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公开(公告)号：US20060172298A1
公开(公告)日：2006-08-03
申请号：US10526445
申请日：2003-09-02
申请人： Wangxia Wang , Dan Pelah , Tal Alergand
发明人： Wangxia Wang , Dan Pelah , Tal Alergand
CPC分类号： C07K14/415 , C07K16/16 , C07K2319/20 , C07K2319/35 , C12N9/96 , C12N15/8257 , C12N15/8273 , C12P21/02
摘要： Novel denaturant-stable, protease resistant, homo-oligomeric proteins, also referred to herein as stable proteins (SPs), having chaperone-like activity; methods of production and purification of SPs; nucleic acids encoding SPs; methods of isolating nucleic acids encoding SPs; antibodies recognizing SPs; the use of SPs for stabilizing, refolding, repairing, preventing aggregation and de-aggregating macromolecules such as proteins; fusion proteins including SPs; nucleic acid constructs encoding the fusion proteins; and their uses in a variety of methods and applications.
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2.发明申请Denaturat stable and/or protease resistant, chaperone-like oligomeric proteins, polynucleotides encoding same, their uses and methods of increasing a specific activity thereof 审中-公开变性稳定和/或蛋白酶抗性，伴侣样寡聚蛋白，编码它们的多核苷酸，其使用和增加其比活性的方法公开(公告)号：US20090253125A9
公开(公告)日：2009-10-08
申请号：US10526445
申请日：2003-09-02
申请人： Wangxia Wang , Dan Pelah , Tal Alergand
发明人： Wangxia Wang , Dan Pelah , Tal Alergand
CPC分类号： C07K14/415 , C07K16/16 , C07K2319/20 , C07K2319/35 , C12N9/96 , C12N15/8257 , C12N15/8273 , C12P21/02
摘要： Novel denaturant-stable, protease resistant, homo-oligomeric proteins, also referred to herein as stable proteins (SPs), having chaperone-like activity; methods of production and purification of SPs; nucleic acids encoding SPs; methods of isolating nucleic acids encoding SPs; antibodies recognizing SPs; the use of SPs for stabilizing, refolding, repairing, preventing aggregation and de-aggregating macromolecules such as proteins; fusion proteins including SPs; nucleic acid constructs encoding the fusion proteins; and their uses in a variety of methods and applications.
摘要翻译： 新型变性剂稳定，蛋白酶抗性，同源寡聚蛋白，本文也称为具有伴侣样活性的稳定蛋白（SP）; SP的生产和净化方法; 编码SP的核酸; 分离编码SP的核酸的方法; 识别SP的抗体; 使用SP来稳定，重折叠，修复，防止聚集和聚集大分子如蛋白质; 融合蛋白包括SP; 编码融合蛋白的核酸构建体; 及其在各种方法和应用中的应用。
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公开(公告)号：US20050186645A1
公开(公告)日：2005-08-25
申请号：US11018077
申请日：2004-12-20
申请人： Yehudit Amor , Ofer Markman , Mirit Gulko , Albena Samokovlisky , Fredi Kleinman , Tal Alergand , Rakefet Rosenfeld , Ruth Maya , Sabina Rebe , Idil Kasuto , Haim Bangio
发明人： Yehudit Amor , Ofer Markman , Mirit Gulko , Albena Samokovlisky , Fredi Kleinman , Tal Alergand , Rakefet Rosenfeld , Ruth Maya , Sabina Rebe , Idil Kasuto , Haim Bangio
IPC分类号： G01N33/53 , G01N33/537 , G01N33/543
CPC分类号： G01N33/5308 , G01N2333/42 , G01N2333/924 , G01N2400/02
摘要： The invention relates generally the structural analysis of glycomolecule-containing macromolecules, such as those that occur either attached to proteins (proteoglycans, glycoproteins), lipids, or as free saccharides.
摘要翻译： 本发明一般涉及含糖分子的大分子的结构分析，例如与蛋白质（蛋白聚糖，糖蛋白），脂质或游离糖连接的那些。
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公开(公告)号：US20110021376A1
公开(公告)日：2011-01-27
申请号：US12895064
申请日：2010-09-30
申请人： Yehudit Amor , Ofer Markman , Mirit Kolog Gulko , Albena Samokovlisky , Fredi Kleinman , Tal Alergand , Rakefet Rosenfeld , Ruth Maya , Sabina Rebe , Idil Kelson Kasuto , Haim Bangio
发明人： Yehudit Amor , Ofer Markman , Mirit Kolog Gulko , Albena Samokovlisky , Fredi Kleinman , Tal Alergand , Rakefet Rosenfeld , Ruth Maya , Sabina Rebe , Idil Kelson Kasuto , Haim Bangio
IPC分类号： C40B30/04
CPC分类号： G01N33/5308 , G01N2333/42 , G01N2333/924 , G01N2400/02
摘要： The invention relates generally the structural analysis of glycomolecule-containing macromolecules, such as those that occur either attached to proteins (proteoglycans, glycoproteins), lipids, or as free saccharides.
摘要翻译： 本发明一般涉及含糖分子的大分子的结构分析，例如与蛋白质（蛋白聚糖，糖蛋白），脂质或游离糖连接的那些。
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公开(公告)号：US08119357B2
公开(公告)日：2012-02-21
申请号：US12895064
申请日：2010-09-30
申请人： Yehudit Amor , Ofer Markman , Mirit Kolog Gulko , Albena Samokovlisky , Fredi Kleinman , Tal Alergand , Rakefet Rosenfeld , Ruth Maya , Sabina Rebe , Idil Kelson Kasuto , Haim Bangio
发明人： Yehudit Amor , Ofer Markman , Mirit Kolog Gulko , Albena Samokovlisky , Fredi Kleinman , Tal Alergand , Rakefet Rosenfeld , Ruth Maya , Sabina Rebe , Idil Kelson Kasuto , Haim Bangio
IPC分类号： G01N33/53
CPC分类号： G01N33/5308 , G01N2333/42 , G01N2333/924 , G01N2400/02
摘要： The invention relates generally the structural analysis of glycomolecule-containing macromolecules, such as those that occur either attached to proteins (proteoglycans, glycoproteins), lipids, or as free saccharides.
摘要翻译： 本发明一般涉及含糖分子的大分子的结构分析，例如与蛋白质（蛋白聚糖，糖蛋白），脂质或游离糖连接的那些。
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