aqueous extract of Radix Glycyrrhizae inflatae or licochalcone A, one or more ethoxylated or propoxylated raw materials, optionally one or more polyols.
摘要翻译： 化妆品或皮肤病学制剂，其含量为甘草酸甘草或丙酸查耳酮A的水提取物，一种或多种乙氧基化或丙氧基化原料，任选的一种或多种多元醇。
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