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公开(公告)号：US20230348571A1
公开(公告)日：2023-11-02
申请号：US17917174
申请日：2021-04-06
申请人： VANDERBILT UNIVERSITY , BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , TRUSTEES OF DARTMOUTH COLLEGE
发明人： Ivelin Stefanov Georgiev , Andrea R. Shiakolas , Kevin J. Kramer , James E. Crowe, Jr. , Robert Carnahan , Nianshuang Wang , Daniel Wrapp , Jason McLellan
CPC分类号： C07K16/1003 , A61P31/14 , A61K2039/505
摘要： The present disclosure relates to antibodies and uses thereof for treating, preventing, and detecting coronavirus infection.
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公开(公告)号：US20230113170A1
公开(公告)日：2023-04-13
申请号：US17798021
申请日：2021-02-11
申请人： The United States of America, as represented by the Secretary, Department of Health and Human , Board of Regents, The University of Texas System , Trustees of Dartmouth College
发明人： Barney Graham , Kizzmekia Corbett , Olubukola Abiona , Geoffrey Hutchinson , Jason McLellan , Daniel Wrapp , Nianshuang Wang
IPC分类号： A61K39/215 , C12N15/86 , A61P31/14
摘要： SARS-CoV-2 S ectodomain trimers stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the SARS-CoV-2 S ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to SARS-CoV-2 S in a subject, for example, an immune response that inhibits SARS-CoV-2 infection in the subject.
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公开(公告)号：US12077563B2
公开(公告)日：2024-09-03
申请号：US18411284
申请日：2024-01-12
发明人： Jason McLellan , Ching-Lin Hsieh , Scott Rush , Nianshuang Wang
IPC分类号： C07K14/08 , C07K14/115 , C07K14/135
CPC分类号： C07K14/08
摘要： Provided herein are engineered hMPV F proteins. In some aspects, the engineered F proteins exhibit enhanced conformational stability and/or antigenicity. Methods are also provided for use of the engineered F proteins as diagnostics, in screening platforms, and/or in vaccine compositions.
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公开(公告)号：US11919927B2
公开(公告)日：2024-03-05
申请号：US18296771
申请日：2023-04-06
发明人： Jason McLellan , Ching-Lin Hsieh , Scott Rush , Nianshuang Wang
IPC分类号： C07K14/08 , C07K14/115 , C07K14/135 , C12N7/00
CPC分类号： C07K14/08
摘要： Provided herein are engineered hMPV F proteins. In some aspects, the engineered F proteins exhibit enhanced conformational stability and/or antigenicity. Methods are also provided for use of the engineered F proteins as diagnostics, in screening platforms, and/or in vaccine compositions.
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公开(公告)号：US11248039B2
公开(公告)日：2022-02-15
申请号：US16566542
申请日：2019-09-10
申请人： VIB VZW , UNIVERSITEIT GENT , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , TRUSTEES OF DARTMOUTH COLLEGE
发明人： Xavier Saelens , Bert Schepens , Iebe Rossey , Barney Graham , Jason McLellan , Morgan Gilman
摘要： The present invention relates to immunoglobulin single variable domains (ISVDs) that are directed against respiratory syncytial virus (RSV). More specifically, it relates to ISVDs that bind to the prefusion form of the fusion (F) protein of RSV. The invention relates further to the use of these ISVDs for prevention and/or treatment of RSV infections, and to pharmaceutical compositions comprising these ISVDs.
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公开(公告)号：US20210275664A1
公开(公告)日：2021-09-09
申请号：US17194834
申请日：2021-03-08
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic , The Scripps Research Institute , Trustees of Dartmouth College
发明人： Barney Graham , Jason McLellan , Andrew Ward , Robert Kirchdoerfer , Christopher Cottrell , Michael Gordon Joyce , Masaru Kanekiyo , Nianshuang Wang , Jesper Pallesen , Hadi Yassine , Hannah Turner , Kizzmekia Corbett
IPC分类号： A61K39/215 , A61P31/14 , C07K14/005 , C12N7/00
摘要： Coronavirus S ectodomain trimers stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the coronavirus S ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to coronavirus in a subject. In additional embodiments, the therapeutically effective amount of the coronavirus S ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing coronavirus infection.
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公开(公告)号：US20200061185A1
公开(公告)日：2020-02-27
申请号：US16344774
申请日：2017-10-25
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic , The Scripps Research Institute , Trustees of Dartmouth College
发明人： Barney Graham , Jason McLellan , Andrew Ward , Robert Kirchdoerfer , Christopher Cottrell , Michael Gordon Joyce , Masaru Kanekiyo , Nianshuang Wang , Jesper Pallesen , Hadi Yassine , Hannah Turner , Kizzmekia Corbett
IPC分类号： A61K39/215 , C07K14/005 , A61P31/14 , C12N7/00
摘要： Coronavirus S ectodomain trimers stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the coronavirus S ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to coronavirus in a subject. In additional embodiments, the therapeutically effective amount of the coronavirus S ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing coronavirus infection.
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公开(公告)号：US11890339B2
公开(公告)日：2024-02-06
申请号：US17261828
申请日：2019-08-05
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , Trustees of Dartmouth College
IPC分类号： A61K39/155 , A61P31/14 , C07K14/005 , A61K39/00
CPC分类号： A61K39/155 , A61P31/14 , C07K14/005 , A61K2039/70 , C07K2319/03 , C12N2760/18222 , C12N2760/18223 , C12N2760/18234
摘要： Embodiments of immunogens comprising a recombinant Nipah virus (NiV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also provided are embodiments of immunogens comprising chimeric proteins comprising the recombinant NiV F ectodomain trimer and one or more G ectodomains, a multimer of NiV G ectodomains, and protein nanoparticles comprising the recombinant NiV F ectodomain trimer or an NiV G ectodomain. Also disclosed are nucleic acids encoding the immunogens and methods of their production. Methods for inducing an immune response in a subject by administering a disclosed immunogen to the subject are also provided. In some embodiments, the immune response treats or inhibits NiV infection in a subject.
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公开(公告)号：US20210299242A1
公开(公告)日：2021-09-30
申请号：US17261828
申请日：2019-08-05
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic , Trustees of Dartmouth College
IPC分类号： A61K39/155 , C07K14/005 , A61P31/14
摘要： Embodiments of immunogens comprising a recombinant Nipah virus (NiV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also provided are embodiments of immunogens comprising chimeric proteins comprising the recombinant NiV F ectodomain trimer and one or more G ectodomains, a multimer of NiV G ectodomains, and protein nanoparticles comprising the recombinant NiV F ectodomain trimer or an NiV G ectodomain. Also disclosed are nucleic acids encoding the immunogens and methods of their production. Methods for inducing an immune response in a subject by administering a disclosed immunogen to the subject are also provided. In some embodiments, the immune response treats or inhibits NiV infection in a subject.
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公开(公告)号：US10960070B2
公开(公告)日：2021-03-30
申请号：US16344774
申请日：2017-10-25
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , The Scripps Research Institute , Trustees of Dartmouth College
发明人： Barney Graham , Jason McLellan , Andrew Ward , Robert Kirchdoerfer , Christopher Cottrell , Michael Gordon Joyce , Masaru Kanekiyo , Nianshuang Wang , Jesper Pallesen , Hadi Yassine , Hannah Turner , Kizzmekia Corbett
IPC分类号： A61K39/215 , C12N7/00 , A61P31/14 , C07K14/005
摘要： Coronavirus S ectodomain trimers stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the coronavirus S ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to coronavirus in a subject. In additional embodiments, the therapeutically effective amount of the coronavirus S ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing coronavirus infection.
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