公开(公告)号：US20230348571A1

公开(公告)日：2023-11-02

申请号：US17917174

申请日：2021-04-06

申请人： VANDERBILT UNIVERSITY ,  BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  TRUSTEES OF DARTMOUTH COLLEGE

发明人： Ivelin Stefanov Georgiev ,  Andrea R. Shiakolas ,  Kevin J. Kramer ,  James E. Crowe, Jr. ,  Robert Carnahan ,  Nianshuang Wang ,  Daniel Wrapp ,  Jason McLellan

IPC分类号： C07K16/10 ,  A61P31/14

CPC分类号： C07K16/1003 ,  A61P31/14 ,  A61K2039/505

摘要： The present disclosure relates to antibodies and uses thereof for treating, preventing, and detecting coronavirus infection.

公开(公告)号：US20230113170A1

公开(公告)日：2023-04-13

申请号：US17798021

申请日：2021-02-11

申请人： The United States of America, as represented by the Secretary, Department of Health and Human ,  Board of Regents, The University of Texas System ,  Trustees of Dartmouth College

发明人： Barney Graham ,  Kizzmekia Corbett ,  Olubukola Abiona ,  Geoffrey Hutchinson ,  Jason McLellan ,  Daniel Wrapp ,  Nianshuang Wang

IPC分类号： A61K39/215 ,  C12N15/86 ,  A61P31/14

摘要： SARS-CoV-2 S ectodomain trimers stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the SARS-CoV-2 S ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to SARS-CoV-2 S in a subject, for example, an immune response that inhibits SARS-CoV-2 infection in the subject.

公开(公告)号：US12077563B2

公开(公告)日：2024-09-03

申请号：US18411284

申请日：2024-01-12

申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

发明人： Jason McLellan ,  Ching-Lin Hsieh ,  Scott Rush ,  Nianshuang Wang

IPC分类号： C07K14/08 ,  C07K14/115 ,  C07K14/135

CPC分类号： C07K14/08

摘要： Provided herein are engineered hMPV F proteins. In some aspects, the engineered F proteins exhibit enhanced conformational stability and/or antigenicity. Methods are also provided for use of the engineered F proteins as diagnostics, in screening platforms, and/or in vaccine compositions.

公开(公告)号：US11919927B2

公开(公告)日：2024-03-05

申请号：US18296771

申请日：2023-04-06

申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

发明人： Jason McLellan ,  Ching-Lin Hsieh ,  Scott Rush ,  Nianshuang Wang

IPC分类号： C07K14/08 ,  C07K14/115 ,  C07K14/135 ,  C12N7/00

CPC分类号： C07K14/08

摘要： Provided herein are engineered hMPV F proteins. In some aspects, the engineered F proteins exhibit enhanced conformational stability and/or antigenicity. Methods are also provided for use of the engineered F proteins as diagnostics, in screening platforms, and/or in vaccine compositions.

公开(公告)号：US11964010B2

公开(公告)日：2024-04-23

申请号：US17194834

申请日：2021-03-08

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services ,  The Scripps Research Institute ,  Trustees of Dartmouth College

发明人： Barney Graham ,  Jason Mclellan ,  Andrew Ward ,  Robert Kirchdoerfer ,  Christopher Cottrell ,  Michael Gordon Joyce ,  Masaru Kanekiyo ,  Nianshuang Wang ,  Jesper Pallesen ,  Hadi Yassine ,  Hannah Turner ,  Kizzmekia Corbett

IPC分类号： A61K39/215 ,  A61P31/14 ,  C07K14/005 ,  C12N7/00

CPC分类号： A61K39/215 ,  A61P31/14 ,  C07K14/005 ,  C12N7/00 ,  C12N2770/20022 ,  C12N2770/20034 ,  C12N2770/20071

摘要： Coronavirus S ectodomain trimers stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the coronavirus S ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to coronavirus in a subject. In additional embodiments, the therapeutically effective amount of the coronavirus S ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing coronavirus infection.

公开(公告)号：US20210275664A1

公开(公告)日：2021-09-09

申请号：US17194834

申请日：2021-03-08

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic ,  The Scripps Research Institute ,  Trustees of Dartmouth College

发明人： Barney Graham ,  Jason McLellan ,  Andrew Ward ,  Robert Kirchdoerfer ,  Christopher Cottrell ,  Michael Gordon Joyce ,  Masaru Kanekiyo ,  Nianshuang Wang ,  Jesper Pallesen ,  Hadi Yassine ,  Hannah Turner ,  Kizzmekia Corbett

IPC分类号： A61K39/215 ,  A61P31/14 ,  C07K14/005 ,  C12N7/00

摘要： Coronavirus S ectodomain trimers stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the coronavirus S ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to coronavirus in a subject. In additional embodiments, the therapeutically effective amount of the coronavirus S ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing coronavirus infection.

公开(公告)号：US20200061185A1

公开(公告)日：2020-02-27

申请号：US16344774

申请日：2017-10-25

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic ,  The Scripps Research Institute ,  Trustees of Dartmouth College

发明人： Barney Graham ,  Jason McLellan ,  Andrew Ward ,  Robert Kirchdoerfer ,  Christopher Cottrell ,  Michael Gordon Joyce ,  Masaru Kanekiyo ,  Nianshuang Wang ,  Jesper Pallesen ,  Hadi Yassine ,  Hannah Turner ,  Kizzmekia Corbett

IPC分类号： A61K39/215 ,  C07K14/005 ,  A61P31/14 ,  C12N7/00

摘要： Coronavirus S ectodomain trimers stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the coronavirus S ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to coronavirus in a subject. In additional embodiments, the therapeutically effective amount of the coronavirus S ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing coronavirus infection.

公开(公告)号：US10960070B2

公开(公告)日：2021-03-30

申请号：US16344774

申请日：2017-10-25

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services ,  The Scripps Research Institute ,  Trustees of Dartmouth College

发明人： Barney Graham ,  Jason McLellan ,  Andrew Ward ,  Robert Kirchdoerfer ,  Christopher Cottrell ,  Michael Gordon Joyce ,  Masaru Kanekiyo ,  Nianshuang Wang ,  Jesper Pallesen ,  Hadi Yassine ,  Hannah Turner ,  Kizzmekia Corbett

IPC分类号： A61K39/215 ,  C12N7/00 ,  A61P31/14 ,  C07K14/005

摘要： Coronavirus S ectodomain trimers stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the coronavirus S ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to coronavirus in a subject. In additional embodiments, the therapeutically effective amount of the coronavirus S ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing coronavirus infection.