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公开(公告)号：US08796182B2
公开(公告)日：2014-08-05
申请号：US13382620
申请日：2010-07-09
申请人： Valgerdur Steinthorsdottir , Gudmar Thorleifsson , Daniel Gudbjartsson , Gisli Masson , Augustine Kong
发明人： Valgerdur Steinthorsdottir , Gudmar Thorleifsson , Daniel Gudbjartsson , Gisli Masson , Augustine Kong
CPC分类号： C12Q1/6883 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The invention relates to variants that predispose to risk of type 2 diabetes, basal cell carcinoma and breast cancer. It has been discovered that certain genetic variants confer risk of these diseases when inherited from one parent, but not the other. The invention provides methods of disease management, including diagnostic methods, utilizing such parental origin effects.
摘要翻译： 本发明涉及易患2型糖尿病，基底细胞癌和乳腺癌风险的变体。 已经发现，某些遗传变异体在遗传于一种亲本而不是另一种亲本时会引起这些疾病的风险。 本发明提供了疾病管理方法，包括利用这种亲本起源作用的诊断方法。
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公开(公告)号：US20100086921A1
公开(公告)日：2010-04-08
申请号：US12442233
申请日：2007-11-30
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： Association analysis has shown that certain genetic variants are susceptibility variants for Type 2 diabetes. The invention relates to diagnostic applications of such susceptibility variants, including methods of determining increased susceptibility to Type 2 diabetes, as well as methods of determining decreased susceptibility to Type 2 diabetes in an individual. The invention further relates to kits for determining a susceptibility to Type 2 diabetes based on the variants described herein.
摘要翻译： 关联分析表明，某些遗传变异体是2型糖尿病的易感性变异体。 本发明涉及这种敏感性变体的诊断应用，包括确定增加的对2型糖尿病的易感性的方法，以及确定个体对2型糖尿病易感性降低的方法。 本发明还涉及用于基于本文所述变体确定对2型糖尿病易感性的试剂盒。
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公开(公告)号：US20120220477A1
公开(公告)日：2012-08-30
申请号：US13382620
申请日：2010-07-09
申请人： Valgerdur Steinthorsdottir , Gudmar Thorleifsson , Daniel Gudbjartsson , Gisli Masson , Augustine Kong
发明人： Valgerdur Steinthorsdottir , Gudmar Thorleifsson , Daniel Gudbjartsson , Gisli Masson , Augustine Kong
CPC分类号： C12Q1/6883 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The invention relates to variants that predispose to risk of type 2 diabetes, basal cell carcinoma and breast cancer. It has been discovered that certain genetic variants confer risk of these diseases when inherited from one parent, but not the other. The invention provides methods of disease management, including diagnostic methods, utilizing such parental origin effects.
摘要翻译： 本发明涉及易患2型糖尿病，基底细胞癌和乳腺癌风险的变体。 已经发现，某些遗传变异体在遗传于一种亲本而不是另一种亲本时会引起这些疾病的风险。 本发明提供了疾病管理方法，包括利用这种亲本起源作用的诊断方法。
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公开(公告)号：US20050287551A1
公开(公告)日：2005-12-29
申请号：US11091018
申请日：2005-03-25
CPC分类号： C12Q1/6883 , C12N9/16 , C12Q1/6886 , C12Q2600/106 , C12Q2600/16 , C12Q2600/172
摘要： A role of the human PDE4D gene in stroke is disclosed. Methods for diagnosis, prediction of clinical course and treatment for stroke using polymorphisms in the PDE4D gene are also disclosed.
摘要翻译： 公开了人类PDE4D基因在中风中的作用。 还披露了PDE4D基因多态性的诊断方法，临床病程预测和中风治疗方法。
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5.发明申请GENETIC VARIANTS USEFUL FOR RISK ASSESSMENTS OF CORONARY ARTERY DISEASE AND MYOCARDIAL INFARCTION 审中-公开有用于冠状动脉疾病和心肌梗塞风险评估的遗传变异公开(公告)号：US20100120045A1
公开(公告)日：2010-05-13
申请号：US12598180
申请日：2008-04-30
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172
摘要： The invention relates to methods of risk assessment and diagnosis of susceptibility to coronary artery disease and myocardial infarction, by assessing the presence or absence of alleles of certain polymorphic markers found to be associated with coronary artery disease and myocardial infarction. The invention also relates to methods for use of such polymorphic markers for predicting drug response to drugs for treating cardiovascular disease, or for monitoring the effectiveness of such drugs. The invention further relates to kits encompassing reagents for use in these methods.
摘要翻译： 本发明涉及通过评估发现与冠状动脉疾病和心肌梗死相关的某些多态性标志物的等位基因的存在或不存在而对冠状动脉疾病和心肌梗死的易感性进行风险评估和诊断的方法。 本发明还涉及使用这种多态性标记物预测用于治疗心血管疾病的药物的药物应答或用于监测这些药物的有效性的方法。 本发明还涉及包含用于这些方法的试剂的试剂盒。
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6.发明申请GENETIC VARIANTS ON CHR 15Q24 AS MARKERS FOR USE IN DIAGNOSIS, PROGNOSIS AND TREATMENT OF EXFOLIATION SYNDROME AND GLAUCOMA 审中-公开作为诊断，预防和治疗异常综合征和糖尿病的标记使用CHR 15Q24的遗传变异公开(公告)号：US20090035279A1
公开(公告)日：2009-02-05
申请号：US12139374
申请日：2008-06-13
IPC分类号： A61K35/76 , C12Q1/68 , C12M1/00 , A61K38/00 , A61P27/00 , A01K67/027 , A61K31/7088
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The present invention relates to methods of diagnosing a susceptibility to an ocular disorder, including glaucoma and exfoliation syndrome. The invention provides methods of diagnosing an increased or decreased susceptibility to exfoliation syndrome and glaucoma, and methods for risk assessment, treatment and prognosis. The invention further relates to kits for use in the methods of the invention.
摘要翻译： 本发明涉及诊断眼部疾病易感性的方法，包括青光眼和剥脱综合征。 本发明提供诊断增加或减少的剥脱综合征和青光眼易感性的方法，以及风险评估，治疗和预后的方法。 本发明还涉及用于本发明方法的试剂盒。
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公开(公告)号：US09617597B2
公开(公告)日：2017-04-11
申请号：US12302538
申请日：2008-02-21
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/172 , Y02A90/26
摘要： The invention relates to methods of diagnosing susceptibility to cardiovascular disease, including coronary artery disease. MI, abdominal aorta aneurysm, intracranial aneurysm restenosis and peripheral arterial disease, by assessing the presence or absence of alleles of certain polymorphic markers found to be associated with cardiovascular disease. The invention further relates to kits encompassing reagents for assessing such markers, and methods for assessing the probability of response to therapeutic agents and methods using such markers.
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8.发明申请公开(公告)号：US20060141462A1
公开(公告)日：2006-06-29
申请号：US10533365
申请日：2003-10-31
IPC分类号： C12Q1/68
CPC分类号： C07K14/47 , C12Q1/6883 , C12Q2600/156
摘要： Association of Type II diabetes and a locus on chromosome 5q35 is disclosed. In particular, the gene SLIT-3 with this locus is shown by linkage analysis to be a susceptibility gene for Type II diabetes. Pathway targeting for drug delivery and diagnosis applications in identifying those have Type II diabetes or at risk of developing Type II diabetes, in particular those that are non-obese are described.
摘要翻译： 公开了II型糖尿病和染色体5q35上的位点的关联。 特别地，通过连锁分析显示具有该基因座的基因SLIT-3是II型糖尿病的易感基因。 描述药物递送和诊断应用的途径，用于鉴定具有II型糖尿病或具有发展II型糖尿病风险，特别是非肥胖者的风险。
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公开(公告)号：US20050164220A1
公开(公告)日：2005-07-28
申请号：US10868397
申请日：2004-06-14
CPC分类号： C12Q1/44 , C12N9/16 , C12Q1/6883 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , C12Q2600/172
摘要： A role of the human PDE4D gene in stroke is disclosed. Methods for diagnosis, prediction of clinical course and treatment for stroke using polymorphisms in the PDE4D gene are also disclosed.
摘要翻译： 公开了人类PDE4D基因在中风中的作用。 还披露了PDE4D基因多态性的诊断方法，临床病程预测和中风治疗方法。
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10.发明申请公开(公告)号：US20120208709A1
公开(公告)日：2012-08-16
申请号：US13451210
申请日：2012-04-19
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/172 , Y02A90/26
摘要： The invention relates to methods of diagnosing susceptibility to cardiovascular disease, including coronary artery disease, MI, abdominal aorta aneurysm, intracranial aneurysm restenosis and peripheral arterial disease, by assessing the presence or absence of alleles of certain polymorphic markers found to be associated with cardiovascular disease. The invention further relates to kits encompassing reagents for assessing such markers, and methods for assessing the probability of response to therapeutic agents and methods using such markers.
摘要翻译： 本发明涉及通过评估发现与心血管疾病相关的某些多态性标记的等位基因的存在或不存在来诊断心血管疾病易感性的方法，包括冠状动脉疾病，MI，腹主动脉动脉瘤，颅内动脉瘤再狭窄和外周动脉疾病 。 本发明还涉及包含用于评估这种标记的试剂的试剂盒，以及评估对治疗剂的应答可能性的方法和使用这种标记物的方法。
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