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公开(公告)号：US07259146B2
公开(公告)日：2007-08-21
申请号：US09863600
申请日：2001-05-23
申请人： Virginia Smith-Swintosky , Michael Renzi , Carlos Plata-Salaman , Linda Jolliffe , Francis Farrell , Dana Johnson
发明人： Virginia Smith-Swintosky , Michael Renzi , Carlos Plata-Salaman , Linda Jolliffe , Francis Farrell , Dana Johnson
CPC分类号： C07K14/505 , A61K38/00
摘要： Methods of treating diseases of the nervous system by administration of compositions having the neurological therapeutic activity of human erythropoietin are disclosed. These compositions include therapeutic agents such as peptides, peptide dimers, polypeptides, and proteins that have the full range of biological activity of human erythropoietin or only certain biological activities of erythropoietin. Improved therapeutic regimens where the erythropoietin is administered at concentrations below those required to stimulate hematopoiesis are also provided.
摘要翻译： 公开了通过施用具有人促红细胞生成素神经学治疗活性的组合物治疗神经系统疾病的方法。 这些组合物包括治疗剂，例如肽，肽二聚体，多肽和蛋白质，其具有人类促红细胞生成素的全部生物学活性或只有促红细胞生成素的某些生物学活性。 还提供了改善的促红细胞生成素以低于刺激造血所需浓度的浓度给药的治疗方案。
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公开(公告)号：US20090170759A1
公开(公告)日：2009-07-02
申请号：US11776003
申请日：2007-07-11
申请人： Virginia Smith-Swintosky , Michael Renzi , Carlos Plata-Salaman , Linda Jolliffe , Francis Farrell , Dana Johnson
发明人： Virginia Smith-Swintosky , Michael Renzi , Carlos Plata-Salaman , Linda Jolliffe , Francis Farrell , Dana Johnson
CPC分类号： A61K38/1816 , A61K47/60 , C07K14/505
摘要： Methods of treating diseases of the nervous system by administration of compositions having the neurological therapeutic activity of human erythropoietin are disclosed. These compositions include therapeutic agents such as peptides, peptide dimers, polypeptides, and proteins that have the full range of biological activity of human erythropoietin or only certain biological activities of erythropoietin. Improved therapeutic regimens where the erythropoietin is administered at concentrations below those required to stimulate hematopoiesis are also provided.
摘要翻译： 公开了通过施用具有人促红细胞生成素神经学治疗活性的组合物治疗神经系统疾病的方法。 这些组合物包括治疗剂，例如肽，肽二聚体，多肽和蛋白质，其具有人类促红细胞生成素的全部生物学活性或只有促红细胞生成素的某些生物学活性。 还提供了改善的促红细胞生成素以低于刺激造血所需浓度的浓度给药的治疗方案。
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公开(公告)号：US20060030604A1
公开(公告)日：2006-02-09
申请号：US11236097
申请日：2005-09-27
申请人： Magdalena Elsinger , Louis Fitzpatrick , Daniel Lee , Kevin Pan , Carlos Plata-Salaman , Allen Reitz , Virginia Smith-Swintosky , Boyu Zhao
发明人： Magdalena Elsinger , Louis Fitzpatrick , Daniel Lee , Kevin Pan , Carlos Plata-Salaman , Allen Reitz , Virginia Smith-Swintosky , Boyu Zhao
IPC分类号： C07D285/08 , A61K31/433
CPC分类号： C07D285/08 , A61K8/49 , A61Q5/006 , A61Q19/00 , A61Q19/007 , C07D333/16 , C07D417/12 , C07F9/4018
摘要： The present invention is directed to novel 1,2,4-thiadiazol-2-ium derivatives useful as agonists or antagonists of the melanocortin receptor. More particularly, the compounds of the present invention are useful for the treatment of metabolic, CNS and dermatological disorders such as obesity, impaired oral glucose tolerance, elevated blood glucose levels, type II diabetes, Syndrome X, diabetic retinopathy, spinal cord injury, nerve injury, acute neurodegenerative disorders, chronic neurodegenerative disorders, plexopathies, male erectile dysfunction, dry eyes, acne, dry skin, aged skin, seborrheic dermatitis, rosacea, excessive ear wax, meibomian gland disorder, pseudofolliculitis, yeast infections, dandruff, hidradenitis suppurativa, ocular rosacea and eccrine gland disorder.
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公开(公告)号：US20060128772A1
公开(公告)日：2006-06-15
申请号：US11344772
申请日：2006-02-01
申请人： Magdalena Eisinger , Louis Fitzpatrick , Daniel Lee , Kevin Pan , Carlos Plata-Salaman , Allen Reitz , Virginia Smith-Swintosky , Boyu Zhao
发明人： Magdalena Eisinger , Louis Fitzpatrick , Daniel Lee , Kevin Pan , Carlos Plata-Salaman , Allen Reitz , Virginia Smith-Swintosky , Boyu Zhao
IPC分类号： A61K31/433 , C07D285/08
CPC分类号： C07D285/08 , A61K8/49 , A61Q5/006 , A61Q19/00 , A61Q19/007 , C07D417/12
摘要： The present invention is directed to novel 1,2,4-thiadiazole derivatives useful as agonists or antagonists of the melanocortin receptor. More particularly, the compounds of the present invention are useful for the treatment of metabolic, CNS and dermatological disorders such as obesity, impaired oral glucose tolerance, elevated blood glucose levels, type II diabetes, Syndrome X, diabetic retinopathy, spinal cord injury, nerve injury, acute neurodegenerative disorders, chronic neurodegenerative disorders, plexopathies, male erectile dysfunction, dry eyes, acne, dry skin, aged skin, seborrheic dermatitis, rosacea, excessive ear wax, meibomian gland disorder, pseudofolliculitis, yeast infections, dandruff, hidradenitis suppurativa, ocular rosacea and eccrine gland disorder.
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5.发明授权Treatment of neurological dysfunction comprising fructopyranose sulfamates and erythropoietin 失效治疗神经功能障碍包括果寡糖氨基磺酸盐和促红细胞生成素公开(公告)号：US06908902B2
公开(公告)日：2005-06-21
申请号：US10056828
申请日：2002-01-24
IPC分类号： A61K38/22 , A61K31/357 , A61K31/7004 , A61K31/7016 , A61K38/18 , A61K45/06 , A61P9/00 , A61P25/00 , A61P25/02 , A61P25/08 , A61P25/16 , A61P25/28 , A61P43/00 , A61K31/00 , A01N43/04 , A61K31/70
CPC分类号： A61K45/06 , A61K31/357 , A61K38/1816 , A61K2300/00
摘要： Co-therapy for the treatment of neurological dysfunctions comprising administration of one or more fructopyranose sulfamates and erythropoietin.
摘要翻译： 用于治疗神经功能障碍的联合治疗，包括施用一种或多种果寡糖氨基磺酸盐和促红细胞生成素。
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6.发明申请公开(公告)号：US20050261182A1
公开(公告)日：2005-11-24
申请号：US11047420
申请日：2005-01-31
IPC分类号： A61K38/22 , A61K31/357 , A61K31/7004 , A61K31/7016 , A61K38/18 , A61K45/06 , A61P9/00 , A61P25/00 , A61P25/02 , A61P25/08 , A61P25/16 , A61P25/28 , A61P43/00 , A61K31/7008
CPC分类号： A61K45/06 , A61K31/357 , A61K38/1816 , A61K2300/00
摘要： Co-therapy for the treatment of neurological dysfunctions comprising administration of one or more fructopyranose sulfamates and erythropoietin.
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7.发明申请USE OF BENZO-FUSED HETEROCYLE SULFAMIDE DERIVATIVES FOR THE TREATMENT OF MANIA AND BIPOLAR DISORDER 有权苯并呋喃磺酰胺衍生物用于治疗MAN IA AR AR ER ER ER ER ER ER ER ER ER公开(公告)号：US20070155826A1
公开(公告)日：2007-07-05
申请号：US11612222
申请日：2006-12-18
IPC分类号： A61K31/36 , A61K31/353
CPC分类号： A61K31/353 , A61K31/357
摘要： The present invention is a method for the treatment of mania and/or bipolar disorder comprising administering to a subject in need thereof a therapeutically effective amount of one or more novel benzo-fused heterocycle sulfamide derivatives of formula (I) and formula (II) as herein defined.
摘要翻译： 本发明是一种治疗躁狂症和/或双相性躁动症的方法，包括向有需要的受试者施用治疗有效量的一种或多种式（I）和式（II）的新型苯并稠合的杂环磺酰胺衍生物作为 在此定义。
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8.发明申请USE OF BENZO-FUSED HETEROCYCLE SULFAMIDE DERIVATIVES FOR DISEASE MODIFICATION / EPILEPTOGENESIS 审中-公开苯并呋喃磺酰胺衍生物用于疾病改变/ EPILEPTOGENESIS的应用公开(公告)号：US20070155824A1
公开(公告)日：2007-07-05
申请号：US11612174
申请日：2006-12-18
IPC分类号： A61K31/36 , A61K31/335
CPC分类号： A61K31/353 , A61K31/357
摘要： The present invention is a method for treating, preventing, reversing, arresting or inhibiting the occurrence, development and maturation of seizures or seizure-related disorders. More specifically, the present invention is directed to methods for the use of benzo-fused heterocycle sulfamide derivatives of formula (I) and formula (II) as described herein to therapeutically or prophylactically treat, prevent, reverse, arrest or inhibit epileptogenesis and epilepsy.
摘要翻译： 本发明是治疗，预防，逆转，阻止或抑制癫痫发作或癫痫相关疾病的发生，发展和成熟的方法。 更具体地，本发明涉及使用如本文所述的式（I）和式（II）的苯并稠合的杂环磺酰胺衍生物以治疗或预防性治疗，预防，逆转，阻止或抑制癫痫发作和癫痫的方法。
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9.发明申请USE OF BENZO-FUSED HETEROCYCLE SULFAMIDE DERIVATIVES FOR THE TREATMENT OF SUBSTANCE ABUSE AND ADDICTION 失效用于治疗物质滥用和添加剂的苯并 - 氟化异硫氰酸酯衍生物的使用公开(公告)号：US20070155825A1
公开(公告)日：2007-07-05
申请号：US11612202
申请日：2006-12-18
IPC分类号： A61K31/36 , A61K31/353
CPC分类号： A61K31/353 , A23V2002/00 , A61K31/357 , A23V2200/334
摘要： The present invention is a method for the treatment of alcohol abuse and/or addiction comprising administering to a subject in need thereof a therapeutically effective amount of one or more novel benzo-fused heterocycle sulfamide derivatives of formula (I) and/or formula (II) as herein defined.
摘要翻译： 本发明是用于治疗酒精滥用和/或成瘾的方法，包括向有需要的受试者施用治疗有效量的一种或多种式（I）和/或式（II）的新型苯并稠合的杂环磺酰胺衍生物 ）。
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10.发明申请USE OF BENZO-FUSED HETEROCYCLE SULFAMIDE DERIVATIVES FOR LOWERING LIPIDS AND LOWERING BLOOD GLUCOSE LEVELS 失效用于降低脂肪和降低血液葡萄糖水平的苯并稠合的脂质体磺酰胺衍生物公开(公告)号：US20070155821A1
公开(公告)日：2007-07-05
申请号：US11611961
申请日：2006-12-18
IPC分类号： A61K31/335
CPC分类号： A61K31/352 , A61K31/353 , A61K31/357
摘要： The present invention is a method for the glucose related disorders and lipid related disorders comprising administering to a subject in need thereof a therapeutically effective amount of one or more novel benzo-fused heterocycle sulfamide derivatives of formula (I) or formula (II) as herein defined. The present invention is further directed to methods of treatment comprising co-therapy with an anti-diabetic agent, and anti-lipid agent and/or an anti-obesity agent.
摘要翻译： 本发明是一种葡萄糖相关疾病和脂质相关病症的方法，包括向有需要的受试者施用治疗有效量的本文所述的一种或多种式（I）或式（II）的新型苯并稠合的杂环磺酰胺衍生物 定义 本发明进一步涉及包括与抗糖尿病药物和抗脂质剂和/或抗肥胖剂的协同治疗的治疗方法。
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