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公开(公告)号：US20240344044A1
公开(公告)日：2024-10-17
申请号：US18650024
申请日：2024-04-29
Applicant: VedaBio, Inc.
Inventor： Joshua Miller , Andrew Garst , Robert Plasschaert , Swetha Murali , Anurup Ganguli
IPC: C12N9/22
CPC classification number: C12N9/22 , C12N2310/122 , C12N2310/20
Abstract: The present disclosure relates to compositions of matter and methods used to activate effector nucleic acids and effector targets in vivo via a CRISPR-based cascade system. The compositions and methods achieve non-specific delivery of cascade system components to cells yet the cascade system works in a cell-specific manner.
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公开(公告)号：US20240247304A1
公开(公告)日：2024-07-25
申请号：US18612868
申请日：2024-03-21
Applicant: VedaBio, Inc.
Inventor： Swetha Murali , Andrew Garst , Anurup Ganguli , Ketki Sawant , Ravi Vijayendran
CPC classification number: C12Q1/682 , C12N9/22 , C12N2310/20
Abstract: The present disclosure relates to compositions of matter and assay methods used to detect one or more non-nucleic acid targets of interest in a sample. The compositions and methods provide signal boost upon detection of non-nucleic acid targets of interest in less than one minute and in some instances instantaneously at ambient temperatures down to 25° C. or less, allow for massive multiplexing, high accuracy, minimal non-specific signal generation, and are easily reprogrammable.
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公开(公告)号：US20240228993A1
公开(公告)日：2024-07-11
申请号：US18402680
申请日：2024-01-02
Applicant: VedaBio, Inc.
Inventor： Andrew Garst , Anurup Ganguli , Ashish Pandey
IPC: C12N9/22 , C12N15/11 , C12Q1/44 , C12Q1/6823
CPC classification number: C12N9/22 , C12N15/11 , C12Q1/44 , C12Q1/6823 , C12N2310/20 , G01N2333/922
Abstract: The present disclosure relates to variant engineered nucleic acid-guided nucleases that may be used in CRISPR-based cascade assay systems to detect one or more target nucleic acids in a sample. The variant nucleases comprise an activity such that double-stranded DNA substrates do not bind to or are not cleaved by variant LbCas12a nuclease, or bind to or are cleaved very slowly by the variant nuclease, however single-stranded DNA substrates can bind and are cleaved by the variant nuclease, and wherein the variant nuclease exhibits both cis- and trans-cleavage activity
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Patent Agency Ranking
公开(公告)号：US20240110164A1
公开(公告)日：2024-04-04
申请号：US18375415
申请日：2023-09-29
Applicant: VedaBio, Inc.
Inventor： Anurup Ganguli , Joshua Miller , Andrew Garst , Robert Plasschaert , Swetha Murali
IPC: C12N9/22
CPC classification number: C12N9/22 , C12N2310/122 , C12N2310/20
Abstract: The present disclosure relates to compositions of matter and methods used to activate effector nucleic acids and effector targets in vivo via a CRISPR-based cascade system. The compositions and methods achieve non-specific delivery of cascade system components to cells yet the cascade system works in a cell-specific manner.
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公开(公告)号：US12091690B2
公开(公告)日：2024-09-17
申请号：US18402680
申请日：2024-01-02
Applicant: VedaBio, Inc.
Inventor： Andrew Garst , Anurup Ganguli , Ashish Pandey
IPC: C12N9/22 , C12N15/11 , C12Q1/44 , C12Q1/6823
CPC classification number: C12N9/22 , C12N15/11 , C12Q1/44 , C12Q1/6823 , C12N2310/20 , G01N2333/922
Abstract: The present disclosure relates to variant engineered nucleic acid-guided nucleases that may be used in CRISPR-based cascade assay systems to detect one or more target nucleic acids in a sample. The variant nucleases comprise an activity such that double-stranded DNA substrates do not bind to or are not cleaved by variant LbCas12a nuclease, or bind to or are cleaved very slowly by the variant nuclease, however single-stranded DNA substrates can bind and are cleaved by the variant nuclease, and wherein the variant nuclease exhibits both cis- and trans-cleavage activity.
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公开(公告)号：US12091707B2
公开(公告)日：2024-09-17
申请号：US18612868
申请日：2024-03-21
Applicant: VedaBio, Inc.
Inventor： Swetha Murali , Andrew Garst , Anurup Ganguli , Ketki Sawant , Ravi Vijayendran
CPC classification number: C12Q1/682 , C12N9/22 , C12N2310/20
Abstract: The present disclosure relates to compositions of matter and assay methods used to detect one or more non-nucleic acid targets of interest in a sample. The compositions and methods provide signal boost upon detection of non-nucleic acid targets of interest in less than one minute and in some instances instantaneously at ambient temperatures down to 25° C. or less, allow for massive multiplexing, high accuracy, minimal non-specific signal generation, and are easily reprogrammable.
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公开(公告)号：US12091689B2
公开(公告)日：2024-09-17
申请号：US18375415
申请日：2023-09-29
Applicant: VedaBio, Inc.
Inventor： Anurup Ganguli , Joshua Miller , Andrew Garst , Robert Plasschaert , Swetha Murali
IPC: C12N9/22
CPC classification number: C12N9/22 , C12N2310/122 , C12N2310/20
Abstract: The present disclosure relates to compositions of matter and methods used to activate effector nucleic acids and effector targets in vivo via a CRISPR-based cascade system. The compositions and methods achieve non-specific delivery of cascade system components to cells yet the cascade system works in a cell-specific manner.
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公开(公告)号：US20240417780A1
公开(公告)日：2024-12-19
申请号：US18786446
申请日：2024-07-27
Applicant: VedaBio, Inc.
Inventor： Swetha Murali , Andrew Garst , Anurup Ganguli , Ketki Sawant , Ravi Vijayendran
Abstract: The present disclosure relates to compositions of matter and assay methods used to detect one or more non-nucleic acid targets of interest in a sample. The compositions and methods provide signal boost upon detection of non-nucleic acid targets of interest in less than one minute and in some instances instantaneously at ambient temperatures down to 25° C. or less, allow for massive multiplexing, high accuracy, minimal non-specific signal generation, and are easily reprogrammable.
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