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公开(公告)号：US20250155401A1
公开(公告)日：2025-05-15
申请号：US18916683
申请日：2024-10-15
IPC: G01N27/327 , G01N33/543
Abstract: An electrochemical biosensing method using screen-printed gold electrodes functionalized with a redox probe modified DNA aptamer that binds specifically to CRP is provided. Binding-induced conformational switching of the CRP-targeting aptamer induces a specific and selective signal-ON event, which enables single-step and reagentless detection of CRP in as little as 1 minute. The aptasensor limit of detection spans approximately 20-60 nM in 50% human serum with dynamic response windows spanning 1-200 or 1-500 nM (R=0.97/R=0.98 respectively). The sensor also operates in undiluted human blood producing an LOD of 45 nM equating to 5.4 mg/L. The sensor is stable for at least 1 week and can be reused numerous times, as judged from repeated real-time dosing and dose-response assays.
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公开(公告)号：US20240345078A1
公开(公告)日：2024-10-17
申请号：US18633513
申请日：2024-04-12
Inventor： Yang CAO , Ho Cheung SHUM , Haisong LIN
IPC: G01N33/543 , G01N33/569
CPC classification number: G01N33/54388 , G01N33/56983 , G01N2333/11 , G01N2333/135 , G01N2333/165
Abstract: The present invention relates to an ultrasensitive rapid antigen detection kit for detecting N protein from SARS-CoV-2 virus in a sample, and methods for detecting N protein. The kit includes a sample collector, a collection and enrichment tube and a rapid antigen detection component with a test strip. The collection and enrichment tube contains a first part containing lyophilized ATPS reagents and a second part containing a lysis buffer. The sample is mixed with the lyophilized ATPS reagents and the lysis buffer to form a mixture. The enrichment is realized by concentrating the target analyte into one of the two phases formed by ATPS.
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公开(公告)号：US20240301517A1
公开(公告)日：2024-09-12
申请号：US18590291
申请日：2024-02-28
Applicant: Versitech Limited , Advanced Biomedical Instrumentation Centre Limited , Centre for Immunology & Infection Limited
Inventor： Ho Cheung SHUM , Lit Man POON , Lang NAN , Man Yuk Alison LAI
IPC: C12Q1/70 , B01L3/00 , C12N15/10 , C12Q1/6874 , G01N21/64
CPC classification number: C12Q1/70 , B01L3/502784 , C12N15/1096 , C12Q1/6874 , G01N21/6486 , B01L2200/0636 , B01L2300/0663 , B01L2300/0809 , B01L2400/0487
Abstract: The subject invention pertains to a microfluidic pipeline which enables isolation and analysis of single viruses. Single viruses are encapsulated and manipulated within microfluidic droplets. The subject invention further pertains to the amplification of single viral genomes are amplified and confined within the droplets, followed by extraction and isolation of the single-droplet contents for sequencing analysis.
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公开(公告)号：US20230382944A1
公开(公告)日：2023-11-30
申请号：US18307992
申请日：2023-04-27
Inventor： Shing Fung CHOW , Kam Hung LOW , Si Nga WONG
CPC classification number: C07J9/00 , C07B2200/13 , A61K9/0075 , C07C37/84
Abstract: The subject invention pertains to cocrystals of dexamethasone (DEX) and a benzenediol cocrystal composed of a 1:1 molar ratio of DEX and the benzenediol. The benzenediol can be catechol (CAT) or resorcinol (RES). The DEX and benzenediol cocrystal are formed by grinding crystalline DEX where the crystalline benzenediol are combined in the 1:1 molar ratio. Grinding can be performed at room temperature. Cocrystals can be thermally annealed or exposed to humidity to enhance cocrystal formation. The DEX−CAT or DEX-RES cocrystals can be included in a medicament for use in treatments for allergies, asthma, rhinitis, cancer, diabetes, anemia, ulcers, and viral infections. The DEX−benzenediol cocrystal can be sieved to provide particles that are in the range of 10 to 45 μm that can be used for intranasal administration with improved dissolution performance.
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5.发明申请公开(公告)号：US20250135715A1
公开(公告)日：2025-05-01
申请号：US18912551
申请日：2024-10-10
Inventor： Yafeng Yu , Ho Cheung Shum , Yi Pan , Jingxuan Tian , Wei Guo
IPC: B29C64/124 , B29C64/209 , B29K33/00 , B33Y10/00 , B33Y30/00 , B33Y80/00 , C08L33/26
Abstract: A method and apparatus for forming vascular-like channels involves liquid-in-liquid 3D printing utilizing two polymer solutions used as a printing ink and a matrix. Anionic polyacrylamide (APAM) is one of the polymer solutions and acts as the matrix material. Chitosan is the other polymer solution and acts as the printing ink. The chitosan printing ink is extruded through a print nozzle of a 3D printer onto the APAM matrix which covers the bottom of a petri dish while the nozzle is moved in a desired pattern for the channels. The chitosan and APAM polymer complexes self-assemble on the ink-matrix interface, locking chitosan polymers inside the matrix before they can spread and causing the formation of soft elastic membranous walls. The chitosan ink and APAM matrix can be removed after the polymer complex self-assembly. The printed chamber with membranous walls allows for liquid infusion to work as fluidic channels.
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Patent Agency Ranking
公开(公告)号：US20250121373A1
公开(公告)日：2025-04-17
申请号：US18910845
申请日：2024-10-09
Inventor： Ruotong Zhang , Ho Cheung Shum , Haisong Lin
IPC: B01L3/00
Abstract: A droplet gripper for a polarizable droplet including a top plate formed of magnetically responsive material and movable in a defined sequence in response to a regionalized electromagnetic field. The gripper further has electret sheets downwardly depending from the top plate. The electret sheets are separated from each other and are chargeable to the same polarities so as to capture the droplet between them due to electret-induced polarization on droplet (EPD). The gripper may be included in a Multiphysics droplet robotic system for automatically manipulating and moving a liquid droplet. The system includes a programmable control matrix that generates a movable regionalized electromagnetic field through coils so as to engage the magnetic material on the top plate and move the EPD gripper and a captured polarizable drop in the defined sequence along a specific path as well as to achieve other microfluidic operations according to a control matrix program.
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公开(公告)号：US20240384236A1
公开(公告)日：2024-11-21
申请号：US18667906
申请日：2024-05-17
Inventor： Pui Barbara Chan , Hoi Lam Cheung , Yu Hung Anskar Leung , Jessica Evangeline Tan Kabigting
Abstract: Provided herein is a platform that supports the survival and phenotype maintenance of leukemia cells by co-culturing the cells with 3DON. The 3D osteogenic niche (3DON) mimics that in bone marrow to support AML cell survival in cultures before treatment with sample chemotherapy drug. The 3DON is comprised of osteogenically differentiated mesenchymal stromal cells (MSCs) microencapsulated in 3D microspheres made from extracellular matrix (ECM). Also provided is a method that increases the chemo-sensitivity of leukemia cells by co-culturing them with 3DON. The platform may be used for drug screening applications and the 3DON may be used as an adjuvant for chemotherapy.
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公开(公告)号：US20240280567A1
公开(公告)日：2024-08-22
申请号：US18437652
申请日：2024-02-09
Inventor： Sammer Ul Hassan , Ho Cheung Shum , Pui Chung Lee
IPC: G01N33/543 , B01L3/00
CPC classification number: G01N33/54333 , B01L3/502761 , B01L2300/069 , B01L2400/0406
Abstract: A process and an apparatus conduct microfluidic loading and unloading of fluids into microchannels for performing assays, such as immunoassays. The apparatus includes a sequential loading and unloading unit having a movable member dipping a chip having a microchannel including a sample into a cartridge retaining a substance to guide the predetermined substance into the microchannel by capillary action to mix the predetermined substance with the sample. A signal detection unit performs an analysis of the mixed sample and generates an analysis message corresponding to the sample. An output device outputs the analysis message. The process implements operation of the apparatus.
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公开(公告)号：US20240255506A1
公开(公告)日：2024-08-01
申请号：US18419328
申请日：2024-01-22
Applicant: Versitech Limited , Centre for Oncology and Immunology Limited , Advanced Biomedical Instrumentation Centre Limited
Inventor： Siu Lun Wong , Ching Gee Choi , Ho Cheung Shum , Wai Fong Chan , Bei Wang , Lang Nan
IPC: G01N33/569 , C12N9/22 , C12N15/11 , G01N21/64
CPC classification number: G01N33/56983 , C12N9/22 , C12N15/11 , G01N21/6486 , C12N2310/20 , G01N2333/165
Abstract: Provided is a high throughput screening method for identifying cell fusion or syncytium formation potential. In particular, the cell fusion or syncytium formation potential of a viral spike protein. Also provided is a method for identifying a cellular factor that promotes spike protein-induced syncytium formation. Also provided is a method of inhibiting or suppressing syncytium formation induced by a viral spike protein.
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公开(公告)号：US20240408365A1
公开(公告)日：2024-12-12
申请号：US18731433
申请日：2024-06-03
Inventor： Lizhi XU , Hongzhen LIU
Abstract: A mechanoionic current generator comprising: a working electrode including an activated carbon cloth; and a counter electrode including a raw carbon cloth and a hydrogel; wherein the hydrogel has a plurality of flexible and asymmetrically shaped structures; and the working electrode has a surface immersed in the hydrogel and provided with a plurality of oxygen-containing functional groups. The ionic current generation mechanism of the current generator is naturally compatible with living organisms and living hydrogels, as exemplified by a self-powered drug delivery patch for wound healing. The current generator provides excellent outputs of current and charge transfer which are advantageous for various biomedical applications.
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