公开(公告)号：US10800751B2

公开(公告)日：2020-10-13

申请号：US14913180

申请日：2014-08-21

Applicant: Virginia Commonwealth University

Inventor： Martin Safo ,  Jurgen Venitz ,  Richmond Danso-Danquah ,  Tanvi Deshpande ,  Yan Zhang

IPC: C07D307/58 ,  C07D213/30

Abstract: The invention provides new aromatic aldehyde compounds that have greater potency in increasing the affinity of Hb for oxygen, greater potency for preventing sickling, and additional pharmacologic properties that ameliorate other symptoms of SCD. The invention further provides methods for treating SCD by providing a subject having SCD with a compound according to the invention.

公开(公告)号：US10858331B1

公开(公告)日：2020-12-08

申请号：US16987609

申请日：2020-08-07

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Martin Safo ,  Yan Zhang ,  Jurgen Venitz ,  Richmond Danso-Danqua ,  Tanvi Deshpande

IPC: C07D307/58 ,  C07D213/30

Abstract: The invention provides new aromatic aldehyde compounds that have greater potency in increasing the affinity of Hb for oxygen, greater potency for preventing sickling, and additional pharmacologic properties that ameliorate other symptoms of SCD. The invention further provides methods for treating SCD by providing a subject having SCD with a compound according to the invention.

公开(公告)号：US20200369638A1

公开(公告)日：2020-11-26

申请号：US16987609

申请日：2020-08-07

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Martin Safo ,  Yan Zhang ,  Jurgen Venitz ,  Richmond Danso-Danqua ,  Tanvi Deshpande

IPC: C07D307/58 ,  C07D213/30

Abstract: The invention provides new aromatic aldehyde compounds that have greater potency in increasing the affinity of Hb for oxygen, greater potency for preventing sickling, and additional pharmacologic properties that ameliorate other symptoms of SCD. The invention further provides methods for treating SCD by providing a subject having SCD with a compound according to the invention.

公开(公告)号：US20210053931A1

公开(公告)日：2021-02-25

申请号：US17088063

申请日：2020-11-03

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Martin Safo ,  Yan Zhang ,  Jurgen Venitz ,  Richmond Danso-Danqua ,  Tanvi Deshpande

IPC: C07D307/58 ,  C07D213/30

Abstract: The invention provides new aromatic aldehyde compounds that have greater potency in increasing the affinity of Hb for oxygen, greater potency for preventing sickling, and additional pharmacologic properties that ameliorate other symptoms of SCD. The invention further provides methods for treating SCD by providing a subject having SCD with a compound according to the invention.

公开(公告)号：US09765017B2

公开(公告)日：2017-09-19

申请号：US15107962

申请日：2014-12-22

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Martin K. Safo ,  Richmond Danso-Danquah ,  Mohini Ghatge ,  Jurgen Venitz ,  Martin Mangino ,  Kevin R. Ward

IPC: C07C235/38 ,  A61K31/655 ,  C07C245/24 ,  A61K31/216 ,  A61K31/40 ,  A61K33/00 ,  A61K45/06

CPC classification number: C07C235/38 ,  A61K31/216 ,  A61K31/40 ,  A61K31/655 ,  A61K33/00 ,  A61K45/06 ,  C07C245/24 ,  Y02A50/411 ,  A61K2300/00

Abstract: Allosteric hemoglobin (Hb) modifiers of hemoglobin which contain nitric oxide (NO) moieties allowing for the release of NO in vivo. The compounds retain the oxygen delivery capability of the allosteric hemoglobin modifier to bind Hb and enhance Hb's ability to deliver oxygen to cells and tissues, and also release NO from the NO moiety. Methods of delivering oxygen and/or NO to cells and tissues are also provided.