公开(公告)号：US10123750B2

公开(公告)日：2018-11-13

申请号：US14759092

申请日：2014-01-03

Applicant: Wake Forest University Health Sciences

Inventor： Mark R. Witcher ,  Robert E. Hampson ,  Sam Deadwyler ,  Daniel E. Couture ,  Gautam Popli

IPC: A61B5/04 ,  A61B5/00 ,  A61B5/0476 ,  A61N1/05 ,  A61N1/36

Abstract: The present invention provides methods and devices for predicting, preventing, detecting and/or treating seizures. In some embodiments, the present invention provides methods/devices for predicting a seizure prior to its inception, wherein the seizure is predicted based upon neuronal activity in the CA3 region of a patient's hippocampus.

公开(公告)号：US20140249445A1

公开(公告)日：2014-09-04

申请号：US14196707

申请日：2014-03-04

Applicant: Wake Forest University Health Sciences

Inventor： Sam Deadwyler ,  Robert E. Hampson ,  Mark R. Witcher ,  Daniel E. Couture ,  Gautam Popli ,  Stephen Tatter ,  Thomas L. Ellis

IPC: A61N1/36 ,  A61B5/0476

CPC classification number: A61N1/36082 ,  A61B5/04001 ,  A61B5/04012 ,  A61B5/0478 ,  A61B5/0482 ,  A61B5/4064 ,  A61B5/4088 ,  A61B5/4094 ,  A61B5/4836 ,  A61B5/486 ,  A61B5/6868 ,  A61B2562/0209 ,  A61N1/0529 ,  A61N1/36025 ,  A61N1/36064

Abstract: The present invention provides methods and devices for improving cognitive function. In some embodiments, cognitive function is improved by detecting neuronal activity in the CA3 region of a patient's hippocampus and stimulating the CA3 region of the patient's hippocampus responsive to the neuronal activity detected.

Abstract translation: 本发明提供用于改善认知功能的方法和装置。 在一些实施方案中，通过检测患者海马CA3区域中的神经元活性并且响应于所检测的神经元活性刺激患者海马CA3区域来改善认知功能。

公开(公告)号：US20200016407A1

公开(公告)日：2020-01-16

申请号：US16580764

申请日：2019-09-24

Applicant: Wake Forest University Health Sciences

Inventor： Sam Deadwyler ,  Robert E. Hampson ,  Mark R. Witcher ,  Daniel E. Couture ,  Gautam Popli ,  Stephen Tatter ,  Thomas L. Ellis

IPC: A61N1/36 ,  A61B5/00 ,  A61B5/04 ,  A61B5/0478 ,  A61B5/0482 ,  A61N1/05

Abstract: The present invention provides methods and devices for improving cognitive function. In some embodiments, cognitive function is improved by detecting neuronal activity in the CA3 region of a patient's hippocampus and stimulating the CA3 region of the patient's hippocampus responsive to the neuronal activity detected.

公开(公告)号：US20170151435A1

公开(公告)日：2017-06-01

申请号：US15429436

申请日：2017-02-10

Applicant: Wake Forest University Health Sciences

Inventor： Sam Deadwyler ,  Robert E. Hampson ,  Mark R. Witcher ,  Daniel E. Couture ,  Gautam PopIi ,  Stephen Tatter ,  Thomas L. Ellis

IPC: A61N1/36 ,  A61B5/0478 ,  A61B5/00 ,  A61N1/05 ,  A61B5/04 ,  A61B5/0482

CPC classification number: A61N1/36082 ,  A61B5/04001 ,  A61B5/04012 ,  A61B5/0478 ,  A61B5/0482 ,  A61B5/4064 ,  A61B5/4088 ,  A61B5/4094 ,  A61B5/4836 ,  A61B5/486 ,  A61B5/6868 ,  A61B2562/0209 ,  A61N1/0529 ,  A61N1/36025 ,  A61N1/36064

Abstract: The present invention provides methods and devices for improving cognitive function. In some embodiments, cognitive function is improved by detecting neuronal activity in the CA3 region of a patient's hippocampus and stimulating the CA3 region of the patient's hippocampus responsive to the neuronal activity detected.

公开(公告)号：US20150335294A1

公开(公告)日：2015-11-26

申请号：US14759092

申请日：2014-01-03

Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES

Inventor： Mark R. Witcher ,  Robert E. Hampson ,  Sam Deadwyler ,  Daniel E. Couture ,  Gautam Popli

IPC: A61B5/00 ,  A61N1/05 ,  A61N1/36 ,  A61B5/0476

CPC classification number: A61B5/7275 ,  A61B5/0476 ,  A61B5/4094 ,  A61N1/0529 ,  A61N1/36025 ,  A61N1/36064 ,  G06F19/00

Abstract: The present invention provides methods and devices for predicting, preventing, detecting and/or treating seizures. In some embodiments, the present invention provides methods/devices for predicting a seizure prior to its inception, wherein the seizure is predicted based upon neuronal activity in the CA3 region of a patient's hippocampus.

Abstract translation: 本发明提供了用于预测，预防，检测和/或治疗癫痫发作的方法和装置。 在一些实施方案中，本发明提供用于在其开始之前预测癫痫发作的方法/装置，其中基于患者海马CA3区域中的神经元活动预测癫痫发作。