公开(公告)号：US11254639B1

公开(公告)日：2022-02-22

申请号：US17015932

申请日：2020-09-09

申请人： Vitaworks IP, LLC

发明人： Songzhou Hu

IPC分类号： C07C303/44 ,  C07C303/02 ,  C07C303/24 ,  C07C213/08 ,  C01C1/247 ,  C01C1/246

摘要： There is disclosed a cyclic process for producing taurine from monoethanolamine comprising the steps of: (a) recovering monoethanolamine sulfate from an aqueous mother liquor solution; (b) reacting the monoethanolamine sulfate with sulfuric acid to form an aqueous solution comprised of monoethanolamine bisulfate; (c) heating the aqueous solution comprised of the monoethanolamine sulfate and optionally added monoethanolamine sulfate to yield 2-aminoethyl hydrogen sulfate ester; (d) reacting the ester with ammonium sulfite or an alkali sulfite to yield taurine and ammonium or alkali sulfate; (e) separating taurine and ammonium or alkali sulfate to give an aqueous mother liquor solution; and (f) recovering the monoethanolamine sulfate from the aqueous mother liquor solution and recycling to the monoethanolamine sulfate to step (b).

公开(公告)号：US10343978B2

公开(公告)日：2019-07-09

申请号：US15880293

申请日：2018-01-25

申请人： Vitaworks IP, LLC

发明人： Songzhou Hu

IPC分类号： C07C227/00 ,  C07C227/08 ,  C07C229/08 ,  C07C51/47 ,  C07C227/40 ,  C07C209/62 ,  C07C227/20

摘要： There is disclosed a process for the production of long chain amino acid and long chain dibasic acid, comprising: (1) reacting long chain keto fatty acid with hydroxylamine or subjecting keto fatty acid to an ammoximation reaction to yield an oxime fatty acid; (2) reacting the oxime fatty acid with an alcohol or a primary amine or a secondary amine to prepare an ester or amide; (3) subjecting the oxime fatty acid ester or amide to the Beckmann rearrangement to yield a mixture of two amide fatty acids; (4) hydrolyzing the mixed amide fatty acids to produce long chain amino acid, long chain dibasic acid, short chain alkylamine, and alkanoic acid.

公开(公告)号：US10329240B2

公开(公告)日：2019-06-25

申请号：US15644665

申请日：2017-07-07

申请人： VITAWORKS IP, LLC

发明人： Songzhou Hu

IPC分类号： C07C227/42 ,  C07C227/40 ,  C07C51/44 ,  C07C51/43 ,  C07C209/86 ,  B01D3/36 ,  B01D9/00 ,  B01D11/04 ,  C07C51/46 ,  C07C51/47 ,  C07C51/48 ,  B01D21/26

摘要： There is disclosed a process for the separation of long chain amino acid and long chain dibasic acid, comprising: (1) recovering alkylamine from an aqueous solution of an alkali hydroxide hydrolysis of the mixed amide derivatives by distilling or by extracting with an extractant solvent; (2) cooling the aqueous solution of step (1) to precipitate a mixed alkali salts of long chain amino acid and dibasic acid; (3) recovering the mixed alkali salts of long chain amino acid and dibasic acid to provide a mother liquor; (4) separating long chain amino acid and dibasic acid by acidification-extraction of long chain dibasic acid with an extractant solvent or by selective dissolution of alkali salt of long chain amino acid in an aqueous solvent; and (4) adding an acid to the mother liquor of step (3) to obtain alkanoic acid.

公开(公告)号：US10239823B2

公开(公告)日：2019-03-26

申请号：US15686500

申请日：2017-08-25

申请人： VITAWORKS IP, LLC

发明人： Songzhou Hu ,  William S. Hu

IPC分类号： C07C227/40 ,  C07C227/42

摘要： There is disclosed a process for the purification of long chain amino acids by recrystallization in an aqueous solution of organic carboxylic acid in the absence or presence of solvent, comprising: (1) dissolving a long chain amino acid in an aqueous solution of organic carboxylic acid by heating; (2) cooling the solution of step (1) to crystallize the long chain amino acid; and (3) recovering the long chain amino acid of step (2) by means of solid-liquid separation.

公开(公告)号：US10131621B2

公开(公告)日：2018-11-20

申请号：US15366835

申请日：2016-12-01

申请人： VITAWORKS IP, LLC

发明人： Songzhou Hu

IPC分类号： C07C209/86 ,  C07C29/86 ,  C07B63/00 ,  C02F1/66 ,  C02F1/26 ,  B01D11/04 ,  C07C41/38 ,  C02F103/36

摘要： There is disclosed an extraction process for recovering aminoalcohols and glycols from aqueous streams of taurine production. The aqueous streams which contain aminoalcohols and/or glycols are first mixed with a base to increase pH and then extracted with C3-C6 alcohols, ketones, and ethers. The aqueous streams are then returned to their respective cyclic process for the production of taurine.

公开(公告)号：US09850200B1

公开(公告)日：2017-12-26

申请号：US15366783

申请日：2016-12-01

申请人： VITAWORKS IP, LLC

发明人： Songzhou Hu

IPC分类号： C07C303/02 ,  C07C303/32 ,  C07C303/44

CPC分类号： C07C303/02 ,  C07C303/32 ,  C07C303/44 ,  C07C309/18 ,  C07C309/08

摘要： There is disclosed a process for preparing taurine from alkali isethionate by reacting alkali taurinates in the solution of ammonolysis reaction of alkali isethionate with ammonium bisulfite or ammonium sulfite to obtain taurine and to regenerate alkali bisulfite or alkali sulfite, which is used to react with ethylene oxide to afford alkali isethionate.

公开(公告)号：US09745258B1

公开(公告)日：2017-08-29

申请号：US15268071

申请日：2016-09-16

申请人： VITAWORKS IP, LLC

发明人： Songzhou Hu

IPC分类号： C07C303/02 ,  C07C303/32 ,  C07C303/44

CPC分类号： C07C303/02 ,  C07C303/22 ,  C07C303/32 ,  C07C303/44 ,  C07C309/14 ,  C07C309/08

摘要： There is disclosed a process for producing taurine from ammonium isethionate by the ammonolysis of alkali isethionate in the presence of alkali ditaurinate or alkali tritaurinate, or their mixture, to inhibit the formation of byproducts and to continuously convert the byproducts of the ammonolysis reaction to alkali taurinate. Alkali taurinate is reacted with ammonium isethionate to obtain taurine and to regenerate alkali isethionate. The production yield is increased to from 90% to nearly quantitative. The ammonolysis reaction is catalyzed by alkali salts of hydroxide, sulfate, sulfite, phosphate, or carbonate.

公开(公告)号：US09593076B2

公开(公告)日：2017-03-14

申请号：US15238621

申请日：2016-08-16

申请人： VITAWORKS IP, LLC

发明人： Songzhou Hu

IPC分类号： C07C303/02

CPC分类号： C07C303/02 ,  C07C303/32 ,  C07C303/44 ,  C07C309/14

摘要： There is disclosed a process for producing taurine by the ammonolysis of alkali isethionate in the presence of alkali ditaurinate or alkali tritaurinate, or their mixture, to inhibit the formation of byproducts and to continuously convert the byproducts of the ammonolysis reaction to alkali taurinate. Alkali taurinate is neutralized with isethionic acid to obtain taurine and to regenerate alkali isethionate. The production yield is increased to from 90% to nearly quantitative. The ammonolysis reaction is catalyzed by alkali salts of hydroxide, sulfate, sulfite, phosphate, or carbonate.

摘要翻译： 公开了通过碱金属羟乙基磺酸盐在二磺酸三钠或三氯三酸二钠或其混合物的存在下的氨解生产牛磺酸的方法，以抑制副产物的形成，并将氨解反应的副产物连续转化成碱金牛磺酸盐。 碱性牛磺酸钠用羟乙磺酸中和，得到牛磺酸，再生碱羟乙基磺酸盐。 生产产量从90％提高到接近数量。 氨解反应由氢氧化物，硫酸盐，亚硫酸盐，磷酸盐或碳酸盐的碱金属盐催化。

公开(公告)号：US11623914B2

公开(公告)日：2023-04-11

申请号：US17576609

申请日：2022-01-14

申请人： Vitaworks IP, LLC

发明人： Songzhou Hu

IPC分类号： C07C303/02 ,  C07C303/44 ,  C07C303/24 ,  C07C213/08 ,  C01C1/246 ,  C01C1/247

摘要： There is disclosed a cyclic process for producing taurine from monoethanolamine comprising the steps of: (a) recovering monoethanolamine sulfate from an aqueous mother liquor solution; (b) reacting the monoethanolamine sulfate with sulfuric acid to form an aqueous solution comprised of monoethanolamine bisulfate; (c) heating the aqueous solution comprised of the monoethanolamine sulfate and optionally added monoethanolamine sulfate to yield 2-aminoethyl hydrogen sulfate ester; and (d) reacting the ester with ammonium sulfite or an alkali sulfite to yield taurine.

公开(公告)号：US20220242819A1

公开(公告)日：2022-08-04

申请号：US17166662

申请日：2021-02-03

申请人： Vitaworks IP, LLC

发明人： Songzhou Hu

IPC分类号： C07C253/30 ,  C07D207/27

摘要： There is disclosed a method for preparing levetiracetam and intermediates from a compound of the formula: wherein CR is selected from the group consisting of cyano, carboxylic acid, carboxamide, alkali carboxylate, alkaline earth metal carboxylate, alkyl carboxylate, and a mixture thereof.