公开(公告)号：US10196433B2

公开(公告)日：2019-02-05

申请号：US15587708

申请日：2017-05-05

申请人： Wyeth LLC

发明人： Stephen Berasi ,  Robert Vincent Martinez ,  Michael John Cain ,  John Martin Wozney ,  Howard Joel Seeherman ,  Zong Sean Juo ,  Valerie Perrine Calabro ,  Christopher Todd Brown

IPC分类号： A61K38/16 ,  A61K38/17 ,  A61K38/19 ,  C07K14/00 ,  C07K14/435 ,  C07K14/46 ,  C07K14/47 ,  C07K14/475 ,  C12N15/12 ,  C12N15/00 ,  C07K14/51

摘要： The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. The designer BMPs demonstrate altered biological characteristics and provide potential useful novel therapeutics.

公开(公告)号：US11008373B2

公开(公告)日：2021-05-18

申请号：US16211493

申请日：2018-12-06

申请人： Wyeth LLC

发明人： Stephen Berasi ,  Robert Vincent Martinez ,  Michael John Cain ,  John Martin Wozney ,  Howard Seeherman ,  Zong Sean Juo ,  Valerie Perrine Calabro ,  Christopher Todd Brown

IPC分类号： C07K14/51 ,  C12N15/63 ,  C12N5/10 ,  A61K38/16 ,  A61K38/18

摘要： The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. The designer BMPs demonstrate altered biological characteristics and provide potential useful novel therapeutics.

公开(公告)号：US20190241634A1

公开(公告)日：2019-08-08

申请号：US16211493

申请日：2018-12-06

申请人： Wyeth LLC

发明人： Stephen BERASI ,  Robert Vincent Martinez ,  Michael John Cain ,  John Martin Wozney ,  Howard Joel Seeherman ,  Zong Sean Juo ,  Valerie Perrine Calabro ,  Christopher Todd Brown

IPC分类号： C07K14/51

CPC分类号： C07K14/51

摘要： The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. The designer BMPs demonstrate altered biological characteristics and provide potential useful novel therapeutics.

公开(公告)号：US20180134762A1

公开(公告)日：2018-05-17

申请号：US15587708

申请日：2017-05-05

申请人： Wyeth LLC

发明人： Stephen BERASI ,  Robert Vincent Martinez ,  Michael John Cain ,  John Martin Wozney ,  Howard Joel Seeherman ,  Zong Sean Juo ,  Valerie Perrine Calabro ,  Christopher Todd Brown

IPC分类号： C07K14/51

CPC分类号： C07K14/51

摘要： The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. The designer BMPs demonstrate altered biological characteristics and provide potential useful novel therapeutics.

公开(公告)号：US09856305B2

公开(公告)日：2018-01-02

申请号：US14679705

申请日：2015-04-06

申请人： WYETH LLC

发明人： John Wozney ,  Howard Seeherman ,  Christopher Todd Brown

IPC分类号： A61K38/18 ,  C07K14/51 ,  C12N15/09 ,  A61K38/00

CPC分类号： C07K14/51 ,  A61K38/00 ,  A61K38/1875 ,  C12N15/09

摘要： The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. The designer BMPs demonstrate altered biological characteristics and provide potential useful novel therapeutics.

公开(公告)号：US10370424B2

公开(公告)日：2019-08-06

申请号：US15820527

申请日：2017-11-22

申请人： WYETH LLC

发明人： John Wozney ,  Howard Seeherman ,  Christopher Todd Brown

IPC分类号： A61K38/18 ,  C07K14/51 ,  C12N15/09 ,  A61K38/00

摘要： The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. The designer BMPs demonstrate altered biological characteristics and provide potential useful novel therapeutics.

公开(公告)号：US20180072787A1

公开(公告)日：2018-03-15

申请号：US15820527

申请日：2017-11-22

申请人： WYETH LLC

发明人： John Wozney ,  Howard Seeherman ,  Christopher Todd Brown

IPC分类号： C07K14/51 ,  C12N15/09 ,  A61K38/18 ,  A61K38/00

CPC分类号： C07K14/51 ,  A61K38/00 ,  A61K38/1875 ,  C12N15/09

摘要： The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. The designer BMPs demonstrate altered biological characteristics and provide potential useful novel therapeutics.