公开(公告)号：US20050020576A1

公开(公告)日：2005-01-27

申请号：US10807113

申请日：2004-03-23

Applicant: Wei Zhang ,  Alan Maycock ,  Michael Marella ,  Virendra Kumar ,  Forrest Gaul ,  Michael Chang ,  Deqi Guo

Inventor： Wei Zhang ,  Alan Maycock ,  Michael Marella ,  Virendra Kumar ,  Forrest Gaul ,  Michael Chang ,  Deqi Guo

IPC: A61K31/404 ,  A61K31/4439 ,  A61K45/06 ,  C07D207/12 ,  C07D209/42 ,  C07D213/56 ,  C07D241/04 ,  C07D295/073 ,  C07D403/06 ,  A61K31/55 ,  A61K31/40 ,  A61K31/445

CPC classification number: C07D295/073 ,  A61K31/404 ,  A61K31/4439 ,  A61K45/06 ,  C07D207/12 ,  C07D209/42 ,  C07D213/56 ,  C07D241/04 ,  C07D403/06

Abstract: Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics are provided. The compounds of formulae I, II, IIA, III, IIIA, IIIB, IIB-i, IV and IVA have the structure: wherein R1, R2, R3, R4; and X, X4, X5, X7, X9; Y, Z and n are as described in the specification.

Abstract translation: 提供了具有κ阿片样物质激动剂活性的化合物，含有它们的组合物和使用它们作为止痛剂的方法。 式I，II，IIA，III，IIIA，IIIB，IIB-i，IV和IVA的化合物具有以下结构：其中R1，R2，R3，R4; X，X4，X5，X7，X9; Y，Z和n如说明书中所述。

公开(公告)号：US06750216B2

公开(公告)日：2004-06-15

申请号：US10146693

申请日：2002-05-15

Applicant: Virendra Kumar ,  Deqi Guo ,  Michael Anthony Marella ,  Alan L. Maycock

Inventor： Virendra Kumar ,  Deqi Guo ,  Michael Anthony Marella ,  Alan L. Maycock

IPC: A61K3144

CPC classification number: C07D295/073 ,  A61K31/404 ,  A61K31/4439 ,  A61K45/06 ,  C07D207/12 ,  C07D209/42 ,  C07D213/56 ,  C07D241/04 ,  C07D403/06

Abstract: Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics are provided. The compounds of formula IIIB have the structure: wherein R1, R2, R, Ar and n are as described in the specification.

Abstract translation: 提供了具有κ阿片样物质激动剂活性的化合物，含有它们的组合物和使用它们作为止痛剂的方法。 式IIIB的化合物具有以下结构：其中R1，R2，R，Arand n如说明书中所述。

公开(公告)号：US06180623B2

公开(公告)日：2001-01-30

申请号：US09436057

申请日：1999-11-08

Applicant: Lawrence I. Kruse ,  An-Chih Chang ,  Diane L. DeHaven-Hudkins ,  John J. Farrar ,  Forrest Gaul ,  Virendra Kumar ,  Michael Anthony Marella ,  Alan L. Maycock ,  Wei Yuan Zhang

Inventor： Lawrence I. Kruse ,  An-Chih Chang ,  Diane L. DeHaven-Hudkins ,  John J. Farrar ,  Forrest Gaul ,  Virendra Kumar ,  Michael Anthony Marella ,  Alan L. Maycock ,  Wei Yuan Zhang

IPC: A61K31337

CPC classification number: A61K31/404 ,  A61K31/40 ,  A61K31/4439 ,  C07D209/42 ,  C07D213/56 ,  C07D241/04 ,  Y02A50/422

Abstract: Compounds having kappa opioid agonist activity, compositions containing them and methods of using them as analgesics and anti-pruritic agents are provided. The compounds of formula IV have the structure: wherein X9; R1, R2, R3, R4; and n are as described in the specification.

Abstract translation: 提供了具有κ阿片样物质激动剂活性的化合物，含有它们的组合物和使用它们作为止痛剂和抗瘙痒剂的方法。式IV化合物具有以下结构：其中X 9; R 1，R 2，R 3，R 4; andn如说明书中所述。

公开(公告)号：US6004964A

公开(公告)日：1999-12-21

申请号：US184393

申请日：1998-11-02

Applicant: John J. Farrar ,  An-Chih Chang ,  Virendra Kumar ,  Wei Yuan Zhang ,  Alan Cowan

Inventor： John J. Farrar ,  An-Chih Chang ,  Virendra Kumar ,  Wei Yuan Zhang ,  Alan Cowan

IPC: C07D295/12 ,  A61K31/166 ,  A61K31/22 ,  A61K31/397 ,  A61K31/40 ,  A61K31/4025 ,  A61K31/445 ,  A61K31/47 ,  A61K31/495 ,  A61K31/50 ,  A61K31/505 ,  A61K31/655 ,  A61P17/04 ,  C07D205/04 ,  C07D207/12 ,  C07D307/79 ,  C07D307/87 ,  C07D317/72 ,  C07D333/08 ,  C07D493/10 ,  C07D495/10

CPC classification number: A61K31/4025 ,  A61K31/40 ,  A61K31/445 ,  A61K31/47 ,  A61K31/495 ,  A61K31/50 ,  A61K31/505

Abstract: Anti-pruritic pharmaceutical formulations containing kappa agonist compounds and methods of prevention or treatment of pruritus in a mammal with the anti-pruritic formulations.

Abstract translation: 含有卡帕激动剂化合物的抗瘙痒药物制剂以及用抗瘙痒制剂预防或治疗哺乳动物瘙痒的方法。

公开(公告)号：US5843956A

公开(公告)日：1998-12-01

申请号：US801679

申请日：1997-02-18

Applicant: Virendra Kumar ,  John Alan Dority, Jr.

Inventor： Virendra Kumar ,  John Alan Dority, Jr.

IPC: A61K31/435 ,  A61K31/4745 ,  A61P9/00 ,  A61P9/12 ,  C07D471/04 ,  A61K31/47 ,  A61K31/495 ,  C07D215/46

CPC classification number: C07D471/04 ,  A61K31/4745

Abstract: Substituted N-arylmethyl and heterocyclylmethyl-1H-pyrazolo�3,4-b!quinolin-4-amines, pharmaceutical compositions containing them and methods for a) effecting c-GMP-phosphodiesterase inhibition, b) treating heart failure and/or hypertension, c) reversing or reducing nitrate-induced tolerance and d) treating angina pectoris, congestive heart disease and myocardial infarction utilizing them.

Abstract translation: 取代的N-芳基甲基和杂环基甲基-1H-吡唑并[3,4-b]喹啉-4-胺，含有它们的药物组合物和a）影响c-GMP-磷酸二酯酶抑制的方法，b）治疗心力衰竭和/或高血压， c）逆转或减少硝酸盐诱导的耐受性，以及d）利用它们治疗心绞痛，充血性心脏病和心肌梗死。

公开(公告)号：US5455248A

公开(公告)日：1995-10-03

申请号：US121810

申请日：1993-09-14

Applicant: Diane L. DeHaven-Hudkins ,  William G. Earley ,  Virendra Kumar ,  John P. Mallamo ,  Matthew S. Miller ,  Chakrapani Subramanyam

Inventor： Diane L. DeHaven-Hudkins ,  William G. Earley ,  Virendra Kumar ,  John P. Mallamo ,  Matthew S. Miller ,  Chakrapani Subramanyam

IPC: C07D471/08 ,  C07D471/10 ,  A61K31/47

CPC classification number: C07D471/08 ,  C07D471/10

Abstract: Substituted 6,11-ethano-6,11-dihydrobenzo[b]quinolizinium salts, pharmaceutical compositions containing them, and methods for the treatment or prevention of neurodegenerative disorders or neurotoxic injuries utilizing them.

Abstract translation: 取代的6,11-乙炔-6,11-二氢苯并[b]喹啉鎓盐，含有它们的药物组合物，以及利用它们治疗或预防神经变性疾病或神经毒性损伤的方法。

公开(公告)号：US5380729A

公开(公告)日：1995-01-10

申请号：US122039

申请日：1993-09-14

Applicant: Diane L. DeHaven-Hudkins ,  William G. Earley ,  Virendra Kumar ,  John P. Mallamo ,  Matthew S. Miller

Inventor： Diane L. DeHaven-Hudkins ,  William G. Earley ,  Virendra Kumar ,  John P. Mallamo ,  Matthew S. Miller

IPC: C07D455/03 ,  A61K31/435 ,  A61P9/10 ,  A61P25/00 ,  A61P25/28 ,  C07D471/18 ,  A61K31/44 ,  C07D471/00 ,  C07D521/00

CPC classification number: C07D471/18

Abstract: 1-Hetero substituted 6,11-ethano-6,11-dihydrobenzo[b]quinolizinium salts, pharmaceutical compositions containing them, and methods for the treatment or prevention of neurodegenerative disorders or neurotoxic injuries utilizing them.

Abstract translation: 1-取代的6,11-乙基-6,11-二氢苯并[b]喹啉鎓盐，含有它们的药物组合物，以及利用它们治疗或预防神经变性疾病或神经毒性损伤的方法。

公开(公告)号：US5292736A

公开(公告)日：1994-03-08

申请号：US23452

申请日：1993-02-26

Applicant: Virendra Kumar ,  Susan J. Ward

Inventor： Virendra Kumar ,  Susan J. Ward

IPC: A61K31/535

CPC classification number: A61K31/535

Abstract: Compounds of the formula ##STR1## wherein Alk is lower-alkylene;R.sub.1 is hydrogen, lower-alkyl, Ar or ArCOO;R.sub.2 is hydrogen or lower-alkyl;R.sub.3 and R.sub.4 are the same or different hydrogen, fluoro, chloro, bromo, hydroxy, lower-alkoxy, lower-alkyl, or trifluoromethyl;Ar is phenyl, naphthyl, anthryl, 2-phenylethenyl or a 5- or 6-membered monocyclic or 9- or 10-membered bicyclic fused aromatic heterocyclic ring containing carbon and one or two heteroatoms independently selected from oxygen, nitrogen and sulfur, or such carbocyclic or heterocyclic rings substituted with from 1 to about 3 of lower-alkoxy, lower-alkyl, lower-alkylthio, lower-alkyl sulfinyl, lower-alkyl sulfonyl, hydroxy, cyano, amino, lower-alkylamino, dilower-alkylamino or halo;or pharmaceutically acceptable acid addition salts thereof are useful as analgesics and in the treatment of glaucoma.

Abstract translation: 下式的化合物其中Alk是低级亚烷基; R1是氢，低级烷基，Ar或ArCOO; R2是氢或低级烷基; R3和R4是相同或不同的氢，氟，氯，溴，羟基，低级烷氧基，低级烷基或三氟甲基; Ar是苯基，萘基，蒽基，2-苯基乙烯基或含有碳和一个或两个独立地选自氧，氮和硫的杂原子的5或6元单环或9或10元双环稠合芳族杂环，等等 被1至约3个低级烷氧基，低级烷基，低级烷硫基，低级烷基亚磺酰基，低级烷基磺酰基，羟基，氰基，氨基，低级烷基氨基，二元 - 烷基氨基或卤素取代的碳环或杂环。 或其药学上可接受的酸加成盐可用作镇痛药和治疗青光眼。

公开(公告)号：US4888352A

公开(公告)日：1989-12-19

申请号：US327212

申请日：1989-03-22

Applicant: Denis M. Bailey ,  Virendra Kumar

Inventor： Denis M. Bailey ,  Virendra Kumar

IPC: A61K31/415 ,  A61K31/4427 ,  A61K31/445 ,  A61P9/06 ,  C07D231/12 ,  C07D401/12 ,  C07D403/12

CPC classification number: C07D231/12

Abstract: N-[(disubstituted amino)alkyl]-3,4 or 5-aryl-1H-pyrazole-1-acetamides, useful for treating cardiac arrhythmias in mammals, are prepared by reacting a lower-alkyl ester of pyrazole-1-acetic acid with an appropriate diamine.

公开(公告)号：US08881295B2

公开(公告)日：2014-11-04

申请号：US13173612

申请日：2011-06-30

Applicant: Vladimir Kolesnikov ,  Virendra Kumar

Inventor： Vladimir Kolesnikov ,  Virendra Kumar

IPC: G06F7/04 ,  H04L9/06

CPC classification number: H04L9/0662 ,  H04L9/14 ,  H04L9/28 ,  H04L9/3249 ,  H04L2209/12 ,  H04L2209/127 ,  H04L2209/46

Abstract: Methods and apparatus are provided for generating a garbled circuit for a client in a leakage-resilient manner, for use in secure function evaluation between the client and a server. The garbled circuit is generated by obtaining a token from the server, wherein said token comprises a leakage-protected area; querying the token gate-by-gate, wherein for each gate of said garbled circuit, the token interacts with the leakage-protected area to generate a garbled table for the gate; and receiving the garbled circuit from the token. The client can interact with the server to obtain garbled inputs; and then evaluate the garbled circuit on the garbled inputs to obtain a garbled output. A final output can be obtained by matching the garbled output with an output table in the garbled circuit.

Abstract translation: 提供了用于以泄漏弹性方式为客户端生成乱码电路的方法和装置，用于客户机和服务器之间的安全功能评估。 通过从服务器获取令牌来产生乱码电路，其中所述令牌包括泄漏保护区域; 逐个询问令牌，其中对于所述乱码电路的每个门令牌，令牌与泄漏保护区域相互作用以产生用于门的乱码表; 并从令牌接收乱码电路。 客户端可以与服务器交互以获得乱码输入; 然后评估乱码输入上的乱码电路，以获得乱码。 可以通过将乱码输出与乱码电路中的输出表相匹配来获得最终输出。