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公开(公告)号：US20210275664A1
公开(公告)日：2021-09-09
申请号：US17194834
申请日：2021-03-08
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic , The Scripps Research Institute , Trustees of Dartmouth College
发明人： Barney Graham , Jason McLellan , Andrew Ward , Robert Kirchdoerfer , Christopher Cottrell , Michael Gordon Joyce , Masaru Kanekiyo , Nianshuang Wang , Jesper Pallesen , Hadi Yassine , Hannah Turner , Kizzmekia Corbett
IPC分类号： A61K39/215 , A61P31/14 , C07K14/005 , C12N7/00
摘要： Coronavirus S ectodomain trimers stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the coronavirus S ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to coronavirus in a subject. In additional embodiments, the therapeutically effective amount of the coronavirus S ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing coronavirus infection.
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公开(公告)号：US20200061185A1
公开(公告)日：2020-02-27
申请号：US16344774
申请日：2017-10-25
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic , The Scripps Research Institute , Trustees of Dartmouth College
发明人： Barney Graham , Jason McLellan , Andrew Ward , Robert Kirchdoerfer , Christopher Cottrell , Michael Gordon Joyce , Masaru Kanekiyo , Nianshuang Wang , Jesper Pallesen , Hadi Yassine , Hannah Turner , Kizzmekia Corbett
IPC分类号： A61K39/215 , C07K14/005 , A61P31/14 , C12N7/00
摘要： Coronavirus S ectodomain trimers stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the coronavirus S ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to coronavirus in a subject. In additional embodiments, the therapeutically effective amount of the coronavirus S ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing coronavirus infection.
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公开(公告)号：US10960070B2
公开(公告)日：2021-03-30
申请号：US16344774
申请日：2017-10-25
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , The Scripps Research Institute , Trustees of Dartmouth College
发明人： Barney Graham , Jason McLellan , Andrew Ward , Robert Kirchdoerfer , Christopher Cottrell , Michael Gordon Joyce , Masaru Kanekiyo , Nianshuang Wang , Jesper Pallesen , Hadi Yassine , Hannah Turner , Kizzmekia Corbett
IPC分类号： A61K39/215 , C12N7/00 , A61P31/14 , C07K14/005
摘要： Coronavirus S ectodomain trimers stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the coronavirus S ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to coronavirus in a subject. In additional embodiments, the therapeutically effective amount of the coronavirus S ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing coronavirus infection.
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公开(公告)号：US11964010B2
公开(公告)日：2024-04-23
申请号：US17194834
申请日：2021-03-08
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , The Scripps Research Institute , Trustees of Dartmouth College
发明人： Barney Graham , Jason Mclellan , Andrew Ward , Robert Kirchdoerfer , Christopher Cottrell , Michael Gordon Joyce , Masaru Kanekiyo , Nianshuang Wang , Jesper Pallesen , Hadi Yassine , Hannah Turner , Kizzmekia Corbett
IPC分类号： A61K39/215 , A61P31/14 , C07K14/005 , C12N7/00
CPC分类号： A61K39/215 , A61P31/14 , C07K14/005 , C12N7/00 , C12N2770/20022 , C12N2770/20034 , C12N2770/20071
摘要： Coronavirus S ectodomain trimers stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the coronavirus S ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to coronavirus in a subject. In additional embodiments, the therapeutically effective amount of the coronavirus S ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing coronavirus infection.
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公开(公告)号：US20240136019A1
公开(公告)日：2024-04-25
申请号：US18547705
申请日：2022-02-24
发明人： Andrew B. Ward , Aleksandar Antanasijevic , Charles Bowman , Christopher Cottrell , Gabriel Ozorowski , Robert Kirchdoerfer
IPC分类号： G16B30/10 , G01N33/577
CPC分类号： G16B30/10 , G01N33/577
摘要： Provided herein are methods for discovery of epitope specific monoclonal antibodies to pathogens directly from immune sera for immunotherapeutic use. Further provided herein are methods to determine molecular structure of antibodies targeting an antigen from convalescent or vaccinated individuals for the purpose of rational vaccine design.
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公开(公告)号：US20240233873A9
公开(公告)日：2024-07-11
申请号：US18547705
申请日：2022-02-24
发明人： Andrew B. Ward , Aleksandar Antanasijevic , Charles Bowman , Christopher Cottrell , Gabriel Ozorowski , Robert Kirchdoerfer
IPC分类号： G16B30/10 , G01N33/577
CPC分类号： G16B30/10 , G01N33/577
摘要： Provided herein are methods for discovery of epitope specific monoclonal antibodies to pathogens directly from immune sera for immunotherapeutic use. Further provided herein are methods to determine molecular structure of antibodies targeting an antigen from convalescent or vaccinated individuals for the purpose of rational vaccine design.
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