公开(公告)号：US06922585B2

公开(公告)日：2005-07-26

申请号：US10117465

申请日：2002-04-05

申请人： Xiaohong Zhou ,  Vinod Sharma ,  Walter H. Olson

发明人： Xiaohong Zhou ,  Vinod Sharma ,  Walter H. Olson

IPC分类号： A61B5/0452 ,  A61B5/0402 ,  A61B5/046 ,  A61B5/0464 ,  A61N1/362 ,  A61N1/37 ,  A61N1/39

CPC分类号： A61B5/4035 ,  A61B5/046 ,  A61B5/0464 ,  A61N1/3622 ,  A61N1/3962

摘要： An implantable medical device and method are provided for assessing autonomic tone and risk factors associated with arrhythmias and, based on this assessment, an early recurrence of ventricular tachycardia or ventricular fibrillation is predicted. Specifically, changes in R—R interval, heart rate variability, patient activity, and myocardial ischemia are measured prior to and after a detected an arrhythmia episode. A recurrence score is calculated as a weighted sum of measured parameters and compared to a prediction criterion. The prediction criterion may be a preset threshold score or an individualized episode template based on previously calculated recurrence scores associated with recurring episodes. Stored parameters and episode-related data may be downloaded for offline analyses for optimizing prediction criteria and monitoring patient status.

摘要翻译： 提供了一种用于评估与心律失常相关的自主神经和风险因素的可植入医疗装置和方法，并且基于该评估，预测了室性心动过速或心室颤动的早期复发。 具体地，在检测到心律失常发作之前和之后测量R-R间期，心率变异性，患者活动和心肌缺血的变化。 计算复发得分作为测量参数的加权和并与预测标准进行比较。 预测标准可以是基于先前计算的与重复发作相关联的复发评分的预设阈值评分或个体化发作模板。 可以下载存储的参数和与剧集相关的数据用于离线分析，以优化预测标准和监测患者状态。

公开(公告)号：US20120109240A1

公开(公告)日：2012-05-03

申请号：US12915877

申请日：2010-10-29

申请人： Xiaohong Zhou ,  Robert Stadler ,  Bruce D. Gunderson ,  Walter H. Olson

发明人： Xiaohong Zhou ,  Robert Stadler ,  Bruce D. Gunderson ,  Walter H. Olson

IPC分类号： A61N1/39 ,  A61N1/365

CPC分类号： A61N1/3706 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/4836 ,  A61N1/3621

摘要： Methods and/or devices for initiating an automatic adjustment of arrhythmia detection parameters (e.g., upon delivery of cardiac therapy after detection of VT/VF).

摘要翻译： 用于启动心律失常检测参数的自动调整的方法和/或装置（例如，在检测到VT / VF之后递送心脏治疗）。

公开(公告)号：US07076298B2

公开(公告)日：2006-07-11

申请号：US10171231

申请日：2002-06-14

申请人： Vasant Padmanabhan ,  Walter H. Olson ,  Rahul Mehra ,  Xiaohong Zhou ,  Thomas J. Mullen ,  William J. George

发明人： Vasant Padmanabhan ,  Walter H. Olson ,  Rahul Mehra ,  Xiaohong Zhou ,  Thomas J. Mullen ,  William J. George

IPC分类号： A61N1/36

CPC分类号： A61N1/3622

摘要： An implantable medical device that includes a microprocessor that characterizes cardiac activity of a patient to enable the implantable medical device to deliver therapy in response to an identified arrhythmia event. A monitor/controller monitors the characterized cardiac activity and the delivered therapy, and controls activation of triggered overdrive pacing subsequent to the delivered therapy.

公开(公告)号：US07027856B2

公开(公告)日：2006-04-11

申请号：US10261316

申请日：2002-09-30

申请人： Xiaohong Zhou ,  Bruce D. Gunderson ,  Walter H. Olson ,  Robert W. Stadler

发明人： Xiaohong Zhou ,  Bruce D. Gunderson ,  Walter H. Olson ,  Robert W. Stadler

IPC分类号： A61B5/0452

CPC分类号： A61B5/0452 ,  A61N1/3956

摘要： An implantable medical device and associated method are provided for detecting non-sustained arrhythmias and determining a metric of non-sustained arrhythmias. The metric may be used for predicting the occurrence of a sustained arrhythmia or for automatically adjusting the parameters used for detecting a sustained arrhythmia.

摘要翻译： 提供可植入医疗装置和相关方法用于检测非持续性心律失常并确定非持续性心律失常的度量。 该度量可以用于预测持续性心律失常的发生或用于自动调整用于检测持续性心律失常的参数。

公开(公告)号：US20110105929A1

公开(公告)日：2011-05-05

申请号：US12610062

申请日：2009-10-30

申请人： Vinod Sharma ,  Xiaohong Zhou

发明人： Vinod Sharma ,  Xiaohong Zhou

IPC分类号： A61B5/0432 ,  A61B5/0452 ,  A61N1/39 ,  A61N1/362

CPC分类号： A61B5/0452

摘要： Techniques for monitoring T-wave alternans (TWAs) in a patient are described. An implantable medical device (IMD), such as an implantable pacemaker, cardioverter, or diagnostic device, generates an EGM signal, e.g., a far field EGM signal, samples the EGM signal to obtain a single T-wave amplitude value for each T-wave over a plurality of beats, and stores the T-wave amplitude values in memory. The IMD creates a time series of the T-wave amplitude values stored in memory, calculates the power spectral density for the times series, and selects a power spectral density of a particular frequency, e.g., 0.5 cycles per beat, as the TWA value. The IMD may periodically determine TWA values for the patient and store the values in memory. The TWA values may be presented to medical personnel, e.g., as a trend. The IMD may deliver or modify therapy, or provide an alert, based on the TWA values.

摘要翻译： 描述了用于监测患者中的T波交替（TWAs）的技术。 诸如可植入心脏起搏器，心律转复器或诊断装置的可植入医疗装置（IMD）生成例如远场EGM信号的EGM信号，对EGM信号进行采样，以获得每个T- 在多个节拍中波动，并将T波幅度值存储在存储器中。 IMD产生存储在存储器中的T波幅度值的时间序列，计算时间序列的功率谱密度，并选择特定频率的功率谱密度，例如每个节拍0.5个周期作为TWA值。 IMD可以周期性地确定患者的TWA值并将值存储在存储器中。 TWA值可以呈现给医务人员，例如作为趋势。 IMD可以根据TWA值提供或修改治疗或提供警报。

公开(公告)号：US07177680B2

公开(公告)日：2007-02-13

申请号：US10403636

申请日：2003-03-31

申请人： Vinod Sharma ,  Xiaohong Zhou

发明人： Vinod Sharma ,  Xiaohong Zhou

IPC分类号： A61N1/05 ,  A61N1/36

CPC分类号： A61N1/0573 ,  A61N1/0587

摘要： Improved pacing thresholds for capturing the heart are achieved by forming a discontinuity in the cardiac tissue of the heart chamber, disposing a pacing electrode at a distance less than a space constant of the cardiac tissue from the discontinuity in the cardiac tissue, and applying a stimulus of a first polarity at an energy insufficient to cause the directly stimulated tissue adjacent to the pacing electrode to propagate a depolarization wave through the cardiac tissue mass of the heart chamber but sufficient to induce a transmembrane potential change at the tissue adjacent to the discontinuity that results in a propagated wave front. Thus, pacing energy is advantageously reduced.

摘要翻译： 通过在心脏室的心脏组织中形成不连续性来实现用于捕获心脏的改善的起搏阈值，将起搏电极设置在心脏组织的距离小于心脏组织的间隔常数的距离处，并施加刺激 第一极性的能量不足以引起与起搏电极相邻的直接受刺激的组织通过心室的心脏组织块传播去极化波，但是足以在与不连续性相邻的组织处诱导跨膜电位变化， 在传播的波前。 因此，起搏能量有利地降低。

公开(公告)号：US08396539B2

公开(公告)日：2013-03-12

申请号：US11676128

申请日：2007-02-16

申请人： Vinod Sharma ,  Xiaohong Zhou

发明人： Vinod Sharma ,  Xiaohong Zhou

IPC分类号： A61B5/04

CPC分类号： A61B5/0071 ,  A61B5/0084 ,  A61B5/0452

摘要： An implantable medical device for optically sensing action potential signals in excitable body tissue. The device includes an elongated tubular lead body carrying an optical fiber extending from a proximal lead end to a distal lead end to position the optical fiber at a target site. The lead body additionally carries a conduit for dispensing a voltage-sensitive fluorescent dye into tissue surrounding the target site. The optical fiber transmits excitation light to the fluorescent dye to cause the dye to fluoresce with varying intensity as the transmembrane potentials of local tissue cells vary due to passing depolarization wavefronts. The optical fiber transmits the fluorescence signal to the device to generate an action potential signal or fiducial points of an action potential signal for use in accurately measuring and characterizing electrical activity of excitable tissue.

摘要翻译： 一种用于在可兴奋的身体组织中光学感测动作电位信号的可植入医疗装置。 该装置包括细长的管状引线体，其承载从近侧引线端延伸到远端引线端的光纤，以将光纤定位在目标部位。 引线体还带有用于将电压敏感的荧光染料分配到靶区域周围的组织中的导管。 光纤将激发光透射到荧光染料，以使得染料以不同的强度发荧光，因为局部组织细胞的跨膜电位由于通过去极化波前而变化。 光纤将荧光信号传输到设备以产生动作电位信号或动作电位信号的基准点，用于精确测量和表征可兴奋组织的电活动。

公开(公告)号：US20080200769A1

公开(公告)日：2008-08-21

申请号：US11676128

申请日：2007-02-16

申请人： VINOD SHARMA ,  Xiaohong Zhou

发明人： VINOD SHARMA ,  Xiaohong Zhou

IPC分类号： A61N5/06

CPC分类号： A61B5/0071 ,  A61B5/0084 ,  A61B5/0452

摘要： An implantable medical device for optically sensing action potential signals in excitable body tissue. The device includes an elongated tubular lead body carrying an optical fiber extending from a proximal lead end to a distal lead end to position the optical fiber at a target site. The lead body additionally carries a conduit for dispensing a voltage-sensitive fluorescent dye into tissue surrounding the target site. The optical fiber transmits excitation light to the fluorescent dye to cause the dye to fluoresce with varying intensity as the transmembrane potentials of local tissue cells vary due to passing depolarization wavefronts. The optical fiber transmits the fluorescence signal to the device to generate an action potential signal or fiducial points of an action potential signal for use in accurately measuring and characterizing electrical activity of excitable tissue.

摘要翻译： 一种用于在可兴奋的身体组织中光学感测动作电位信号的可植入医疗装置。 该装置包括细长的管状引线体，其承载从近侧引线端延伸到远端引线端的光纤，以将光纤定位在目标部位。 引线体还带有用于将电压敏感的荧光染料分配到靶区域周围的组织中的导管。 光纤将激发光透射到荧光染料，以使得染料以不同的强度发荧光，因为局部组织细胞的跨膜电位由于通过去极化波前而变化。 光纤将荧光信号传输到设备以产生动作电位信号或动作电位信号的基准点，用于精确测量和表征可兴奋组织的电活动。

公开(公告)号：US07142928B2

公开(公告)日：2006-11-28

申请号：US10308302

申请日：2002-12-03

申请人： Vinod Sharma ,  Xiaohong Zhou

发明人： Vinod Sharma ,  Xiaohong Zhou

IPC分类号： A61N1/05 ,  A61N1/04

CPC分类号： A61N1/0587 ,  A61N1/0573

摘要： Improved pacing thresholds for capturing the heart are achieved by forming a discontinuity in the cardiac tissue of the heart chamber, disposing a pacing electrode at a distance exceeding a space constant of the cardiac tissue from the discontinuity in the cardiac tissue, and applying a stimulus of a first polarity at an energy insufficient to cause the directly stimulated tissue adjacent to the pacing electrode to propagate a depolarization wave through the cardiac tissue mass of the heart chamber but sufficient to induce a transmembrane potential change at the tissue adjacent to the discontinuity that results in a propagated wave front. Thus, pacing energy is advantageously reduced.

公开(公告)号：US08634903B2

公开(公告)日：2014-01-21

申请号：US12610062

申请日：2009-10-30

申请人： Vinod Sharma ,  Xiaohong Zhou

发明人： Vinod Sharma ,  Xiaohong Zhou

IPC分类号： A61B5/0468

CPC分类号： A61B5/0452

摘要： An implantable medical device (IMD), such as an implantable pacemaker, cardioverter, or diagnostic device, generates an EGM signal, e.g., a far field EGM signal, samples the EGM signal to obtain a single T-wave amplitude value for each T-wave over a plurality of beats, and stores the T-wave amplitude values in memory. The IMD creates a time series of the T-wave amplitude values stored in memory, calculates the power spectral density for the times series, and selects a power spectral density of a particular frequency, e.g., 0.5 cycles per beat, as the TWA value. The IMD may periodically determine TWA values for the patient and store the values in memory. The TWA values may be presented to medical personnel, e.g., as a trend. The IMD may deliver or modify therapy, or provide an alert, based on the TWA values.

摘要翻译： 诸如可植入心脏起搏器，心律转复器或诊断装置的可植入医疗装置（IMD）生成例如远场EGM信号的EGM信号，对EGM信号进行采样，以获得每个T- 在多个节拍中波动，并将T波幅度值存储在存储器中。 IMD产生存储在存储器中的T波幅度值的时间序列，计算时间序列的功率谱密度，并选择特定频率的功率谱密度，例如每个节拍0.5个周期作为TWA值。 IMD可以周期性地确定患者的TWA值并将值存储在存储器中。 TWA值可以呈现给医务人员，例如作为趋势。 IMD可以根据TWA值提供或修改治疗或提供警报。