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公开(公告)号：US20090078574A1
公开(公告)日：2009-03-26
申请号：US12132198
申请日：2008-06-03
申请人： Victor Lyamichev , Zbigniev Skrzypczynski , Hatim T. Allawi , Sarah R. Wayland , Tsetska Y. Takova , Bruce P. Neri , James R. Prudent , Jeff G. Hall
发明人： Victor Lyamichev , Zbigniev Skrzypczynski , Hatim T. Allawi , Sarah R. Wayland , Tsetska Y. Takova , Bruce P. Neri , James R. Prudent , Jeff G. Hall
CPC分类号： C12N9/22 , C07F9/2408 , C07F9/59 , C12Q1/6816 , C12Q1/6823 , C12Q1/683 , C12Q2525/197 , C12Q2565/125 , C12Q2563/107
摘要： The present invention relates to novel phosphoramidites, including positive and neutrally charged compounds. The present invention also provides charge tags for attachment to materials including solid supports and nucleic acids, wherein the charge tags increase or decrease the net charge of the material. The present invention further provides methods for separating and characterizing molecules based on the charge differentials between modified and unmodified materials.
摘要翻译： 本发明涉及新型亚磷酰胺，包括正中和中性化合物。 本发明还提供用于附着到包括固体支持物和核酸的材料的电荷标签，其中电荷标签增加或减少材料的净电荷。 本发明还提供了基于修饰材料和未改性材料之间的电荷差异分离和表征分子的方法。
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公开(公告)号：US07678542B2
公开(公告)日：2010-03-16
申请号：US12132198
申请日：2008-06-03
申请人： Victor Lyamichev , Zbigniev Skrzypczynski , Hatim T. Allawi , Sarah R. Wayland , Tsetska Y. Takova , Bruce P. Neri , James R. Prudent , Jeff G. Hall
发明人： Victor Lyamichev , Zbigniev Skrzypczynski , Hatim T. Allawi , Sarah R. Wayland , Tsetska Y. Takova , Bruce P. Neri , James R. Prudent , Jeff G. Hall
CPC分类号： C12N9/22 , C07F9/2408 , C07F9/59 , C12Q1/6816 , C12Q1/6823 , C12Q1/683 , C12Q2525/197 , C12Q2565/125 , C12Q2563/107
摘要： The present invention relates to novel phosphoramidites, including positive and neutrally charged compounds. The present invention also provides charge tags for attachment to materials including solid supports and nucleic acids, wherein the charge tags increase or decrease the net charge of the material. The present invention further provides methods for separating and characterizing molecules based on the charge differentials between modified and unmodified materials.
摘要翻译： 本发明涉及新型亚磷酰胺，包括正中和中性化合物。 本发明还提供用于附着到包括固体支持物和核酸的材料的电荷标签，其中电荷标签增加或减少材料的净电荷。 本发明还提供了基于修饰材料和未改性材料之间的电荷差异分离和表征分子的方法。
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公开(公告)号：US07384746B2
公开(公告)日：2008-06-10
申请号：US10875094
申请日：2004-06-23
申请人： Victor Lyamichev , Zbigniev Skrzypczynski , Hatim T. Allawi , Sarah R. Wayland , Tsetska Y. Takova , Bruce P. Neri , James R. Prudent , Jeff G. Hall
发明人： Victor Lyamichev , Zbigniev Skrzypczynski , Hatim T. Allawi , Sarah R. Wayland , Tsetska Y. Takova , Bruce P. Neri , James R. Prudent , Jeff G. Hall
CPC分类号： C12N9/22 , C07F9/2408 , C07F9/59 , C12Q1/6816 , C12Q1/6823 , C12Q1/683 , C12Q2525/197 , C12Q2565/125 , C12Q2563/107
摘要： The present invention relates to novel phosphoramidites, including positive and neutrally charged compounds. The present invention also provides charge tags for attachment to materials including solid supports and nucleic acids, wherein the charge tags increase or decrease the net charge of the material. The present invention further provides methods for separating and characterizing molecules based on the charge differentials between modified and unmodified materials.
摘要翻译： 本发明涉及新型亚磷酰胺，包括正中和中性化合物。 本发明还提供用于附着到包括固体支持物和核酸的材料的电荷标签，其中电荷标签增加或减少材料的净电荷。 本发明还提供了基于修饰材料和未改性材料之间的电荷差异分离和表征分子的方法。
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公开(公告)号：US20090142754A1
公开(公告)日：2009-06-04
申请号：US11929404
申请日：2007-10-30
申请人： Hatim T. Allawi , Brad T. Argue , Christian Tor Bartholomay , LuAnne Chehak , Michelle L. Curtis , Peggy S. Eis , Jeff G. Hall , Hon S. Ip , Lin Ji , Michael W. Kaiser , Robert W. Kwiatkowski , Andrew A. Lukowiak , Victor Lyamichev , Natalie E. Lyamicheva , WuPo Ma , Bruce P. Neri , Sarah M. Olson , Marilyn C. Olson-Munoz , James J. Schaefer , Zbigniev Skrzypczynski , Tsetska Y. Takova , Lisa C. Thompson , Kevin L. Vedvik
发明人： Hatim T. Allawi , Brad T. Argue , Christian Tor Bartholomay , LuAnne Chehak , Michelle L. Curtis , Peggy S. Eis , Jeff G. Hall , Hon S. Ip , Lin Ji , Michael W. Kaiser , Robert W. Kwiatkowski , Andrew A. Lukowiak , Victor Lyamichev , Natalie E. Lyamicheva , WuPo Ma , Bruce P. Neri , Sarah M. Olson , Marilyn C. Olson-Munoz , James J. Schaefer , Zbigniev Skrzypczynski , Tsetska Y. Takova , Lisa C. Thompson , Kevin L. Vedvik
CPC分类号： C12Q1/6823 , C12N9/1252 , C12N9/22 , C12Q1/683 , Y10T436/143333 , C12Q2561/109
摘要： The present invention provides novel cleavage agents and polymerases for the cleavage and modification of nucleic acid. The cleavage agents and polymerases find use, for example, for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. In some embodiments, the 5′ nuclease activity of a variety of enzymes is used to cleave a target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
摘要翻译： 本发明提供了用于切割和修饰核酸的新型切割剂和聚合酶。 裂解剂和聚合酶可用于例如核酸序列的检测和表征以及核酸序列的变化。 在一些实施方案中，使用各种酶的5'核酸酶活性来切割靶依赖性切割结构，从而指示特异性核酸序列的存在或其特定变体。
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公开(公告)号：US07150982B2
公开(公告)日：2006-12-19
申请号：US10084839
申请日：2002-02-26
申请人： Hatim T. Allawi , Brad T. Argue , Christian Tor Bartholomay , LuAnne Chehak , Michelle L. Curtis , Peggy S. Eis , Jeff G. Hall , Hon S. Ip , Lin Ji , Michael W. Kaiser , Robert W. Kwiatkowski , Andrew A. Lukowiak , Victor Lyamichev , Natalie E. Lyamicheva , WuPo Ma , Bruce P. Neri , Sarah M. Olson , Marilyn C. Olson-Munoz , James J. Schaefer , Zbigniev Skrzypczynski , Tsetska Y. Takova , Lisa C. Thompson , Kevin L. Vedvik
发明人： Hatim T. Allawi , Brad T. Argue , Christian Tor Bartholomay , LuAnne Chehak , Michelle L. Curtis , Peggy S. Eis , Jeff G. Hall , Hon S. Ip , Lin Ji , Michael W. Kaiser , Robert W. Kwiatkowski , Andrew A. Lukowiak , Victor Lyamichev , Natalie E. Lyamicheva , WuPo Ma , Bruce P. Neri , Sarah M. Olson , Marilyn C. Olson-Munoz , James J. Schaefer , Zbigniev Skrzypczynski , Tsetska Y. Takova , Lisa C. Thompson , Kevin L. Vedvik
IPC分类号： C12N9/22
CPC分类号： C12N9/1252 , C12N9/22 , C12Q1/6809 , C12Q1/6823 , C12Q1/6827 , H04L29/06 , H04L29/06027 , H04L69/32 , C12Q2561/109 , C12Q2537/162 , C12Q2525/161
摘要： The present invention provides novel cleavage agents and polymerases for the cleavage and modification of nucleic acid. The cleavage agents and polymerases find use, for example, for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. In some embodiments, the 5′ nuclease activity of a variety of enzymes is used to cleave a target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
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公开(公告)号：US07935800B2
公开(公告)日：2011-05-03
申请号：US11642815
申请日：2006-12-19
申请人： Hatim T. Allawi , Brad T. Argue , Christian Tor Bartholomay , LuAnne Chehak , Michelle L. Curtis , Peggy S. Eis , Jeff G. Hall , Hon S. Ip , Lin Ji , Michael W. Kaiser , Robert W. Kwiatkowski , Andrew A. Lukowiak , Victor Lyamichev , Natalie E. Lyamicheva , WuPo Ma , Bruce P. Neri , Sarah M. Olson , Marilyn C. Olson-Munoz , James J. Schaefer , Zbigniev Skrzypczynski , Tsetska Y Takova , Lisa C. Thompson , Kevin L. Vedvik
发明人： Hatim T. Allawi , Brad T. Argue , Christian Tor Bartholomay , LuAnne Chehak , Michelle L. Curtis , Peggy S. Eis , Jeff G. Hall , Hon S. Ip , Lin Ji , Michael W. Kaiser , Robert W. Kwiatkowski , Andrew A. Lukowiak , Victor Lyamichev , Natalie E. Lyamicheva , WuPo Ma , Bruce P. Neri , Sarah M. Olson , Marilyn C. Olson-Munoz , James J. Schaefer , Zbigniev Skrzypczynski , Tsetska Y Takova , Lisa C. Thompson , Kevin L. Vedvik
CPC分类号： C12Q1/6823 , C12N9/1252 , C12N9/22 , C12Q1/683 , Y10T436/143333 , C12Q2561/109
摘要： The present invention provides novel cleavage agents and polymerases for the cleavage and modification of nucleic acid. The cleavage agents and polymerases find use, for example, for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. In some embodiments, the 5′ nuclease activity of a variety of enzymes is used to cleave a target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
摘要翻译： 本发明提供了用于切割和修饰核酸的新型切割剂和聚合酶。 裂解剂和聚合酶可用于例如核酸序列的检测和表征以及核酸序列的变化。 在一些实施方案中，使用各种酶的5'核酸酶活性来切割靶依赖性切割结构，从而指示特异性核酸序列的存在或其特定变体。
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公开(公告)号：US07807806B2
公开(公告)日：2010-10-05
申请号：US11929404
申请日：2007-10-30
申请人： Hatim T. Allawi , Brad T. Argue , Christian Tor Bartholomay , LuAnne Chehak , Michelle L. Curtis , Peggy S. Eis , Jeff G. Hall , Hon S. Ip , Lin Ji , Michael W. Kaiser , Robert W. Kwiatkowski , Andrew A. Lukowiak , Victor Lyamichev , Natalie E. Lyamicheva , Wupo Ma , Bruce P. Neri , Sarah M. Olson , Marilyn C. Olson-Munoz , James J. Schaefer , Zbigniev Skrzypczynski , Tsetska Y. Takova , Lisa C. Thompson , Kevin L. Vedvik
发明人： Hatim T. Allawi , Brad T. Argue , Christian Tor Bartholomay , LuAnne Chehak , Michelle L. Curtis , Peggy S. Eis , Jeff G. Hall , Hon S. Ip , Lin Ji , Michael W. Kaiser , Robert W. Kwiatkowski , Andrew A. Lukowiak , Victor Lyamichev , Natalie E. Lyamicheva , Wupo Ma , Bruce P. Neri , Sarah M. Olson , Marilyn C. Olson-Munoz , James J. Schaefer , Zbigniev Skrzypczynski , Tsetska Y. Takova , Lisa C. Thompson , Kevin L. Vedvik
CPC分类号： C12Q1/6823 , C12N9/1252 , C12N9/22 , C12Q1/683 , Y10T436/143333 , C12Q2561/109
摘要： The present invention provides novel cleavage agents and polymerases for the cleavage and modification of nucleic acid. The cleavage agents and polymerases find use, for example, for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. In some embodiments, the 5′ nuclease activity of a variety of enzymes is used to cleave a target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
摘要翻译： 本发明提供了用于切割和修饰核酸的新型切割剂和聚合酶。 裂解剂和聚合酶可用于例如核酸序列的检测和表征以及核酸序列的变化。 在一些实施方案中，使用各种酶的5'核酸酶活性来切割靶依赖性切割结构，从而指示特异性核酸序列的存在或其特定变体。
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公开(公告)号：US20110104682A1
公开(公告)日：2011-05-05
申请号：US12898490
申请日：2010-10-05
申请人： Hatim Allawi , Brad T. Argue , Christian Tor Bartholomay , LuAnne Chehak , Michelle L. Curtis , Peggy S. Eis , Jeff G. Hall , Hon S. Ip , Lin Ji , Michael Kaiser , Robert W. Kwiatkowski, JR. , Andrew A. Lukowiak , Victor Lyamichev , Natalie E. Lyamicheva , WuPo Ma , Bruce P. Neri , Sarah M. Olson , Marilyn C. Olson-Munoz , James J. Schaefer , Zbigniev Skrzypczynski , Tsetska Y. Takova , Lisa C. Thompson , Kevin L. Vedvik
发明人： Hatim Allawi , Brad T. Argue , Christian Tor Bartholomay , LuAnne Chehak , Michelle L. Curtis , Peggy S. Eis , Jeff G. Hall , Hon S. Ip , Lin Ji , Michael Kaiser , Robert W. Kwiatkowski, JR. , Andrew A. Lukowiak , Victor Lyamichev , Natalie E. Lyamicheva , WuPo Ma , Bruce P. Neri , Sarah M. Olson , Marilyn C. Olson-Munoz , James J. Schaefer , Zbigniev Skrzypczynski , Tsetska Y. Takova , Lisa C. Thompson , Kevin L. Vedvik
CPC分类号： C12Q1/6823 , C12N9/1252 , C12N9/22 , C12Q1/683 , Y10T436/143333 , C12Q2561/109
摘要： The present invention provides novel cleavage agents and polymerases for the cleavage and modification of nucleic acid. The cleavage agents and polymerases find use, for example, for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. In some embodiments, the 5′ nuclease activity of a variety of enzymes is used to cleave a target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
摘要翻译： 本发明提供了用于切割和修饰核酸的新型切割剂和聚合酶。 裂解剂和聚合酶可用于例如核酸序列的检测和表征以及核酸序列的变化。 在一些实施方案中，使用各种酶的5'核酸酶活性来切割靶依赖性切割结构，从而指示特异性核酸序列的存在或其特定变体。
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公开(公告)号：US08063184B2
公开(公告)日：2011-11-22
申请号：US12898490
申请日：2010-10-05
申请人： Hatim Allawi , Brad T. Argue , Christian Tor Bartholomay , LuAnne Chehak , Michelle L. Curtis , Peggy S. Eis , Jeff G. Hall , Hon S. Ip , Lin Ji , Michael Kaiser , Robert W. Kwiatkowski, Jr. , Andrew A. Lukowiak , Victor Lyamichev , Natalie E. Lyamicheva , WuPo Ma , Bruce P. Neri , Sarah M. Olson , Marilyn C. Olson-Munoz , James J. Schaefer , Zbigniev Skrzypczynski , Tsetska Y. Takova , Lisa C. Thompson , Kevin L. Vedvik
发明人： Hatim Allawi , Brad T. Argue , Christian Tor Bartholomay , LuAnne Chehak , Michelle L. Curtis , Peggy S. Eis , Jeff G. Hall , Hon S. Ip , Lin Ji , Michael Kaiser , Robert W. Kwiatkowski, Jr. , Andrew A. Lukowiak , Victor Lyamichev , Natalie E. Lyamicheva , WuPo Ma , Bruce P. Neri , Sarah M. Olson , Marilyn C. Olson-Munoz , James J. Schaefer , Zbigniev Skrzypczynski , Tsetska Y. Takova , Lisa C. Thompson , Kevin L. Vedvik
CPC分类号： C12Q1/6823 , C12N9/1252 , C12N9/22 , C12Q1/683 , Y10T436/143333 , C12Q2561/109
摘要： The present invention provides novel cleavage agents and polymerases for the cleavage and modification of nucleic acid. The cleavage agents and polymerases find use, for example, for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. In some embodiments, the 5′ nuclease activity of a variety of enzymes is used to cleave a target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
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公开(公告)号：US20080293046A1
公开(公告)日：2008-11-27
申请号：US11642815
申请日：2006-12-19
申请人： Hatim Allawi , Brad T. Argue , Christian Tor Bartholomay , LuAnne Chehak , Michelle L. Curtis , Peggy S. Eis , Jeff G. Hall , Hon S. Ip , Lin Ji , Michael Kaiser , Robert W. Kwiatkowski, JR. , Andrew A. Lukowiak , Victor Lyamichev , Natalie E. Lyamicheva , WuPo Ma , Bruce P. Neri , Sarah M. Olson , Marilyn C. Olson-Munoz , James J. Schaefer , Zbigniev Skrzypczynski , Tsetska Y. Takova , Lisa C. Thompson , Kevin L. Vedvik
发明人： Hatim Allawi , Brad T. Argue , Christian Tor Bartholomay , LuAnne Chehak , Michelle L. Curtis , Peggy S. Eis , Jeff G. Hall , Hon S. Ip , Lin Ji , Michael Kaiser , Robert W. Kwiatkowski, JR. , Andrew A. Lukowiak , Victor Lyamichev , Natalie E. Lyamicheva , WuPo Ma , Bruce P. Neri , Sarah M. Olson , Marilyn C. Olson-Munoz , James J. Schaefer , Zbigniev Skrzypczynski , Tsetska Y. Takova , Lisa C. Thompson , Kevin L. Vedvik
CPC分类号： C12Q1/6823 , C12N9/1252 , C12N9/22 , C12Q1/683 , Y10T436/143333 , C12Q2561/109
摘要： The present invention provides novel cleavage agents and polymerases for the cleavage and modification of nucleic acid. The cleavage agents and polymerases find use, for example, for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. In some embodiments, the 5′ nuclease activity of a variety of enzymes is used to cleave a target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
摘要翻译： 本发明提供了用于切割和修饰核酸的新型切割剂和聚合酶。 裂解剂和聚合酶可用于例如核酸序列的检测和表征以及核酸序列的变化。 在一些实施方案中，使用各种酶的5'核酸酶活性来切割靶依赖性切割结构，从而指示特异性核酸序列的存在或其特定变体。
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