-
公开(公告)号：US08435943B2
公开(公告)日：2013-05-07
申请号：US13089683
申请日：2011-04-19
CPC分类号： A61K38/1875 , A61K9/19 , A61K47/183 , A61K47/26 , A61K47/42
摘要： The present invention is directed to stabilizing Bone Morphogenetic Protein in various lyophilized formulations and compositions. The present invention comprises formulations primarily including trehalose as an excipient for lyophilized compositions and their subsequent storage and reconstitution, and can also optionally include other excipients, including buffers and surfactants.
摘要翻译： 本发明涉及在各种冻干制剂和组合物中稳定骨形态发生蛋白。 本发明包括主要包括海藻糖作为冻干组合物的赋形剂及其随后的储存和重构的制剂，还可任选地包括其它赋形剂，包括缓冲液和表面活性剂。
-
公开(公告)号：US20110237506A1
公开(公告)日：2011-09-29
申请号：US13089683
申请日：2011-04-19
CPC分类号： A61K38/1875 , A61K9/19 , A61K47/183 , A61K47/26 , A61K47/42
摘要： The present invention is directed to stabilizing Bone Morphogenetic Protein in various lyophilized formulations and compositions. The present invention comprises formulations primarily including trehalose as an excipient for lyophilized compositions and their subsequent storage and reconstitution, and can also optionally include other excipients, including buffers and surfactants.
摘要翻译： 本发明涉及在各种冻干制剂和组合物中稳定骨形态发生蛋白。 本发明包括主要包括海藻糖作为冻干组合物的赋形剂及其随后的储存和重构的制剂，还可任选地包括其它赋形剂，包括缓冲液和表面活性剂。
-
公开(公告)号：US20080147077A1
公开(公告)日：2008-06-19
申请号：US11950127
申请日：2007-12-04
CPC分类号： A61K38/1875 , A61K9/19 , A61K47/183 , A61K47/26 , A61K47/42
摘要： The present invention is directed to stabilizing Bone Morphogenetic Protein in various lyophilized formulations and compositions. The present invention comprises formulations primarily including trehalose as an excipient for lyophilized compositions and their subsequent storage and reconstitution, and can also optionally include other excipients, including buffers and surfactants.
摘要翻译： 本发明涉及在各种冻干制剂和组合物中稳定骨形态发生蛋白。 本发明包括主要包括海藻糖作为冻干组合物的赋形剂及其随后的储存和重构的制剂，还可任选地包括其它赋形剂，包括缓冲液和表面活性剂。
-
公开(公告)号：US07956028B2
公开(公告)日：2011-06-07
申请号：US11950127
申请日：2007-12-04
IPC分类号： A61K38/00 , A61K38/16 , A61K38/17 , A61K38/18 , C07K14/00 , C07K14/435 , C07K14/46 , C07K14/47 , C07K14/475 , C07K14/51
CPC分类号： A61K38/1875 , A61K9/19 , A61K47/183 , A61K47/26 , A61K47/42
摘要： The present invention is directed to stabilizing Bone Morphogenetic Protein in various lyophilized formulations and compositions. The present invention comprises formulations primarily including trehalose as an excipient for lyophilized compositions and their subsequent storage and reconstitution, and can also optionally include other excipients, including buffers and surfactants.
摘要翻译： 本发明涉及在各种冻干制剂和组合物中稳定骨形态发生蛋白。 本发明包括主要包括海藻糖作为冻干组合物的赋形剂及其随后的储存和重构的制剂，还可任选地包括其它赋形剂，包括缓冲液和表面活性剂。
-
公开(公告)号：US20070118127A1
公开(公告)日：2007-05-24
申请号：US11284762
申请日：2005-11-22
申请人： Hassan Serhan , Michael Slivka , Ramon Ruberte , Michael O'Neil , Rehan Khanzada
发明人： Hassan Serhan , Michael Slivka , Ramon Ruberte , Michael O'Neil , Rehan Khanzada
IPC分类号： A61F2/30
CPC分类号： A61F2/0811 , A61F2002/0829 , A61F2002/0858 , A61F2002/0864 , A61F2002/0888
摘要： Various exemplary methods and devices are provided for fixing an implant to native tissue, such as, bone. The devices can include a body having an upper surface, a lower tissue contacting surface, and an implant receiving opening extending therebetween. The body can further include first and second portions each having an implant contacting surface and a hinge for connecting the first and second portions. In use, the hinge can allow pivotal movement between the first and second portions such that an implant can be fixed therebetween.
摘要翻译： 提供各种示例性的方法和装置用于将植入物固定到诸如骨的天然组织。 该装置可以包括具有上表面的主体，下部组织接触表面和在它们之间延伸的植入物接收开口。 主体还可以包括各自具有植入物接触表面的第一和第二部分以及用于连接第一和第二部分的铰链。 在使用中，铰链可以允许第一和第二部分之间的枢转运动，使得植入物可以固定在它们之间。
-
公开(公告)号：US20080234727A1
公开(公告)日：2008-09-25
申请号：US11689757
申请日：2007-03-22
申请人： Venkat Garigapati , Rehan Khanzada
发明人： Venkat Garigapati , Rehan Khanzada
IPC分类号： A61B17/04
CPC分类号： A61B17/06166 , A61B2017/00526 , A61B2017/00893 , A61L17/005 , A61L17/145 , A61L2300/414 , A61L2300/606
摘要： A suture coated with a composition comprising: a) a growth factor, b) a biodegradable, non-polymeric, non-water soluble, liquid carrier material (such as SAIB), c) a growth factor stabilizer, d) a solvent in which both the biodegradable, non-polymeric, non-water soluble, liquid carrier material and the protein stabilizer are miscible, e) a volatile alcohol (such as ethanol).
摘要翻译： 涂覆有组合物的缝线，其包含：a）生长因子，b）可生物降解的非聚合非水溶性液体载体材料（例如SAIB），c）生长因子稳定剂，d）溶剂，其中 可生物降解的，非聚合的，非水溶性的液体载体材料和蛋白质稳定剂都是可混溶的，e）挥发性醇（例如乙醇）。
-
公开(公告)号：US20070118129A1
公开(公告)日：2007-05-24
申请号：US11285503
申请日：2005-11-22
申请人： Robert Fraser , Rehan Khanzada , Michael O'Neil
发明人： Robert Fraser , Rehan Khanzada , Michael O'Neil
CPC分类号： A61F2/0811 , A61F2002/0829 , A61F2002/0858 , A61F2002/0864 , A61F2002/0888
摘要： Various exemplary methods and devices are provided for fixing an implant to native tissue, such as, bone. The devices can include first and second plate bodies, each having an upper surface and a lower tissue contacting surface. The bodies can provides a large contact area for fixing the tissue implant to bone, such that the implant can be securely held in position without requiring penetration of the implant. In one embodiment, the plate bodies can include at least one aperture for receiving a fixation device and a tissue implant receiving opening through which a tissue implant can be threaded prior to fixing the plate bodies to bone.
摘要翻译： 提供各种示例性的方法和装置用于将植入物固定到诸如骨的天然组织。 这些装置可以包括第一和第二板体，每个具有上表面和下组织接触表面。 身体可以提供用于将组织植入物固定到骨头的大的接触区域，使得植入物可以牢固地保持就位而不需要植入物的穿透。 在一个实施例中，板体可以包括用于接收固定装置和组织植入物接收开口的至少一个孔，组织植入物可以在将板体固定到骨之前穿过该孔。
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.022 秒)
