利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

29 条记录 (耗时 0.033 秒)

    Methods of determining the structure of a compound encoded by identifiers having tags
    1.
    发明授权
    Methods of determining the structure of a compound encoded by identifiers having tags 失效
    确定具有标签的标识符编码的化合物的结构的方法

    公开(公告)号：US5789172A

    公开(公告)日：1998-08-04

    申请号：US680716

    申请日：1996-07-11

    申请人： W. Clark Still ,  Michael H. Wigler ,  Michael H. J. Ohlmeyer ,  Lawrence W. Dillard ,  John C. Reader

    发明人： W. Clark Still ,  Michael H. Wigler ,  Michael H. J. Ohlmeyer ,  Lawrence W. Dillard ,  John C. Reader

    IPC分类号： G01N33/566 ,  C07B61/00 ,  C07C43/225 ,  C07C205/59 ,  C07C245/14 ,  C07C317/28 ,  C07D243/24 ,  C07D521/00 ,  C07H21/00 ,  C07K1/00 ,  C07K1/04 ,  C40B70/00 ,  G01N33/532 ,  G01N33/543 ,  G01N33/68 ,  C12Q1/68 ,  G01N33/53

    CPC分类号： G01N33/68 ,  C07D243/24 ,  C07H21/00 ,  C07K1/047 ,  C40B50/16 ,  G01N33/532 ,  G01N33/54353 ,  B01J2219/00572 ,  C07B2200/11 ,  C40B40/00 ,  C40B70/00

    摘要： Encoded combinatorial chemistry is provided, where sequential synthetic schemes are recorded using organic molecules, which define choice of reactant, and stage, as the same or different bit of information. Various products can be produced in the multi-stage synthesis, such as oligomers and synthetic non-repetitive organic molecules. Conveniently, nested families of compounds can be employed as identifiers, where number and/or position of a substituent define the choice. Alternatively, detectable functionalities may be employed, such as radioisotopes, fluorescers, halogens, and the like, where presence and ratios of two different groups can be used to define stage or choice. Particularly, pluralities of identifiers may be used to provide a binary or higher code, so as to define a plurality of choices with only a few detachable tags. The particles may be screened for a characteristic of interest, particularly binding affinity, where the products may be detached from the particle or retained on the particle. The reaction history of the particles which are positive for the characteristic can be determined by the release of the tags and analysis to define the reaction history of the particle.

    摘要翻译： 提供了编码的组合化学，其中使用有机分子记录顺序合成方案，其定义了反应物的选择和阶段，作为相同或不同的信息位。 可以在多级合成中产生各种产物，例如低聚物和合成的非重复有机分子。 方便地，化合物的嵌套族可以用作标识符，其中取代基的数目和/或位置定义了选择。 或者，可以使用可检测的官能团，例如放射性同位素，荧光剂，卤素等，其中两个不同基团的存在和比例可用于限定阶段或选择。 特别地，可以使用多个标识符来提供二进制或更高代码，以便仅限定几个可拆卸标签来定义多个选择。 可以筛选颗粒以获得感兴趣的特征，特别是结合亲和力，其中产物可以与颗粒分离或保留在颗粒上。 对特征呈阳性的颗粒的反应历程可以通过标签的释放和分析来确定以确定颗粒的反应历程。

    Methods for recording the reaction history of a solid support
    2.
    发明授权
    Methods for recording the reaction history of a solid support 失效
    用于记录固体支持物的反应历史的方法

    公开(公告)号：US5968736A

    公开(公告)日：1999-10-19

    申请号：US480821

    申请日：1995-06-07

    申请人： W. Clark Still ,  Michael H. Wigler ,  Michael H. J. Ohlmeyer ,  Lawrence W. Dillard ,  John C. Reader

    发明人： W. Clark Still ,  Michael H. Wigler ,  Michael H. J. Ohlmeyer ,  Lawrence W. Dillard ,  John C. Reader

    IPC分类号： G01N33/566 ,  C07B61/00 ,  C07C43/225 ,  C07C205/59 ,  C07C245/14 ,  C07C317/28 ,  C07D243/24 ,  C07D521/00 ,  C07H21/00 ,  C07K1/00 ,  C07K1/04 ,  C40B70/00 ,  G01N33/532 ,  G01N33/543 ,  G01N33/68 ,  G01N33/53

    CPC分类号： G01N33/68 ,  C07D243/24 ,  C07H21/00 ,  C07K1/047 ,  C40B50/16 ,  G01N33/532 ,  G01N33/54353 ,  B01J2219/00572 ,  C07B2200/11 ,  C40B40/00 ,  C40B70/00

    摘要： Encoded combinatorial chemistry is provided, where sequential synthetic schemes are recorded using organic molecules, which define choice of reactant, and stage, as the same or different bit of information. Various products can be produced in the multi-stage synthesis, such as oligomers and synthetic non-repetitive organic molecules. Conveniently, nested families of compounds can be employed as identifiers, where number and/or position of a substituent define the choice. Alternatively, detectable functionalities may be employed, such as radioisotopes, fluorescers, halogens, and the like, where presence and ratios of two different groups can be used to define stage or choice. Particularly, pluralities of identifiers may be used to provide a binary or higher code, so as to define a plurality of choices with only a few detachable tags. The particles may be screened for a characteristic of interest, particularly binding affinity, where the products may be detached from the particle or retained on the particle. The reaction history of the particles which are positive for the characteristic can be determined by the release of the tags and analysis to define the reaction history of the particle.

    摘要翻译： 提供了编码的组合化学，其中使用有机分子记录顺序合成方案，其定义了反应物的选择和阶段，作为相同或不同的信息位。 可以在多级合成中产生各种产物，例如低聚物和合成的非重复有机分子。 方便地，化合物的嵌套族可以用作标识符，其中取代基的数目和/或位置定义了选择。 或者，可以使用可检测的官能团，例如放射性同位素，荧光剂，卤素等，其中两个不同基团的存在和比例可用于限定阶段或选择。 特别地，可以使用多个标识符来提供二进制或更高代码，以便仅限定几个可拆卸标签来定义多个选择。 可以筛选颗粒以获得感兴趣的特征，特别是结合亲和力，其中产物可以与颗粒分离或保留在颗粒上。 对特征呈阳性的颗粒的反应历程可以通过标签的释放和分析来确定以确定颗粒的反应历程。

    Supports and combinatorial chemical libraries thereof encoded by non-sequencable tags
    3.
    发明授权
    Supports and combinatorial chemical libraries thereof encoded by non-sequencable tags 失效
    由非可序列标签编码的支持体和组合化学文库

    公开(公告)号：US6001579A

    公开(公告)日：1999-12-14

    申请号：US485018

    申请日：1995-06-07

    申请人： W. Clark Still ,  Michael H. Wigler ,  Michael H. J. Ohlmeyer ,  Lawrence W. Dillard ,  John C. Reader

    发明人： W. Clark Still ,  Michael H. Wigler ,  Michael H. J. Ohlmeyer ,  Lawrence W. Dillard ,  John C. Reader

    IPC分类号： C07D243/16 ,  G01N33/53 ,  G01N33/543 ,  G01N33/546 ,  G01N33/566 ,  G01N33/58

    CPC分类号： C07D243/28 ,  C07D491/048 ,  C40B40/04 ,  C40B50/16 ,  C40B70/00 ,  G01N33/54313 ,  G01N33/54353 ,  C07B2200/11

    摘要： Encoded combinatorial chemistry is provided, where sequential synthetic schemes are recorded using organic molecules, which define choice of reactant, and stage, as the same or different bit of information. Various products can be produced in the multi-stage synthesis, such as oligomers and synthetic non-repetitive organic molecules. Conveniently, nested families of compounds can be employed as identifiers, where number and/or position of a substituent define the choice. Alternatively, detectable functionalities may be employed, such as radioisotopes, fluorescers, halogens, and the like, where presence and ratios of two different groups can be used to define stage or choice. Particularly, pluralities of identifiers may be used to provide a binary or higher code, so as to define a plurality of choices with only a few detachable tags. The particles may be screened for a characteristic of interest, particularly binding affinity, where the products may be detached from the particle or retained on the particle. The reaction history of the particles which are positive for the characteristic can be determined by the release of the tags and analysis to define the reaction history of the particle.

    摘要翻译： 提供了编码的组合化学，其中使用有机分子记录顺序合成方案，其定义了反应物的选择和阶段，作为相同或不同的信息位。 可以在多级合成中产生各种产物，例如低聚物和合成的非重复有机分子。 方便地，化合物的嵌套族可以用作标识符，其中取代基的数目和/或位置定义了选择。 或者，可以使用可检测的官能团，例如放射性同位素，荧光剂，卤素等，其中两个不同基团的存在和比例可用于限定阶段或选择。 特别地，可以使用多个标识符来提供二进制或更高代码，以便仅限定几个可拆卸标签来定义多个选择。 可以筛选颗粒以获得感兴趣的特征，特别是结合亲和力，其中产物可以与颗粒分离或保留在颗粒上。 对特征呈阳性的颗粒的反应历程可以通过标签的释放和分析来确定以确定颗粒的反应历程。

    Complex combinatorial chemical libraries encoded with tags
    4.
    发明授权
    Complex combinatorial chemical libraries encoded with tags 失效
    用标签编码的复杂组合化学文库

    公开(公告)号：US06503759B1

    公开(公告)日：2003-01-07

    申请号：US08722014

    申请日：1997-02-07

    申请人： W. Clark Still ,  Michael H. J. Ohlmeyer ,  Lawrence W. Dillard ,  John C. Reader ,  Michael H. Wigler

    发明人： W. Clark Still ,  Michael H. J. Ohlmeyer ,  Lawrence W. Dillard ,  John C. Reader ,  Michael H. Wigler

    IPC分类号： G01N33543

    CPC分类号： G01N33/68 ,  B01J2219/00572 ,  C07B2200/11 ,  C07D243/24 ,  C07H21/00 ,  C07K1/047 ,  C40B50/16 ,  C40B70/00 ,  G01N33/532 ,  G01N33/54353

    摘要： Encoded combinatorial chemistry is provided, where sequential synthetic schemes are recorded using organic molecules, which define choice of reactant, and stage, as the same or different bit of information. Various products can be produced in the multi-stage synthesis, such as oligomers and synthetic non-repetitive organic molecules. Conveniently, nested families of compounds can be employed as identifiers, where number and/or position of a substituent define the choice. Alternatively, detectable functionalities may be employed, such as radioisotopes, fluorescers, halogens, and the like, where presence and ratios of two different groups can be used to define stage or choice. Particularly, pluralities of identifiers may be used to provide a binary or higher code, so as to define a plurality of choices with only a few detachable tags. The particles may be screened for a characteristic of interest, particularly binding affinity, where the products may be detached from the particle or retained on the particle. The reaction history of the particles which are positive for the characteristic can be determined by the release of the tags and analysis to define the reaction history of the particle.

    摘要翻译： 提供了编码的组合化学，其中使用有机分子记录顺序合成方案，其定义了反应物的选择和阶段，作为相同或不同的信息位。 可以在多级合成中产生各种产物，例如低聚物和合成的非重复有机分子。 方便地，化合物的嵌套族可以用作标识符，其中取代基的数目和/或位置定义了选择。 或者，可以使用可检测的官能团，例如放射性同位素，荧光剂，卤素等，其中两个不同基团的存在和比例可用于限定阶段或选择。 特别地，可以使用多个标识符来提供二进制或更高代码，以便仅限定几个可拆卸标签来定义多个选择。 可以筛选颗粒以获得感兴趣的特征，特别是结合亲和力，其中产物可以与颗粒分离或保留在颗粒上。 对特征呈阳性的颗粒的反应历程可以通过标签的释放和分析来确定以确定颗粒的反应历程。

    Complex combinatorial chemical libraries encoded with tags
    5.
    发明授权
    Complex combinatorial chemical libraries encoded with tags 失效
    用标签编码的复杂组合化学文库

    公开(公告)号：US06936477B2

    公开(公告)日：2005-08-30

    申请号：US10150141

    申请日：2002-05-17

    申请人： W. Clark Still ,  Michael H. J. Ohlmeyer ,  Lawrence W. Dillard ,  John C. Reader ,  Michael H. Wigler

    发明人： W. Clark Still ,  Michael H. J. Ohlmeyer ,  Lawrence W. Dillard ,  John C. Reader ,  Michael H. Wigler

    IPC分类号： G01N33/543 ,  C12Q1/68

    CPC分类号： G01N33/54353 ,  G01N33/543

    摘要： Encoded combinatorial chemistry is provided, where sequential synthetic schemes are recorded using organic molecules, which define choice of reactant, and stage, as the same or different bit of information. Various products can be produced in the multi-stage synthesis, such as oligomers and synthetic non-repetitive organic molecules. Conveniently, nested families of compounds can be employed as identifiers, where number and/or position of a substituent define the choice. Alternatively, detectable functionalities may be employed, such as radioisotopes, fluorescers, halogens, and the like, where presence and ratios of two different groups can be used to define stage or choice. Particularly, pluralities of identifiers may be used to provide a binary or higher code, so as to define a plurality of choices with only a few detachable tags. The particles may be screened for a characteristic of interest, particularly binding affinity, where the products may be detachable from the particle or retained on the particle. The reaction history of the particles which are positive for the characteristic can be determined by the release of the tags and analysis to define the reaction history of the particle.

    摘要翻译： 提供了编码的组合化学，其中使用有机分子记录顺序合成方案，其定义了反应物的选择和阶段，作为相同或不同的信息位。 可以在多级合成中产生各种产物，例如低聚物和合成的非重复有机分子。 方便地，化合物的嵌套族可以用作标识符，其中取代基的数目和/或位置定义了选择。 或者，可以使用可检测的官能团，例如放射性同位素，荧光剂，卤素等，其中两个不同基团的存在和比例可用于限定阶段或选择。 特别地，可以使用多个标识符来提供二进制或更高代码，以便仅限定几个可拆卸标签来定义多个选择。 可以筛选颗粒以获得感兴趣的特征，特别是结合亲和力，其中产物可以与颗粒分离或保留在颗粒上。 对特征呈阳性的颗粒的反应历程可以通过标签的释放和分析来确定以确定颗粒的反应历程。

    Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules
    9.
    发明授权
    Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules 失效
    产生包含多种抗体DNA扩增的抗体基因库的方法以及使用这些文库生产多种抗原结合分子的方法

    公开(公告)号：US5780225A

    公开(公告)日：1998-07-14

    申请号：US315269

    申请日：1994-09-29

    申请人： Michael H. Wigler ,  Joseph A. Sorge

    发明人： Michael H. Wigler ,  Joseph A. Sorge

    IPC分类号： C12N15/10 ,  C12Q1/68 ,  C12P21/00

    CPC分类号： C12Q1/6811 ,  C12N15/10 ,  C07K2319/00

    摘要： A method of producing libraries of genes encoding antigen-combining molecules or antibodies; a method of producing antigen-combining molecules which does not require an in vivo procedure; a method of obtaining antigen-combining molecules of selected specificity which does not require an in vivo procedure; vectors useful in the present method; and antigen-combining molecules produced by the method. The antigen-combining molecules are useful for the detection, quantitation, purification and neutralization of antigens, as well as for diagnostic, therapeutic and prophylactic purposes.

    摘要翻译： 一种产生编码抗原结合分子或抗体的基因文库的方法; 生产不需要体内程序的抗原结合分子的方法; 获得不需要体内过程的所选特异性的抗原结合分子的方法; 本方法有用的载体; 和通过该方法产生的抗原结合分子。 抗原结合分子可用于抗原的检测，定量，纯化和中和，以及用于诊断，治疗和预防目的。