公开(公告)号：US20240210288A1

公开(公告)日：2024-06-27

申请号：US18599067

申请日：2024-03-07

申请人： Ventana Medical Systems, Inc.

发明人： Nelson Alexander ,  Aoune Barhoumi ,  Melinda Day ,  Lisa Gallegos ,  Katherine Leith ,  Samantha Rajkovich ,  Esteban Roberts ,  Stacey Stanislaw ,  Eric Walk

IPC分类号： G01N1/28 ,  A01N1/02 ,  G01N1/30 ,  G01N1/36 ,  G01N33/483

CPC分类号： G01N1/286 ,  A01N1/0226 ,  A01N1/0278 ,  G01N1/30 ,  G01N1/36 ,  G01N33/4833 ,  G01N2001/2866 ,  G01N2001/368

摘要： The disclosure generally relates to the preparation of representative samples from clinical samples, e.g., tumors (whole or in part), lymph nodes, metastases, cysts, polyps, or a combination or portion thereof, using mechanical and/or biochemical dissociation methods to homogenize intact samples or large portions thereof. The resulting homogenate provides the ability to obtain a correct representative sample despite spatial heterogeneity within the sample, increasing detection likelihood of low prevalence subclones, and is suitable for use in various diagnostic assays as well as the production of therapeutics, especially “personalized” anti-tumor vaccines or immune cell based therapies.

公开(公告)号：US20200049599A1

公开(公告)日：2020-02-13

申请号：US15965786

申请日：2018-04-27

申请人： Ventana Medical Systems, Inc.

发明人： Nelson Alexander ,  Aoune Barhoumi ,  Melinda Day ,  Lisa Gallegos ,  Katherine Leith ,  Samantha Rajkovich ,  Esteban Roberts ,  Stacey Stanislaw ,  Eric Walk

IPC分类号： G01N1/28 ,  A01N1/02 ,  G01N33/483 ,  G01N1/30 ,  G01N1/36

摘要： The disclosure generally relates to the preparation of representative samples from clinical samples, e.g., tumors (whole or in part), lymph nodes, metastases, cysts, polyps, or a combination or portion thereof, using mechanical and/or biochemical dissociation methods to homogenize intact samples or large portions thereof. The resulting homogenate provides the ability to obtain a correct representative sample despite spatial heterogeneity within the sample, increasing detection likelihood of low prevalence subclones, and is suitable for use in various diagnostic assays as well as the production of therapeutics, especially “personalized” anti-tumor vaccines or immune cell based therapies.

公开(公告)号：US11959838B2

公开(公告)日：2024-04-16

申请号：US15965786

申请日：2018-04-27

申请人： Ventana Medical Systems, Inc.

发明人： Nelson Alexander ,  Aoune Barhoumi ,  Melinda Day ,  Lisa Gallegos ,  Katherine Leith ,  Samantha Rajkovich ,  Esteban Roberts ,  Stacey Stanislaw ,  Eric Walk

IPC分类号： G01N1/28 ,  A01N1/02 ,  G01N1/30 ,  G01N1/36 ,  G01N33/483

CPC分类号： G01N1/286 ,  A01N1/0226 ,  A01N1/0278 ,  G01N1/30 ,  G01N1/36 ,  G01N33/4833 ,  G01N2001/2866 ,  G01N2001/368

摘要： The disclosure generally relates to the preparation of representative samples from clinical samples, e.g., tumors (whole or in part), lymph nodes, metastases, cysts, polyps, or a combination or portion thereof, using mechanical and/or biochemical dissociation methods to homogenize intact samples or large portions thereof. The resulting homogenate provides the ability to obtain a correct representative sample despite spatial heterogeneity within the sample, increasing detection likelihood of low prevalence subclones, and is suitable for use in various diagnostic assays as well as the production of therapeutics, especially “personalized” anti-tumor vaccines or immune cell based therapies.