公开(公告)号：US20250057668A1

公开(公告)日：2025-02-20

申请号：US18934949

申请日：2024-11-01

Applicant: Warsaw Orthopedic, Inc.

Inventor： Benjamin T. Reves ,  Joseph Thomas Hirsch ,  Mark R. Grizzard ,  Daniel A. Shimko ,  Jonathan M. Dewey

IPC: A61F2/46

Abstract: A bone material dispensing device is provided. The bone material dispensing device comprises a housing having a proximal end, a distal end, and a longitudinal axis, the proximal end having a first opening and the distal end comprising a frame having a front wall, a back wall, and an air gap, the back wall having a back opening and the front wall having a second opening such that the first opening, the back opening and the second opening are configured to slidably receive at least a portion of a plunger, the front wall comprising a generally flat contact surface configured to engage a funnel; and a locking member pivotably connected to an upper surface of the housing and extending adjacent to the upper surface of the housing, the locking member comprising a locking surface extending adjacent to the distal end of the housing, the locking member being movable in a locking position to lock the portion of the funnel with the housing. A bone material dispensing system and a method of implanting bone material with the bone material dispensing system are also provided.

公开(公告)号：US20230019406A1

公开(公告)日：2023-01-19

申请号：US17379545

申请日：2021-07-19

Applicant: Warsaw Orthopedic, Inc.

Inventor： Benjamin T. Reves ,  Joseph Thomas Hirsch ,  Mark R. Grizzard ,  Daniel A. Shimko

IPC: A61B17/88

Abstract: A bone material dispensing system is provided. The bone material dispensing system comprises a funnel having a proximal portion, the proximal portion comprising a top end and a bottom end, the top end opposite the bottom end, the top end comprising a surface having a protrusion configured to receive a locking member of a bone material dispensing device and the bottom end comprising a connector configured to secure the funnel to the bone material dispensing device. A bone material dispensing system comprises a pusher and a holder is provided. A method of dispensing bone material with the bone material dispensing system is also provided.

公开(公告)号：US20230014311A1

公开(公告)日：2023-01-19

申请号：US17379555

申请日：2021-07-19

Applicant: Warsaw Orthopedic, Inc.

Inventor： Benjamin T. Reves ,  Joseph Thomas Hirsch ,  Mark R. Grizzard ,  Daniel A. Shimko ,  Jonathan M. Dewey

IPC: A61F2/46

Abstract: A bone material dispensing device is provided. The bone material dispensing device comprises a housing having a proximal end, a distal end, and a longitudinal axis, the proximal end having a first opening and the distal end comprising a frame having a front wall, a back wall, and an air gap, the back wall having a back opening and the front wall having a second opening such that the first opening, the back opening and the second opening are configured to slidably receive at least a portion of a plunger, the front wall comprising a generally flat contact surface configured to engage a funnel; and a locking member pivotably connected to an upper surface of the housing and extending adjacent to the upper surface of the housing, the locking member comprising a locking surface extending adjacent to the distal end of the housing, the locking member being movable in a locking position to lock the portion of the funnel with the housing. A bone material dispensing system and a method of implanting bone material with the bone material dispensing system are also provided.

公开(公告)号：US20200330648A1

公开(公告)日：2020-10-22

申请号：US16918673

申请日：2020-07-01

Applicant: Warsaw Orthopedic, Inc.

Inventor： Benjamin T. Reves ,  David S. Scher ,  Roger E. Harrington ,  Jerbrena C. Jacobs

IPC: A61L27/54 ,  A61L27/24 ,  A61L27/58 ,  A61L27/10 ,  A61L27/44 ,  A61L27/46 ,  A61K31/575 ,  A61K38/17 ,  A61K38/18 ,  A61L27/26 ,  A61L27/42

Abstract: Provided is a compression resistant implant configured to fit at or near a bone defect to promote bone growth. The compression resistant implant comprises a biodegradable polymer in an amount of about 0.1 wt % to about 20 wt % of the implant and a freeze-dried oxysterol in an amount of about 5 wt % to about 90 wt % of the implant. Methods of making and use are further provided.

公开(公告)号：US09877836B2

公开(公告)日：2018-01-30

申请号：US14796564

申请日：2015-07-10

Applicant: Warsaw Orthopedic, Inc.

Inventor： Benjamin T. Reves ,  David S. Scher ,  Susan J. Drapeau ,  Roger E. Harrington ,  Jerbrena C. Jacobs

IPC: A61F2/28 ,  A61L27/54 ,  A61L27/56 ,  A61L27/44 ,  B29C41/00 ,  B29C41/22 ,  A61L27/46 ,  B29B7/00 ,  B29K105/16 ,  B29K509/02 ,  B29L31/00

CPC classification number: A61F2/2846 ,  A61F2002/2835 ,  A61F2210/0004 ,  A61L27/446 ,  A61L27/46 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/222 ,  A61L2430/02 ,  A61L2430/38 ,  B29B7/002 ,  B29C41/003 ,  B29C41/22 ,  B29K2105/16 ,  B29K2509/02 ,  B29K2995/006 ,  B29L2031/7532 ,  C08L89/06

Abstract: Provided is a compression resistant implant configured to fit at or near a bone defect to promote bone growth, the compression resistant implant comprising porous ceramic particles in a biodegradable polymer, and an oxysterol disposed in or on the compression resistant implant. Methods of making and use are further provided.

公开(公告)号：US20170007407A1

公开(公告)日：2017-01-12

申请号：US14796564

申请日：2015-07-10

Applicant: Warsaw Orthopedic, Inc.

Inventor： Benjamin T. Reves ,  David S. Scher ,  Susan J. Drapeau ,  Roger E. Harrington ,  Jerbrena C. Jacobs

IPC: A61F2/28 ,  A61L27/54 ,  A61L27/58 ,  A61L27/56 ,  A61L27/10 ,  B29B7/00 ,  A61L27/22 ,  A61L27/44 ,  A61L27/12 ,  B29C41/00 ,  B29C41/22 ,  A61L27/36 ,  A61L27/24

CPC classification number: A61F2/2846 ,  A61F2002/2835 ,  A61F2210/0004 ,  A61L27/446 ,  A61L27/46 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/222 ,  A61L2430/02 ,  A61L2430/38 ,  B29B7/002 ,  B29C41/003 ,  B29C41/22 ,  B29K2105/16 ,  B29K2509/02 ,  B29K2995/006 ,  B29L2031/7532 ,  C08L89/06

Abstract: Provided is a compression resistant implant configured to fit at or near a bone defect to promote bone growth, the compression resistant implant comprising porous ceramic particles in a biodegradable polymer, and an oxysterol disposed in or on the compression resistant implant. Methods of making and use are further provided.

Abstract translation: 提供一种抗压植入物，被配置成装配在骨缺损附近或附近以促进骨生长，抗压植入物包括可生物降解的聚合物中的多孔陶瓷颗粒，以及设置在抗压植入物中或其上的氧固醇。 进一步提供制造和使用方法。

公开(公告)号：US12171909B2

公开(公告)日：2024-12-24

申请号：US17535102

申请日：2021-11-24

Applicant: WARSAW ORTHOPEDIC, INC.

Inventor： Benjamin T. Reves ,  David S. Scher ,  Roger E. Harrington ,  Jerbrena C. Jacobs

IPC: A61L27/36 ,  A61K38/18 ,  A61L27/54

Abstract: Provided is a compression resistant implant configured to fit at or near a bone defect to promote bone growth. The compression resistant implant comprises a biodegradable polymer in an amount of about 0.1 wt % to about 20 wt % of the implant and a freeze-dried oxysterol in an amount of about 5 wt % to about 90 wt % of the implant. Methods of making and use are further provided.

公开(公告)号：US20230241350A1

公开(公告)日：2023-08-03

申请号：US18297913

申请日：2023-04-10

Applicant: Warsaw Orthopedic, Inc.

Inventor： Benjamin T. Reves ,  Todd M. Boyce ,  Daniel A. Shimko ,  Jared T. Wilsey

IPC: A61M25/00 ,  A61M25/06 ,  A61M29/00 ,  A61M5/32 ,  A61K9/06 ,  A61B17/16

CPC classification number: A61M25/0084 ,  A61M25/065 ,  A61M29/00 ,  A61M5/32 ,  A61K9/06 ,  A61B17/1671 ,  A61M2202/10 ,  A61M2025/09183

Abstract: A method of delivering a therapeutic agent to a nucleus pulposus of an intervertebral disc is provided. The method comprises inserting a delivery tool containing the therapeutic agent through an anterior portion, a lateral portion, or an anterolateral portion of an annulus fibrosus and into the nucleus pulposus of the intervertebral disc and delivering the therapeutic agent to the nucleus pulposus of the intervertebral disc. Devices and kits are also provided.

公开(公告)号：US11464888B2

公开(公告)日：2022-10-11

申请号：US15620189

申请日：2017-06-12

Applicant: Warsaw Orthopedic, Inc.

Inventor： Benjamin T. Reves ,  Roger E. Harrington ,  Jerbrena C. Jacobs ,  David S. Scher ,  Daniel A. Shimko

IPC: A61L27/54 ,  A61L27/44 ,  A61L27/36

Abstract: Provided is an implant configured to fit at or near a bone defect to promote bone growth. The implant comprises an oxysterol uniformly disposed in an acellular tissue matrix (ATM). The acellular tissue matrix can be porcine collagen, which in some cases is crosslinked. The implant can contain an acellular porcine crosslinked collagen in an amount of about 5 wt. % to about 25 wt. % of the implant and an oxysterol in an amount of about 5 wt. % to about 90 wt. % of the implant. The oxysterol can be Oxy133 monohydrate or an Oxy133 polymorph. Methods of making and using the implant are further provided.

公开(公告)号：US20200330702A1

公开(公告)日：2020-10-22

申请号：US16391242

申请日：2019-04-22

Applicant: Warsaw Orthopedic, Inc.

Inventor： JARED T. WILSEY ,  Keith E. Miller ,  Benjamin T. Reves

IPC: A61M5/32

Abstract: An approach is provided for delivering therapeutic materials to an intervertebral disc via a sub-ligamentous space. The approach includes positioning a tool at an interface of a longitudinal ligament and an outer surface of the intervertebral disc, in which the interface is the sub-ligamentous space. The tool may include a first needle and a second needle housed within the first needle. An insertion end of the first needle may include a shallow beveled end. The approach includes inserting the insertion end of the first needle into the sub-ligamentous space. The approach includes deploying the second needle from within the first needle into at least one of an annulus and a nucleus of the intervertebral disc. The approach includes delivering the therapeutic materials to the at least one of the annulus and the nucleus.