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公开(公告)号：US10421798B2
公开(公告)日：2019-09-24
申请号：US14379192
申请日：2012-07-11
申请人： Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , Sheng Ding , Joshua Silverman , Chia-wei Wang , Benjamin Spink , Willem P. Stemmer , Volker Schellenberger , Nathan Geething , John Kulman , Tongyao Liu , Garabet G. Toby , Haiyan Jiang , Robert Peters , Deping Wang , Baisong Mei
发明人： Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , Sheng Ding , Joshua Silverman , Chia-wei Wang , Benjamin Spink , Willem P. Stemmer , Nathan Geething , John Kulman , Tongyao Liu , Garabet G. Toby , Haiyan Jiang , Robert Peters , Deping Wang , Baisong Mei
IPC分类号： C07K14/755 , A61K38/00
摘要： The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor VIII-related diseases, disorders, and conditions.
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公开(公告)号：US20150158929A1
公开(公告)日：2015-06-11
申请号：US14379192
申请日：2012-07-11
申请人： Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , Sheng Ding , Joshua Silverman , Chia-wei Wang , Benjamin Spink , Willem P. Stemmer , Nathan Geething , John Kulman , Tongyao Liu , Garabet G. Toby , Haiyan Jiang , Robert Peters , Deping Wang , Baisong Mei
发明人： Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , Sheng Ding , Joshua Silverman , Chia-wei Wang , Benjamin Spink , Willem P. Stemmer , Nathan Geething , John Kulman , Tongyao Liu , Garabet G. Toby , Haiyan Jiang , Robert Peters , Deping Wang , Baisong Mei
IPC分类号： C07K14/755
摘要： The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor VIII-related diseases, disorders, and conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的因子VIII凝血因子的组合物，编码组合物的分离的核酸和含有它们的载体和宿主细胞，以及制备和使用这些组合物治疗因子VIII相关的方法 疾病，病症和状况。
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公开(公告)号：US20120178691A1
公开(公告)日：2012-07-12
申请号：US13423031
申请日：2012-03-16
申请人： Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , Joshua Silverman , Chia-Wei Wang , Benjamin Spink , Nathan Geething
发明人： Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , Joshua Silverman , Chia-Wei Wang , Benjamin Spink , Nathan Geething
IPC分类号： A61K38/37 , C12N15/62 , C12N15/63 , A61P7/04 , C12N1/19 , C12N1/15 , C12N1/21 , C07K19/00 , C12N5/10
CPC分类号： C07K14/755 , A61K38/00 , C07K14/001 , C07K2319/00 , C07K2319/21 , C07K2319/31 , C07K2319/41 , C07K2319/50 , C07K2319/95
摘要： The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor VIII-related diseases, disorders, and conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的因子VIII凝血因子的组合物，编码组合物的分离的核酸和含有它们的载体和宿主细胞，以及制备和使用这些组合物治疗因子VIII相关的方法 疾病，病症和状况。
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公开(公告)号：US20130017997A1
公开(公告)日：2013-01-17
申请号：US13365166
申请日：2012-02-02
申请人： Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , John Kulman , Tongyao Liu , Garabet G. Toby , Haiyan Jiang , Robert Peters , Deping Wang , Baisong Mei , Joshua Silverman , Chia-Wei Wang , Benjamin Spink , Nathan Geething
发明人： Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , John Kulman , Tongyao Liu , Garabet G. Toby , Haiyan Jiang , Robert Peters , Deping Wang , Baisong Mei , Joshua Silverman , Chia-Wei Wang , Benjamin Spink , Nathan Geething
CPC分类号： C07K14/755 , A61K38/00 , C07K14/001 , C07K2319/00 , C07K2319/21 , C07K2319/31 , C07K2319/41 , C07K2319/50 , C07K2319/95
摘要： The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor VIII-related diseases, disorders, and conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的因子VIII凝血因子的组合物，编码组合物的分离的核酸和含有它们的载体和宿主细胞，以及制备和使用这些组合物治疗因子VIII相关的方法 疾病，病症和状况。
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5.发明授权公开(公告)号：US08716448B2
公开(公告)日：2014-05-06
申请号：US12806005
申请日：2010-08-02
申请人： Volker Schellenberger , Joshua Silverman , Willem Stemmer , Chia-wei Wang , Benjamin Spink , Nathan Geething , Wayne To
发明人： Volker Schellenberger , Joshua Silverman , Willem Stemmer , Chia-wei Wang , Benjamin Spink , Nathan Geething , Wayne To
IPC分类号： A61K38/36 , C07K14/745
CPC分类号： C12N9/644 , A61K38/00 , C07K14/001 , C07K2319/00 , C07K2319/31 , C07K2319/50 , C12N9/6437 , C12N15/70 , C12Y304/21022
摘要： The present invention relates to compositions comprising factor VII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of coagulation factor-related diseases, disorders, and conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的因子VII凝血因子的组合物，编码组合物的分离的核酸和载体以及含有它们的宿主细胞，以及制备和使用这些组合物治疗凝血因子相关的方法 疾病，病症和状况。
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公开(公告)号：US20160137711A1
公开(公告)日：2016-05-19
申请号：US14343111
申请日：2012-09-12
申请人： Volker Schellenberger , Joshua Silverman , Willem P. Stemmer , Chia-Wei Wang , Nathan Geething , Benjamin Spink
发明人： Volker Schellenberger , Joshua Silverman , Willem P. Stemmer , Chia-Wei Wang , Nathan Geething , Benjamin Spink
IPC分类号： C07K14/605
CPC分类号： C07K14/605 , A61K38/00 , C07K2319/31
摘要： The present invention relates to compositions comprising GLP-2 protein or variants thereof linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in the treatment of GLP-2-related conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的GLP-2蛋白或其变体的组合物，编码组合物的分离的核酸和含有该组合物的载体和宿主细胞，以及制备和使用该组合物治疗 GLP-2相关条件。
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7.发明申请公开(公告)号：US20110046060A1
公开(公告)日：2011-02-24
申请号：US12806004
申请日：2010-08-02
申请人： Volker Schellenberger , Joshua Silverman , Willem Stemmer , Chia-wei Wang , Benjamin Spink , Nathan Geething , Wayne To
发明人： Volker Schellenberger , Joshua Silverman , Willem Stemmer , Chia-wei Wang , Benjamin Spink , Nathan Geething , Wayne To
IPC分类号： A61K38/36 , C07K14/745 , A61P7/04
CPC分类号： C12N9/644 , A61K38/00 , C07K14/001 , C07K2319/00 , C07K2319/31 , C07K2319/50 , C12N9/6437 , C12N15/70 , C12Y304/21022
摘要： The present invention relates to compositions comprising factor IX coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of coagulation factor-related diseases, disorders, and conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的因子IX凝血因子的组合物，编码组合物的分离的核酸和载体以及含有它们的宿主细胞，以及制备和使用这些组合物治疗凝血因子相关的方法 疾病，病症和状况。
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8.发明申请BINDING FUSION PROTEINS, BINDING FUSION PROTEIN-DRUG CONJUGATES, XTEN-DRUG CONJUGATES AND METHODS OF MAKING AND USING SAME 有权结合融合蛋白，结合融合蛋白 - 药物结合物，XTEN-DRUG结合体及其制备和使用方法公开(公告)号：US20130165389A1
公开(公告)日：2013-06-27
申请号：US13631361
申请日：2012-09-28
申请人： Volker Schellenberger , Joshua Silverman , Chia-wei Wang , Benjamin Spink , Willem P. Stemmer , Susan E. Alters , Nathan Geething
发明人： Volker Schellenberger , Joshua Silverman , Chia-wei Wang , Benjamin Spink , Willem P. Stemmer , Susan E. Alters , Nathan Geething
CPC分类号： C12P21/02 , A61K38/00 , C07K14/00 , C07K14/70521 , C07K14/7155 , C07K14/8125 , C07K16/18 , C07K16/241 , C07K16/244 , C07K16/2809 , C07K16/2863 , C07K16/2878 , C07K16/32 , C07K16/40 , C07K2317/31 , C07K2317/569 , C07K2317/622 , C07K2317/92 , C07K2317/94 , C07K2319/31 , C07K2319/70 , C07K2319/74 , C12N15/625
摘要： The present invention relates to binding fusion protein compositions comprising targeting moieties linked to extended recombinant polypeptide (XTEN), binding fusion protein-drug conjugate compositions, and XTEN-drug conjugate compositions, isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of using such compositions in treatment of diseases, disorders, and conditions.
摘要翻译： 本发明涉及包含与延伸重组多肽（XTEN）连接的靶向部分，结合融合蛋白 - 药物共轭组合物和XTEN-药物共轭组合物的结合融合蛋白组合物，编码组合物和载体的分离的核酸和含有该重组多肽的宿主细胞 以及使用这些组合物治疗疾病，病症和病症的方法。
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9.发明申请公开(公告)号：US20110046061A1
公开(公告)日：2011-02-24
申请号：US12806005
申请日：2010-08-02
申请人： Volker Schellenberger , Joshua Silverman , Willem Stemmer , Chia-wei Wang , Benjamin Spink , Nathan Geething , Wayne To
发明人： Volker Schellenberger , Joshua Silverman , Willem Stemmer , Chia-wei Wang , Benjamin Spink , Nathan Geething , Wayne To
CPC分类号： C12N9/644 , A61K38/00 , C07K14/001 , C07K2319/00 , C07K2319/31 , C07K2319/50 , C12N9/6437 , C12N15/70 , C12Y304/21022
摘要： The present invention relates to compositions comprising factor VII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of coagulation factor-related diseases, disorders, and conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的因子VII凝血因子的组合物，编码组合物的分离的核酸和载体以及含有它们的宿主细胞，以及制备和使用这些组合物治疗凝血因子相关的方法 疾病，病症和状况。
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10.发明申请公开(公告)号：US20120263703A1
公开(公告)日：2012-10-18
申请号：US13392511
申请日：2010-08-02
申请人： Volker Schellenberger , Willem P. Stemmer , Nathan C. Geething , Wayne To , Joshua Silverman , Chia-wei Wang , Benjamin Spink
发明人： Volker Schellenberger , Willem P. Stemmer , Nathan C. Geething , Wayne To , Joshua Silverman , Chia-wei Wang , Benjamin Spink
CPC分类号： C12N9/644 , A61K38/00 , C07K14/001 , C07K2319/00 , C07K2319/31 , C07K2319/50 , C12N9/6437 , C12N15/70 , C12Y304/21022
摘要： The present invention relates to compositions comprising factor DC coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of coagulation factor-related diseases, disorders, and conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的因子DC凝血因子的组合物，编码组合物的分离的核酸和载体以及含有它们的宿主细胞，以及制备和使用这些组合物治疗凝血因子相关的方法 疾病，病症和状况。
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