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1.发明授权公开(公告)号：US11357844B2
公开(公告)日：2022-06-14
申请号：US17061891
申请日：2020-10-02
发明人： Larry R. Ellingsworth , David Flyer , Jing-Hui Tian , Steven R. Fuhrmann , Stefanie Kluepfel-Stahl , Gregory M. Glenn , Kerstin Westritschnig
摘要： This present invention provides C-TAB.G5 and C-TAB.G5.1 isolated polypeptides comprising the receptor binding domains of C. difficile toxin A and toxin B as set forth in the amino acid sequences of SEQ ID NO: 2 and SEQ ID NO: 4. The C-TAB.G5 and C-TAB.G5.1 isolated polypeptides may be used to neutralize toxic effects of C. difficile toxin A and/or toxin B.
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2.发明申请公开(公告)号：US20210121554A1
公开(公告)日：2021-04-29
申请号：US17061891
申请日：2020-10-02
发明人： Larry R. Ellingsworth , David Flyer , Jing-Hui Tian , Steven R. Fuhrmann , Stefanie Kluepfel-Stahl , Gregory M. Glenn , Kerstin Westritschnig
摘要： This present invention provides C-TAB.G5 and C-TAB.G5.1 isolated polypeptides comprising the receptor binding domains of C. difficile toxin A and toxin B as set forth in the amino acid sequences of SEQ ID NO: 2 and SEQ ID NO: 4. The C-TAB.G5 and C-TAB.G5.1 isolated polypeptides may be used to neutralize toxic effects of C. difficile toxin A and/or toxin B.
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3.发明授权公开(公告)号：US10821166B2
公开(公告)日：2020-11-03
申请号：US16295031
申请日：2019-03-07
发明人： Larry R. Ellingsworth , David Flyer , Jing-Hui Tian , Steven R. Fuhrmann , Stefanie Kluepfel-Stahl , Gregory M. Glenn , Kerstin Westritschnig
摘要： This present invention provides C-TAB.G5 and C-TAB.G5.1 isolated polypeptides comprising the receptor binding domains of C. difficile toxin A and toxin B as set forth in the amino acid sequences of SEQ ID NO: 2 and SEQ ID NO: 4. The C-TAB.G5 and C-TAB.G5.1 isolated polypeptides may be used to neutralize toxic effects of C. difficile toxin A and/or toxin B.
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4.发明公开公开(公告)号：US20230173052A1
公开(公告)日：2023-06-08
申请号：US17930742
申请日：2022-09-09
发明人： Larry R. Ellingsworth , David Flyer , Jing-Hui Tian , Steven R. Fuhrmann , Stefanie Kluepfel-Stahl , Gregory M. Glenn , Kerstin Westritschnig
CPC分类号： A61K39/08 , C07K14/33 , C07K16/1282 , A61K2039/55505
摘要： This present invention provides C-TAB.G5 and C-TAB.G5.1 isolated polypeptides comprising the receptor binding domains of C. difficile toxin A and toxin B as set forth in the amino acid sequences of SEQ ID NO: 2 and SEQ ID NO: 4. The C-TAB.G5 and C-TAB.G5.1 isolated polypeptides may be used to neutralize toxic effects of C. difficile toxin A and/or toxin B.
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5.发明授权公开(公告)号：US11478540B2
公开(公告)日：2022-10-25
申请号：US17406765
申请日：2021-08-19
发明人： Larry R. Ellingsworth , David Flyer , Jing-Hui Tian , Steven R. Fuhrmann , Stefanie Kluepfel-Stahl , Gregory M. Glenn , Kerstin Westritschnig
摘要： This present invention provides C-TAB.G5 and C-TAB.G5.1 isolated polypeptides comprising the receptor binding domains of C. difficile toxin A and toxin B as set forth in the amino acid sequences of SEQ ID NO: 2 and SEQ ID NO: 4. The C-TAB.G5 and C-TAB.G5.1 isolated polypeptides may be used to neutralize toxic effects of C. difficile toxin A and/or toxin B.
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6.发明申请公开(公告)号：US20210393761A1
公开(公告)日：2021-12-23
申请号：US17406765
申请日：2021-08-19
发明人： Larry R. Ellingsworth , David Flyer , Jing-Hui Tian , Steven R. Fuhrmann , Stefanie Kluepfel-Stahl , Gregory M. Glenn , Kerstin Westritschnig
摘要： This present invention provides C-TAB.G5 and C-TAB.G5.1 isolated polypeptides comprising the receptor binding domains of C. difficile toxin A and toxin B as set forth in the amino acid sequences of SEQ ID NO: 2 and SEQ ID NO: 4. The C-TAB.G5 and C-TAB.G5.1 isolated polypeptides may be used to neutralize toxic effects of C. difficile toxin A and/or toxin B.
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7.发明申请公开(公告)号：US20190290747A1
公开(公告)日：2019-09-26
申请号：US16295031
申请日：2019-03-07
申请人： Valneva Austria GmbH
发明人： Larry R. Ellingsworth , David Flyer , Jing-Hui Tian , Steven R. Fuhrmann , Stefanie Kluepfel-Stahl , Gregory M. Glenn , Kerstin Westritschnig
摘要： This present invention provides C-TAB.G5 and C-TAB.G5.1 isolated polypeptides comprising the receptor binding domains of C. difficile toxin A and toxin B as set forth in the amino acid sequences of SEQ ID NO: 2 and SEQ ID NO: 4. The C-TAB.G5 and C-TAB.G5.1 isolated polypeptides may be used to neutralize toxic effects of C. difficile toxin A and/or toxin B.
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8.发明申请公开(公告)号：US20170239340A1
公开(公告)日：2017-08-24
申请号：US15421808
申请日：2017-02-01
发明人： LARRY R. ELLINGSWORTH , David Flyer , Jing-Hui Tian , Steven R. Fuhrmann , Stefanie Kluepfel-Stahl , Gregory M. Glenn , Kerstin Westritschnig
CPC分类号： A61K39/08 , A61K2039/53 , A61K2039/55505 , A61K2039/55544 , A61K2039/575 , C07K14/33 , C07K16/1282 , C07K2317/76 , C07K2319/00 , C07K2319/40 , C07K2319/55
摘要： This present invention provides C-TAB.G5 and C-TAB.G5.1 isolated polypeptides comprising the receptor binding domains of C. difficile toxin A and toxin B as set forth in the amino acid sequences of SEQ ID NO: 2 and SEQ ID NO: 4. The C-TAB.G5 and C-TAB.G5.1 isolated polypeptides may be used to neutralize toxic effects of C. difficile toxin A and/or toxin B.
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9.发明授权公开(公告)号：US10357557B2
公开(公告)日：2019-07-23
申请号：US15421808
申请日：2017-02-01
发明人： Larry R. Ellingsworth , David Flyer , Jing-Hui Tian , Steven R. Fuhrmann , Stefanie Kluepfel-Stahl , Gregory M. Glenn , Kerstin Westritschnig
摘要： This present invention provides C-TAB.G5 and C-TAB.G5.1 isolated polypeptides comprising the receptor binding domains of C. difficile toxin A and toxin B as set forth in the amino acid sequences of SEQ ID NO: 2 and SEQ ID NO: 4. The C-TAB.G5 and C-TAB.G5.1 isolated polypeptides may be used to neutralize toxic effects of C. difficile toxin A and/or toxin B.
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