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1.发明授权Random peptides that bind to gastro-intestinal tract (GIT) transport receptors and related methods 失效结合胃肠道（GIT）转运受体的随机肽和相关方法公开(公告)号：US07053177B1
公开(公告)日：2006-05-30
申请号：US09079678
申请日：1998-05-15
申请人： Vernon L. Alvarez , Daniel J. O'Mahony , Imelda J. Lambkin , Catherine A. Patterson , Judith Singleton , Benjamin A. Belinka, Jr. , John M. Carter , Gerard M. Cagney
发明人： Vernon L. Alvarez , Daniel J. O'Mahony , Imelda J. Lambkin , Catherine A. Patterson , Judith Singleton , Benjamin A. Belinka, Jr. , John M. Carter , Gerard M. Cagney
IPC分类号： A61K38/00
CPC分类号： A61K38/28 , A61K47/58 , A61K47/593 , A61K47/60 , A61K47/62 , A61K47/6937
摘要： This invention relates to proteins (e.g., peptides) that are capable of facilitating transport of an active agent through a human or animal gastrointestinal tissue, and derivatives (e.g., fragments) and analogs thereof, and nucleotide sequences coding for said proteins and derivatives. The proteins of the invention have use in facilitating transport of active agents from the lumenal side of the GIT into the systemic blood system, and/or in targeting active agents to the GIT. Thus, for example, by binding (covalently or noncovalently) a protein of the invention to an orally administered drug, the drug can be targeted to specific receptor sites or transport pathways which are known to operate in the human gastrointestinal tract, thus facilitating its absorption into the systemic system.
摘要翻译： 本发明涉及能够促进活性剂通过人或动物胃肠组织及其衍生物（例如片段）及其类似物以及编码所述蛋白质和衍生物的核苷酸序列的蛋白质（例如肽）。 本发明的蛋白质用于促进活性剂从GIT的内腔侧进入全身血液系统，和/或将活性剂靶向GIT。 因此，例如，通过将本发明的蛋白质（共价或非共价）结合到口服给药的药物，该药物可以靶向已知在人胃肠道中操作的特异性受体位点或转运途径，从而有助于其吸收 进入系统系统。
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2.发明授权Random peptides that bind to gastro-intestinal tract (GIT) transport receptors and related methods 失效结合胃肠道（GIT）转运受体的随机肽和相关方法公开(公告)号：US06703362B1
公开(公告)日：2004-03-09
申请号：US09079723
申请日：1998-05-15
申请人： Vernon L. Alvarez , Daniel J. O'Mahony , Imelda J. Lambkin , Catherine A. Patterson , Judith Singleton , Benjamin A. Belinka, Jr. , John M. Carter , Gerard M. Cagney
发明人： Vernon L. Alvarez , Daniel J. O'Mahony , Imelda J. Lambkin , Catherine A. Patterson , Judith Singleton , Benjamin A. Belinka, Jr. , John M. Carter , Gerard M. Cagney
IPC分类号： C12D2106
CPC分类号： C07K7/08 , A61K38/00 , C07K1/047 , C07K5/1013 , C07K5/1016 , C07K14/001
摘要： This invention relates to proteins (e.g., peptides) that are capable of facilitating transport of an active agent through a human or animal gastro-intestinal tissue, and derivatives (e.g., fragments) and analogs thereof, and nucleotide sequences coding for said proteins and derivatives. The proteins of the invention have use in facilitating transport of active agents from the lumenal side of the GIT into the systemic blood system, and/or in targeting active agents to the GIT. Thus, for example, by binding (covalently or noncovalently) a protein of the invention to an orally administered drug, the drug can be targeted to specific receptor sites or transport pathways which are known to operate in the human gastrointestinal tract, thus facilitating its absorption into the systemic system.
摘要翻译： 本发明涉及能够促进活性剂通过人或动物胃肠组织及其衍生物（例如片段）及其类似物以及编码所述蛋白质和衍生物的核苷酸序列的蛋白质（例如肽） 。 本发明的蛋白质用于促进活性剂从GIT的内腔侧输送到全身血液系统中，和/或将活性剂靶向GIT。 因此，例如，通过将本发明的蛋白质（共价或非共价）结合到口服给药的药物，该药物可以靶向已知在人胃肠道中操作的特异性受体位点或转运途径，从而有助于其吸收 进入系统系统。
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3.发明授权Random peptides that bind to gastro-intestinal tract (GIT) transport receptors and related methods 失效结合胃肠道（GIT）转运受体的随机肽和相关方法公开(公告)号：US07135457B1
公开(公告)日：2006-11-14
申请号：US09079819
申请日：1998-05-15
申请人： Vernon L. Alvarez , Daniel J. O'Mahony , Imelda J. Lambkin , Catherine A. Patterson , Judith Singleton , Benjamin A. Belinka, Jr. , John M. Carter , Gerard M. Cagney
发明人： Vernon L. Alvarez , Daniel J. O'Mahony , Imelda J. Lambkin , Catherine A. Patterson , Judith Singleton , Benjamin A. Belinka, Jr. , John M. Carter , Gerard M. Cagney
CPC分类号： A61K38/28 , A61K9/1635 , A61K9/5153 , A61K47/593 , A61K47/60 , A61K47/62 , A61K47/6937 , B82Y5/00 , C07K14/001
摘要： This invention relates to proteins (e.g., peptides) that are capable of facilitating transport of an active agent through a human or animal gastro-intestinal tissue, and derivatives (e.g., fragments) and analogs thereof, and nucleotide sequences coding for said proteins and derivatives. The proteins of the invention have use in facilitating transport of active agents from the lumenal side of the GIT into the systemic blood system, and/or in targeting active agents to the GIT. Thus, for example, by binding (covalently or noncovalently) a protein of the invention to an orally administered drug, the drug can be targeted to specific receptor sites or transport pathways which are known to operate in the human gastrointestinal tract, thus facilitating its absorption into the systemic system.
摘要翻译： 本发明涉及能够促进活性剂通过人或动物胃肠组织及其衍生物（例如片段）及其类似物以及编码所述蛋白质和衍生物的核苷酸序列的蛋白质（例如肽） 。 本发明的蛋白质用于促进活性剂从GIT的内腔侧输送到全身血液系统中，和/或将活性剂靶向GIT。 因此，例如，通过将本发明的蛋白质（共价或非共价）结合到口服给药的药物，该药物可以靶向已知在人胃肠道中操作的特异性受体位点或转运途径，从而有助于其吸收 进入系统系统。
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公开(公告)号：US06780846B1
公开(公告)日：2004-08-24
申请号：US09671089
申请日：2000-09-27
IPC分类号： A61K3800
CPC分类号： A61K9/5153 , A61K9/1271 , A61K38/28 , A61K47/62 , A61K47/65 , A61K48/00 , C07K7/08 , C07K14/50 , C07K14/665 , C07K2319/00 , C12N15/88
摘要： The present invention relates to a novel membrane translocating full-length peptide sequence, fragment, motif, derivative, analog or peptidomimetic thereof (MTLPs), to nucleotide sequences coding therefor, and to compositions comprising a MTLP-active agent complex and a MTLP-active particle complex. The MTLP or the nucleotide sequence coding therefor enhance movement of the active agent or of the active particle across a lipid membrane. More particularly, the present invention relates to a MTLP-active agent complex and a MTLP-active particle complex, wherein the MTLP enhances uptake of the active agent into a cell, into or out of an intracellular compartment and across a cell layer. Methods of making and methods of using MTLPs also are included.
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公开(公告)号：US07268214B2
公开(公告)日：2007-09-11
申请号：US10764235
申请日：2004-01-23
IPC分类号： C07K1/00
CPC分类号： A61K9/5153 , A61K9/1271 , A61K38/28 , A61K47/62 , A61K47/65 , A61K48/00 , C07K7/08 , C07K14/50 , C07K14/665 , C07K2319/00 , C12N15/88
摘要： The present invention relates to a novel membrane translocating full-length peptide sequence, fragment, motif, derivative, analog or peptidomimetic thereof (MTLPs), to nucleotide sequences coding therefor, and to compositions comprising a MTLP-active agent complex and a MTLP-active particle complex. The MTLP or the nucleotide sequence coding therefor enhance movement of the active agent or of the active particle across a lipid membrane. More particularly, the present invention relates to a MTLP-active agent complex and a MTLP-active particle complex, wherein the MTLP enhances uptake of the active agent into a cell, into or out of an intracellular compartment and across a cell layer. Methods of making and methods of using MTLPs also are included.
摘要翻译： 本发明涉及将全长肽序列，片段，基序，衍生物，类似物或肽模拟物（MTLP）转移到其编码的核苷酸序列的新型膜以及包含MTLP活性剂复合物和MTLP活性的组合物 颗粒复合物。 MTLP或其编码的核苷酸序列增强活性剂或活性颗粒穿过脂质膜的运动。 更具体地说，本发明涉及MTLP活性剂复合物和MTLP活性粒子复合物，其中MTLP增强了活性剂对细胞，细胞内区室和细胞层的吸收。 制作方法和使用MTLP的方法也包括在内。
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6.发明授权公开(公告)号：US07566766B2
公开(公告)日：2009-07-28
申请号：US10104603
申请日：2002-03-22
IPC分类号： C07K14/00
CPC分类号： C40B40/02 , A61K9/167 , A61K47/42 , A61K47/62 , A61K47/6937 , B82Y5/00 , C12N15/1037 , G01N33/68 , Y10S977/805
摘要： A method of identifying a peptide which permits or facilitates the transport of an active agent through a human or animal tissue. A predetermined amount of phage from a random phage library or a preselected phage library is administered in vivo or in situ to a site in an animal, such as into the gastro-intestinal tract. At a predetermined time, the phage which is transported across a tissue barrier is harvested at a harvesting site, such as in portal or systemic blood or brain tissue, which is separated from the site of administration by the tissue barrier to select transported phage. This transported phage is amplified in a host. This cycle of events is repeated (using the transported phage produced in the most recent cycle) a predetermined number of times to obtain a selected phage library containing phage which can be transported from the site of administration to the harvesting site. The identity of at least one peptide coded by phage in the selected phage library is determined to identify a peptide which permits or facilitates the transport of an active agent through a human or animal tissue.
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7.发明授权Composition and method for enhancing paracellular transport across cell layers 有权用于增强跨细胞层的细胞旁转运的组合物和方法公开(公告)号：US06346613B1
公开(公告)日：2002-02-12
申请号：US09160496
申请日：1998-09-24
申请人： Daniel J. O'Mahony , Gerard Cagney
发明人： Daniel J. O'Mahony , Gerard Cagney
IPC分类号： C07H2104
CPC分类号： C12N15/1138 , A61K38/00 , A61K48/00 , C12N2310/315
摘要： A composition and method for enhancing paracellular transport across cell layers in an animal comprising an antisense oligonucleotide hybridizable with a region of the messenger RNA coding for the protein occludin which, when hybridized to the occludin mRNA, interferes with its translation such that occludin function is disrupted and paracellular permeability is increased across an epithelial cell layer or and endothelial cell layer in an animal.
摘要翻译： 一种用于增强动物中跨细胞层的细胞外转运的组合物和方法，包括可与编码蛋白质闭塞蛋白的信使RNA区域杂交的反义寡核苷酸，其与闭合蛋白mRNA杂交时会干扰其翻译，使得闭塞蛋白功能被破坏 并且跨动物的上皮细胞层或内皮细胞层增加细胞旁渗透性。
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公开(公告)号：US07485321B2
公开(公告)日：2009-02-03
申请号：US11147083
申请日：2005-06-07
申请人： Daniel J. O'Mahony , Imelda Lambkin , Lisa Higgins
发明人： Daniel J. O'Mahony , Imelda Lambkin , Lisa Higgins
CPC分类号： C07K7/08 , A61K38/00 , C07K7/02 , C07K7/06 , C07K14/001 , C07K14/47 , C07K14/4725 , C07K2319/00
摘要： Purified synthetic polypeptide ligands for targeting pharmaceutical agents and carriers comprising such agents to intestinal epithelial tissue, especially Peyer's patch and/or M-Cell tissue. Also methods of using the ligands.
摘要翻译： 纯化的合成多肽配体，用于将药物和包含这些试剂的载体靶向肠上皮组织，特别是派耶氏贴剂和/或M细胞组织。 也是使用配体的方法。
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