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公开(公告)号：US4801585A
公开(公告)日：1989-01-31
申请号：US945038
申请日：1986-12-22
IPC分类号： C07D207/09 , C07D211/26 , C07D223/04 , A61K31/55 , A61K31/455 , C07D401/06
CPC分类号： C07D223/04 , C07D207/09 , C07D211/26
摘要： A compound of formula (I): ##STR1## or a salt or solvate thereof in which R. CO is an acyl group containing a substituted or unsubstituted carbocyclic or heterocyclic aromatic ring, R.sub.1 and R.sub.2 are independently C.sub.1-6 alkyl or together form a C.sub.3-6 polymethylene or alkylene group, and p is 1, 2, 3 or 4, is useful for treating pain.
摘要翻译： 式（I）的化合物：其中R CO为含有取代或未取代的碳环或杂环芳环的酰基的盐或其溶剂化物，R 1和R 2独立地为C 1-6烷基或 一起形成C3-6聚亚甲基或亚烷基，p为1,2,3或4，可用于治疗疼痛。
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公开(公告)号：USRE33906E
公开(公告)日：1992-04-28
申请号：US562887
申请日：1990-08-03
IPC分类号： C07D207/09 , C07D211/26 , C07D223/04
CPC分类号： C07D223/04 , C07D207/09 , C07D211/26
摘要： A compound of formula (I): ##STR1## or a salt or solvate thereof in which R. CO is an acyl group containing a substituted or unsubstituted carbocyclic or heterocyclic aromatic ring, R.sub.1 and R.sub.2 are independently C.sub.1-6 alkyl or together form a C.sub.3-6 polymethylene or alkylene group, and p is 1, 2, 3 or 4, is useful for treating pain.
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公开(公告)号：US4826819A
公开(公告)日：1989-05-02
申请号：US91275
申请日：1987-08-31
IPC分类号： C07D211/26 , A61K31/55 , A61K31/445 , C07D401/06
CPC分类号： C07D211/26
摘要： A compound of formula (I): ##STR1## or a salt or solvate thereof in which R.CO is an acyl group in which R is of formula (II) ##STR2## in which R.sub.3 is Br, NO.sub.2 or CF.sub.3 ; and, R.sub.1 and R.sub.2 are independently C.sub.1-6 alkyl or together form a C.sub.3-6 polymethylene or alkylene group, is useful for treating pain.
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4.发明授权
公开(公告)号：US4570013A
公开(公告)日：1986-02-11
申请号：US668650
申请日：1984-11-06
IPC分类号： C07D333/38 , A61K31/215 , A61K31/22 , A61K31/38 , A61K31/381 , A61K31/4406 , A61K31/455 , A61P25/04 , A61P29/00 , A61P43/00 , C07C69/003 , C07C69/616 , C07D213/80 , C12N9/99 , C07C69/76
CPC分类号： C07C69/616
摘要： Novel compounds of formula ##STR1## are described which have antipyretic, analgesic and antiinflammatory activity. R is hydrogen, C.sub.1 -C.sub.3 linear or branched alkyl; R.sub.1 and R.sub.2 are hydrogen, halogen, unsubstituted or esterified hydroxy, alcoxy, and may be the same or different; R.sub.3 is hydrogen, C.sub.1 -C.sub.4 linear or branched aliphatic acyl, unsubstituted or substituted aroyl, alkylaroyl or hetaroyl groups.
摘要翻译： 描述了具有解热，止痛和抗炎活性的新颖的式“IMAGE”化合物。 R是氢，C 1 -C 3直链或支链烷基; R 1和R 2是氢，卤素，未取代或酯化的羟基，烷氧基，可以相同或不同; R 3是氢，C 1 -C 4直链或支链脂族酰基，未取代或取代的芳酰基，烷酰基或己基。
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公开(公告)号：US4753952A
公开(公告)日：1988-06-28
申请号：US944931
申请日：1986-12-22
IPC分类号： A61K31/47 , A61K31/472 , A61P25/04 , C07D217/14 , C07D217/16 , C07D401/06
CPC分类号： C07D217/14
摘要： A compound of formula I: ##STR1## or a solvate or salt thereof in which: R is an acyl group containing a substituted or unsubstituted carbocyclic or heterocyclic aromatic ring and R.sub.1 and R.sub.2 are independently C.sub.1-6 alkyl groups or together form a C.sub.3-6 polymethylene or alkenylene group, is useful for treating pain in mammals.
摘要翻译： 式I的化合物或其溶剂合物或盐，其中：R为含有取代或未取代的碳环或杂环芳香环的酰基，R 1和R 2独立地为C 1-6烷基或一起形成C 3 -6多亚甲基或亚烯基，可用于治疗哺乳动物的疼痛。
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6.发明授权Process for preparing 1-(3,5-dimethoxy-4-hydroxy phenyl)-2-(N-methylamino) ethanol hydrochloride 失效制备1-（3,5-二甲氧基-4-羟基苯基）-2-（N-甲基氨基）乙醇盐酸盐的方法
公开(公告)号：US4408074A
公开(公告)日：1983-10-04
申请号：US317517
申请日：1981-11-02
申请人： Massimo Signorini , Attilio Trebbi , Luigi Molteni
发明人： Massimo Signorini , Attilio Trebbi , Luigi Molteni
IPC分类号： C07B61/00 , A61K31/135 , B01J25/00 , C07C43/23 , C07C67/00 , C07C213/00 , C07C217/70 , C07C91/16
CPC分类号： C07C43/23 , C07C309/00
摘要： A process for preparing 1-(3,5-dimethoxy-4-hydroxy phenyl)-2-(N-methylamino) ethanol hydrochloride is described by reacting 2,6-dimethoxyphenol with anhydrous chloral in the presence of a catalyst, hydrolyzing 1-(3,5-dimethoxy-4-hydroxyphenyl)2,2,2-trichloro ethanol and subsequently isolating the 3,5-dimethoxy-4-hydroxyphenyl glyoxal thus obtained; finally, this compound, in the form of the bisulfite, is directly converted to the desired product by amination with methylamine in the presence of hydrogen with a hydrogenation catalyst and the final product is converted into the hydrochloride.
摘要翻译： 通过在催化剂存在下使2,6-二甲氧基苯酚与无水氯醛反应来描述制备1-（3,5-二甲氧基-4-羟基苯基）-2-（N-甲基氨基）乙醇盐酸盐的方法， （3,5-二甲氧基-4-羟基苯基）2,2,2-三氯乙醇，随后分离得到的3,5-二甲氧基-4-羟基苯基乙二醛; 最后，该亚硫酸氢盐形式的化合物通过在氢气存在下用甲胺与氢化催化剂进行胺化直接转化为所需产物，并将最终产物转化成盐酸盐。
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7.发明授权
公开(公告)号：US5182265A
公开(公告)日：1993-01-26
申请号：US562657
申请日：1990-08-03
CPC分类号： C07K5/0806 , C07K5/081 , A61K38/00
摘要： Peptide derivatives and their salts with pharmaceutically acceptable acids or bases, having the general formula (I), ##STR1## wherein R=--H, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 acyl, alkoxycarbonyl with C.sub.1 -C.sub.4 alkyl;R.sub.1 =--H, C.sub.1 -C.sub.3 alkyl;R.sub.2 =--H, --OH, --OR'.sub.2, wherein R'.sub.2 =C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 acyl, benzyl;R.sub.3 =--H, --CH.sub.3 ;n=1,2R.sub.4 =--H, --COOH, --CONH.sub.2, --COOR'.sub.4, wherein R'.sub.4 =C.sub.1 -C.sub.3 alkyl, benzyl;R.sub.5 =--H, 4--OH, 3,4--OH, --OR'.sub.5 wherein R'.sub.5 =C.sub.1 -3 alkyl, C.sub.1 -C.sub.3 acyl, benzyl;R.sub.6 =--OH, --NH.sub.2, --OR'.sub.6 wherein R'.sub.6 =C.sub.1 -C.sub.3 alkyl, benzyl; endowed with analgesic, antiviral, immuno-modulating pharmacological properties, and the pharmaceutical forms containing them as active ingredients.
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