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1.发明申请Apparatuses for Detecting and Recognizing Analytes Based on Their Crystallization Patterns 审中-公开基于其结晶模式检测和识别分析物的装置公开(公告)号：US20110105344A1
公开(公告)日：2011-05-05
申请号：US12941650
申请日：2011-01-19
IPC分类号： C40B30/00
CPC分类号： C30B7/00 , C30B29/58 , Y10T436/105831 , Y10T436/12 , Y10T436/25 , Y10T436/2575
摘要： The invention contemplates apparatuses for recognition of proteins and other biological molecules by imaging morphology, size and distribution of crystalline and amorphous dry residues in droplets (further referred to as “crystallization patterns”) containing predetermined amount of certain crystal-forming organic compounds (reporters) to which protein to be analyzed is added. Changes in the crystallization patterns of a number of amino-acids can be used as a “signature” of a protein added. Also, changes in the crystallization patterns, as well as the character of such changes, can be used as recognition elements in analysis of protein molecules.
摘要翻译： 本发明考虑通过成像含有预定量的某些结晶形成有机化合物（记者）的液滴中的结晶和无定形干燥残余物（进一步称为“结晶图案”）的形态，尺寸和分布来识别蛋白质和其它生物分子的装置， 加入待分析的蛋白质。 许多氨基酸的结晶模式的变化可以用作加入的蛋白质的“特征”。 此外，结晶模式的变化以及这种变化的特征可以用作分析蛋白质分子的识别元件。
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2.发明授权公开(公告)号：US07368288B2
公开(公告)日：2008-05-06
申请号：US11397908
申请日：2006-04-05
IPC分类号： G01N21/00
CPC分类号： C30B7/00 , C30B29/58 , Y10T436/105831 , Y10T436/12 , Y10T436/25 , Y10T436/2575
摘要： The invention contemplates a method for recognition of proteins and other biological molecules by imaging morphology, size and distribution of crystalline and amorphous dry residues in droplets (further referred to as “crystallization pattern”) containing predetermined amount of certain crystal-forming organic compounds (reporters) to which protein to be analyzed is added. It has been shown that changes in the crystallization patterns of a number of amino-acids can be used as a “signature” of a protein added. It was also found that both the character of changer in the crystallization patter and the fact of such changes can be used as recognition elements in analysis of protein molecules.
摘要翻译： 本发明考虑了通过将含有预定量的某些成晶有机化合物的液滴（进一步称为“结晶图案”）的晶体和无定形干燥残余物的形态，尺寸和分布进行成像，鉴定蛋白质和其他生物分子的方法。 ）加入待分析的蛋白质。 已经表明，许多氨基酸的结晶模式的变化可以用作加入的蛋白质的“特征”。 还发现，结晶模式中变换器的特征和这种变化的事实都可以用作分析蛋白质分子的识别元件。
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3.发明授权Apparatus for detecting and recognizing analytes based on their crystallization patterns 有权用于根据其结晶模式检测和识别分析物的装置公开(公告)号：US07850915B2
公开(公告)日：2010-12-14
申请号：US12041295
申请日：2008-03-03
CPC分类号： C30B7/00 , C30B29/58 , Y10T436/105831 , Y10T436/12 , Y10T436/25 , Y10T436/2575
摘要： The invention contemplates apparatuses for recognition of proteins and other biological molecules by imaging morphology, size and distribution of crystalline and amorphous dry residues in droplets (further referred to as “crystallization patterns”) containing predetermined amount of certain crystal-forming organic compounds (reporters) to which protein to be analyzed is added. Changes in the crystallization patterns of a number of amino-acids can be used as a “signature” of a protein added. Also, changes in the crystallization patterns, as well as the character of such changes, can be used as recognition elements in analysis of protein molecules.
摘要翻译： 本发明考虑通过成像含有预定量的某些结晶形成有机化合物（记者）的液滴中的结晶和无定形干燥残余物（进一步称为“结晶图案”）的形态，尺寸和分布来识别蛋白质和其他生物分子的装置， 加入待分析的蛋白质。 许多氨基酸的结晶模式的变化可以用作加入的蛋白质的“特征”。 此外，结晶模式的变化以及这种变化的特征可以用作分析蛋白质分子的识别元件。
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4.发明申请公开(公告)号：US20080152233A1
公开(公告)日：2008-06-26
申请号：US12041295
申请日：2008-03-03
IPC分类号： G06K9/00
CPC分类号： C30B7/00 , C30B29/58 , Y10T436/105831 , Y10T436/12 , Y10T436/25 , Y10T436/2575
摘要： The invention contemplates apparatuses for recognition of proteins and other biological molecules by imaging morphology, size and distribution of crystalline and amorphous dry residues in droplets (further referred to as “crystallization patterns”) containing predetermined amount of certain crystal-forming organic compounds (reporters) to which protein to be analyzed is added. Changes in the crystallization patterns of a number of amino-acids can be used as a “signature” of a protein added. Also, changes in the crystallization patterns, as well as the character of such changes, can be used as recognition elements in analysis of protein molecules.
摘要翻译： 本发明考虑通过成像含有预定量的某些结晶形成有机化合物（记者）的液滴中的结晶和无定形干燥残余物（进一步称为“结晶图案”）的形态，尺寸和分布来识别蛋白质和其他生物分子的装置， 加入待分析的蛋白质。 许多氨基酸的结晶模式的变化可以用作加入的蛋白质的“特征”。 此外，结晶模式的变化以及这种变化的特征可以用作分析蛋白质分子的识别元件。
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5.发明授权Electrospray neutralization process and apparatus for generation of nano-aerosol and nano-structured materials 有权用于生成纳米气溶胶和纳米结构材料的电喷雾中和过程和装置公开(公告)号：US07776405B2
公开(公告)日：2010-08-17
申请号：US11561138
申请日：2006-11-17
IPC分类号： B05D1/04
CPC分类号： B01D46/0001 , B01D39/1623 , B01D46/10 , B01D2239/0435 , B01D2275/10 , D01D5/0007
摘要： The claimed invention describes methods and apparatuses for manufacturing nano-aerosols and nano-structured materials based on the neutralization of charged electrosprayed products with oppositely charged electrosprayed products. Electrosprayed products include molecular ions, nano-clusters and nano-fibers. Nano-aerosols can be generated when neutralization occurs in the gas phase. Neutralization of electrospan nano-fibers with molecular ions and charged nano-clusters may result in the formation of fibrous aerosols or free nano-mats. Nano-mats can also be produced on a suitable substrate, forming efficient nano-filters.
摘要翻译： 所要求保护的发明描述了基于带有相反电荷的电喷雾产物的带电电喷雾产物的中和来制造纳米气溶胶和纳米结构材料的方法和装置。 电喷产品包括分子离子，纳米簇和纳米纤维。 当在气相中发生中和时，可产生纳米气溶胶。 用分子离子和带电荷的纳米簇中和电纺丝纳米纤维可能导致纤维状气溶胶或游离纳米垫的形成。 纳米垫也可以在合适的基底上生产，形成有效的纳米过滤器。
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6.发明授权公开(公告)号：US08597932B2
公开(公告)日：2013-12-03
申请号：US11419593
申请日：2006-05-22
摘要： The invention involves developing and stabilizing cultivating droplets within a matrix of a porous medium. A cultivation medium may be selected, prepared and mixed with a surfactant. Where cells are desired to be cultured in droplets, cells may be added. The mixture may be converted into cultivating droplets. The cultivating droplets may be stabilized by introducing them to a porous medium. The porous medium may contain hydrophobic particles. Stabilized, cultivating droplets having one or more cells may form an aseptic microenvironment for the concentrated growth of cells.
摘要翻译： 本发明涉及在多孔介质的基质内培养和稳定培养液滴。 培养基可以选择，制备并与表面活性剂混合。 当需要细胞培养液滴时，可加入细胞。 混合物可以转化为培养液滴。 培养液滴可以通过将它们引入多孔介质来稳定。 多孔介质可能含有疏水性颗粒。 具有一个或多个细胞的稳定化培养液滴可形成用于细胞浓缩生长的无菌微环境。
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7.发明申请Electrospray Neutralization Process and Apparatus for Generation of Nan-Aerosol and Nano-Structured Materials 审中-公开用于生成纳米气溶胶和纳米结构材料的电喷雾中和过程和装置公开(公告)号：US20100275780A1
公开(公告)日：2010-11-04
申请号：US12832323
申请日：2010-07-08
CPC分类号： B01D46/0001 , B01D39/1623 , B01D46/10 , B01D2239/0435 , B01D2275/10 , D01D5/0007
摘要： The claimed invention describes methods and apparatuses for manufacturing nano-aerosols and nano-structured materials based on the neutralization of charged electrosprayed products with oppositely charged electrosprayed products. Electrosprayed products include molecular ions, nano-clusters and nano-fibers. Nano-aerosols can be generated when neutralization occurs in the gas phase. Neutralization of electrospan nano-fibers with molecular ions and charged nano-clusters may result in the formation of fibrous aerosols or free nano-mats. Nano-mats can also be produced on a suitable substrate, forming efficient nano-filters.
摘要翻译： 所要求保护的发明描述了基于带有相反电荷的电喷雾产物的带电电喷雾产物的中和来制造纳米气溶胶和纳米结构材料的方法和装置。 电喷产品包括分子离子，纳米簇和纳米纤维。 当在气相中发生中和时，可产生纳米气溶胶。 用分子离子和带电荷的纳米簇中和电纺丝纳米纤维可能导致纤维状气溶胶或游离纳米垫的形成。 纳米垫也可以在合适的基底上生产，形成有效的纳米过滤器。
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公开(公告)号：US20120076694A1
公开(公告)日：2012-03-29
申请号：US12891135
申请日：2010-09-27
IPC分类号： G01N30/00
CPC分类号： G01N33/543 , G01N27/447
摘要： Analytes using an active assay may be detected by introducing an analyte solution containing a plurality of analytes to a lacquered membrane. The lacquered membrane may be a membrane having at least one surface treated with a layer of polymers. The lacquered membrane may be semi-permeable to nonanalytes. The layer of polymers may include cross-linked polymers. A plurality of probe molecules may be arrayed and immobilized on the lacquered membrane. An external force may be applied to the analyte solution to move the analytes towards the lacquered membrane. Movement may cause some or all of the analytes to bind to the lacquered membrane. In cases where probe molecules are presented, some or all of the analytes may bind to probe molecules. The direction of the external force may be reversed to remove unbound or weakly bound analytes. Bound analytes may be detected using known detection types.
摘要翻译： 使用活性测定法的分析物可以通过将含有多种分析物的分析物溶液引入涂漆膜来检测。 漆膜可以是具有用聚合物层处理的至少一个表面的膜。 漆膜可能对非分析物半渗透。 聚合物层可以包括交联聚合物。 可以将多个探针分子排列并固定在涂漆膜上。 可以将外力施加到分析物溶液以将分析物移动到漆膜。 运动可能导致部分或全部分析物结合到漆膜上。 在存在探针分子的情况下，部分或全部分析物可能与探针分子结合。 外力的方向可以颠倒以去除未结合或弱结合的分析物。 可以使用已知的检测类型检测结合的分析物。
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公开(公告)号：US07824927B2
公开(公告)日：2010-11-02
申请号：US11397905
申请日：2006-04-05
IPC分类号： G01N33/549 , C12M3/00
CPC分类号： G01N33/544 , Y10T436/25375 , Y10T436/255
摘要： Analytes using an active assay may be detected by introducing an analyte solution containing a plurality of analytes to a lacquered membrane. The lacquered membrane may be a membrane having at least one surface treated with a layer of polymers. The lacquered membrane may be semi-permeable to nonanalytes. The layer of polymers may include cross-linked polymers. A plurality of probe molecules may be arrayed and immobilized on the lacquered membrane. An external force may be applied to the analyte solution to move the analytes towards the lacquered membrane. Movement may cause some or all of the analytes to bind to the lacquered membrane. In cases where probe molecules are presented, some or all of the analytes may bind to probe molecules. The direction of the external force may be reversed to remove unbound or weakly bound analytes. Bound analytes may be detected using known detection types.
摘要翻译： 使用活性测定法的分析物可以通过将含有多种分析物的分析物溶液引入涂漆膜来检测。 漆膜可以是具有用聚合物层处理的至少一个表面的膜。 漆膜可能对非分析物半渗透。 聚合物层可以包括交联聚合物。 可以将多个探针分子排列并固定在涂漆膜上。 可以将外力施加到分析物溶液以将分析物移动到漆膜。 运动可能导致部分或全部分析物结合到漆膜上。 在存在探针分子的情况下，部分或全部分析物可能与探针分子结合。 外力的方向可以颠倒以去除未结合或弱结合的分析物。 可以使用已知的检测类型检测结合的分析物。
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公开(公告)号：US20060275824A1
公开(公告)日：2006-12-07
申请号：US11397908
申请日：2006-04-05
IPC分类号： G06F19/00
CPC分类号： C30B7/00 , C30B29/58 , Y10T436/105831 , Y10T436/12 , Y10T436/25 , Y10T436/2575
摘要： The invention contemplates a method for recognition of proteins and other biological molecules by imaging morphology, size and distribution of crystalline and amorphous dry residues in droplets (further referred to as “crystallization pattern”) containing predetermined amount of certain crystal-forming organic compounds (reporters) to which protein to be analyzed is added. It has been shown that changes in the crystallization patterns of a number of amino-acids can be used as a “signature” of a protein added. It was also found that both the character of changer in the crystallization patter and the fact of such changes can be used as recognition elements in analysis of protein molecules.
摘要翻译： 本发明考虑了通过将含有预定量的某些成晶有机化合物的液滴（进一步称为“结晶图案”）的晶体和无定形干燥残余物的形态，尺寸和分布进行成像，鉴定蛋白质和其他生物分子的方法。 ）加入待分析的蛋白质。 已经表明，许多氨基酸的结晶模式的变化可以用作加入的蛋白质的“特征”。 还发现，结晶模式中变换器的特征和这种变化的事实都可以用作分析蛋白质分子的识别元件。
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