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公开(公告)号：US20210275664A1
公开(公告)日：2021-09-09
申请号：US17194834
申请日：2021-03-08
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic , The Scripps Research Institute , Trustees of Dartmouth College
发明人： Barney Graham , Jason McLellan , Andrew Ward , Robert Kirchdoerfer , Christopher Cottrell , Michael Gordon Joyce , Masaru Kanekiyo , Nianshuang Wang , Jesper Pallesen , Hadi Yassine , Hannah Turner , Kizzmekia Corbett
IPC分类号： A61K39/215 , A61P31/14 , C07K14/005 , C12N7/00
摘要： Coronavirus S ectodomain trimers stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the coronavirus S ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to coronavirus in a subject. In additional embodiments, the therapeutically effective amount of the coronavirus S ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing coronavirus infection.
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公开(公告)号：US20200061185A1
公开(公告)日：2020-02-27
申请号：US16344774
申请日：2017-10-25
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic , The Scripps Research Institute , Trustees of Dartmouth College
发明人： Barney Graham , Jason McLellan , Andrew Ward , Robert Kirchdoerfer , Christopher Cottrell , Michael Gordon Joyce , Masaru Kanekiyo , Nianshuang Wang , Jesper Pallesen , Hadi Yassine , Hannah Turner , Kizzmekia Corbett
IPC分类号： A61K39/215 , C07K14/005 , A61P31/14 , C12N7/00
摘要： Coronavirus S ectodomain trimers stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the coronavirus S ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to coronavirus in a subject. In additional embodiments, the therapeutically effective amount of the coronavirus S ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing coronavirus infection.
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公开(公告)号：US20210299242A1
公开(公告)日：2021-09-30
申请号：US17261828
申请日：2019-08-05
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic , Trustees of Dartmouth College
IPC分类号： A61K39/155 , C07K14/005 , A61P31/14
摘要： Embodiments of immunogens comprising a recombinant Nipah virus (NiV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also provided are embodiments of immunogens comprising chimeric proteins comprising the recombinant NiV F ectodomain trimer and one or more G ectodomains, a multimer of NiV G ectodomains, and protein nanoparticles comprising the recombinant NiV F ectodomain trimer or an NiV G ectodomain. Also disclosed are nucleic acids encoding the immunogens and methods of their production. Methods for inducing an immune response in a subject by administering a disclosed immunogen to the subject are also provided. In some embodiments, the immune response treats or inhibits NiV infection in a subject.
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公开(公告)号：US20210198324A1
公开(公告)日：2021-07-01
申请号：US17202231
申请日：2021-03-15
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic
发明人： Peter Kwong , Ivelin Georgiev , Michael Gordon Joyce , Masaru Kanekiyo , Aliaksandr Druz , Ulrich Baxa , Joseph Van Galen , Cheng Cheng , John Mascola , Yaroslav Tsybovsky , Yongping Yang , Barney Graham , Syed Mohammad Moin , Jeffrey Boyington
IPC分类号： C07K14/11 , A61K39/21 , C07K14/08 , C07K14/16 , C07K14/165 , C07K14/435 , C12N7/00
摘要： Disclosed are recombinant insect ferritin nanoparticles that can be used to display two different trimeric antigens at an equal ratio. Also disclosed are nucleic acids encoding the recombinant insect ferritin nanoparticles and methods of producing the recombinant insect ferritin nanoparticles. Methods for eliciting an immune response in a subject are also provided.
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公开(公告)号：US20220064222A1
公开(公告)日：2022-03-03
申请号：US17524380
申请日：2021-11-11
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic
发明人： Peter Kwong , Barney Graham , John Mascola , Li Ou , Aliaksandr Druz , Man Chen , Wing-Pui Kong , Ivelin Stefanov Georgiev , Emily Rundlet , Michael Gordon Joyce , Yaroslav Tsybovsky , Paul Thomas , Marie Pancera , Mallika Sastry , Cinque Soto , Joseph Van Galen , Guillaume Stewart-Jones , Yongping Yang , Baoshan Zhang , Ulrich Baxa
IPC分类号： C07K14/005 , A61K39/12 , A61P37/04 , A61P31/14
摘要： Embodiments of a recombinant Respiratory Syncytial Virus (RSV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the RSV F ectodomain trimer and methods of producing the RSV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the recombinant RSV F ectodomain trimer to the subject.
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6.发明公开公开(公告)号：US20240309053A1
公开(公告)日：2024-09-19
申请号：US18665309
申请日：2024-05-15
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic
发明人： Peter Collins , Bo Liang , Shirin Munir , Anne Schaap Nutt , Ursula Buchholz , Natalie Mackow , Peter Kwong , Barney Graham , Jason McLellan
IPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/155 , A61P31/14
CPC分类号： C07K14/005 , A61K39/12 , A61K39/155 , A61P31/14 , A61K2039/5254 , A61K2039/5256 , A61K2039/575 , A61K2039/70 , C07K2319/03 , C07K2319/033 , C12N2760/00022 , C12N2760/18534 , C12N2760/18571 , C12N2760/18622 , C12N2760/18634 , C12N2760/18641 , C12N2760/18643 , C12N2760/18671 , C12N2760/18722 , C12N2760/18734 , C12N2760/18741 , C12N2760/18743 , C12N2760/18771
摘要： Recombinant paramyxoviruses including a viral genome encoding a heterologous gene are provided. In several embodiments, the recombinant paramyxovirus is a recombinant parainfluenza virus, such as a recombinant PIV3 including a viral genome encoding a heterologous respiratory syncytial virus F ectodomain linked to the transmembrane domain and the cytoplasmic tail of the F protein from the PIV3. Nucleic acid molecules including the genome of a recombinant paramyxoviruses are also provided. The recombinant viruses may advantageously be used in vaccine formulations, such as for vaccines against parainfluenza virus and respiratory syncytial virus.
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公开(公告)号：US20230053555A1
公开(公告)日：2023-02-23
申请号：US17784605
申请日：2020-12-11
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic
IPC分类号： A61K39/165 , A61P31/14 , C07K14/12
摘要： Embodiments of immunogens comprising a recombinant Mumps (MuV) F ectodomain trimer stabilized in a prefusion conformation or a recombinant Measles (MeV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also provided are embodiments of immunogens comprising chimeric proteins comprising the recombinant MuV or MeV F ectodomain trimer and one or more MuV HN or MeV H ectodomains. Also disclosed are nucleic acids encoding the immunogens and methods of their production. Methods for inducing an immune response in a subject by administering a disclosed immunogen to the subject are also provided. In some embodiments, the immune response treats or inhibits MuV and/or MeV infection in a subject.
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8.发明申请公开(公告)号：US20200277338A1
公开(公告)日：2020-09-03
申请号：US16877319
申请日：2020-05-18
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic
发明人： Peter Collins , Bo Liang , Shirin Munir , Anne Schaap Nutt , Ursula Buchholz , Natalie Mackow , Peter Kwong , Barney Graham , Jason McLellan
IPC分类号： C07K14/005 , A61K39/12 , A61P31/14 , A61K39/155
摘要： Recombinant paramyxoviruses including a viral genome encoding a heterologous gene are provided. In several embodiments, the recombinant paramyxovirus is a recombinant parainfluenza virus, such as a recombinant PIV3 including a viral genome encoding a heterologous respiratory syncytial virus F ectodomain linked to the transmembrane domain and the cytoplasmic tail of the F protein from the PIV3. Nucleic acid molecules including the genome of a recombinant paramyxoviruses are also provided. The recombinant viruses may advantageously be used in vaccine formulations, such as for vaccines against parainfluenza virus and respiratory syncytial virus.
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公开(公告)号：US11964010B2
公开(公告)日：2024-04-23
申请号：US17194834
申请日：2021-03-08
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , The Scripps Research Institute , Trustees of Dartmouth College
发明人： Barney Graham , Jason Mclellan , Andrew Ward , Robert Kirchdoerfer , Christopher Cottrell , Michael Gordon Joyce , Masaru Kanekiyo , Nianshuang Wang , Jesper Pallesen , Hadi Yassine , Hannah Turner , Kizzmekia Corbett
IPC分类号： A61K39/215 , A61P31/14 , C07K14/005 , C12N7/00
CPC分类号： A61K39/215 , A61P31/14 , C07K14/005 , C12N7/00 , C12N2770/20022 , C12N2770/20034 , C12N2770/20071
摘要： Coronavirus S ectodomain trimers stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the coronavirus S ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to coronavirus in a subject. In additional embodiments, the therapeutically effective amount of the coronavirus S ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing coronavirus infection.
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公开(公告)号：US10960070B2
公开(公告)日：2021-03-30
申请号：US16344774
申请日：2017-10-25
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , The Scripps Research Institute , Trustees of Dartmouth College
发明人： Barney Graham , Jason McLellan , Andrew Ward , Robert Kirchdoerfer , Christopher Cottrell , Michael Gordon Joyce , Masaru Kanekiyo , Nianshuang Wang , Jesper Pallesen , Hadi Yassine , Hannah Turner , Kizzmekia Corbett
IPC分类号： A61K39/215 , C12N7/00 , A61P31/14 , C07K14/005
摘要： Coronavirus S ectodomain trimers stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the coronavirus S ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to coronavirus in a subject. In additional embodiments, the therapeutically effective amount of the coronavirus S ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing coronavirus infection.
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