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    METHODS FOR MODULATING TAU EXPRESSION FOR REDUCING SEIZURE AND MODIFYING A NEURODEGENERATIVE SYNDROME
    2.
    发明申请
    METHODS FOR MODULATING TAU EXPRESSION FOR REDUCING SEIZURE AND MODIFYING A NEURODEGENERATIVE SYNDROME 审中-公开
    调节TAU表达以减少癫痫发作和修饰神经营养因子的方法

    公开(公告)号：US20150275205A1

    公开(公告)日：2015-10-01

    申请号：US14387853

    申请日：2013-03-14

    申请人： WASHINGTON UNIVERSITY ,  ISIS PHARMACEUTICALS, INC.

    发明人： Timothy M. Miller ,  Sarah Devos ,  C. Frank Bennett ,  Frank Rigo

    IPC分类号： C12N15/113

    CPC分类号： C12N15/113 ,  C07H21/02 ,  C07H21/04 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3525

    摘要： Disclosed herein are methods for reducing expression of Tau mRNA and protein in an animal with Tau antisense compounds. Also disclosed are methods for modulating splicing of Tau mRNA in an animal with Tau antisense compounds. Such methods are useful to treat, prevent, or ameliorate neurodegenerative diseases in an individual in need thereof. Examples of neurodegenerative diseases that can be treated, prevented, and ameliorated with the administration Tau antisense oligonucleotides include Alzheimer's Disease, Fronto-temporal Dementia (FTD), FTDP-17, Progressive Supranuclear Palsy, Chronic Traumatic Encephalopathy, Epilepsy, and Dravet's Syndrome.

    摘要翻译： 本文公开了用Tau反义化合物减少动物中Tau mRNA和蛋白质的表达的方法。 还公开了用Tau反义化合物调节动物中Tau mRNA的剪接的方法。 这样的方法可用于治疗，预防或改善有需要的个体中的神经变性疾病。 可以用施用Tau反义寡核苷酸治疗，预防和改善的神经变性疾病的实例包括阿尔茨海默氏病，颞痴呆（FTD），FTDP-17，进行性核核麻痹，慢性创伤性脑病，癫痫和德拉维特综合征。

    METABOLISM OF SOD1 IN CSF
    9.
    发明申请
    METABOLISM OF SOD1 IN CSF 审中-公开
    SOD1在脑脊液中的代谢

    公开(公告)号：US20140302520A1

    公开(公告)日：2014-10-09

    申请号：US14352560

    申请日：2012-10-17

    申请人： The Washington University

    发明人： Randall J. Bateman ,  Timothy M. Miller ,  Ling Munsell

    IPC分类号： G01N33/577

    CPC分类号： G01N33/577 ,  C12Q1/26 ,  G01N33/5058 ,  G01N33/5088 ,  G01N33/6896 ,  G01N2333/90283 ,  G01N2560/00 ,  G01N2800/28

    摘要： The disclosure relates to methods for the diagnosis and treatment of neurological and neurodegenerative diseases, disorders, and associated processes. Specifically, the disclosure relates to a method for measuring the metabolism of central nervous system derived biomolecules in a subject in vivo. Further disclosed are methods for measuring the in vivo metabolism (e.g. the rate of synthesis, the rate of clearance) of neurally derived biomolecules, such as superoxide dismutase 1 (SOD1).

    摘要翻译： 本公开涉及用于诊断和治疗神经和神经退行性疾病，病症和相关过程的方法。 具体地，本公开涉及一种用于测量受试者体内衍生的中枢神经系统生物分子的代谢的方法。 还公开了用于测量神经衍生的生物分子例如超氧化物歧化酶1（SOD1）的体内代谢（例如合成速率，清除速率）的方法。