公开(公告)号：US06914109B2

公开(公告)日：2005-07-05

申请号：US10100343

申请日：2002-03-18

申请人： Walter Kuhn ,  Oskar Koch ,  Hans-Ulrich Funk ,  Gerhard Senft

发明人： Walter Kuhn ,  Oskar Koch ,  Hans-Ulrich Funk ,  Gerhard Senft

IPC分类号： C07D313/00 ,  A61K8/49 ,  A61Q13/00 ,  C07B61/00 ,  C07D315/00 ,  C11B9/00 ,  A61K7/46

CPC分类号： C07D315/00

摘要： The invention relates to a process for the preparation of 15-pentadecanolide by hydrogenating 15-pentadecenolide and to its use.

摘要翻译： 本发明涉及通过氢化15-十五碳烯醇酯及其用途制备15-十五内酯的方法。

公开(公告)号：US20070100160A1

公开(公告)日：2007-05-03

申请号：US11553770

申请日：2006-10-27

申请人： Marcus Betzer ,  Walter Kuhn ,  Burghard Wilkening ,  Dietmar Schatkowski ,  Oskar Koch

发明人： Marcus Betzer ,  Walter Kuhn ,  Burghard Wilkening ,  Dietmar Schatkowski ,  Oskar Koch

IPC分类号： C07C69/02 ,  C07C35/18

CPC分类号： C07C29/88 ,  C07B2200/09 ,  C07C67/03 ,  C07C2601/16 ,  C07C69/78 ,  C07C69/44 ,  C07C33/14 ,  C07C29/56

摘要： Process for esterification of farnesol in an initial mixture comprising alpha-bisabolol, farnesol and optionally other components, with the following steps: 1. Preparation or production of the initial mixture, 2. Adding (i) a transesterification catalyst and (ii) one or more compounds of formula (B) R2YnCO2R1  (B) in which the following applies: R1 stands for an alkyl residue with 1 to 12 C atoms; R2 stands for hydrogen, an alkyl residue with 1 to 20 C atoms, a cycloalkyl residue with 5 to 20 C atoms, an aryl residue with 6 to 20 C atoms or a heteroaryl residue with 5 to 20 C atoms; and Y stands for CH2, CH(Me), CH(Et), C(Me)2, CH2—CH(Me), CH(Me)-CH2 or CH2—CH(Me)-CH2 and n stands for a whole number from 0 to 6; or R2 stands for a group CO2R3, R3 standing for an alkyl residue with 1 to 12 C atoms; and Y stands for CH2, CH(Me), CH(Et), C(Me)2, CH2—CH(Me), CH(Me)-CH2 or CH2—CH(Me)-CH2 and n stands for a whole number from 0 to 8, or Y stands for an optionally substituted phenyl or naphthyl ring with a total of at most four substituents on the ring, n=1 applying.

公开(公告)号：US06512126B2

公开(公告)日：2003-01-28

申请号：US10001592

申请日：2001-10-19

申请人： Oskar Koch ,  Walter Kuhn

发明人： Oskar Koch ,  Walter Kuhn

IPC分类号： C07D30779

CPC分类号： C07D307/83

摘要： Mint lactone can be prepared by hydrogenating hydroxymenthofurolactone to give the intermediate dihydrohydroxymenthofurolactone with the subsequent elimination of water.

公开(公告)号：US07399880B2

公开(公告)日：2008-07-15

申请号：US11553770

申请日：2006-10-27

申请人： Marcus Betzer ,  Walter Kuhn ,  Burghard Wilkening ,  Dietmar Schatkowski ,  Oskar Koch

发明人： Marcus Betzer ,  Walter Kuhn ,  Burghard Wilkening ,  Dietmar Schatkowski ,  Oskar Koch

IPC分类号： C07C67/40 ,  C07C67/02

CPC分类号： C07C29/88 ,  C07B2200/09 ,  C07C67/03 ,  C07C2601/16 ,  C07C69/78 ,  C07C69/44 ,  C07C33/14 ,  C07C29/56

摘要： Process for esterification of farnesol in an initial mixture comprising alpha-bisabolol, farnesol and optionally other components, with the following steps: 1. Preparation or production of the initial mixture, 2. Adding (i) a transesterification catalyst and (ii) one or more compounds of formula (B) R2YnCO2R1  (B) in which the following applies: R1 stands for an alkyl residue with 1 to 12 C atoms; R2 stands for hydrogen, an alkyl residue with 1 to 20 C atoms, a cycloalkyl residue with 5 to 20 C atoms, an aryl residue with 6 to 20 C atoms or a heteroaryl residue with 5 to 20 C atoms; and Y stands for CH2, CH(Me), CH(Et), C(Me)2, CH2—CH(Me), CH(Me)-CH2 or CH2—CH(Me)-CH2 and n stands for a whole number from 0 to 6; or R2 stands for a group CO2R3, R3 standing for an alkyl residue with 1 to 12 C atoms; and Y stands for CH2, CH(Me), CH(Et), C(Me)2, CH2—CH(Me), CH(Me)-CH2 or CH2—CH(Me)-CH2 and n stands for a whole number from 0 to 8, or Y stands for an optionally substituted phenyl or naphthyl ring with a total of at most four substituents on the ring, n=1 applying.

公开(公告)号：US09066880B2

公开(公告)日：2015-06-30

申请号：US13639646

申请日：2010-04-08

申请人： Imke Meyer ,  Oskar Koch ,  Jean Krutmann

发明人： Imke Meyer ,  Oskar Koch ,  Jean Krutmann

IPC分类号： A61K8/49 ,  A61K31/343 ,  A61K45/06 ,  A61Q90/00 ,  A61Q19/08 ,  A61Q1/10 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q5/06 ,  A61Q5/12 ,  A61Q7/00 ,  A61Q17/04

CPC分类号： A61K8/4973 ,  A61K31/343 ,  A61K45/06 ,  A61K2800/59 ,  A61K2800/782 ,  A61K2800/92 ,  A61Q1/10 ,  A61Q5/004 ,  A61Q5/02 ,  A61Q5/06 ,  A61Q5/12 ,  A61Q7/00 ,  A61Q17/04 ,  A61Q19/08

摘要： This invention relates to cosmetic and pharmaceutical preparations comprising (i) a diastereomer or a mixture of two or more diastereomers of the compound of formula (I) or (ii) a salt of a diastereomer or of a mixture of two or more diastereomers of the compound of formula (I) or (iii) a mixture of two or more salts of a diastereomer or of a mixture of two or more diastereomers of the compound of formula (I), a diastereomer, salt or a mixture as defined above as a drug for topical application and/or for the treatment of lipoatrophy; the non-therapeutic use of a diastereomer, salt or a mixture as defined above for the prevention, treatment or reduction of skin aging, especially skin wrinkles; the use of a diastereomer, salt or a mixture as defined above for the production of an orally administered non-pharmaceutical preparation.

摘要翻译： 本发明涉及化妆品和药物制剂，其包含（i）式（I）化合物的非对映异构体或两种或更多种非对映体的混合物或（ii）非对映异构体的盐或两种或更多种非对映异构体的混合物 式（I）化合物或（iii）两种或更多种非对映异构体盐或两种或更多种式（I）化合物的非对映异构体的混合物的混合物，如上所定义的非对映异构体，盐或混合物 用于局部应用和/或治疗脂肪萎缩的药物; 如上定义的非对映异构体，盐或混合物的非治疗用途，用于预防，治疗或减少皮肤老化，特别是皮肤皱纹; 使用如上定义的非对映异构体，盐或混合物来生产口服非药物制剂。

公开(公告)号：US20110104089A1

公开(公告)日：2011-05-05

申请号：US12938137

申请日：2010-11-02

申请人： Ingo Wöhrle ,  Oskar Koch ,  Manfred Meier ,  Gerhard Schmaus

发明人： Ingo Wöhrle ,  Oskar Koch ,  Manfred Meier ,  Gerhard Schmaus

IPC分类号： A61K8/97 ,  A61Q17/04 ,  A61Q15/00 ,  A61Q19/00 ,  A61Q5/00 ,  A61K8/36 ,  A61K8/37 ,  A61Q13/00

CPC分类号： C11B9/00 ,  A61K8/375 ,  A61K2800/88 ,  A61Q5/06 ,  A61Q13/00 ,  A61Q15/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/10

摘要： The invention relates to the use of neopentyl glycol diisononanoate (CAS No. 27841-07-2) as a fixative for perfume oils or as a fixative for (top note) fragrance substances. The invention also relates to certain compositions containing neopentyl glycol diisononanoate and one or more top note fragrance substances. Furthermore, the invention relates to a method for producing such compositions and (cosmetic) products containing a composition according to the invention. Additionally the invention relates to a method for imparting, intensifying or modifying an odor on the (human) skin. A particular aspect of the present invention relates to the improved adherence of volatile fragrance substances to (human) skin and/or (human) hair. Apart from this the invention relates to a combination (kit) comprising neopentyl glycol diisononanoate and one or more top note fragrance substances.

摘要翻译： 本发明涉及新戊二醇二异壬酸酯（CAS号27841-07-2）作为香料油的固定剂或作为（顶部香料）香料的固定剂的用途。 本发明还涉及含有新戊二醇二异壬酸酯和一种或多种顶级香料物质的某些组合物。 此外，本发明涉及一种生产这种组合物的方法和含有本发明组合物的（化妆品）产品。 此外，本发明涉及一种赋予（强化）或改变（人）皮肤上的气味的方法。 本发明的特定方面涉及挥发性芳香物质对（人）皮肤和/或（人）头发的粘附性的改善。 除此之外，本发明涉及包含新戊二醇二异壬酸酯和一种或多种顶级香料物质的组合（试剂盒）。

公开(公告)号：US20080050319A1

公开(公告)日：2008-02-28

申请号：US11568606

申请日：2005-04-26

申请人： Oskar Koch ,  William Johncock

发明人： Oskar Koch ,  William Johncock

IPC分类号： A61K8/37 ,  A61K8/35 ,  A61Q17/04

CPC分类号： A61K8/35 ,  A61K8/37 ,  A61Q17/04

摘要： The use of a compound of the formula wherein R1-R3 independently of one another are hydrogen, C1-C8-alkyl or C1-C8-alkoxy, R4 is COR, CO2R, CONR2, where R is C1-C8-alkyl or C3-C8-cycloalkyl R5 is H or C1-C8-alkyl, R6 is aryl, aryl substituted by up to three C1-C8-alkyl- or C1-C8-alkoxy, or C3-C8-cycloalkyl as UV filters in cosmetic formulations, in particular in combination with UV filters from the group consisting of methoxycinnamate derivatives and/or dibenzoylmethane derivatives, with the proviso that R5 is H if R4 is COR, is described.

摘要翻译： 使用下式化合物其中R 1〜R 3彼此独立地为氢，C 1 -C 8烷基 C 1 -C 6烷基或C 1 -C 8 - 烷氧基，R 4是COR，CO 2 CO 2， R，CONR 2，其中R是C 1 -C 8 - 烷基或C 3 -C 3 > 8个环烷基R 5是H或C 1 -C 8 - 烷基，R 6 O >是芳基，被至多三个C 1 -C 8 - 烷基 - 或C 1 -C 8 - 取代的芳基， 作为化妆品制剂中的UV过滤剂，特别是与来自甲氧基肉桂酸酯衍生物和/或其盐的UV过滤器组合， 或二苯甲酰甲烷衍生物，条件是如果R 4为COR，则R 5为H。

公开(公告)号：US06222076B1

公开(公告)日：2001-04-24

申请号：US09215495

申请日：1998-12-18

申请人： Alfred Krempel ,  Oskar Koch ,  Harry Erfurt

发明人： Alfred Krempel ,  Oskar Koch ,  Harry Erfurt

IPC分类号： C07C4921

CPC分类号： C07C45/69 ,  C07C67/293 ,  C07C69/14

摘要： The invention relates to a novel process for the preparation of hydroxyalkyl- and acyloxyalkyl-substituted cycloketones by free-radical addition of hydroxyalkenes and acyloxyalkenes respectively to cyclic ketones.

摘要翻译： 本发明涉及通过将羟基烯丙基和酰氧基烯基分别自由基加成到环酮中制备羟烷基和酰氧基烷基取代的环酮的新方法。

公开(公告)号：US5965066A

公开(公告)日：1999-10-12

申请号：US905258

申请日：1997-08-01

申请人： Oskar Koch ,  Horst Surburg ,  Roland Langner ,  Horst Sommer

发明人： Oskar Koch ,  Horst Surburg ,  Roland Langner ,  Horst Sommer

IPC分类号： A61K8/30 ,  A61K8/00 ,  A61K8/40 ,  A61K8/42 ,  A61K8/46 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q17/04 ,  A61Q19/08 ,  C07C255/41 ,  C07C309/60 ,  C09K3/00 ,  F21V9/04 ,  A61K7/42

CPC分类号： C07C309/60 ,  A61K8/40 ,  A61K8/466 ,  A61Q17/04 ,  C07C255/41 ,  A61Q5/02 ,  C07C2102/08

摘要： Compounds of the formula I according to claim 1 are excellently suitable as UV absorbers for use in cosmetic products, in particular sunscreen compositions, daytime care products and hair care products. They are furthermore suitable for protection of products.

公开(公告)号：US09676691B2

公开(公告)日：2017-06-13

申请号：US14241964

申请日：2012-08-24

申请人： Oskar Koch ,  Dietmar Schatkowski ,  William Johncock ,  Christel Jahnke ,  Karl-Georg Fahlbusch

发明人： Oskar Koch ,  Dietmar Schatkowski ,  William Johncock ,  Christel Jahnke ,  Karl-Georg Fahlbusch

IPC分类号： C07C45/65 ,  C07C49/755 ,  A61K8/35 ,  A61Q17/04 ,  A61Q19/00 ,  C07C45/74 ,  C07C45/72

CPC分类号： C07C45/65 ,  A61K8/35 ,  A61Q17/04 ,  A61Q19/00 ,  C07C45/72 ,  C07C45/74 ,  C07C49/755 ,  C07C49/683

摘要： A method is described for producing a compound having the formula (I) or an admixture comprising a compound having the formula (I), having the following steps: dissolving an indanone having the formula (II) in a solvent or in an admixture which contains a solvent, the solvent being selected from the group of solvents which form an azeotrope with water, converting the indanone having the formula (II) with an aromatic aldehyde having the formula (III) in the presence of at least one organic base, according to the drawing: where R1 and R2 independently of each other signify hydrogen or a branched or unbranched alkyl group having from 1 to 12 carbon atoms and where R3, R4, R5, R6, R7, R8, R9, R10 and R11 independently of each other signify hydrogen, hydroxy or a branched or unbranched alkyl or alkoxy group having from 1 to 12 carbon atoms and removing water formed from the reaction admixture during the conversion. An admixture comprising a compound of the formula (I) and other components is further described.