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公开(公告)号：US10471254B2
公开(公告)日：2019-11-12
申请号：US15310114
申请日：2015-05-12
Applicant: Virginia Tech Intellectual Properties, Inc. , Michael B. Sano , Christopher B. Arena , Scott S. Verbridge , Rafael V. Davalos
Inventor： Michael B. Sano , Christopher B. Arena , Scott S. Verbridge , Rafael V. Davalos
IPC: A61B18/14 , A61N1/32 , A61N1/40 , A61B90/00 , A61B18/12 , A61N1/06 , A61N1/08 , A61B18/00 , A61B17/00
Abstract: A system and method for selectively treating aberrant cells such as cancer cells through administration of a train of electrical pulses is described. The pulse length and delay between successive pulses is optimized to produce effects on intracellular membrane potentials. Therapies based on the system and method produce two treatment zones: an ablation zone surrounding the electrodes within which aberrant cells are non-selectively killed and a selective treatment zone surrounding the ablation zone within which target cells are selectively killed through effects on intracellular membrane potentials. As a result, infiltrating tumor cells within a tumor margin can be effectively treated while sparing healthy tissue. The system and method are useful for treating various cancers in which solid tumors form and have a chance of recurrence from microscopic disease surrounding the tumor.
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公开(公告)号：US20230355968A1
公开(公告)日：2023-11-09
申请号：US18027824
申请日：2021-09-22
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Rafael V. Davalos , Irving C. Allen , Scott S. Verbridge , Nastaran Alinezhadbalalami
IPC: A61N1/32 , A61N1/36 , C12N5/0783
CPC classification number: A61N1/327 , A61N1/36002 , C12N5/0638 , C12N2529/00 , C12N2502/1121
Abstract: Expansion of cytotoxic T lymphocytes (CTLs) is a crucial step in almost all cancer immunotherapeutic methods. Current techniques for expansion of tumor-reactive CTLs present major limitations. The present invention comprises a novel method to effectively produce and expand tumor-activated CTLs using high-voltage pulsed electric fields. Tumor cells were subjected to high-frequency irreversible electroporation (HFIRE) with various electric field magnitudes and pulse widths, or irreversible electroporation (IRE). The treated tumor cells were subsequently cocultured with CD8+ cytotoxic T cells along with antigen-presenting cells. Tumor-activated CTLs can be produced and expanded when exposed to treated tumor cells. The activated CTLs produced with the present invention could be used for clinical applications with the goal of targeting and eliminating tumors.
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公开(公告)号：US20230248414A1
公开(公告)日：2023-08-10
申请号：US18123719
申请日：2023-03-20
Applicant: Virginia Tech Intellectual Properties Inc.
Inventor： Michael B. Sano , Christopher B. Arena , Scott S. Verbridge , Rafael V. Davalos
CPC classification number: A61B18/14 , A61N1/327 , A61B2018/00761
Abstract: The present invention relates to the field of biomedical engineering and medical treatment of diseases and disorders. Methods, devices, and systems for in vivo treatment of cell proliferative disorders are provided. In embodiments, the methods comprise the delivery of high-frequency bursts of bipolar pulses to achieve the desired modality of cell death. More specifically, embodiments of the invention relate to a device and method for destroying aberrant cells, including tumor tissues, using high-frequency, bipolar electrical pulses having a burst width on the order of microseconds and duration of single polarity on the microsecond to nanosecond scale. In embodiments, the methods rely on conventional electroporation with adjuvant drugs or irreversible electroporation to cause cell death in treated tumors. The invention can be used to treat solid tumors, such as brain tumors.
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公开(公告)号：US11638603B2
公开(公告)日：2023-05-02
申请号：US16443351
申请日：2019-06-17
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Michael B. Sano , Christopher B. Arena , Scott S. Verbridge , Rafael V. Davalos
Abstract: The present invention relates to the field of biomedical engineering and medical treatment of diseases and disorders. Methods, devices, and systems for in vivo treatment of cell proliferative disorders are provided. In embodiments, the methods comprise the delivery of high-frequency bursts of bipolar pulses to achieve the desired modality of cell death. More specifically, embodiments of the invention relate to a device and method for destroying aberrant cells, including tumor tissues, using high-frequency, bipolar electrical pulses having a burst width on the order of microseconds and duration of single polarity on the microsecond to nanosecond scale. In embodiments, the methods rely on conventional electroporation with adjuvant drugs or irreversible electroporation to cause cell death in treated tumors. The invention can be used to treat solid tumors, such as brain tumors.
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公开(公告)号：US20190328445A1
公开(公告)日：2019-10-31
申请号：US16443351
申请日：2019-06-17
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Michael B. Sano , Christopher B. Arena , Scott S. Verbridge , Rafael V. Davalos
Abstract: The present invention relates to the field of biomedical engineering and medical treatment of diseases and disorders. Methods, devices, and systems for in vivo treatment of cell proliferative disorders are provided. In embodiments, the methods comprise the delivery of high-frequency bursts of bipolar pulses to achieve the desired modality of cell death. More specifically, embodiments of the invention relate to a device and method for destroying aberrant cells, including tumor tissues, using high-frequency, bipolar electrical pulses having a burst width on the order of microseconds and duration of single polarity on the microsecond to nanosecond scale. In embodiments, the methods rely on conventional electroporation with adjuvant drugs or irreversible electroporation to cause cell death in treated tumors. The invention can be used to treat solid tumors, such as brain tumors.
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Patent Agency Ranking
公开(公告)号：US12083339B2
公开(公告)日：2024-09-10
申请号：US16340106
申请日：2017-10-06
Inventor： Jill W. Ivey , Eduardo L. Latouche , Scott S. Verbridge , Rafael V. Davalos , Glenn J. Lesser , Waldemar Debinski
CPC classification number: A61N1/327 , A61B18/12 , A61B18/1233 , A61K38/19 , A61N1/05 , A61N1/06 , A61B2017/00172 , A61B2018/00613 , A61B2018/00732 , A61B2018/00767 , A61B2018/126 , A61B2018/128 , A61K38/1793
Abstract: Described herein are methods of electroporation that can include the steps of contacting a cell that is responsive to an EphA2 receptor ligand with an amount of an EphA2 receptor ligand and applying high-frequency irreversible electroporation to the cell. Also described herein are methods of treating cancer in a subject in need thereof, wherein the methods can include the steps of administering an amount of an EphA2 receptor ligand and applying high-frequency irreversible electroporation to a location on or within the subject.
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公开(公告)号：US20220362549A1
公开(公告)日：2022-11-17
申请号：US17862486
申请日：2022-07-12
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Michael B. Sano , Chirstopher B. Arena , Scott S. Verbridge , Rafael V. Davalos
Abstract: A system and method for selectively treating aberrant cells such as cancer cells through administration of a train of electrical pulses is described. The pulse length and delay between successive pulses is optimized to produce effects on intracellular membrane potentials. Therapies based on the system and method produce two treatment zones: an ablation zone surrounding the electrodes within which aberrant cells are non-selectively killed and a selective treatment zone surrounding the ablation zone within which target cells are selectively killed through effects on intracellular membrane potentials. As a result, infiltrating tumor cells within a tumor margin can be effectively treated while sparing healthy tissue. The system and method are useful for treating various cancers in which solid tumors form and have a chance of recurrence from microscopic disease surrounding the tumor.
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公开(公告)号：US11406820B2
公开(公告)日：2022-08-09
申请号：US16520901
申请日：2019-07-24
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Michael B. Sano , Christopher B. Arena , Scott S. Verbridge , Rafael V. Davalos
IPC: A61B18/12 , A61B18/14 , A61N1/32 , A61N1/40 , A61B90/00 , A61N1/06 , A61N1/08 , A61B18/00 , A61B17/00
Abstract: A system and method for selectively treating aberrant cells such as cancer cells through administration of a train of electrical pulses is described. The pulse length and delay between successive pulses is optimized to produce effects on intracellular membrane potentials. Therapies based on the system and method produce two treatment zones: an ablation zone surrounding the electrodes within which aberrant cells are non-selectively killed and a selective treatment zone surrounding the ablation zone within which target cells are selectively killed through effects on intracellular membrane potentials. As a result, infiltrating tumor cells within a tumor margin can be effectively treated while sparing healthy tissue. The system and method are useful for treating various cancers in which solid tumors form and have a chance of recurrence from microscopic disease surrounding the tumor.
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公开(公告)号：US20190351224A1
公开(公告)日：2019-11-21
申请号：US16520901
申请日：2019-07-24
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Michael B. Sano , Christopher B. Arena , Scott S. Verbridge , Rafeal V. Davalos
Abstract: A system and method for selectively treating aberrant cells such as cancer cells through administration of a train of electrical pulses is described. The pulse length and delay between successive pulses is optimized to produce effects on intracellular membrane potentials. Therapies based on the system and method produce two treatment zones: an ablation zone surrounding the electrodes within which aberrant cells are non-selectively killed and a selective treatment zone surrounding the ablation zone within which target cells are selectively killed through effects on intracellular membrane potentials. As a result, infiltrating tumor cells within a tumor margin can be effectively treated while sparing healthy tissue. The system and method are useful for treating various cancers in which solid tumors form and have a chance of recurrence from microscopic disease surrounding the tumor.
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公开(公告)号：US20170266438A1
公开(公告)日：2017-09-21
申请号：US15310114
申请日：2015-05-12
Applicant: Michael B. SANO , Christopher B. ARENA , Scott S. VERBRIDGE , Rafael V. DAVALOS , Virginia Tech Intellectual Properties, Inc.
Inventor： Michael B. Sano , Christopher B. Arena , Scott S. Verbridge , Rafeal V. Davalos
Abstract: A system and method for selectively treating aberrant cells such as cancer cells through administration of a train of electrical pulses is described. The pulse length and delay between successive pulses is optimized to produce effects on intracellular membrane potentials. Therapies based on the system and method produce two treatment zones: an ablation zone surrounding the electrodes within which aberrant cells are non-selectively killed and a selective treatment zone surrounding the ablation zone within which target cells are selectively killed through effects on intracellular membrane potentials. As a result, infiltrating tumor cells within a tumor margin can be effectively treated while sparing healthy tissue. The system and method are useful for treating various cancers in which solid tumors form and have a chance of recurrence from microscopic disease surrounding the tumor.
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