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    Lipase inhibiting polymers
    5.
    发明授权
    Lipase inhibiting polymers 失效
    脂肪酶抑制聚合物

    公开(公告)号：US06352692B1

    公开(公告)日：2002-03-05

    申请号：US09226585

    申请日：1999-01-06

    申请人： W. Harry Mandeville, III ,  Molly Kate Boie ,  Venkata R. Garigapati

    发明人： W. Harry Mandeville, III ,  Molly Kate Boie ,  Venkata R. Garigapati

    IPC分类号： A61K3174

    CPC分类号： A61K31/00 ,  Y10S514/909

    摘要： The invention features a method for treating obesity in a patient by administering to the patient a polymer that has been substituted with one or more groups that inhibit lipases, which are enzymes responsible for the hydrolysis of fat. The invention further relates to the polymers employed in the methods described herein as well as novel intermediates and methods for preparing the polymers.

    摘要翻译： 本发明的特征在于通过向患者施用已经被一种或多种抑制脂肪酶的基团取代的聚合物来治疗患者的肥胖的方法，脂肪酶是负责脂肪水解的酶。 本发明还涉及本文所述方法中使用的聚合物以及新型中间体和制备聚合物的方法。

    Fat-binding polymers
    6.
    发明授权
    Fat-binding polymers 失效
    脂肪结合聚合物

    公开(公告)号：US06299868B1

    公开(公告)日：2001-10-09

    申请号：US09353329

    申请日：1999-07-14

    申请人： Thomas Jozefiak ,  Stephen Randall Holmes-Farley ,  W. Harry Mandeville, III ,  Chad Cori Huval ,  Venkata R. Garigapati ,  Keith K. Shackett ,  Danny Concagh

    发明人： Thomas Jozefiak ,  Stephen Randall Holmes-Farley ,  W. Harry Mandeville, III ,  Chad Cori Huval ,  Venkata R. Garigapati ,  Keith K. Shackett ,  Danny Concagh

    IPC分类号： A61K31795

    CPC分类号： A61K45/06 ,  A61K31/785 ,  A61K2300/00

    摘要： The present invention relates to a method for treating obesity, a method for reducing the absorption of dietary fat, and a method for treating hypertriglyceridemia in a patient and to particular polymers for use in the methods or in a manufacture of a medicament. The methods comprise the step of orally administering to a mammal, such as a human, a therapeutically effective amount of one or more fat-binding polymers. The administration of the fat-binding polymer of the invention facilitates the removal of fat from the body prior to digestion, with minimal side effects and low toxicity. In a preferred embodiment, the one or more fat-binding polymers are administered in combination with one or more lipase inhibitors, for example, lipstatin and tetrahydrolipstatin.

    摘要翻译： 本发明涉及一种治疗肥胖症的方法，一种减少膳食脂肪吸收的方法，以及用于治疗患者中的高甘油三酯血症的方法以及用于该方法或用于制备药物的具体聚合物。 所述方法包括向哺乳动物（例如人）口服施用治疗有效量的一种或多种脂肪结合聚合物的步骤。 本发明的脂肪结合聚合物的施用有利于在消化之前从身体去除脂肪，具有最小的副作用和低毒性。 在一个优选的实施方案中，一种或多种脂肪结合聚合物与一种或多种脂肪酶抑制剂，例如脂抑素和四氢脂抑素组合施用。

    Fat-binding polymers
    7.
    发明授权
    Fat-binding polymers 失效
    脂肪结合聚合物

    公开(公告)号：US07048917B1

    公开(公告)日：2006-05-23

    申请号：US09721291

    申请日：2000-11-22

    申请人： Thomas Jozefiak ,  Stephen Randall Holmes-Farley ,  W. Harry Mandeville, III ,  Chad Cori Huval ,  Venkata R. Garigapati ,  Keith K. Shackett ,  Danny Concagh

    发明人： Thomas Jozefiak ,  Stephen Randall Holmes-Farley ,  W. Harry Mandeville, III ,  Chad Cori Huval ,  Venkata R. Garigapati ,  Keith K. Shackett ,  Danny Concagh

    IPC分类号： A61K31/795 ,  A61K31/785 ,  A61K31/74

    CPC分类号： A61K31/74 ,  A61K31/785 ,  A61K31/795 ,  Y10S514/909

    摘要： The present invention relates to a method for treating obesity, a method for reducing the absorption of dietary fat, and a method for treating hypertriglyceridemia in a patient and to particular polymers for use in the methods or in a manufacture of a medicament. The methods comprise the step of orally administering to a mammal, such as a human, a therapeutically effective amount of one or more fat-binding polymers. The administration of the fat-binding polymer of the invention facilitates the removal of fat from the body prior to digestion, with minimal side effects and low toxicity. In a preferred embodiment, the one or more fat-binding polymers are administered in combination with one or more lipase inhibitors, for example, lipstatin and tetrahydrolipstatin.

    摘要翻译： 本发明涉及一种治疗肥胖症的方法，一种减少膳食脂肪吸收的方法，以及用于治疗患者中的高甘油三酯血症的方法以及用于该方法或用于制备药物的具体聚合物。 所述方法包括向哺乳动物（例如人）口服施用治疗有效量的一种或多种脂肪结合聚合物的步骤。 本发明的脂肪结合聚合物的施用有利于在消化之前从身体去除脂肪，具有最小的副作用和低毒性。 在一个优选的实施方案中，一种或多种脂肪结合聚合物与一种或多种脂肪酶抑制剂，例如脂抑素和四氢脂抑素组合施用。

    Acid-functionalized saccharides as polyvalent anti-infectives
    9.
    发明授权
    Acid-functionalized saccharides as polyvalent anti-infectives 失效
    酸官能化糖作为多价抗感染药

    公开(公告)号：US5700458A

    公开(公告)日：1997-12-23

    申请号：US717264

    申请日：1996-09-20

    申请人： W. Harry Mandeville, III ,  Venkata R. Garigapati

    发明人： W. Harry Mandeville, III ,  Venkata R. Garigapati

    IPC分类号： C07H15/04 ,  A61K31/785 ,  C08F12/14 ,  C08F16/26 ,  C08F20/26 ,  C08F20/28 ,  C08F20/38 ,  C08F20/58 ,  C08F26/02 ,  C08F220/56 ,  A61K31/765

    CPC分类号： A61K31/785 ,  C08F20/28 ,  C08F20/38 ,  C08F20/58

    摘要： The present invention includes polymerizable monomers comprising an acid-functionalized glycoside moiety. In one embodiment, the monomer has a polymerizable functional group, such as an olefinic bond, to which the acid-functionalized glycoside moiety is attached by a spacer group, for example, an alkylene group, or an alkylene group wherein one or more carbon atoms are substituted by heteroatoms, such as oxygen, nitrogen or sulfur atoms. The present invention also includes polymers comprising one or more acid-functionalized glycoside moieties, such as pendant acid-functionalized glycoside moieties, which can inhibit or prevent rotavirus infection in a mammal. Such a polymer can comprise, for example, a monomer of the present invention. The polymer can be a homopolymer or a copolymer, and can have, for example, a polyacrylamide, polyacrylate or polystyrene backbone. In another embodiment, the present invention comprises a method for treating a rotaviral infection in a mammal, for example, a human, by administering to the mammal a therapeutically effective amount of a polymer comprising one or more glycoside moieties, such as pendant glycoside moieties. The polymer can be a homopolymer or a copolymer. In one embodiment, the polymer is a copolymer which comprises an acid-functionalized glycoside-bearing monomer and acrylamide.

    摘要翻译： 本发明包括包含酸官能化的糖苷部分的可聚合单体。 在一个实施方案中，单体具有可聚合官能团，例如烯键，酸官能化糖苷部分通过间隔基团连接到其上，例如亚烷基或其中一个或多个碳原子 被杂原子，如氧，氮或硫原子所取代。 本发明还包括可以抑制或预防哺乳动物轮状病毒感染的一种或多种酸官能化糖苷部分的聚合物，例如侧酸官能化糖苷部分。 这样的聚合物可以包括例如本发明的单体。 聚合物可以是均聚物或共聚物，并且可以具有例如聚丙烯酰胺，聚丙烯酸酯或聚苯乙烯主链。 在另一个实施方案中，本发明包括通过向哺乳动物施用治疗有效量的包含一个或多个糖苷部分的聚合物，例如侧链糖苷部分，来治疗哺乳动物例如人类的轮状病毒感染的方法。 聚合物可以是均聚物或共聚物。 在一个实施方案中，聚合物是包含酸官能化的含糖单体和丙烯酰胺的共聚物。