Preparation and stabilization of cells using aged transition metal solutions
    1.
    发明授权
    Preparation and stabilization of cells using aged transition metal solutions 失效
    使用老化的过渡金属溶液制备和稳定细胞

    公开(公告)号:US06197540B1

    公开(公告)日:2001-03-06

    申请号:US08578591

    申请日:1996-06-21

    IPC分类号: A61K944

    摘要: The invention is directed to novel stabilized blood compositions and methods of stabilizing blood compositions for use in the quality control of analytical techniques. The novel blood compositions comprise leucocytes and an effective amount of an aged transition metal solution. The novel method comprises removing leucocytes from a blood composition to yield a depleted blood composition, stabilizing the leucocytes by treatment with an effective amount of a stabilizing agent comprising an aged transition metal solution, and then, adding the resultant stabilized leucocytes to the depleted blood composition or a second blood component composition.

    摘要翻译: 本发明涉及新颖的稳定血液组合物和稳定血液组合物的方法,用于分析技术的质量控制。 新型血液组合物包含白细胞和有效量的老化过渡金属溶液。 该新方法包括从血液组合物中除去白细胞以产生耗尽的血液组合物,通过用有效量的包含老化过渡金属溶液的稳定剂进行处理来稳定白细胞,然后将所得稳定的白细胞加入贫血血液组合物 或第二血液成分组合物。

    Method to stabilize cell suspensions using aged heavy metal solution and
paraformaldehyde
    3.
    发明授权
    Method to stabilize cell suspensions using aged heavy metal solution and paraformaldehyde 失效
    使用老化重金属溶液和多聚甲醛稳定细胞悬浮液的方法

    公开(公告)号:US5858699A

    公开(公告)日:1999-01-12

    申请号:US718359

    申请日:1997-01-27

    摘要: A stabilized cell suspension is prepared by treating the cell suspension with a solution of a heavy metal compound, which has been aged at pH 6.5-7.5 prior to use to allow a precipitate to form, removing the precipitate from the heavy metal solution, mixing the aged heavy metal solution with the cell suspension to form a first mixture, and mixing the first mixture with a paraformaldehyde solution to form a stabilized cell suspension which is still capable of lysis.

    摘要翻译: PCT No.PCT / EP95 / 01259 Sec。 371日期1997年1月27日 102(e)日期1997年1月27日PCT提交1995年4月5日PCT公布。 WO95 / 27203 PCT出版物 日期1995年10月12日通过用重金属化合物的溶液处理细胞悬浮液来制备稳定的细胞悬浮液,重金属化合物在使用之前已经在pH 6.5-7.5下老化以允许形成沉淀物,从沉淀物中除去沉淀物 将老化的重金属溶液与细胞悬浮液混合以形成第一混合物,并将第一混合物与多聚甲醛溶液混合以形成仍然能够裂解的稳定的细胞悬浮液。

    Specimen collection fluid
    4.
    发明授权
    Specimen collection fluid 失效
    标本采集液

    公开(公告)号:US06579672B1

    公开(公告)日:2003-06-17

    申请号:US09194333

    申请日:1999-04-26

    IPC分类号: A01N102

    摘要: A sterile aqueous specimen collection fluid containing a buffer, an aliphatic aldehyde at a concentration of 0.15M to 3.4M, and one or more heavy metal salts at a concentration of 0.2×10−3M to 0.2M, and having a pH of 6.8 to 8.0. Also disclosed is a method of colleting a specimen with such a fluid for haematological analysis.

    摘要翻译: 含有缓冲液,浓度为0.15M至3.4M的脂族醛和一种或多种浓度为0.2×10-3M至0.2M的重金属盐,pH为6.8至8.0的无菌水样本收集液 。 还公开了一种使用这种用于血液学分析的流体的样本的收集方法。