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公开(公告)号：US11518555B2
公开(公告)日：2022-12-06
申请号：US15950480
申请日：2018-04-11
发明人： Nick Broadbent , Jeroen Immerzeel , Christopher Procyshyn , Ross M. Gold , Steve Sang Joon Park
IPC分类号： B65B7/16 , B65B7/28 , B65D51/00 , B65B55/02 , B65B3/00 , B65D41/28 , B65B55/08 , B65B55/10 , B65B55/04 , B65D1/02
摘要： In one general aspect, a method for filling multiple containers with a pharmaceutical product is disclosed, which comprises decontaminating sealed nested materials in a transfer chamber, removing from the sealed nested materials one or both of a container nest holding the multiple containers and a closure nest holding multiple closures, transferring from the transfer chamber to a controlled environment enclosure the removed nest, aseptically filling the containers with the pharmaceutical product, and closing the containers with the multiple closures. The nests are configured to allow multiple closures and containers to be simultaneously aligned concentrically, and closed simultaneously. Spring-loaded retaining structures on the closure nest allow it to releasably retain multiple closures above the corresponding multiple containers. In some embodiments the spring-loaded features are monolithically integrated with the closure nest. The product may be lyophilized in partially sealed containers while the sealing closures are releasably retained by the closure nest.
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公开(公告)号：US11186390B2
公开(公告)日：2021-11-30
申请号：US16238433
申请日：2019-01-02
发明人： Nick Broadbent , Jeroen Immerzeel , Christopher Procyshyn , Ross M. Gold , Steve Sang Joon Park
IPC分类号： B65B7/16 , B65B55/02 , B65B3/00 , B65B7/28 , B65D41/28 , B65B55/08 , B65B55/10 , B65B55/04 , B65D1/02 , B65D51/00
摘要： In one general aspect, a method for filling multiple containers with a pharmaceutical product is disclosed, which comprises decontaminating sealed nested materials in a transfer chamber, removing from the sealed nested materials one or both of a container nest holding the multiple containers and a closure nest holding multiple closures, transferring from the transfer chamber to a controlled environment enclosure the removed nest, aseptically filling the containers with the pharmaceutical product, and closing the containers with the multiple closures. The nests are configured to allow multiple closures and containers to be simultaneously aligned concentrically, and closed simultaneously. Spring-loaded retaining structures on the closure nest allow it to releasably retain multiple closures above the corresponding multiple containers. In some embodiments the spring-loaded features are monolithically integrated with the closure nest. The product may be lyophilized in partially sealed containers while the sealing closures are releasably retained by the closure nest.
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公开(公告)号：US11065759B2
公开(公告)日：2021-07-20
申请号：US14377696
申请日：2013-02-08
摘要： A hermetically sealed multi-axis articulated arm apparatus for use within a sealable isolator chamber is disclosed. In one general aspect, it comprises a rotational shaft that passes through an opening in the chamber, a sealing member disposed within the chamber for sealing the shaft to an inner surface of the chamber, interconnected hermetically sealed arm segments operably attached to the linear motion shaft; an end effector operably attached to a terminal arm segment among the arm segments, and at least one fully enclosed drive system for driving and controlling the shaft and the arm segments. The rotational shaft can further be a linear motion shaft for which the sealing member is a bellows. The materials for the parts of the apparatus exposed to the atmosphere of the chamber can be compatible with an aseptic and cleanable environment and the surfaces of the arm segments can be shaped to avoid pooling of contaminants.
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4.发明授权公开(公告)号：US10857666B2
公开(公告)日：2020-12-08
申请号：US16223003
申请日：2018-12-17
摘要： A hermetically sealed multi-axis articulated arm apparatus for use within a sealable isolator chamber comprises a rotational shaft that passes through an opening in the chamber, a sealing member disposed within the chamber for sealing the shaft to an inner surface of the chamber, a plurality of interconnected hermetically sealed arm segments, operably attached to the linear motion shaft; an end effector operably attached to a terminal arm segment among the plurality of arm segments, and at least one fully enclosed drive system for driving and controlling the shaft and the plurality of arm segments. The linear motion shaft may have a sealing member in the form of a bellows. The materials for the parts of the apparatus exposed to the atmosphere of the chamber are compatible with an aseptic and cleanable environment and the surfaces of the arm segments are shaped to avoid pooling of contaminants.
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公开(公告)号：US10196161B2
公开(公告)日：2019-02-05
申请号：US15719736
申请日：2017-09-29
发明人： Nick Broadbent , Jeroen Immerzeel , Christopher Procyshyn , Ross M. Gold , Steve Sang Joon Park
IPC分类号： B65B3/00 , B65B7/16 , B65B7/28 , B65D1/02 , B65B55/02 , B65B55/04 , B65B55/08 , B65B55/10 , B65B63/08 , B65D51/00
摘要： In one general aspect, a method for filling multiple containers with a pharmaceutical product is disclosed, which comprises decontaminating sealed nested materials in a transfer chamber, removing from the sealed nested materials one or both of a container nest holding the multiple containers and a closure nest holding multiple closures, transferring from the transfer chamber to a controlled environment enclosure the removed nest, aseptically filling the containers with the pharmaceutical product, and closing the containers with the multiple closures. The nests are configured to allow multiple closures and containers to be simultaneously aligned concentrically, and closed simultaneously. Spring-loaded retaining structures on the closure nest allow it to releasably retain multiple closures above the corresponding multiple containers. In some embodiments the spring-loaded features are monolithically integrated with the closure nest. The product may be lyophilized in partially sealed containers while the sealing closures are releasably retained by the closure nest.
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公开(公告)号：US20160200461A1
公开(公告)日：2016-07-14
申请号：US14912145
申请日：2014-08-15
发明人： Nick Broadbent , Jeroen Immerzeel , Christopher Procyshyn , Ross M. Gold , Steve Sang Joon Park
摘要： In one general aspect, a method for filling multiple containers with a pharmaceutical product is disclosed, which comprises decontaminating sealed nested materials in a transfer chamber, removing from the sealed nested materials one or both of a container nest holding the multiple containers and a closure nest holding multiple closures, transferring from the transfer chamber to a controlled environment enclosure the removed nest, aseptically filling the containers with the pharmaceutical product, and closing the containers with the multiple closures. The nests are configured to allow multiple closures and containers to be simultaneously aligined concentrically, and closed simultaneously. Spring-loaded retaining structures on the closure nest allow it to releasably retain multiple closures above the corresponding multiple containers. In some embodiments the spring-loaded features are monolithically integrated with the closure nest. The product may be lyophilized in partially sealed containers while the sealing closures are releasably retained by the closure nest.
摘要翻译： 在一个一般方面，公开了一种用药物产品填充多个容器的方法，其包括在传送室中对密封的嵌套材料进行去污染，从密封的嵌套材料中去除容纳多个容器的容器嵌套中的一个或两个，以及封闭嵌套 保持多个封闭件，从传送室转移到包围所移除的嵌套的受控环境中，用药物产品无菌地填充容器，并且用多个封闭件封闭容器。 巢被配置为允许同时密集多个闭合和容器同时闭合并同时闭合。 封闭套管上的弹簧保持结构允许其可释放地将多个封闭件保持在相应的多个容器上方。 在一些实施例中，弹簧加载特征与闭合套筒整体地集成。 产品可以在部分密封的容器中冻干，同时密封封盖由封闭套管可释放地保持。
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公开(公告)号：US11981473B2
公开(公告)日：2024-05-14
申请号：US17681814
申请日：2022-02-27
发明人： Christopher A. Procyshyn , Ross M Gold , Steve Sang Joon Park , Jeroen Immerzeel , Paul Nowakczyk
CPC分类号： B65B69/00 , B25J11/005
摘要： An apparatus and method are presented for removing container covers within a controlled environment enclosure with pre-sterilized nested containers without using gloves. The apparatus comprises an articulated arm apparatus and a gripping apparatus for the pre-sterilized nested containers and can further comprise a controller. The articulated arm apparatus can be configurable for holding and moving a container in three dimensions; and the gripping apparatus can be configured for gripping a container cover sealing the container. The method comprises providing the pre-sterilized nested containers in the form of a container having a plurality of decontaminated parts, moving the container using the articulated arm apparatus while holding a gripping area of the container cover substantially stationary using the gripping apparatus. The apparatus can further comprise a sensor configured for supplying information to the controller for determining the location of the container cover gripping area and an orientation of the container cover. The method can further comprise inspecting the container cover using the sensor. The container can be moved along a path and within a space determined by the controller.
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公开(公告)号：US10781002B2
公开(公告)日：2020-09-22
申请号：US14912145
申请日：2014-08-15
发明人： Nick Broadbent , Jeroen Immerzeel , Christopher Procyshyn , Ross M. Gold , Steve Sang Joon Park
IPC分类号： B65B7/16 , B65B7/28 , B65B3/00 , B65B55/04 , B65B55/02 , B65D1/02 , B65D51/00 , B65D41/28 , B65B55/08 , B65B55/10
摘要： In one general aspect, a method for filling multiple containers with a pharmaceutical product is disclosed, which comprises decontaminating sealed nested materials in a transfer chamber, removing from the sealed nested materials one or both of a container nest holding the multiple containers and a closure nest holding multiple closures, transferring from the transfer chamber to a controlled environment enclosure the removed nest, aseptically filling the containers with the pharmaceutical product, and closing the containers with the multiple closures. The nests are configured to allow multiple closures and containers to be simultaneously aligned concentrically, and closed simultaneously. Spring-loaded retaining structures on the closure nest allow it to releasably retain multiple closures above the corresponding multiple containers. In some embodiments the spring-loaded features are monolithically integrated with the closure nest. The product may be lyophilized in partially sealed containers while the sealing closures are releasably retained by the closure nest.
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9.发明授权公开(公告)号：US10688484B2
公开(公告)日：2020-06-23
申请号：US15898641
申请日：2018-02-18
摘要： A controlled environment enclosure comprises a robotic arm manipulation system used to protect and unprotect a fluid path within the controlled environment enclosure. The apparatus allows the fluid path to be protected against dangerous decontamination vapors and chemicals before the controlled environment enclosure is decontaminated, the method not requiring the use of gloves or other means that degrade the integrity of the controlled environment enclosure. The apparatus similarly allows the fluid path to be unprotected for use without the use of gloves, the method not requiring the use of gloves or other means that degrade the integrity of the controlled environment enclosure when decontaminated is completed. The apparatus and method allow for the protecting, unprotecting and decontaminating sequences to be automated.
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公开(公告)号：US12065347B2
公开(公告)日：2024-08-20
申请号：US17033865
申请日：2020-09-27
CPC分类号： B67B7/14 , B25J21/00 , B65B55/027
摘要： An apparatus and method are presented for removing container covers within a controlled environment enclosure without using gloves. The apparatus comprises an articulated arm apparatus and a gripping apparatus and can further comprise a controller. The articulated arm apparatus can be configurable for holding and moving a container in three dimensions; and the gripping apparatus can be configured for gripping a container cover sealing the container. The method comprises moving the container using the articulated arm apparatus while holding a gripping area of the container cover substantially stationary using the gripping apparatus. The apparatus can further comprise a sensor configured for supplying information to the controller for determining the location of the container cover gripping area and an orientation of the container cover. The method can further comprise inspecting the container cover using the sensor. The container can be moved along a path and within a space determined by the controller.
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