公开(公告)号：US12171909B2

公开(公告)日：2024-12-24

申请号：US17535102

申请日：2021-11-24

Applicant: WARSAW ORTHOPEDIC, INC.

Inventor： Benjamin T. Reves ,  David S. Scher ,  Roger E. Harrington ,  Jerbrena C. Jacobs

IPC: A61L27/36 ,  A61K38/18 ,  A61L27/54

Abstract: Provided is a compression resistant implant configured to fit at or near a bone defect to promote bone growth. The compression resistant implant comprises a biodegradable polymer in an amount of about 0.1 wt % to about 20 wt % of the implant and a freeze-dried oxysterol in an amount of about 5 wt % to about 90 wt % of the implant. Methods of making and use are further provided.

公开(公告)号：US11464888B2

公开(公告)日：2022-10-11

申请号：US15620189

申请日：2017-06-12

Applicant: Warsaw Orthopedic, Inc.

Inventor： Benjamin T. Reves ,  Roger E. Harrington ,  Jerbrena C. Jacobs ,  David S. Scher ,  Daniel A. Shimko

IPC: A61L27/54 ,  A61L27/44 ,  A61L27/36

Abstract: Provided is an implant configured to fit at or near a bone defect to promote bone growth. The implant comprises an oxysterol uniformly disposed in an acellular tissue matrix (ATM). The acellular tissue matrix can be porcine collagen, which in some cases is crosslinked. The implant can contain an acellular porcine crosslinked collagen in an amount of about 5 wt. % to about 25 wt. % of the implant and an oxysterol in an amount of about 5 wt. % to about 90 wt. % of the implant. The oxysterol can be Oxy133 monohydrate or an Oxy133 polymorph. Methods of making and using the implant are further provided.

公开(公告)号：US20200261626A1

公开(公告)日：2020-08-20

申请号：US16280706

申请日：2019-02-20

Applicant: WARSAW ORTHOPEDIC, INC.

Inventor： Roger E. Harrington ,  Jerbrena C. Jacobs ,  Robert Doyle

IPC: A61L27/58 ,  C07C319/20 ,  A61L27/40 ,  A61L27/18 ,  C08G18/38

Abstract: A method of making a hydroxyl-terminated thioketal diol is provided, the method comprising reacting a thioketal ester with a non-pyrophoric reducing agent to form a hydroxyl-terminated thioketal diol. The hydroxyl-terminated thioketal diol can be 2,2-(propane-2,2-diylbis(sulfanediyl)) diethanol. The non-pyrophoric reducing agent can be a sodium aluminum hydride, for example, sodium bis(2-methoxyethoxy)aluminum hydride. The thioketal ester can be dimethyl 2,2-(propane-2,2-diylbis(sulfanediyl)) diacetate. A biodegradable matrix prepared by reacting a hydroxyl-terminated thioketal diol with an isocyanate is provided. A method of making a biodegradable polyurethane composite is also provided.

公开(公告)号：US20190298741A1

公开(公告)日：2019-10-03

申请号：US16433834

申请日：2019-06-06

Applicant: Warsaw Orthopedic, Inc.

Inventor： David S. Scher ,  Benjamin T. Reves ,  Roger E. Harrington ,  Susan J. Drapeau ,  Jerbrena C. Jacobs

IPC: A61K31/575 ,  A61K9/16 ,  A61K9/00

Abstract: Provided is a slow release composition to promote bone growth, the slow release composition comprising: an oxysterol encapsulated in a biodegradable polymer to control the release of the oxysterol. Methods of making and use are further provided.

公开(公告)号：US20180353654A1

公开(公告)日：2018-12-13

申请号：US15620189

申请日：2017-06-12

Applicant: Warsaw Orthopedic, Inc.

Inventor： Benjamin T. Reves ,  Roger E. Harrington ,  Jerbrena C. Jacobs ,  David S. Scher ,  Daniel A. Shimko

IPC: A61L27/54 ,  A61L27/44 ,  A61L27/36

CPC classification number: A61L27/54 ,  A61L27/3608 ,  A61L27/3633 ,  A61L27/44 ,  A61L2300/222 ,  A61L2300/412 ,  A61L2400/06 ,  A61L2430/02

Abstract: Provided is an implant configured to fit at or near a bone defect to promote bone growth. The implant comprises an oxysterol uniformly disposed in an acellular tissue matrix (ATM). The acellular tissue matrix can be porcine collagen, which in some cases is crosslinked. The implant can contain an acellular porcine crosslinked collagen in an amount of about 5 wt. % to about 25 wt. % of the implant and an oxysterol in an amount of about 5 wt. % to about 90 wt. % of the implant. The oxysterol can be Oxy133 monohydrate or an Oxy133 polymorph. Methods of making and using the implant are further provided.

公开(公告)号：US09914758B2

公开(公告)日：2018-03-13

申请号：US15388990

申请日：2016-12-22

Applicant: WARSAW ORTHOPEDIC, INC.

Inventor： David S. Scher ,  Roger E. Harrington

IPC: C12N1/21 ,  C07K14/51 ,  C07K14/475

CPC classification number: C07K14/51 ,  C07K1/14 ,  C07K1/36 ,  C07K14/475

Abstract: Expression vector systems are provided for increased production of a recombinant GDF-5 (rhGDF-5) protein. Also provided are transformed host cells that were engineered to produce and express high levels of rhGDF-5 protein. Methods for production and high expression of rhGDF-5 protein are disclosed herein. The methods of enhancing production and protein expression of rhGDF-5 protein as disclosed are cost-effective, time-saving and are of manufacturing quality.

公开(公告)号：US20170275330A1

公开(公告)日：2017-09-28

申请号：US15082695

申请日：2016-03-28

Applicant: Warsaw Orthopedic, Inc.

Inventor： Roger E. Harrington ,  Jerbrena C. Jacobs

IPC: C07J9/00

CPC classification number: C07J9/00 ,  C07B2200/13 ,  C07J7/002 ,  C07J17/00 ,  C07J51/00

Abstract: Compositions and methods for preparing an OXY133 polymorph are provided. This compositions and methods include subjecting a slurry of OXY133 to conditions sufficient to convert OXY133 to the OXY133 polymorph Form A, polymorph Form B, polymorph Form C, polymorph Form D, polymorph Form E, polymorph Form F, polymorph Form G, polymorph Form H, polymorph Form I or a mixture thereof. A polymorph of OXY133 is also provided and that polymorph can be polymorph Form A, polymorph Form B, polymorph Form C, polymorph Form D, polymorph Form E, polymorph Form F, polymorph Form G, polymorph Form H, polymorph Form I or a mixture thereof. Pharmaceutical compositions including OXY133 polymorphs are also provided.

公开(公告)号：US20170007626A1

公开(公告)日：2017-01-12

申请号：US14796625

申请日：2015-07-10

Applicant: Warsaw Orthopedic, Inc.

Inventor： David S. Scher ,  Benjamin T. Reves ,  Roger E. Harrington ,  Susan J. Drapeau ,  Jerbrena C. Jacobs

IPC: A61K31/575 ,  A61K9/16

CPC classification number: A61K31/575 ,  A61K9/0024 ,  A61K9/1647 ,  A61K9/1682 ,  A61L2300/222 ,  A61L2300/412 ,  A61L2300/604 ,  A61L2300/62 ,  A61L2430/02

Abstract: Provided is a slow release composition to promote bone growth, the slow release composition comprising: an oxysterol encapsulated in a biodegradable polymer to control the release of the oxysterol. Methods of making and use are further provided.

Abstract translation: 提供了促进骨生长的缓释组合物，缓释组合物包含：包封在可生物降解的聚合物中的氧固醇以控制氧固醇的释放。 进一步提供制造和使用方法。

公开(公告)号：US20150153318A1

公开(公告)日：2015-06-04

申请号：US14621004

申请日：2015-02-12

Applicant: Warsaw Orthopedic, Inc.

Inventor： Josee Roy ,  Victor Kelley ,  Roger E. Harrington

IPC: G01N33/15

CPC classification number: G01N33/15 ,  A61K33/06 ,  A61K47/60

Abstract: Methods of preparing compositions for preferential distribution of active agents to injury sites are provided. The compositions may comprise a polymer with hydrophilic properties and one or more active agents, such as compounds comprising hydrophilic metal ions. Because the delivery ligand and the active agent are specifically selected so the interactions between them are mainly of an ionic nature. Methods of identifying suitable components for such compositions are also disclosed.

Abstract translation: 提供了将活性剂优先分配给损伤部位的组合物的制备方法。 组合物可以包含具有亲水性质的聚合物和一种或多种活性剂，例如包含亲水金属离子的化合物。 因为递送配体和活性剂被特异选择，所以它们之间的相互作用主要是离子性质的。 还公开了用于鉴定这些组合物的合适组分的方法。

公开(公告)号：US11679182B2

公开(公告)日：2023-06-20

申请号：US17328531

申请日：2021-05-24

Applicant: Warsaw Orthopedic, Inc.

Inventor： Roger E. Harrington ,  Jerbrena C. Jacobs ,  Robert Doyle

IPC: C07C319/20 ,  A61L27/58 ,  A61L27/18 ,  C08G18/38 ,  A61L27/40

CPC classification number: A61L27/58 ,  A61L27/18 ,  A61L27/40 ,  C07C319/20 ,  C08G18/3868 ,  A61L2300/40 ,  C07C319/20 ,  C07C323/12

Abstract: A method of making a hydroxyl-terminated thioketal diol is provided, the method comprising reacting a thioketal ester with a non-pyrophoric reducing agent to form a hydroxyl-terminated thioketal diol. The hydroxyl-terminated thioketal diol can be 2,2-(propane-2,2-diylbis(sulfanediyl)) diethanol. The non-pyrophoric reducing agent can be a sodium aluminum hydride, for example, sodium bis (2-methoxyethoxy)aluminum hydride. The thioketal ester can be dimethyl 2,2-(propane-2,2-diylbis(sulfanediyl)) diacetate. A biodegradable matrix prepared by reacting a hydroxyl-terminated thioketal diol with an isocyanate is provided. A method of making a biodegradable polyurethane composite is also provided.