公开(公告)号：US5137881A

公开(公告)日：1992-08-11

申请号：US730404

申请日：1991-07-16

申请人： Walter Hubsch ,  Rolf Angerbauer ,  Peter Fey ,  Hilmar Bischoff ,  Joachim Bender ,  Delf Schmidt

发明人： Walter Hubsch ,  Rolf Angerbauer ,  Peter Fey ,  Hilmar Bischoff ,  Joachim Bender ,  Delf Schmidt

IPC分类号： A61K31/535 ,  A61K31/66 ,  A61K31/675 ,  A61P3/06 ,  A61P9/10 ,  A61P43/00 ,  C07D498/04 ,  C07F9/6561 ,  C12N9/99

CPC分类号： C07D498/04 ,  C07F9/6561

摘要： Substituted pyrido-oxazines can be prepared by reduction of the corresponding ketones. They are useful active compounds in medicaments, in particular for the treatment of hyperlipoproteinaemia, lipoproteinaemia and arteriosclerosis.

摘要翻译： 取代的吡啶并恶嗪可以通过还原相应的酮来制备。 它们是药物中有用的活性化合物，特别是用于治疗高脂蛋白血症，脂蛋白血症和动脉硬化。

公开(公告)号：US5120782A

公开(公告)日：1992-06-09

申请号：US724414

申请日：1991-06-28

申请人： Walter Hubsch ,  Rolf Angerbauer ,  Peter Fey ,  Hilmar Bischoff ,  Joachim Bender ,  Delf Schmidt

发明人： Walter Hubsch ,  Rolf Angerbauer ,  Peter Fey ,  Hilmar Bischoff ,  Joachim Bender ,  Delf Schmidt

IPC分类号： A61K31/435 ,  A61K31/675 ,  A61P3/06 ,  A61P9/10 ,  C07D471/04 ,  C07F9/6561

CPC分类号： C07D471/04 ,  C07F9/6561

摘要： Substituted pyrrolo-pyridines can be prepared by reduction of the corresponding ketones. They are useful active compounds for medicaments and can be employed, for example, for the treatment of hyperlipoproteinaemia, lipoproteinaemia and arteriosclerosis.

摘要翻译： 取代的吡咯并 - 吡啶可以通过还原相应的酮来制备。 它们是用于药物的有用的活性化合物，并且可以用于例如治疗高脂蛋白血症，脂蛋白血症和动脉硬化。

公开(公告)号：US4786641A

公开(公告)日：1988-11-22

申请号：US87491

申请日：1987-08-20

申请人： Siegfried Goldmann ,  Hans-Jurgen Ahr ,  Walter Puls ,  Hilmar Bischoff ,  Dieter Petzinna ,  Klaus Schlossmann ,  Joachim Bender

发明人： Siegfried Goldmann ,  Hans-Jurgen Ahr ,  Walter Puls ,  Hilmar Bischoff ,  Dieter Petzinna ,  Klaus Schlossmann ,  Joachim Bender

IPC分类号： A61K31/465 ,  A61K31/445 ,  A61K31/451 ,  A61P3/08 ,  C07D211/90 ,  C07D491/04 ,  C07D491/044 ,  C07D491/048 ,  A61K31/44

CPC分类号： C07D491/04 ,  C07D211/90

摘要： Blood-sugar-lowering dihydropyridines of the formula ##STR1## in which R.sup.1 represents phenyl, naphthyl, thienyl, pyridyl, chromenyl or thiochromenyl, it being possible for the radicals mentioned each to carry up to 2 identical or different substituents from the series comprising halogen, alkyl, alkoxy and alkylthio with in each case up to 6 carbon atoms, fluoroalkyl and fluoroalkoxy with in each case up to 3 carbon atoms and 3 fluorine atoms, nitro and cyano,R.sup.2 represents straight-chain, branched or cyclic alkyl which has up to 8 carbon atoms, can be interrupted in the alkyl chain by an oxygen or a sulphur atom and can be substituted by halogen, phenyl, cyano, hydroxyl, amino, alkylamino or dialkylamino with in each case up to 3 carbon atoms per alkyl group or by N-benzylmethylamino,R.sup.3 represents straight-chain, branched or cyclic alkyl which has up to 6 carbon atoms, can be interrupted in the alkyl chain by an oxygen atom and can be substituted by halogen, hydroxyl, amino, phenyl, morpholino, carboxy or alkoxycarbonyl with up to 4 carbon atoms andR.sup.4 and R.sup.5 each represent hydroxyl, orR.sup.4 and R.sup.5 together represent --O--,or a physiologically acceptable salt thereof.

摘要翻译： 其中R1代表苯基，萘基，噻吩基，吡啶基，色烯基或硫代色烯基的式“IMAGE”的降血糖二氢吡啶类，各自所提及的基团有可能从包含卤素的系列中携带多达2个相同或不同的取代基 ，烷基，烷氧基和烷硫基，在每种情况下最多6个碳原子，氟代烷基和氟代烷氧基，在每种情况下最多3个碳原子和3个氟原子，硝基和氰基，R2表示直链，支链或环状的烷基， 至8个碳原子，可以通过氧或硫原子在烷基链中被中断，并且可以被卤素，苯基，氰基，羟基，氨基，烷基氨基或二烷基氨基取代，在每种情况下，每个烷基最多为3个碳原子，或 通过N-苄基甲基氨基，R3表示具有多至6个碳原子的直链，支链或环状烷基，可以在烷基链中被氧原子中断，并可被卤素，羟基，氨基，苯基， 具有至多4个碳原子的直链，羧基或烷氧基羰基，且R 4和R 5各自表示羟基，或者R 4和R 5一起表示-O-或其生理上可接受的盐。

公开(公告)号：US4894378A

公开(公告)日：1990-01-16

申请号：US210061

申请日：1988-06-22

申请人： Siegfried Goldmann ,  Hilmar Bischoff ,  Walter Puls ,  Joachim Bender ,  Dieter Petzinna ,  Klaus Schlossmann

发明人： Siegfried Goldmann ,  Hilmar Bischoff ,  Walter Puls ,  Joachim Bender ,  Dieter Petzinna ,  Klaus Schlossmann

IPC分类号： A61K31/435 ,  A61P3/08 ,  A61P3/10 ,  C07D491/04 ,  C07D491/048

CPC分类号： C07D491/04

摘要： Blood sugar levels are reduced by administration of novel 4-thienyl-dihydropyridines of the formula ##STR1## in which R.sup.1 represents 1 or 2 halogen atoms, or represents straight-chain, branched or cyclic alkyl with up to 8 carbon atoms,R.sup.2 represents a straight-chain, branched or cyclic, saturated or unsaturated hydrocarbon radical which has up to 15 carbon atoms, is optionally interrupted by one or two oxygen atoms, -N-phenyl or --SO.sub.n -- (n=0, 1 or 2) and is optionally substituted by halogen, phenyl, hydroxyl, cyano, amino, C.sub.1 -C.sub.6 -alkylamino, di-C.sub.1 -C.sub.6 -alkylamino, pyridyl, piperidino, N-phenylpiperazino, N-methylpiperazino, morpholino or N-benzyl-N-methyl-amino,R.sup.3 represents hydrogen, or represents straight-chain, branched or cyclic alkyl which has up to 6 carbon atoms and is optionally substituted by halogen, hydroxyl, amino or amino-C.sub.1 -C.sub.6 -alkoxy, or represents cyano or formyl andR.sup.4 represents hydrogen or a straight-chain, branched or cyclic alkyl radical which has up to 10 carbon atoms, is optionally interrupted by one or two oxygen atoms in the chain and is optionally substituted by halogen, cyano, hydroxyl, phenyl, carboxyl, C.sub.1 -C.sub.6 -alkoxycarbonyl, amino, C.sub.1 14 C.sub.6 -alkylamino, di-C.sub.1 -C.sub.6 -alkylamino, formyl, piperidino, morpholino or thiomorpholino, or physiologically acceptable salts thereof.

公开(公告)号：US4801715A

公开(公告)日：1989-01-31

申请号：US937870

申请日：1986-12-04

申请人： Siegfried Goldmann ,  Hilmar Bischoff ,  Walter Puls ,  Joachim Bender ,  Dieter Petzinna ,  Klaus Schlossmann

发明人： Siegfried Goldmann ,  Hilmar Bischoff ,  Walter Puls ,  Joachim Bender ,  Dieter Petzinna ,  Klaus Schlossmann

IPC分类号： A61K31/435 ,  A61P3/08 ,  A61P3/10 ,  C07D491/04 ,  C07D491/048

CPC分类号： C07D491/04

摘要： Blood sugar levels are reduced by administration of novel 4-thienyl-dihydropyridines of the formula ##STR1## in which R.sup.1 represents 1 or 2 halogen atoms, or represents straight-chain, branched or cyclic alkyl with up to 8 carbon atoms,R.sup.2 represents a straight-chain, branched or cyclic, saturated or unsaturated hydrocarbon radical which has up to 15 carbon atoms, is optionally interrupted by one or two oxygen atoms, -N-phenyl or --SO.sub.n --(n=0, 1 or 2) and is optionally substituted by halogen, phenyl, hydroxyl, cyano, amino, C.sub.1 -C.sub.6 -alkylamino, di-C.sub.1 -C.sub.6 -alkylamino, pyridyl, piperidino, N-phenylpiperazino, N-methylpiperazino, morpholino or N-benzyl-N-benzyl-N-methyl-amino,R.sup.3 represents hydrogen, or represents straight-chain, branched or cyclic alkyl which has up to 6 carbon atoms and is optionally substituted by halogen, hydroxyl, amino or amino-C.sub.1 -C.sub.6 -alkoxy, or represents cyano or formyl andR.sup.4 represents hydrogen or a straight-chain, branched or cyclic alkyl radical which has up to 10 carbon atoms, is optionally interrupted by one or two oxygen atoms in the chain and is optionally substituted by halogen, cyano, hydroxyl, phenyl, carboxyl, C.sub.1 -C.sub.6 -alkoxycarbonyl, amino, C.sub.1 -C.sub.6 -alkylamino, di-C.sub.1 -C.sub.6 -alkylamino, formyl, piperidino, morpholino or thiomorpholino,or physiologically acceptable salts thereof.

摘要翻译： 通过给予式“IMAGE”的新型4-噻吩基 - 二氢吡啶，其中R1代表1或2个卤素原子，或代表具有至多8个碳原子的直链，支链或环状烷基，降低血糖水平，R2代表 具有多至15个碳原子的直链，支链或环状饱和或不饱和烃基任选地被一个或两个氧原子间隔，-N-苯基或-SOn-（n = 0,1或2），并且是 任选被卤素，苯基，羟基，氰基，氨基，C 1 -C 6 - 烷基氨基，二-C 1 -C 6 - 烷基氨基，吡啶基，哌啶子基，N-苯基哌嗪子基，N-甲基哌嗪基，吗啉代或N-苄基-N-苄基-N 甲基 - 氨基，R 3表示氢，或表示具有多至6个碳原子并且任选被卤素，羟基，氨基或氨基-C 1 -C 6 - 烷氧基取代的直链，支链或环状烷基，或表示氰基或甲酰基 并且R 4表示氢或具有至多10个碳的直链，支链或环状烷基 氰基，羟基，苯基，羧基，C 1 -C 6 - 烷氧基羰基，氨基，C 1 -C 6 - 烷基氨基，二-C 1 -C 6烷基氨基，C 1 -C 6 - 烷基氨基， ，甲酰基，哌啶子基，吗啉代或硫代吗啉代，或其生理上可接受的盐。

公开(公告)号：US4721719A

公开(公告)日：1988-01-26

申请号：US900866

申请日：1986-08-27

申请人： Siegfried Goldmann ,  Friedrich Bossert ,  Hans J. Ahr ,  Hilmar Bischoff ,  Walter Puls ,  Dieter Petzinna ,  Klaus Schlossmann ,  Joachim Bender

发明人： Siegfried Goldmann ,  Friedrich Bossert ,  Hans J. Ahr ,  Hilmar Bischoff ,  Walter Puls ,  Dieter Petzinna ,  Klaus Schlossmann ,  Joachim Bender

IPC分类号： C07D307/33 ,  A61K31/435 ,  A61K31/4355 ,  A61K31/44 ,  A61P3/08 ,  A61P3/10 ,  C07D491/04 ,  C07D491/048 ,  C07D495/04

CPC分类号： C07D491/04

摘要： Reducing blood sugar with the novel dihydropyridinelactols, or salts thereof, of the formula ##STR1## in which R.sup.1 represents a phenyl, naphthyl, thienyl, pyridyl, chromonyl, thiochromonyl or thiochromenyl radical, the stated radicals optionally containing 1 or 2 identical or different substituents from the group consisting of fluorine, chlorine and bromine, alkyl, alkoxy and alkylthio, each having 1 to 6 carbon atoms, and fluoroalkyl or fluoroalkoxy, each having up to 3 carbon atoms and 3 fluorine atoms, and nitro and cyano,R.sup.2 represents a straight-chain, branched or cyclic alkyl having up to 12 carbon atoms which is optionally interrupted by 1 or 2 oxygen or sulphur atoms and which is optionally substituted by fluorine, chlorine, phenyl, cyano, hydroxyl, amino, C.sub.1 -C.sub.3 -alkylamino, di-C.sub.1 -C.sub.3 -alkylamino or N-benzylmethylamino,R.sup.3 represents cyano or straight-chain or branched alkyl which has up to 4 carbon atoms and is optionally interrupted in the chain by N-C.sub.1 -C.sub.3 -alkyl and/or oxygen, andR.sup.4 represents straight-chain, branched or cyclic alkyl which has up to 6 carbon atoms and is optionally interrupted by 1 or 2 oxygen atoms and is substituted by one or more radicals from amongst fluorine, chlorine, hydroxyl, phenyl, amino, carboxyl and C.sub.1 -C.sub.4 -alkoxycarbonyl.

摘要翻译： 其中R 1表示苯基，萘基，噻吩基，吡啶基，苯并二氢吡喃基或硫代色烯基的新颖的二氢吡啶类醇或其盐，降低血糖，所述基团任选地含有1或2个相同或不同的取代基 由氟，氯和溴组成的组，每个具有1至6个碳原子的烷基，烷氧基和烷硫基，以及氟烷基或氟烷氧基，各自具有至多3个碳原子和3个氟原子，以及硝基和氰基，R2表示 任选被1或2个氧原子或硫原子间隔的碳原子数为12的直链，支链或环状烷基，任选被氟，氯，苯基，氰基，羟基，氨基，C 1 -C 3 - 烷基氨基， 二-C 1 -C 3 - 烷基氨基或N-苄基甲基氨基，R 3表示氰基或直链或支链烷基，其具有至多4个碳原子并且可选地被N-C 1 -C 3 - 烷基和/或氧中断， R4表示直链，支链或环状烷基，其具有多达6个碳原子，并且任选地被1或2个氧原子中断，并被氟，氯，羟基，苯基，氨基，羧基和C1中的一个或多个基团取代 -C 1-4 - 烷氧基羰基。

公开(公告)号：US07620934B2

公开(公告)日：2009-11-17

申请号：US10856073

申请日：2004-05-28

申请人： Timm Falter ,  Joachim Bender ,  Martin Huvar ,  Vladimir Savchenko ,  Volker Wiechers

发明人： Timm Falter ,  Joachim Bender ,  Martin Huvar ,  Vladimir Savchenko ,  Volker Wiechers

IPC分类号： G06F9/44

CPC分类号： G06F17/30893 ,  G06F17/3056 ,  H04L67/02

摘要： Embodiments of the invention are generally directed to a system and method for a Web service definition. A development environment may receive input selecting a Web service interface. The development environment may also receive input to specify one or more system independent features of the selected interface. In an embodiment, the development environment may create a Web service definition descriptor file that includes the received input specifying the one or more system independent features.

摘要翻译： 本发明的实施例通常涉及用于Web服务定义的系统和方法。 开发环境可以接收选择Web服务接口的输入。 开发环境还可以接收输入以指定所选接口的一个或多个系统独立特征。 在一个实施例中，开发环境可以创建包括指定一个或多个系统独立特征的接收到的输入的Web服务定义描述符文件。

公开(公告)号：US07487513B1

公开(公告)日：2009-02-03

申请号：US10750065

申请日：2003-12-30

申请人： Vladimir Savchenko ,  Timm Falter ,  Martin Huvar ,  Joachim Bender

发明人： Vladimir Savchenko ,  Timm Falter ,  Martin Huvar ,  Joachim Bender

IPC分类号： G06F3/00 ,  G06F9/44 ,  G06F9/46 ,  G06F13/00

CPC分类号： G06F8/30 ,  G06F8/61

摘要： A computing device may define a virtual interface to provide an interface for a Web service implementation. The computing device may also create a Web service definition to specify a behavior of the defined virtual interface. The computing device may then provide a Web service archive that includes the virtual interface and the Web service definition.

摘要翻译： 计算设备可以定义虚拟接口以提供用于Web服务实现的接口。 计算设备还可以创建用于指定所定义的虚拟接口的行为的Web服务定义。 计算设备然后可以提供包括虚拟接口和Web服务定义的Web服务归档。

公开(公告)号：US20050278348A1

公开(公告)日：2005-12-15

申请号：US10856073

申请日：2004-05-28

申请人： Timm Falter ,  Joachim Bender ,  Martin Huvar ,  Vladimir Savchenko ,  Volker Wiechers

发明人： Timm Falter ,  Joachim Bender ,  Martin Huvar ,  Vladimir Savchenko ,  Volker Wiechers

IPC分类号： G06F7/00 ,  G06F17/00 ,  G06F17/30 ,  H04L29/08

CPC分类号： G06F17/30893 ,  G06F17/3056 ,  H04L67/02

摘要： Embodiments of the invention are generally directed to a system and method for a Web service definition. A development environment may receive input selecting a Web service interface. The development environment may also receive input to specify one or more system independent features of the selected interface. In an embodiment, the development environment may create a Web service definition descriptor file that includes the received input specifying the one or more system independent features.

摘要翻译： 本发明的实施例通常涉及用于Web服务定义的系统和方法。 开发环境可以接收选择Web服务接口的输入。 开发环境还可以接收输入以指定所选接口的一个或多个系统独立特征。 在一个实施例中，开发环境可以创建包括指定一个或多个系统独立特征的接收到的输入的Web服务定义描述符文件。

公开(公告)号：US07650590B2

公开(公告)日：2010-01-19

申请号：US10756720

申请日：2004-01-13

申请人： Joachim Bender

发明人： Joachim Bender

IPC分类号： G06F9/44

CPC分类号： G06F8/35

摘要： There are methods and apparatus, including computer program products, for a flexible generation framework. The generation framework encapsulates a variety of different code generation technologies within a common interface. This allows various types of generator cores operating in various development environments to be integrated into the framework, and enables the generation of code using various generating technologies.

摘要翻译： 有一些灵活的生成框架的方法和设备，包括计算机程序产品。 生成框架在通用接口中封装了各种不同的代码生成技术。 这允许在各种开发环境中操作的各种类型的发生器核心被集成到框架中，并且能够使用各种生成技术生成代码。