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公开(公告)号：US11975274B2
公开(公告)日：2024-05-07
申请号：US17945125
申请日：2022-09-15
申请人： Velico Medical, Inc.
发明人： Qiyong Peter Liu , Herman E. Snyder , Kyle D. Erickson , Evan P. Ordway , William J. Merritt , Richard Meehan , Robert R. Andrews , Clair Strohl , Jihae Sohn , Mark A. Popovsky , Lisa A. Buckley
摘要： The present invention relates to a spray dried plasma composition having one or more of the following characteristics: when reconstituted, largely amorphous and has no cholesterol crystals; when reconstituted, the number of large particulates is reduced; has low residual moisture; reconstitutes rapidly in under four minutes; highly stable when stored under refrigeration, at room temperature or at elevated temperatures and allows for storage for longer periods of time; when reconstituted, exhibits recovery of the most fragile of proteins, including von Willebrand's factor; when reconstituted with Sterile Water for Injection (SWFI), reconstituted plasma is at a pH that is near normal plasma pH, and does so without treatment or storage in CO2 or other pH adjustment; and when reconstituted, has reduced complement activation (C5A, C3A).
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公开(公告)号：US20240091666A1
公开(公告)日：2024-03-21
申请号：US18097958
申请日：2023-01-17
申请人： Velico Medical, Inc.
发明人： Richard Meehan , Robert R. Andrews , Herman E. Snyder , William J. Merritt , Evan P. Ordway , Clair Strohl , Qiyong Peter Liu , Jihae Sohn
摘要： The present invention relates to a spray dried plasma composition having one or more of the following characteristics: when reconstituted, largely amorphous and has no cholesterol crystals; when reconstituted, the number of large particulates is reduced; has low residual moisture; reconstitutes rapidly in under four minutes; highly stable when stored under refrigeration, at room temperature or at elevated temperatures and allows for storage for longer periods of time; when reconstituted, exhibits recovery of the most fragile of proteins, including von Willebrand's factor; when reconstituted with Sterile Water for Injection (SWFI), reconstituted plasma is at a pH that is near normal plasma pH, and does so without treatment or storage in CO2 or other pH adjustment; and when reconstituted, has reduced complement activation (C5A, C3A).
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公开(公告)号：US20170370952A1
公开(公告)日：2017-12-28
申请号：US15481573
申请日：2017-04-07
CPC分类号： G01N33/86 , A01N1/0205 , A01N1/0278 , A61K35/16
摘要： The present invention relates to a reconstitution solution for spray dried plasma having a non-anticoagulant compound that does not bind calcium. When the reconstitution solution of the present invention is mixed with spray dry plasma, the reconstituted plasma mediates platelet adhesion and aggregation about the same as or greater than the starting plasma prior to spray drying. The present invention also relates to an assay for determining platelet adhesion and aggregation using microfluidic flow cell system having a shear flow. The assay assesses labeled whole blood samples having reconstituted plasma having spray dried plasma and a reconstitution solution; platelets; and red blood cells. After inducing a shear flow under conditions suitable for clot formation, coverage area of the platelets, intensity of the platelets, morphology, or a combination thereof is detected to determine platelet accumulation (e.g., platelet adhesion and aggregation).
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公开(公告)号：US20170156310A1
公开(公告)日：2017-06-08
申请号：US15436715
申请日：2017-02-17
CPC分类号： A01N1/0226 , A61J1/10
摘要： The present invention relates to a platelet additive solution (PAS) having an amount of one or more β-galactosidase inhibitors with or without an amount of one or more sialidase inhibitors, and optionally one or more glycan-modifying agents; and one or more of PAS components that include a salt, a citrate source, a carbon source, or any combination thereof.
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公开(公告)号：US20160174543A9
公开(公告)日：2016-06-23
申请号：US14047689
申请日：2013-10-07
IPC分类号： A01N1/02
CPC分类号： A01N1/0226 , A61J1/10
摘要： The present invention relates to a platelet additive solution (PAS) having an amount of one or more β-galactosidase inhibitors with or without an amount of one or more sialidase inhibitors, and optionally one or more glycan-modifying agents; and one or more of PAS components that include a salt, a citrate source, a carbon source, or any combination thereof.
摘要翻译： 本发明涉及一种含有一种或多种β-半乳糖苷酶抑制剂的量的一种或多种唾液酸酶抑制剂和任选的一种或多种聚糖调节剂的血小板添加剂溶液（PAS） 和一种或多种包括盐，柠檬酸盐源，碳源或其任何组合的PAS组分。
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6.发明申请公开(公告)号：US20160145573A1
公开(公告)日：2016-05-26
申请号：US15013291
申请日：2016-02-02
申请人： Velico Medical, Inc.
发明人： Qiyong Peter Liu
IPC分类号： C12N5/078
CPC分类号： C12N5/0644 , A01N1/0226
摘要： The present invention relates to a platelet protection solution (PPS) having an amount of one or more β-galactosidase inhibitors with or without an amount of one or more sialidase inhibitors, and optionally one or more glycan-modifying agents; and one or more of PPS components that include a salt, a citrate source, a carbon source, or any combination thereof.
摘要翻译： 本发明涉及一种具有一种或多种β-半乳糖苷酶抑制剂的血小板保护溶液（PPS），其具有或不含有一种或多种唾液酸酶抑制剂，以及任选的一种或多种聚糖修饰剂; 和一种或多种包含盐，柠檬酸盐源，碳源或其任何组合的PPS组分。
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公开(公告)号：US12064518B2
公开(公告)日：2024-08-20
申请号：US17508904
申请日：2021-10-22
申请人： Velico Medical Inc.
发明人： Qiyong Peter Liu , Junqing Cui , Rud Karly Lucien , Ryan Carney , Jihae Sohn , Michelle Arya , Abdul W. Khan
IPC分类号： A61K9/16 , A61K35/16 , B01J19/06 , B65D51/30 , B65D81/26 , F26B3/04 , F26B3/06 , F26B3/12 , F26B5/04 , F26B5/06
CPC分类号： A61K9/1682 , A61K9/16 , A61K9/1617 , A61K9/1688 , A61K35/16 , B01J19/06 , F26B3/04 , F26B3/06 , F26B3/12 , F26B5/04 , B01J2219/00177 , B65D51/30 , B65D81/266 , F26B5/065
摘要： A method of treatment of plasma with a physiologically compatible spray dry stable acidic substance (SDSAS) prior to or contemporaneously with spray drying of the plasma that results in greater recovery and greater long-term stabilization of the dried plasma proteins as compared to spray dried plasma that has not be subject to the formulation method of the present invention, as well as compostions related to plasma dried by the methods of the present invention.
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公开(公告)号：US20240091667A1
公开(公告)日：2024-03-21
申请号：US18467074
申请日：2023-09-14
申请人： Velico Medical, Inc.
CPC分类号： B01D1/18 , A01N1/0242
摘要： A method of treating plasma with a pretreatment solution that has a physiologically compatible spray dry stable acidic substance (SDSAS) and an amino acid, prior to or contemporaneously with spray drying of the plasma that results in greater recovery and greater long-term stabilization of the dried plasma proteins as compared to spray dried plasma that has not be subject to the formulation method of the present invention, as well as compositions related to plasma dried by the methods of the present invention.
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公开(公告)号：US20190203175A1
公开(公告)日：2019-07-04
申请号：US16126505
申请日：2018-09-10
申请人： Velico Medical, Inc.
发明人： Qiyong Peter Liu
CPC分类号： C12N5/0644 , A01N1/0226
摘要： The present invention relates to a platelet protection solution (PPS) having an amount of one or more β-galactosidase inhibitors with or without an amount of one or more sialidase inhibitors, and optionally one or more glycan-modifying agents; and one or more of PPS components that include a salt, a citrate source, a carbon source, or any combination thereof.
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公开(公告)号：US09788539B2
公开(公告)日：2017-10-17
申请号：US15013204
申请日：2016-02-02
IPC分类号： A01N1/02
CPC分类号： A01N1/0226
摘要： The present invention relates to a platelet protection solution (PPS) having an amount of one or more β-galactosidase inhibitors with or without an amount of one or more sialidase inhibitors, and optionally one or more glycan-modifying agents; and one or more of PPS components that include a salt, a citrate source, a carbon source, or any combination thereof.
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