公开(公告)号：US20090062722A1

公开(公告)日：2009-03-05

申请号：US12222994

申请日：2008-08-21

申请人： Wataru Watanabe ,  Yuichiro Asano ,  Yozo Niina

发明人： Wataru Watanabe ,  Yuichiro Asano ,  Yozo Niina

IPC分类号： A61N1/30 ,  A61L15/00

CPC分类号： A61N1/30 ,  A61K9/0009 ,  A61K9/0021

摘要： A drug sheet includes a base fabric carrying a therapeutic agent containing an electrolytic drug component and applied to or impregnated into a skin-abutting surface of the base fabric. Small needle members carrying small needle-shaped protrusions are scattered on the skin-abutting surface so that the needle-shaped protrusions protrude from the skin-abutting surface. The needle members include a first group of needle members made of aluminum and provided on a first area of the skin-abutting surface, and a second group of needle members made of silver and provided on a second area of the skin-abutting surface. Due to a difference in standard electrode potential between the first and second groups of needle members, electric current flows between the first and second groups of needle members through skin when the needle-shaped protrusions are stuck in the skin. This improves the absorption rate of the drug component.

摘要翻译： 药片包括承载含有电解药物成分的治疗剂并且施用于或浸渍到基底织物的与皮肤抵接的表面中的基底织物。 携带小针状突起的小针状部件在皮肤抵接面上散布，使得针状突起从皮肤抵接面突出。 针构件包括由铝制成的第一组针构件，其设置在皮肤抵接表面的第一区域上，第二组由银制成的针构件设置在皮肤抵接表面的第二区域上。 由于第一组和第二组针构件之间的标准电极电位的差异，当针状突起卡在皮肤中时，电流在第一组和第二组针构件之间通过皮肤流动。 这提高了药物成分的吸收速度。

公开(公告)号：US08633219B2

公开(公告)日：2014-01-21

申请号：US11133463

申请日：2005-05-20

申请人： Yuji Matsuzaki ,  Wataru Watanabe ,  Satoru Ikeda ,  Mitsuki Kano

发明人： Yuji Matsuzaki ,  Wataru Watanabe ,  Satoru Ikeda ,  Mitsuki Kano

IPC分类号： A61K31/47 ,  A61K31/675 ,  A61K31/504 ,  C07D401/04

CPC分类号： A61K31/7072 ,  A61K31/39 ,  A61K31/47 ,  A61K31/472 ,  A61K31/496 ,  A61K31/506 ,  A61K31/52 ,  A61K31/536 ,  A61K31/675 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention relates to a combination therapy for treating an HIV infection or inhibiting integrase comprising (S)-6-(3-Chloro-2-fluorobenzyl)-1-(1-hydroxymethyl-2-methylpropyl)-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (“Compound A”) or a pharmaceutically acceptable solvate or salt thereof in combination with at least one other anti-HIV agent. In some embodiments of the present invention, the other anti-HIV agents are chosen from reverse transcriptase inhibitors and protease inhibitors. In certain embodiments of the present invention, the other anti-HIV agents are chosen from AZT, 3TC, PMPA, efavirenz, indinavir, nelfinavir, a combination of AZT/3TC, and a combination of PMPA/3TC. Since Compound A has a high inhibitory activity specific for integrases, when used in combinations with other anti-HIV agents it can provide a combination therapy with fewer side effects for humans.

摘要翻译： 本发明涉及用于治疗HIV感染或抑制整合酶的组合疗法，其包含（S）-6-（3-氯-2-氟苄基）-1-（1-羟甲基-2-甲基丙基）-7-甲氧基-4 - 氧代-1,4-二氢喹啉-3-羧酸（“化合物A”）或其药学上可接受的溶剂合物或其盐与至少一种其它抗HIV剂组合。 在本发明的一些实施方案中，其它抗HIV剂选自逆转录酶抑制剂和蛋白酶抑制剂。 在本发明的某些实施方案中，其它抗HIV剂选自AZT，3TC，PMPA，依法韦仑，茚地那韦，奈非那韦，AZT / 3TC的组合和PMPA / 3TC的组合。 由于化合物A对整合酶具有高的抑制活性，因此当与其它抗HIV剂组合使用时，可以提供对人类副作用较少的组合疗法。

公开(公告)号：US20120189349A1

公开(公告)日：2012-07-26

申请号：US13350076

申请日：2012-01-13

申请人： Yuusuke Okuno ,  Wataru Watanabe

发明人： Yuusuke Okuno ,  Wataru Watanabe

IPC分类号： G03G15/08

CPC分类号： G03G15/0893 ,  G03G15/0189 ,  G03G2215/0132

摘要： A trickle-type developing device comprising: a stirring and conveying tank provided with stirring and conveying screws that circulate the developer; a discharge member via which a part of the developer is conveyed from the tank to a discharge opening through which the developer is discharged, the discharge opening being provided in the discharge member; and a reverse flow generating screw provided inside a portion of the discharge member, sharing one of rotation shafts of the stirring and conveying screws, and pushing back a part of the developer, wherein the portion has a reduced-radius part and in a cross section thereof perpendicular to an axial direction of the one of rotation shafts, an inner radius of the portion is smaller in the reduced-radius part than in the remaining part, the reduced-radius part being located in a lower part of the portion with respect to a vertical direction of the portion.

摘要翻译： 一种涓流型显影装置，包括：搅拌输送箱，设有搅拌和输送螺旋，使显影剂循环; 排出构件，一部分显影剂通过该排出构件从储罐输送到排放开口，显影剂通过该排出口排出，排出口设置在排出构件中; 以及设置在排出构件的一部分内的反向流动产生螺钉，共享搅拌和输送螺杆的旋转轴中的一个，并推回显影剂的一部分，其中该部分具有缩径半径部分和横截面 其中所述部分的半径与所述一个旋转轴的轴向垂直，所述半径部分的内半径比其余部分小，所述缩径部分位于所述部分的下部相对于 该部分的垂直方向。

公开(公告)号：US20100206190A1

公开(公告)日：2010-08-19

申请号：US12680086

申请日：2008-09-26

申请人： Motoshi Aoyama ,  Wataru Watanabe

发明人： Motoshi Aoyama ,  Wataru Watanabe

IPC分类号： B41L25/00

CPC分类号： B41F7/30

摘要： It is, therefore, an object of the present invention to provide a spray dampener which prevents the foreign matter such as ink mist from being introduced into the spray dampener and prevent the dampening water in the spray dampener from being leaked outside that.The spray dampener includes a pair of partitioned spaces. The partitioned spaces are formed along the edges. The spray dampener includes a plurality of air nozzles. The air nozzles are received in the partitioned spaces and spaced from each other longitudinally of the dampening water roller to spout compressed air toward the outer surface of the dampening water roller.

摘要翻译： 因此，本发明的目的是提供一种喷雾阻尼器，其防止诸如墨雾的异物被引入喷雾阻尼器中并防止喷雾阻尼器中的润版水泄漏到该喷雾阻尼器外部。 喷雾阻尼器包括一对分隔空间。 划分的空间沿边缘形成。 喷雾阻尼器包括多个空气喷嘴。 空气喷嘴被容纳在分隔空间中，并且与润湿水辊的纵向间隔开，以朝向润湿水辊的外表面喷出压缩空气。

公开(公告)号：USD532338S1

公开(公告)日：2006-11-21

申请号：US29238414

申请日：2005-09-16

申请人： Takehito Arai ,  Tetsuya Ozasa ,  Wataru Watanabe ,  Hiroyuki Tokuda

设计人： Takehito Arai ,  Tetsuya Ozasa ,  Wataru Watanabe ,  Hiroyuki Tokuda

公开(公告)号：US20050054645A1

公开(公告)日：2005-03-10

申请号：US10958225

申请日：2004-10-05

申请人： Susumu Miyazaki ,  Susumu Katoh ,  Kaoru Adachi ,  Hirotaka Isoshima ,  Satoru Kobayashi ,  Yuji Matsuzaki ,  Wataru Watanabe ,  Kazunobu Yamataka ,  Shinichi Kiyonari ,  Shuichi Wamaki

发明人： Susumu Miyazaki ,  Susumu Katoh ,  Kaoru Adachi ,  Hirotaka Isoshima ,  Satoru Kobayashi ,  Yuji Matsuzaki ,  Wataru Watanabe ,  Kazunobu Yamataka ,  Shinichi Kiyonari ,  Shuichi Wamaki

IPC分类号： A61K31/4985 ,  A61K31/519 ,  A61K31/53 ,  A61K31/551 ,  A61P31/12 ,  A61P31/18 ,  A61P43/00 ,  C07D471/04 ,  C07D487/04

CPC分类号： C07D471/04 ,  C07D487/04

摘要： The present invention relates to a nitrogen-containing fused ring compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof, and an anti-HIV agent containing such compound. The compound of the present invention has an HIV integrase inhibitory activity, and is useful as an agent for the prophylaxis or treatment of AIDS, or as an anti-HIV agent. In addition, by the combined use with other anti-HIV agents such as a protease inhibitor, a reverse transcriptase inhibitor and the like, it can be a more effective anti-HIV agent. Becuae it shows integrase-specific high inhibitory activity, the compound can be a pharmaceutical agent safe on human body, which causes only a fewer side effects.

摘要翻译： 本发明涉及由下式[I]表示的含氮稠环化合物，其中每个符号如说明书中所定义，或其药学上可接受的盐和含有该化合物的抗HIV剂。 本发明的化合物具有HIV整合酶抑制活性，可用作预防或治疗AIDS或作为抗HIV剂的药剂。 此外，通过与其它抗HIV剂如蛋白酶抑制剂，逆转录酶抑制剂等的组合使用，它可以是更有效的抗HIV剂。 它表现出整合酶特异性的高抑制活性，该化合物可以作为人体安全的药物，这只会减少副作用。

公开(公告)号：US5031475A

公开(公告)日：1991-07-16

申请号：US470852

申请日：1990-01-26

申请人： Kazuki Takai ,  Takahiro Asano ,  Wataru Watanabe

发明人： Kazuki Takai ,  Takahiro Asano ,  Wataru Watanabe

IPC分类号： G11B15/10 ,  G11B15/18 ,  G11B15/44

CPC分类号： G11B15/1883 ,  G11B15/106 ,  G11B15/442 ,  Y10T74/20238

摘要： A power mechanism used in a tape recorder for mode changes, etc. does not use a solenoid plunger, but uses a simple arrangement which includes a select plate having a swing portion which swings between a shift position for shifting an operated member and a release position for releasing the operated member when the select plate advances with a rotating force of a power cam and includes a guide mechanism for guiding the swing portion toward the shift and release positions.

摘要翻译： 在磁带录音机中用于模式改变等的功率机构不使用螺线管柱塞，而是使用简单的布置，其包括具有摆动部分的选择板，摆动部分在用于移动被操作构件的换档位置和释放位置之间摆动 用于当选择板以动力凸轮的旋转力前进时释放操作构件，并且包括用于将摆动部分朝向换档位置引导的引导机构。

公开(公告)号：US4626939A

公开(公告)日：1986-12-02

申请号：US566575

申请日：1983-12-29

申请人： Kazuki Takai ,  Toshihiro Ikahata ,  Wataru Watanabe

发明人： Kazuki Takai ,  Toshihiro Ikahata ,  Wataru Watanabe

IPC分类号： G11B15/675 ,  G11B17/04

CPC分类号： G11B15/675

摘要： An ejection mechanism for a tape player includes a guide arm vertically movably supporting a pack guide, a pack stopper connected to the guide arm for frontward and rearward movement, an ejection link connected to the guide arm, and an inversion spring provided connecting the pack stopper to the ejection link to draw and eject a cassette. The ejection mechanism further includes an ejection member disposed along a lateral wall of the frame and mounted for frontward and rearward movement and biased forward by first revival spring, and an operation member similarly disposed alongside the ejection member and similarly mounted for frontward and rearward movement with respect to the frame and biased forward by second revival spring, and an operation rod coupling the ejection link to the motion operation member. An automatically releasing latch couples the ejection member to the operation member during the inward stroke of the ejection member. At the end of the inward stroke the latch releases to allow the operation member to eject the cassette before return of the ejection member.

摘要翻译： 用于磁带播放器的弹出机构包括：可垂直移动地支撑包引导件的引导臂，连接到引导臂的前后向运动的包装止动件，连接到引导臂的弹出连杆，以及连接包装塞 到弹出链接以绘制和弹出盒式磁带。 弹出机构还包括沿着框架的侧壁设置的弹出构件，其安装成用于向前和向后的运动并且通过第一复位弹簧向前偏置;以及操作构件，其类似地设置在排出构件旁边，并且类似地安装用于向前和向后运动， 相对于框架并且由第二复兴弹簧向前偏置，以及将排出连杆联接到运动操作构件的操作杆。 自动释放闩锁在弹出构件的向内冲程期间将排出构件耦合到操作构件。 在向内行程结束时，释放闩锁以允许操作构件在弹出构件返回之前弹出盒式磁带。

公开(公告)号：US08538300B2

公开(公告)日：2013-09-17

申请号：US13050364

申请日：2011-03-17

申请人： Wataru Watanabe

发明人： Wataru Watanabe

IPC分类号： G03G15/08

CPC分类号： G03G15/0822 ,  G03G2215/0802 ,  G03G2215/0822 ,  G03G2215/0827

摘要： Provided is a housing that encloses: a first developer transport member that transports developer, which includes toner, laterally in a first direction; a second developer transport member that transports the developer in a second direction opposite to the first direction; a first communication passage configured to direct the developer transported by the first developer transport member to an upstream edge, along the second direction, of the second developer transport member; and a second communication passage configured to direct the developer transported by the second developer transport member to an upstream edge, along the first direction, of the first developer transport member. The second communication passage progressively reduces the amount of developer directed through the second communication passage to the upstream edge of the first developer transport member as an inclination angle of the housing increases so that the second communication passage is lower than the first communication passage.

摘要翻译： 提供一种壳体，其包围：第一显影剂传送构件，其在第一方向上横向地输送包括调色剂的显影剂; 在与第一方向相反的第二方向上传送显影剂的第二显影剂传送构件; 第一连通通道，其构造成将由第一显影剂传送构件输送的显影剂引导到第二显影剂传送构件的沿着第二方向的上游边缘; 以及构造成将由第二显影剂输送构件输送的显影剂引导到第一显影剂输送构件的沿着第一方向的上游边缘的第二连通通道。 随着壳体的倾斜角度的增加，第二连通通道逐渐地减少了引导通过第二连通通道的显影剂到第一显影剂传送构件的上游边缘的量，使得第二连通通道低于第一连通通道。

公开(公告)号：US07826070B2

公开(公告)日：2010-11-02

申请号：US11840374

申请日：2007-08-17

申请人： Wataru Watanabe ,  Kazutoshi Takahashi

发明人： Wataru Watanabe ,  Kazutoshi Takahashi

IPC分类号： G01B11/14

CPC分类号： G02B26/127

摘要： As a light beam of a scanning optical system unit is adjusted in the state where the scanning optical system unit is assembled, its adjustment work and the assembly work of the scanning optical system are prevented from being useless. Thus, a scanning optical system adjusting device which can adjust the scanning optical system quickly and at a low cost is to be provided. A scanning optical system adjusting device according to the invention includes a static angle control unit configured to maintain a rotation angle of a rotary polygon mirror in the assembly unit of the scanning optical system at a predetermined angle and make the rotary polygon mirror static there, and a light beam parameter measuring unit configured to measure a predetermined parameter of a light beam reflected by the rotary polygon mirror maintained at the predetermined angle by the static angle control unit.

摘要翻译： 由于在组装扫描光学系统单元的状态下调整扫描光学系统单元的光束，所以防止其调整工作和扫描光学系统的组装工作变得无用。 因此，可以提供能够快速且低成本地调整扫描光学系统的扫描光学系统调整装置。 根据本发明的扫描光学系统调节装置包括静态角度控制单元，其构造成将扫描光学系统的组装单元中的旋转多面镜的旋转角度保持在预定角度，并使旋转多面体镜静止， 光束参数测量单元，被配置为测量由所述静态角度控制单元维持在所述预定角度的由所述旋转多面镜反射的光束的预定参数。