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公开(公告)号:US20050130179A1
公开(公告)日:2005-06-16
申请号:US10875094
申请日:2004-06-23
申请人: Victor Lyamichev , Zbigniev Skrzypczynski , Hatim Allawi , Sarah Wayland , Tsetska Takova , Bruce Neri , James Prudent , Jeff Hall
发明人: Victor Lyamichev , Zbigniev Skrzypczynski , Hatim Allawi , Sarah Wayland , Tsetska Takova , Bruce Neri , James Prudent , Jeff Hall
IPC分类号: G01N33/50 , C07F9/24 , C07F9/59 , C12N9/22 , C12N15/09 , C12Q1/68 , G01N27/447 , G01N33/58 , C07H21/04
CPC分类号: C12N9/22 , C07F9/2408 , C07F9/59 , C12Q1/6816 , C12Q1/6823 , C12Q1/683 , C12Q2525/197 , C12Q2565/125 , C12Q2563/107
摘要: The present invention relates to novel phosphoramidites, including positive and neutrally charged compounds. The present invention also provides charge tags for attachment to materials including solid supports and nucleic acids, wherein the charge tags increase or decrease the net charge of the material. The present invention further provides methods for separating and characterizing molecules based on the charge differentials between modified and unmodified materials.
摘要翻译: 本发明涉及新型亚磷酰胺,包括正中和中性化合物。 本发明还提供用于附着到包括固体支持物和核酸的材料的电荷标签,其中电荷标签增加或减少材料的净电荷。 本发明还提供了基于修饰材料和未改性材料之间的电荷差异分离和表征分子的方法。
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公开(公告)号:US06780982B2
公开(公告)日:2004-08-24
申请号:US09777430
申请日:2001-02-06
申请人: Victor Lyamichev , Zbigniew Skrzpczynski , Hatim T. Allawi , Sarah R. Wayland , Tsetska Takova , Bruce P. Neri
发明人: Victor Lyamichev , Zbigniew Skrzpczynski , Hatim T. Allawi , Sarah R. Wayland , Tsetska Takova , Bruce P. Neri
IPC分类号: C07H2100
CPC分类号: C12N9/22 , C07F9/2408 , C07F9/59 , C12Q1/6816 , C12Q1/6823 , C12Q1/683 , C12Q2525/197 , C12Q2565/125 , C12Q2563/107
摘要: The present invention relates to novel phosphoramidites, including positive and neutrally charged compounds. The present invention also provides charge tags for attachment to materials including solid supports and nucleic acids, wherein the charge tags increase or decrease the net charge of the material. The present invention further provides methods for separating and characterizing molecules based on the charge differentials between modified and unmodified materials.
摘要翻译: 本发明涉及新型亚磷酰胺,包括正中和中性化合物。 本发明还提供用于附着到包括固体支持物和核酸的材料的电荷标签,其中电荷标签增加或减少材料的净电荷。 本发明还提供了基于修饰材料和未改性材料之间的电荷差异分离和表征分子的方法。
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