公开(公告)号：US20190177357A1

公开(公告)日：2019-06-13

申请号：US16182302

申请日：2018-11-06

Applicant: WAVE LIFE SCIENCES LTD.

Inventor： Mamoru Shimizu ,  Takeshi Wada

IPC: C07H23/00 ,  C07H19/207 ,  C07H19/10 ,  C07H1/00 ,  C07F7/08 ,  C07D473/34 ,  C07B53/00 ,  C07D405/04 ,  C07D207/08 ,  C07H21/04 ,  C07H19/213 ,  C07H19/11 ,  C07D473/18

Abstract: To provide a chiral reagent or a salt thereof.The chiral reagent has following chemical formula (I). In the formula (I), G1 and G2 are independently a hydrogen atom, a nitro group (—NO2), a halogen atom, a cyano group (—CN), a group of formula (II) or (III), or both G1 and G2 taken together to form a group of formula (IV).

公开(公告)号：US10696711B2

公开(公告)日：2020-06-30

申请号：US16182302

申请日：2018-11-06

Applicant: WAVE LIFE SCIENCES LTD.

Inventor： Mamoru Shimizu ,  Takeshi Wada

IPC: C07H23/00 ,  C07B53/00 ,  C07H21/04 ,  C07H1/00 ,  C07H19/10 ,  C07H19/207 ,  C07D405/04 ,  C07D473/18 ,  C07D473/34 ,  C07H19/11 ,  C07H19/213 ,  C07D207/08 ,  C07F7/08

Abstract: To provide a chiral reagent or a salt thereof.The chiral reagent has following chemical formula (I). In the formula (I), G1 and G2 are independently a hydrogen atom, a nitro group (—NO2), a halogen atom, a cyano group (—CN), a group of formula (II) or (III), or both G1 and G2 taken together to form a group of formula (IV).

公开(公告)号：US20220127301A1

公开(公告)日：2022-04-28

申请号：US17465238

申请日：2021-09-02

Applicant: WAVE LIFE SCIENCES LTD.

Inventor： Mamoru Shimizu ,  Takeshi Wada

IPC: C07H23/00 ,  C07D405/04 ,  C07D473/18 ,  C07D473/34 ,  C07B53/00 ,  C07H19/11 ,  C07H19/213 ,  C07H21/04 ,  C07D207/08 ,  C07F7/08 ,  C07H1/00 ,  C07H19/10 ,  C07H19/207

Abstract: To provide a chiral reagent or a salt thereof.
The chiral reagent has following chemical formula (I). In the formula (I), G1 and G2 are independently a hydrogen atom, a nitro group (—NO2), a halogen atom, a cyano group (—CN), a group of formula (II) or (III), or both G1 and G2 taken together to form a group of formula (IV).

公开(公告)号：US11136346B2

公开(公告)日：2021-10-05

申请号：US16878461

申请日：2020-05-19

Applicant: WAVE LIFE SCIENCES LTD.

Inventor： Mamoru Shimizu ,  Takeshi Wada

IPC: C07H23/00 ,  C07H1/00 ,  C07H19/207 ,  C07D405/04 ,  C07D473/18 ,  C07D473/34 ,  C07B53/00 ,  C07H19/11 ,  C07H19/213 ,  C07H21/04 ,  C07D207/08 ,  C07F7/08 ,  C07H19/10

Abstract: To provide a chiral reagent or a salt thereof.
The chiral reagent has following chemical formula (I). In the formula (I), G1 and G2 are independently a hydrogen atom, a nitro group (—NO2), a halogen atom, a cyano group (—CN), a group of formula (II) or (III), or both G1 and G2 taken together to form a group of formula (IV).

公开(公告)号：US10329318B2

公开(公告)日：2019-06-25

申请号：US15608123

申请日：2017-05-30

Applicant: WAVE LIFE SCIENCES LTD.

Inventor： Takeshi Wada ,  Mamoru Shimizu

IPC: C07H21/00 ,  C07H21/02 ,  C07H21/04 ,  C07H1/00

Abstract: Described herein are methods of syntheses of phosphorous atom-modified nucleic acids comprising chiral X-phosphonate moieties. The methods described herein provide backbone-modified nucleic acids in high diasteteomeric purity via an asymmetric reaction of an achiral molecule comprising a chemically stable H-phophonate moiety with a nucleoside/nucleotide.

公开(公告)号：US10167309B2

公开(公告)日：2019-01-01

申请号：US15294602

申请日：2016-10-14

Applicant: WAVE LIFE SCIENCES LTD

Inventor： Mamoru Shimizu ,  Takeshi Wada

IPC: C07D207/08 ,  C07F7/08 ,  C07H19/10 ,  C07H19/207 ,  C07H1/00 ,  C07H23/00 ,  C07B53/00 ,  C07H19/11 ,  C07H19/213 ,  C07H21/04 ,  C07D405/04 ,  C07D473/18 ,  C07D473/34

Abstract: To provide a chiral reagent or a salt thereof.The chiral reagent has following chemical formula (I). In the formula (I), G1 and G2 are independently a hydrogen atom, a nitro group (—NO2), a halogen atom, a cyano group (—CN), a group of formula (II) or (III), or both G1 and G2 taken together to form a group of formula (IV).