-
1.发明授权2',3'-dideoxy-2'-fluoro-purine nucleosides and methods for using same 失效2'，3'-二脱氧-2'-氟 - 嘌呤核苷及其使用方法
公开(公告)号：US5565437A
公开(公告)日：1996-10-15
申请号：US62520
申请日：1992-11-10
申请人： Victor E. Marquez , John S. Driscoll , Christopher K-H. Tseng , James A. Kelley , David G. Johns , Hiroaki Mitsuya
发明人： Victor E. Marquez , John S. Driscoll , Christopher K-H. Tseng , James A. Kelley , David G. Johns , Hiroaki Mitsuya
CPC分类号： C07H19/16 , Y10S514/885
摘要： Methods of treating a human infected with human immunodeficiency virus (HIV), such as a human with AIDS, with the purina nucleotides 2',3'-dideoxy-2'-beta-fluoroadenosine (FddA) and 2',3'-dideoxy-2'-beta-fluoroinosine (FddI) are disclosed. These nucleotides are stable in an acid environment and thus can be used for oral administration. Methods of inhibiting human immunodeficiency virus replication in a human T cell using these purina nucleotides are also disclosed.
摘要翻译： 用艾滋病人用人类免疫缺陷病毒（HIV）感染的人与嘌呤核苷酸2'，3'-二脱氧-2'-β-氟腺苷（FddA）和2'，3'-双脱氧 -2'-β-氟肌苷（FddI）。 这些核苷酸在酸性环境中是稳定的，因此可用于口服给药。 还公开了使用这些嘌呤核苷酸在人T细胞中抑制人免疫缺陷病毒复制的方法。
-
公开(公告)号：US5459256A
公开(公告)日：1995-10-17
申请号：US683432
申请日：1991-04-10
申请人： Victor E. Marquez , John S. Driscoll , Harry Ford, Jr. , James A. Kelley , Joseph J. Barchi, Jr. , Hiroaki Mitsuya , Christopher K-H. Tseng , David G. Johns , Joseph E. Tomaszewski
发明人： Victor E. Marquez , John S. Driscoll , Harry Ford, Jr. , James A. Kelley , Joseph J. Barchi, Jr. , Hiroaki Mitsuya , Christopher K-H. Tseng , David G. Johns , Joseph E. Tomaszewski
IPC分类号： C07H19/16
CPC分类号： C07H19/16
摘要： The present invention relates, in general, to prodrugs. In particular, the present invention relates to lipophilic, aminohydrolase-activated, anti-viral nucleoside prodrug compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds.
摘要翻译： 本发明一般涉及前药。 特别地，本发明涉及亲脂性，氨基水解酶活化的抗病毒核苷前药化合物，含有这些化合物的药物组合物，以及使用这些化合物的方法。
-
公开(公告)号：US5495010A
公开(公告)日：1996-02-27
申请号：US762082
申请日：1991-09-19
申请人： Victor E. Marquez , John S. Driscoll , Christopher K-H. Tseng , James A. Kelley , David G. Johns , Hiroaki Mitsuya
发明人： Victor E. Marquez , John S. Driscoll , Christopher K-H. Tseng , James A. Kelley , David G. Johns , Hiroaki Mitsuya
CPC分类号： C07H19/16 , Y10S514/885
摘要： Purine nucleosides active against human immunodeficiency virus which are substituted at the 2'-position by a strong electronegative group such as fluorine are stable in an acid environment and thus can be used for oral administration.
摘要翻译： 通过强电负性基团如氟取代在2位上的针对人类免疫缺陷病毒的嘌呤核苷在酸性环境中是稳定的，因此可以用于口服给药。
-
4.发明授权5-substituted-2',3'-dideoxycytidine compounds with anti-HTLV-III activity 失效具有抗HTLV-III活性的5-取代-2'，3'-双脱氧胞苷化合物
公开(公告)号：US4788181A
公开(公告)日：1988-11-29
申请号：US913575
申请日：1986-09-29
IPC分类号： C07D405/04 , A61K31/70 , C07H19/06 , C07H19/10
CPC分类号： C07D405/04
摘要： 5-substituted 2',3'-dideoxycytidine compounds and their monophosphates are disclosed which have been found to have potent activity against retroviruses. The 5-fluoro-and 5-aza-substituted 2',3'-dideoycytidine compounds have been found to be effective against HTLV-III/LAV virus.
摘要翻译： 公开了已经发现其具有对逆转录病毒的有效活性的5-取代的2'，3'-双脱氧胞苷化合物及其单磷酸酯。 已经发现5-氟代和5-氮杂取代的2'，3'-二脱氧胞苷化合物对HTLV-III / LAV病毒有效。
-
5.发明授权Optical character readers for reading characters printed on wires or wire sleeves 有权用于读取电线或电线套筒上印刷字符的光学字符读取器公开(公告)号：US08068671B2
公开(公告)日：2011-11-29
申请号：US12056722
申请日：2008-03-27
申请人： Richard A. Malleck , Phillip McNutt , Charles E. Ince, III , Steven T. Bader , Michael C. Dauwalder , James A. Kelley , Jimmy W. Lynam
发明人： Richard A. Malleck , Phillip McNutt , Charles E. Ince, III , Steven T. Bader , Michael C. Dauwalder , James A. Kelley , Jimmy W. Lynam
IPC分类号： G06K9/18
CPC分类号： G06K9/209 , G06K9/28 , G06K9/36 , Y10T428/2982
摘要： A scanning system for scanning a wire to determine the characters provided on the wire.
摘要翻译： 用于扫描线以确定线上提供的字符的扫描系统。
-
公开(公告)号：US20100308171A1
公开(公告)日：2010-12-09
申请号：US12478596
申请日：2009-06-04
申请人： James A. Kelley , Rick A. Luepke , Lisa M. Vestal , Elizabeth J. Kush , Michael Loren Hestness , Eric C. Patty , Jeff Langevin
发明人： James A. Kelley , Rick A. Luepke , Lisa M. Vestal , Elizabeth J. Kush , Michael Loren Hestness , Eric C. Patty , Jeff Langevin
CPC分类号： B23P19/04 , B23P2700/01 , B64F5/10 , F16B19/109 , Y10T29/49622 , Y10T29/49812 , Y10T29/49947 , Y10T29/49948 , Y10T29/49963
摘要： A temporary fastener and a method of attaching an aircraft skin to a frame using the temporary fastener during a step of the skin to frame assembly process. The fastener secures the skin to the structure while holes for permanent fasteners are drilled through the skin and frame; the fastener is flush mounted so that an automatic drill can drill the holes without interference. The temporary fastener can be removed after the permanent fastener holes are drilled, and before or after permanent fasteners are inserted within their respective holes.
摘要翻译： 临时紧固件和在皮肤到框架组装过程的步骤期间使用临时紧固件将飞行器皮肤附接到框架的方法。 紧固件将皮肤固定在结构上，同时通过皮肤和框架钻出用于永久性紧固件的孔; 紧固件是齐平的安装，使得自动钻头可以钻孔而不受干扰。 在永久性紧固件孔被钻孔之后，以及永久性紧固件插入其相应孔内之前或之后，临时紧固件可被移除。
-
7.发明授权公开(公告)号：US07093351B2
公开(公告)日：2006-08-22
申请号：US10749056
申请日：2003-12-30
CPC分类号： H01R9/2475 , Y10T29/49117 , Y10T29/5187 , Y10T29/532 , Y10T29/53213 , Y10T29/53217 , Y10T428/2982
摘要： A system for assembling wire harnesses with their connectors utilizes a compact computer-based system that is linked to an engineering data base. The data base contains component information, such as harness number, associated wires, and pin location to connector. An integrated tool contains a light panel that is linked to a dummy connector. The dummy connector has a mating end for the connector being pinned. The connector is mated to the dummy connector such that pin holes in the connector align with the light rods in the dummy connector. The wires are identified by voice recognition, bar code, and/or optical character recognition. Once a wire has been identified, the system illuminates the appropriate pin location on the selected connector, thereby providing a visible point of light in which the selected wire is to be terminated.
摘要翻译： 用于将线束与其连接器组装的系统利用与工程数据库相连的紧凑的基于计算机的系统。 数据库包含组件信息，例如线束号，相关电线以及针对连接器的引脚位置。 集成工具包含一个连接到虚拟连接器的灯板。 虚拟连接器具有用于连接器被固定的配合端。 连接器配合到虚拟连接器，使得连接器中的针孔与虚拟连接器中的光棒对准。 电线通过语音识别，条形码和/或光学字符识别来识别。 一旦识别出导线，系统将照亮所选连接器上的适当的引脚位置，从而提供可选择的导线将被终止的可见光点。
-
公开(公告)号：US08209865B2
公开(公告)日：2012-07-03
申请号：US12478596
申请日：2009-06-04
申请人： James A. Kelley , Rick A. Luepke , Lisa M. Vestal , Elizabeth J. Kush , Michael Loren Hestness , Eric C. Patty , Jeff Langevin
发明人： James A. Kelley , Rick A. Luepke , Lisa M. Vestal , Elizabeth J. Kush , Michael Loren Hestness , Eric C. Patty , Jeff Langevin
CPC分类号： B23P19/04 , B23P2700/01 , B64F5/10 , F16B19/109 , Y10T29/49622 , Y10T29/49812 , Y10T29/49947 , Y10T29/49948 , Y10T29/49963
摘要： A temporary fastener and a method of attaching an aircraft skin to a frame using the temporary fastener during a step of the skin to frame assembly process. The fastener secures the skin to the structure while holes for permanent fasteners are drilled through the skin and frame; the fastener is flush mounted so that an automatic drill can drill the holes without interference. The temporary fastener can be removed after the permanent fastener holes are drilled, and before or after permanent fasteners are inserted within their respective holes.
摘要翻译： 临时紧固件和在皮肤到框架组装过程的步骤期间使用临时紧固件将飞行器皮肤附接到框架的方法。 紧固件将皮肤固定在结构上，同时通过皮肤和框架钻出用于永久性紧固件的孔; 紧固件是齐平安装的，使得自动钻头可以钻孔而不受干扰。 在永久性紧固件孔被钻孔之后，以及永久性紧固件插入其相应孔内之前或之后，临时紧固件可被移除。
-
公开(公告)号：US20110024943A1
公开(公告)日：2011-02-03
申请号：US12512238
申请日：2009-07-30
申请人： James A. Kelley , Michael B. Weaver
发明人： James A. Kelley , Michael B. Weaver
IPC分类号： B29C45/14
CPC分类号： B05C17/00573 , B05C11/1002 , B05C17/00513 , B05C17/00516 , B64C3/34 , B64D37/02 , B64F5/10 , F16B19/008 , Y02T50/44
摘要： A system and method for dispensing a sealant over aircraft fasteners secured to a surface in the aircraft. The system includes a nozzle tip having a shroud configured for placement over the fasteners. Sealant is metered to the shroud via an orifice within the nozzle tip. The shroud is sized to leave a space between it and the fastener to control the amount of sealant applied to the fastener upper surface and along the interface between the fastener and aircraft surface. Pressurized fluid urges the sealant through the orifice.
摘要翻译： 一种用于在紧固在飞行器表面上的飞机紧固件上分配密封剂的系统和方法。 该系统包括具有构造成用于放置在紧固件上的护罩的喷嘴尖端。 密封剂通过喷嘴尖端内的孔计量到护罩上。 护罩的尺寸设计成在其与紧固件之间留出一个空间，以控制施加到紧固件上表面并且沿着紧固件和飞行器表面之间的界面的密封剂的量。 加压流体促使密封剂通过孔口。
-
公开(公告)号：US08562888B2
公开(公告)日：2013-10-22
申请号：US12512238
申请日：2009-07-30
IPC分类号： B29C45/14
CPC分类号： B05C17/00573 , B05C11/1002 , B05C17/00513 , B05C17/00516 , B64C3/34 , B64D37/02 , B64F5/10 , F16B19/008 , Y02T50/44
摘要： A system and method for dispensing a sealant over aircraft fasteners secured to a surface in the aircraft. The system includes a nozzle tip having a shroud configured for placement over the fasteners. Sealant is metered to the shroud via an orifice within the nozzle tip. The shroud is sized to leave a space between it and the fastener to control the amount of sealant applied to the fastener upper surface and along the interface between the fastener and aircraft surface. Pressurized fluid urges the sealant through the orifice.
摘要翻译： 一种用于在紧固在飞行器表面上的飞机紧固件上分配密封剂的系统和方法。 该系统包括具有构造成用于放置在紧固件上的护罩的喷嘴尖端。 密封剂通过喷嘴尖端内的孔计量到护罩上。 护罩的尺寸设计成在其与紧固件之间留出一个空间，以控制施加到紧固件上表面并且沿着紧固件和飞行器表面之间的界面的密封剂的量。 加压流体促使密封剂通过孔口。
-
-
-
-
-
-
-
-
-
搜索结果
13 条记录 (耗时 0.031 秒)
