公开(公告)号：US20070010441A1

公开(公告)日：2007-01-11

申请号：US11356452

申请日：2006-02-17

申请人： Vernon Alvarez ,  Daniel O'Mahony ,  Imelda Lambkin ,  Catherine Patterson ,  Judith Singleton ,  Benjamin Belinka ,  John Carter ,  Gerard Cagney

发明人： Vernon Alvarez ,  Daniel O'Mahony ,  Imelda Lambkin ,  Catherine Patterson ,  Judith Singleton ,  Benjamin Belinka ,  John Carter ,  Gerard Cagney

IPC分类号： A61K38/17 ,  C07K14/47

CPC分类号： A61K38/28 ,  A61K47/58 ,  A61K47/593 ,  A61K47/60 ,  A61K47/62 ,  A61K47/6937

摘要： This invention relates to proteins (e.g., peptides) that are capable of facilitating transport of an active agent through a human or animal gastro-intestinal tissue, and derivatives (e.g., fragments) and analogs thereof, and nucleotide sequences coding for said proteins and derivatives. The proteins of the invention have use in facilitating transport of active agents from the lumenal side of the GIT into the systemic blood system, and/or in targeting active agents to the GIT. Thus, for example, by binding (covalently or noncovalently) a protein of the invention to an orally administered drug, the drug can be targeted to specific receptor sites or transport pathways which are known to operate in the human gastrointestinal tract, thus facilitating its absorption into the systemic system.

摘要翻译： 本发明涉及能够促进活性剂通过人或动物胃肠组织及其衍生物（例如片段）及其类似物以及编码所述蛋白质和衍生物的核苷酸序列的蛋白质（例如肽） 。 本发明的蛋白质用于促进活性剂从GIT的内腔侧输送到全身血液系统中，和/或将活性剂靶向GIT。 因此，例如，通过将本发明的蛋白质（共价或非共价）结合到口服给药的药物，该药物可以靶向已知在人胃肠道中操作的特异性受体位点或转运途径，从而有助于其吸收 进入系统系统。

公开(公告)号：US07053177B1

公开(公告)日：2006-05-30

申请号：US09079678

申请日：1998-05-15

申请人： Vernon L. Alvarez ,  Daniel J. O'Mahony ,  Imelda J. Lambkin ,  Catherine A. Patterson ,  Judith Singleton ,  Benjamin A. Belinka, Jr. ,  John M. Carter ,  Gerard M. Cagney

发明人： Vernon L. Alvarez ,  Daniel J. O'Mahony ,  Imelda J. Lambkin ,  Catherine A. Patterson ,  Judith Singleton ,  Benjamin A. Belinka, Jr. ,  John M. Carter ,  Gerard M. Cagney

IPC分类号： A61K38/00

CPC分类号： A61K38/28 ,  A61K47/58 ,  A61K47/593 ,  A61K47/60 ,  A61K47/62 ,  A61K47/6937

摘要： This invention relates to proteins (e.g., peptides) that are capable of facilitating transport of an active agent through a human or animal gastrointestinal tissue, and derivatives (e.g., fragments) and analogs thereof, and nucleotide sequences coding for said proteins and derivatives. The proteins of the invention have use in facilitating transport of active agents from the lumenal side of the GIT into the systemic blood system, and/or in targeting active agents to the GIT. Thus, for example, by binding (covalently or noncovalently) a protein of the invention to an orally administered drug, the drug can be targeted to specific receptor sites or transport pathways which are known to operate in the human gastrointestinal tract, thus facilitating its absorption into the systemic system.

摘要翻译： 本发明涉及能够促进活性剂通过人或动物胃肠组织及其衍生物（例如片段）及其类似物以及编码所述蛋白质和衍生物的核苷酸序列的蛋白质（例如肽）。 本发明的蛋白质用于促进活性剂从GIT的内腔侧进入全身血液系统，和/或将活性剂靶向GIT。 因此，例如，通过将本发明的蛋白质（共价或非共价）结合到口服给药的药物，该药物可以靶向已知在人胃肠道中操作的特异性受体位点或转运途径，从而有助于其吸收 进入系统系统。

公开(公告)号：US07135457B1

公开(公告)日：2006-11-14

申请号：US09079819

申请日：1998-05-15

申请人： Vernon L. Alvarez ,  Daniel J. O'Mahony ,  Imelda J. Lambkin ,  Catherine A. Patterson ,  Judith Singleton ,  Benjamin A. Belinka, Jr. ,  John M. Carter ,  Gerard M. Cagney

发明人： Vernon L. Alvarez ,  Daniel J. O'Mahony ,  Imelda J. Lambkin ,  Catherine A. Patterson ,  Judith Singleton ,  Benjamin A. Belinka, Jr. ,  John M. Carter ,  Gerard M. Cagney

IPC分类号： A61K38/00 ,  A61K39/00 ,  C07K5/00 ,  C07K7/00

CPC分类号： A61K38/28 ,  A61K9/1635 ,  A61K9/5153 ,  A61K47/593 ,  A61K47/60 ,  A61K47/62 ,  A61K47/6937 ,  B82Y5/00 ,  C07K14/001

摘要： This invention relates to proteins (e.g., peptides) that are capable of facilitating transport of an active agent through a human or animal gastro-intestinal tissue, and derivatives (e.g., fragments) and analogs thereof, and nucleotide sequences coding for said proteins and derivatives. The proteins of the invention have use in facilitating transport of active agents from the lumenal side of the GIT into the systemic blood system, and/or in targeting active agents to the GIT. Thus, for example, by binding (covalently or noncovalently) a protein of the invention to an orally administered drug, the drug can be targeted to specific receptor sites or transport pathways which are known to operate in the human gastrointestinal tract, thus facilitating its absorption into the systemic system.

摘要翻译： 本发明涉及能够促进活性剂通过人或动物胃肠组织及其衍生物（例如片段）及其类似物以及编码所述蛋白质和衍生物的核苷酸序列的蛋白质（例如肽） 。 本发明的蛋白质用于促进活性剂从GIT的内腔侧输送到全身血液系统中，和/或将活性剂靶向GIT。 因此，例如，通过将本发明的蛋白质（共价或非共价）结合到口服给药的药物，该药物可以靶向已知在人胃肠道中操作的特异性受体位点或转运途径，从而有助于其吸收 进入系统系统。

公开(公告)号：US06703362B1

公开(公告)日：2004-03-09

申请号：US09079723

申请日：1998-05-15

申请人： Vernon L. Alvarez ,  Daniel J. O'Mahony ,  Imelda J. Lambkin ,  Catherine A. Patterson ,  Judith Singleton ,  Benjamin A. Belinka, Jr. ,  John M. Carter ,  Gerard M. Cagney

发明人： Vernon L. Alvarez ,  Daniel J. O'Mahony ,  Imelda J. Lambkin ,  Catherine A. Patterson ,  Judith Singleton ,  Benjamin A. Belinka, Jr. ,  John M. Carter ,  Gerard M. Cagney

IPC分类号： C12D2106

CPC分类号： C07K7/08 ,  A61K38/00 ,  C07K1/047 ,  C07K5/1013 ,  C07K5/1016 ,  C07K14/001

摘要： This invention relates to proteins (e.g., peptides) that are capable of facilitating transport of an active agent through a human or animal gastro-intestinal tissue, and derivatives (e.g., fragments) and analogs thereof, and nucleotide sequences coding for said proteins and derivatives. The proteins of the invention have use in facilitating transport of active agents from the lumenal side of the GIT into the systemic blood system, and/or in targeting active agents to the GIT. Thus, for example, by binding (covalently or noncovalently) a protein of the invention to an orally administered drug, the drug can be targeted to specific receptor sites or transport pathways which are known to operate in the human gastrointestinal tract, thus facilitating its absorption into the systemic system.

摘要翻译： 本发明涉及能够促进活性剂通过人或动物胃肠组织及其衍生物（例如片段）及其类似物以及编码所述蛋白质和衍生物的核苷酸序列的蛋白质（例如肽） 。 本发明的蛋白质用于促进活性剂从GIT的内腔侧输送到全身血液系统中，和/或将活性剂靶向GIT。 因此，例如，通过将本发明的蛋白质（共价或非共价）结合到口服给药的药物，该药物可以靶向已知在人胃肠道中操作的特异性受体位点或转运途径，从而有助于其吸收 进入系统系统。