公开(公告)号：US09757333B2

公开(公告)日：2017-09-12

申请号：US14564365

申请日：2014-12-09

Applicant: Versitech Limited

Inventor： Ho Cheung Shum ,  Yang Song ,  Zhou Liu

IPC: A61K9/107 ,  A61K47/10 ,  A61K47/36 ,  B01F5/00 ,  B01F3/08 ,  B01F17/00 ,  A61K9/00

CPC classification number: A61K9/107 ,  A61K9/0019 ,  A61K9/0095 ,  A61K47/10 ,  A61K47/36 ,  B01F3/0803 ,  B01F3/0815 ,  B01F5/0085 ,  B01F17/0092

Abstract: Methods for preparing all-aqueous emulsions, including stable emulsions or emulsions having high viscosity and/or ultra-low interfacial tension are described. The method includes mixing, combining, or contacting a first electrically charged phase containing a first solute (e.g., dispersed phase) with at least a second phase containing a second solute (e.g., continuous phase). The solutes are incompatible with each other. The electrostatic forces between the two phases induce the formation of droplets of a dispersed phase in a continuous phase. The dispersed and continuous phases contain oppositely charged molecules, such as surfactants or other macromolecules and colloids which stabilize the drops of the dispersed phase. Complex coacervation of the oppositely charged molecules or colloids at the interface of the two aqueous phases results in formation of a membrane or barrier which prevents coalescence or aggregation of the droplets. The membrane also prevents leakage of any encapsulated agents from the droplets.

公开(公告)号：US11154824B2

公开(公告)日：2021-10-26

申请号：US16109626

申请日：2018-08-22

Applicant: VERSITECH LIMITED

Inventor： Ho Cheung Shum ,  Alban Sauret ,  Zida Li ,  Yang Song

IPC: B01F3/08 ,  B01F13/00 ,  B01F15/02 ,  B01F17/00 ,  G01H3/04

Abstract: A method and apparatus for generating droplets with a high level of uniformity in liquid systems that present a low interfacial tension. This method and apparatus utilize the breakup of the dispersed phase in a controlled fashion by periodically varying the pressure that drives the fluids so as to successfully generate emulsions with a good control over the size. The method and apparatus can be used for the formation of simple emulsion or double emulsion where a larger droplet contains one or more smaller droplets.

公开(公告)号：US10080997B2

公开(公告)日：2018-09-25

申请号：US13839072

申请日：2013-03-15

Applicant: VERSITECH LIMITED

Inventor： Ho Cheung Shum ,  Alban Sauret ,  Zida Li ,  Yang Song

IPC: B01F3/08 ,  B01F17/00 ,  G01H3/04 ,  B01F13/00 ,  B01F15/02

CPC classification number: B01F3/0819 ,  B01F3/0807 ,  B01F13/0062 ,  B01F15/024 ,  B01F17/00 ,  G01H3/04

Abstract: A method and apparatus for generating droplets with a high level of uniformity in liquid systems that present a low interfacial tension. This method and apparatus utilize the breakup of the dispersed phase in a controlled fashion by periodically varying the pressure that drives the fluids so as to successfully generate emulsions with a good control over the size. The method and apparatus can be used for the formation of simple emulsion or double emulsion where a larger droplet contains one or more smaller droplets.

公开(公告)号：US11260080B2

公开(公告)日：2022-03-01

申请号：US15720246

申请日：2017-09-29

Applicant: Versitech Limited

Inventor： Ho Cheung Shum ,  Yang Song

IPC: A61K35/36 ,  A61K35/22 ,  A61K35/12 ,  A61K35/33 ,  A61K35/34 ,  A61K35/30 ,  A61K35/32 ,  A61K9/50

Abstract: Methods for preparing capsules, such as micro- and/or nanocapsules from all-aqueous emulsions are described herein. The method includes mixing, combining, or contacting a first electrically charged phase containing a first solute with at least an optionally charged second phase containing a second solute. The solutes are incompatible with each other. The electrostatic forces between the two solutions induce the formation of droplets of a dispersed phase in a continuous phase. The droplets are then solidified to form the capsules.

公开(公告)号：US20180021386A1

公开(公告)日：2018-01-25

申请号：US15720246

申请日：2017-09-29

Applicant: Versitech Limited

Inventor： Ho Cheung Shum ,  Yang Song

IPC: A61K35/36 ,  A61K35/22 ,  A61K35/12 ,  A61K35/33 ,  A61K35/34 ,  A61K35/32 ,  A61K35/30 ,  A61K9/50

CPC classification number: A61K35/36 ,  A61K9/5031 ,  A61K9/5036 ,  A61K35/12 ,  A61K35/22 ,  A61K35/30 ,  A61K35/32 ,  A61K35/33 ,  A61K35/34

Abstract: Methods for preparing capsules, such as micro- and/or nanocapsules from all-aqueous emulsions are described herein. The method includes mixing, combining, or contacting a first electrically charged phase containing a first solute with at least an optionally charged second phase containing a second solute. The solutes are incompatible with each other. The electrostatic forces between the two solutions induce the formation of droplets of a dispersed phase in a continuous phase. The droplets are then solidified to form the capsules.

公开(公告)号：US09782442B2

公开(公告)日：2017-10-10

申请号：US14564372

申请日：2014-12-09

Applicant: Versitech Limited

Inventor： Ho Cheung Shum ,  Yang Song

IPC: A61K35/12 ,  A61K35/36 ,  A61K35/33 ,  A61K35/34 ,  A61K35/30 ,  A61K35/22 ,  A61K35/32 ,  A61K9/50

CPC classification number: A61K35/36 ,  A61K9/5031 ,  A61K9/5036 ,  A61K35/12 ,  A61K35/22 ,  A61K35/30 ,  A61K35/32 ,  A61K35/33 ,  A61K35/34

Abstract: Methods for preparing capsules, such as micro- and/or nanocapsules from all-aqueous emulsions are described herein. The method includes mixing, combining, or contacting a first electrically charged phase containing a first solute with at least an optionally charged second phase containing a second solute. The solutes are incompatible with each other. The electrostatic forces between the two solutions induce the formation of droplets of a dispersed phase in a continuous phase. The droplets are then solidified to form the capsules.

公开(公告)号：US20240280567A1

公开(公告)日：2024-08-22

申请号：US18437652

申请日：2024-02-09

Applicant: VERSITECH LIMITED ,  Advanced Biomedical Instrumentation Centre Limited

Inventor： Sammer Ul Hassan ,  Ho Cheung Shum ,  Pui Chung Lee

IPC: G01N33/543 ,  B01L3/00

CPC classification number: G01N33/54333 ,  B01L3/502761 ,  B01L2300/069 ,  B01L2400/0406

Abstract: A process and an apparatus conduct microfluidic loading and unloading of fluids into microchannels for performing assays, such as immunoassays. The apparatus includes a sequential loading and unloading unit having a movable member dipping a chip having a microchannel including a sample into a cartridge retaining a substance to guide the predetermined substance into the microchannel by capillary action to mix the predetermined substance with the sample. A signal detection unit performs an analysis of the mixed sample and generates an analysis message corresponding to the sample. An output device outputs the analysis message. The process implements operation of the apparatus.

公开(公告)号：US20240277892A1

公开(公告)日：2024-08-22

申请号：US18571747

申请日：2022-08-03

Applicant: VERSITECH LIMITED ,  THE TRUSTEES OF PRINCETON UNIVERSITY ,  THE UNIVERSITY OF HONG KONG

Inventor： Yuan Liu ,  Yanting Shen ,  Ho Cheung Shum ,  Janine K. Nunes ,  Howard A. Stone

IPC: A61L26/00

CPC classification number: A61L26/008 ,  A61L26/0085 ,  A61L26/0095

Abstract: Provided are a vehicle body assembling method and a vehicle body assembling apparatus which allow a simple configuration in the vicinity of the connecting portion between an upper jig and a lower jig and allow an increase in the efficiency of assembling work (welding work

公开(公告)号：US20240255506A1

公开(公告)日：2024-08-01

申请号：US18419328

申请日：2024-01-22

Applicant: Versitech Limited ,  Centre for Oncology and Immunology Limited ,  Advanced Biomedical Instrumentation Centre Limited

Inventor： Siu Lun Wong ,  Ching Gee Choi ,  Ho Cheung Shum ,  Wai Fong Chan ,  Bei Wang ,  Lang Nan

IPC: G01N33/569 ,  C12N9/22 ,  C12N15/11 ,  G01N21/64

CPC classification number: G01N33/56983 ,  C12N9/22 ,  C12N15/11 ,  G01N21/6486 ,  C12N2310/20 ,  G01N2333/165

Abstract: Provided is a high throughput screening method for identifying cell fusion or syncytium formation potential. In particular, the cell fusion or syncytium formation potential of a viral spike protein. Also provided is a method for identifying a cellular factor that promotes spike protein-induced syncytium formation. Also provided is a method of inhibiting or suppressing syncytium formation induced by a viral spike protein.

公开(公告)号：US20180361328A1

公开(公告)日：2018-12-20

申请号：US16109626

申请日：2018-08-22

Applicant: VERSITECH LIMITED

Inventor： Ho Cheung Shum ,  Alban Sauret ,  Zida Li ,  Yang Song

IPC: B01F3/08 ,  G01H3/04 ,  B01F17/00 ,  B01F13/00 ,  B01F15/02

Abstract: A method and apparatus for generating droplets with a high level of uniformity in liquid systems that present a low interfacial tension. This method and apparatus utilize the breakup of the dispersed phase in a controlled fashion by periodically varying the pressure that drives the fluids so as to successfully generate emulsions with a good control over the size. The method and apparatus can be used for the formation of simple emulsion or double emulsion where a larger droplet contains one or more smaller droplets.